Detailed information of ENSQPTP00000005304.1 in Actinia mediterranea

Genomic Location: chr1:10877529...10906470
NR annotation: XP_031551320.1, eIF-2-alpha kinase GCN2-like [Actinia tenebrosa]
Species Actinia mediterranea · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q9P2K8eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3
Q9QZ05eIF-2-alpha kinase GCN2 OS=Mus musculus OX=10090 GN=Eif2ak4 PE=1 SV=2
D4A7V9eIF-2-alpha kinase GCN2 OS=Rattus norvegicus OX=10116 GN=Eif2ak4 PE=3 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0002771 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00069
all species →
PkinaseProtein kinase domainDomainInterproscan
PF13393
all species →
tRNA-synt_HisHistidyl-tRNA synthetaseDomainInterproscan
PF12745
all species →
HGTP_anticodon2Anticodon binding domain of tRNAsDomainInterproscan
PF05773
all species →
RWDRWD domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR016135
all species →
Homologous_superfamilyUbiquitin-conjugating enzyme/RWD-likeInterproscan
IPR016255
all species →
FamilyeIF-2-alpha kinase Gcn2Interproscan
IPR011009
all species →
Homologous_superfamilyProtein kinase-like domain superfamilyInterproscan
IPR006575
all species →
DomainRWD domainInterproscan
IPR000719
all species →
DomainProtein kinase domainInterproscan
IPR008271
all species →
Active_siteSerine/threonine-protein kinase, active siteInterproscan
IPR050339
all species →
FamilyCell Cycle and Stress Response KinaseInterproscan
IPR036621
all species →
Homologous_superfamilyAnticodon-binding domain superfamilyInterproscan
IPR045864
all species →
Homologous_superfamilyClass II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)Interproscan
IPR017441
all species →
Binding_siteProtein kinase, ATP binding siteInterproscan
IPR041715
all species →
DomainClass II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domainInterproscan
IPR024435
all species →
DomainHistidyl tRNA synthetase-related domainInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11042
all species →
EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATEDInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0000077
all species →
Biological ProcessDNA damage checkpoint signalingInterproscan
GO:0004694
all species →
Molecular Functioneukaryotic translation initiation factor 2alpha kinase activityInterproscan
GO:0006468
all species →
Biological Processprotein phosphorylationInterproscan
GO:0010998
all species →
Biological Processregulation of translational initiation by eIF2 alpha phosphorylationInterproscan
GO:0005515
all species →
Molecular Functionprotein bindingInterproscan
GO:0004672
all species →
Molecular Functionprotein kinase activityInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan
GO:0005634
all species →
Cellular ComponentnucleusInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0005829
all species →
Cellular ComponentcytosolInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K16196EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4EC:2.7.11.1
Protein kinasesko01001deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Actinia mediterranea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Actinia mediterranea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.no expression matrix
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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