Genomic Location: chr1:10877529...10906470
NR annotation: XP_031551320.1, eIF-2-alpha kinase GCN2-like [Actinia tenebrosa]
Species Actinia mediterranea · all data for this species · gene families
| CDS |
| ENSQPTT00000006465 |
| Transcript |
| ENSQPTT00000006465 |
| Protein |
| ENSQPTP00000005304.1 |
| UniProt accession | Description |
|---|---|
| Q9P2K8 | eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3 |
| Q9QZ05 | eIF-2-alpha kinase GCN2 OS=Mus musculus OX=10090 GN=Eif2ak4 PE=1 SV=2 |
| D4A7V9 | eIF-2-alpha kinase GCN2 OS=Rattus norvegicus OX=10116 GN=Eif2ak4 PE=3 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002771 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00069 all species → | Pkinase | Protein kinase domain | Domain | Interproscan |
| PF13393 all species → | tRNA-synt_His | Histidyl-tRNA synthetase | Domain | Interproscan |
| PF12745 all species → | HGTP_anticodon2 | Anticodon binding domain of tRNAs | Domain | Interproscan |
| PF05773 all species → | RWD | RWD domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR016135 all species → | Homologous_superfamily | Ubiquitin-conjugating enzyme/RWD-like | Interproscan |
| IPR016255 all species → | Family | eIF-2-alpha kinase Gcn2 | Interproscan |
| IPR011009 all species → | Homologous_superfamily | Protein kinase-like domain superfamily | Interproscan |
| IPR006575 all species → | Domain | RWD domain | Interproscan |
| IPR000719 all species → | Domain | Protein kinase domain | Interproscan |
| IPR008271 all species → | Active_site | Serine/threonine-protein kinase, active site | Interproscan |
| IPR050339 all species → | Family | Cell Cycle and Stress Response Kinase | Interproscan |
| IPR036621 all species → | Homologous_superfamily | Anticodon-binding domain superfamily | Interproscan |
| IPR045864 all species → | Homologous_superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Interproscan |
| IPR017441 all species → | Binding_site | Protein kinase, ATP binding site | Interproscan |
| IPR041715 all species → | Domain | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | Interproscan |
| IPR024435 all species → | Domain | Histidyl tRNA synthetase-related domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11042 all species → | EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000077 all species → | Biological Process | DNA damage checkpoint signaling | Interproscan |
| GO:0004694 all species → | Molecular Function | eukaryotic translation initiation factor 2alpha kinase activity | Interproscan |
| GO:0006468 all species → | Biological Process | protein phosphorylation | Interproscan |
| GO:0010998 all species → | Biological Process | regulation of translational initiation by eIF2 alpha phosphorylation | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0004672 all species → | Molecular Function | protein kinase activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K16196 | EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 | EC:2.7.11.1 | Protein kinases | ko01001 | deepkoala |
Genes whose expression across the transcriptome samples of Actinia mediterranea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Actinia mediterranea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |