Gene detail

Detailed information of ENSQPTP00000002343.1 in Actinia mediterranea

Genomic Location: chr10:8217674...8226321
NR annotation: XP_001630995.3, D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1 [Nematostella vectensis]
Species Actinia mediterranea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSQPTT00000003018

AGAAGGATGGCTCTTCGTAGCAGTGTGCATTTATCTCGTCTTCTGCACACTCTAGGCCGGAGAAAATTAtgtttaaaatacaaaaatatattttcaagctTAAATGTGAGGCTCAGTGTATGTTTTTATGGAAGTAAAAGGCTTTACAGCTCTGAAAATCAAGTAGAATTGACCAGTGTCCGATATCCAAATGTAAAGAGAGGCGAGTTTGCAAAGGTCACTGATGCCGATATTGCCACATTTGAAAGAATAATCCCAGGGGGTGTGGTGACAGAACCAGGTGAATTAGAGCCTTACAACACTGATTGGCTAAAGATAGTGAGAGGGCAAAGTCAAGTTTTACTCAAACCCAAGACAACTTCACAAGTGTCTGCAATCTTAGGTTACTGTAACTCAAAAAGACTATCATTAGTTCCACAAGGTGGCAACACTGGACTTGTTGGCGGAAGTGTTCCAGTCTTTGATGAGATAATTCTGTCGTTATCCAACATGAATCAAGTCCTTGATCTGGATGAAATATCAGGTATTTTAACATGTGAAGCAGGGTGCATACTTGAGAATCTTGATAATTTTTTAGAAGATAAAGGTTTTATGATGCCACTGGATCTGGGAGCCAAGGGCAGCTGTCATATTGGAGGGAATATTGCCACCAATGCTGGAGGACTCAGACTCTTGCGATATGGATCCCTACATGGTAGTGTACTTGGCCTGGAGGTGGTTTTGGCAGATGGAACAATTCTGGACTGCCTATCCAAAATGAGAAAGGACAATACAGGTTATGATCTAAAGCAGTTATTCATAGGTTCTGAAGGAACCCTTGGTGTGATTACTAAAGCAGCAATACTTGTCCCCAGTAGACCTAAGGCTATCAATGTTGCTTTCCTTGCTTGCGACAactttgaaaatgttttacaAACATTCATGACtgcaaagaaaaaacttggagAAATCTTATCAGCTTGTGAATTTTTGGATGACTACTCTATGACACTAGTTGAAAGGAACTTAGGAATGCACAATCCCATTAGTAAGAGCCCATTCTATGTCTTGGTAGAAACCTCAGGATCGAATGGGGAACATGATGAAGAGaAATTGAATAAATTCTTAGAGGTGGCAATGTCAAGTGGGAGTGTACAAAATGGAACAGTAGCAACTGATATTGCCAAGATAAATGAAATATGGAAAATCAGGGAATCTGTAGCTGAAAGTTTAAAGAAAGAAGGCTACAATTATAAGTACGATCTATCTATTCCAATAACCAAGCTATATGACCTTGTACCTCACATGAGAGAAAGACTTGGACCTGAAGCAACAAATGTCCTTGGCTATGGTCACCTTGGTGATGGGAACCTTCACTTCAACGTCACTAGCCTGGAGTATGATGAAGAACTTGTGAAGGCTATTGAACCATACATTTATAACTGGACAGCTCAATACCGTGGCAGCATCAGTTCTGAACATGGCCTTGGCTTCAAGAAGGCTAAATTCATTCATCTGTCCAAGTCAGAGGaggctgtcaaaatcatgaaaaACATCAAAACCTTGATGGATCCCAATGGTATTCTCAATCCATACAAAACCCTTCCTTgatatcattattaatatatattcggaaatatgtatatacagccaaatatttagaaaaaaaatgcttGGACAAGATAGAAAAATGGTAGCAGGCAAAAGTGACAGGCAGTGATTGAAAAGGCAACTGAAAAGCTACTGGTATTTGTGGTGTGTGCTCAAGTGCAAGGCAAAAGTAAGTGAATGTAGTACAGAACCGGTGAATTCTTCTGAGCTCTATCATATTGATATTAATACAtttgtatatataatattagtCAAGAATATTGTATCTTTAGAATATGTCCTTATGCGGATACCACTTAGAAAGAGCGGCTTTATCTTTCCTATTTTTGCTAAATTATATCCACTAAATTTCAACCCCACTTTTAGCCGTTTGTATCATACTAGTCTGCTATGTTTTCCAatattagcccccccccccccccccccccagtttAAAGGTTCTCTGGAGTCCTTGTTATTATAACTTTTATACAAAGTGCAGGGAGGGGTTGGACAGGATTGTGAGTTATCAAGACCAGCAATGAAGCATGATGGAGGATTCACTGCTGAGGCAAACCAGGAGAAGCAATTTGACCACATGGGGTACAAGCCAACCTCCAAATTATATCAATACTCTTTAACAAACTTTGGGCTGATCAGAATCAGAAACAGATTTAATTAGAATTTAGCAGCTCAAGTTTAGTGTCAATAAGAGGTGCCCATGCCCATGCTTACTAAAACATGGAAGTTTTTAATCAACATCCTTAAGTTAAaacattgttttgaaataGAAACGGCATGAATACTTTTTATACTTTAAAATCTATTTTAGTTTACTTTGCTACATGCTGAGCTAAAACATATCCATAAGTTGTATTATAAAATACGTCAAAATATTCATGAATCTTATCCATGGAATGTCTCTATTCATTCATCTTTATTTATCTTGGTCATTTATCTATGAACTAGTTGTAGACAACATCACTGGTTTCTTtctgaaatgaataaatgaatttaaaa

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
A1L258	D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio OX=7955 GN=d2hgdh PE=2 SV=1
Q8N465	D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3
Q1JPD3	D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=D2HGDH PE=2 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0004170 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02913 all species →	FAD-oxidase_C	FAD linked oxidases, C-terminal domain	Domain	Interproscan
PF01565 all species →	FAD_binding_4	FAD binding domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR051264 all species →	Family	FAD-binding Oxidoreductase/Transferase Type 4	Interproscan
IPR004113 all species →	Domain	FAD-binding oxidoreductase/transferase, type 4, C-terminal	Interproscan
IPR016166 all species →	Domain	FAD-binding domain, PCMH-type	Interproscan
IPR016171 all species →	Homologous_superfamily	Vanillyl-alcohol oxidase, C-terminal subdomain 2	Interproscan
IPR016169 all species →	Homologous_superfamily	FAD-binding, type PCMH, subdomain 2	Interproscan
IPR036318 all species →	Homologous_superfamily	FAD-binding, type PCMH-like superfamily	Interproscan
IPR016164 all species →	Homologous_superfamily	FAD-linked oxidase-like, C-terminal	Interproscan
IPR016167 all species →	Homologous_superfamily	FAD-binding, type PCMH, subdomain 1	Interproscan
IPR006094 all species →	Domain	FAD linked oxidase, N-terminal	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR43716 all species →	D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0050660 all species →	Molecular Function	flavin adenine dinucleotide binding	Interproscan
GO:0071949 all species →	Molecular Function	FAD binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K18204	D2HGDH; D-2-hydroxyglutarate dehydrogenase	EC:1.1.99.39	Enzymes with EC numbers	-	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Actinia mediterranea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Actinia mediterranea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →