Gene detail

Detailed information of ENSQPTP00000014238.1 in Actinia mediterranea

Genomic Location: chr17:7906581...7925288
NR annotation: XP_031567624.1, cullin-5-like isoform X1 [Actinia tenebrosa]
Species Actinia mediterranea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSQPTT00000017552

ATGTCCTTGTTACTGTCCAACAATTCTACCATacaatttgaagaaaaatggCACGATTTACGACCTACAGTTAACAAACTACTCAAACAGAAGCCTGTTACCTCTGAAGAATGGCAGAGTTTATTCTGGGATATACATAAAGTGTGTAACTGGGTAGATAAAGGGTCACAGAAAGTCTACAAGGCTCTTAAAGATGAAGTATTGATATTCATCAGACAAGTACAAGAGAGAGTCCTAAGACATGAAGATGATCATTCACTTCTCAAAGCTTACAATGCAGAATGGAAAAAGTTCTTTACCCAGTGTGATTACCTGCCGAAGCCATTCAGTACTCTAGAATCAAATCTACAGGGAAAGACGGGAAGTGGTGGCAGCAAAAGACCTCTGTCTGATGGAGTCACTGTACAAAAGTTAATGTTGGATGCATGGAACGAGGGTATATTCTCAAGCATTAAAGGTCGTTTACAGTCAAGTGCAATGAAGCTGGTTCATGCAGAAAGGAATGGAGAAGCTTTTGATTCACAACTAGTAATAGGTGTTAGGGAATCTTATGTGAATCTAAGTTCAGATATAACAGACAAATTAAAGATTTACGTAGAAAACTTTGAGAAAGCTTACATTGATGCCACCAGAGAGTTCTACAAGACTCAAGCTTCTGCATACCTCCAGGAAAATGGAGTTCAAAACTACATGAAATACGCTGAAACAAAActaaaggaagaagaagagagaGCTAATAGATATTTAGAGACCAGAAAAGGCTGCAACTCTGTCAGTGCATTGACAGAATGTTGTGTGAATGTTTTAGTCGGTGATTTCAAAGAAACCATCCTTGCTGAGTGTCCAGGGATGATCGCTGATAACGAAACAGAAAAATTACTCCTGATGTTCAAACTAATGGATCGAGTTCCGGGTGGCGTAGACCCAATGATTCAAAGTCTAGAGTCATATATTGTAACGACAGGTCTGGATGATATGATGGCAGCAGCCGAGACCATCACCATGGATTCAGAGAAATATGTCGAGCAGTTGTTAGGCCTGTTTAACAGGTTTAGTACACTGGTAAAAGAAGCATTTAATGATGATCCACGTTTCTTGACCTCTAGAGACAAGGCATTCAAGTCAGTAGTCAATGATATAACAATATTCAAGTTAGAACTACCTAGTAAATCCAAACTTGGGGGTGGCCTGTCAGTCAAACCTCAACCAGAGTCAAGATGTCCAGAACTTCTTGCCAATTACTGCGACATGTTGCTAAGGAAAACACCGTATAGCAAAAAGCTGACGTCAGATGAGATTGAAGCCAAGCTAAAAGATGTGTTATTGGTTCTGAAATACGTGGTTAATAAAGATGTCTTCATGAGGTATCATAAGGCGCATTTAACAAGACGACTCATTCTGGACACATCAGCTGACAGTGAAATGGAAGAGAATATGGTAGAATGGCTCAGGGATGTTGGAATGCCTGCCGACTACATCAATAAATTAGCTCGTATGTTCCAGGACATTAAAGTCAGTGAAGACTTGAACCAGGAATTTAAAAAGAATTACAAGACAAAAGGTGACGTCGCAGATTCTATTAATATCAAGATACTAAACGCGGGAGCCTGGTCGCGAGCCTCTGAAAGGATTCCTGTTTCTTTGCCTACAGATTTAGAGGACTGTATCCCAGAAGTAGAAGAATTTTACCGTAAAAACCACAGCGGACGGAAACTGCAATGGCATCACTTAATGTCTAATGGAGTTATAACGTTTGCTAACAAGATTGGCAAGTTCGATCTAGAAGTAACAACATTTCAAATGTCTGTTCTCTTCGCGTGGAACGAACGACCGCAAGAAAAGATATCATTTGAAAACCTGAGGTTAGCGACCGAATTACCTGATTCTGAATTACGAAAAACATTATGGTCAATGGTAGCTTTATCAAAACTCAAGCGTCAAGTACTCCTCTGCGACTCACCAGTTCGTTCACCCAAGGATTTCACTGACGCCTCTATGTTCCGGGTGAACCAGGAATTCGCTCTGATtaaaaATGGGAAAGTACAAAAACGAGGTAAAGTGAATCTGATTGGAAGACTTCAGCTATCGACTGAGAAAACAAagcaagaagaaaatgaagggATTGTGGCTCTAAGAATTCTAAGAATACagGAAGCGATTGTTAAAATTATGAAAATGAGAAAGCGAATCACAAACGCTGCGCTCCAAACAGAACTGGTGGAAATCCTGAAAAACATGTTTATaccacaaaagaaaatgataaaagaaCAGATAGAATGGCTGATAGAACATAAGTACTTAAAGAGAGACGAAGAAGACATCAATACCTTTATATATCTCGTCTAA

Transcript

ENSQPTT00000017552

GAAAAAGCGAAAAAATCCGGATAGAAAAATGTCCTTGTTACTGTCCAACAATTCTACCATacaatttgaagaaaaatggCACGATTTACGACCTACAGTTAACAAACTACTCAAACAGAAGCCTGTTACCTCTGAAGAATGGCAGAGTTTATTCTGGGATATACATAAAGTGTGTAACTGGGTAGATAAAGGGTCACAGAAAGTCTACAAGGCTCTTAAAGATGAAGTATTGATATTCATCAGACAAGTACAAGAGAGAGTCCTAAGACATGAAGATGATCATTCACTTCTCAAAGCTTACAATGCAGAATGGAAAAAGTTCTTTACCCAGTGTGATTACCTGCCGAAGCCATTCAGTACTCTAGAATCAAATCTACAGGGAAAGACGGGAAGTGGTGGCAGCAAAAGACCTCTGTCTGATGGAGTCACTGTACAAAAGTTAATGTTGGATGCATGGAACGAGGGTATATTCTCAAGCATTAAAGGTCGTTTACAGTCAAGTGCAATGAAGCTGGTTCATGCAGAAAGGAATGGAGAAGCTTTTGATTCACAACTAGTAATAGGTGTTAGGGAATCTTATGTGAATCTAAGTTCAGATATAACAGACAAATTAAAGATTTACGTAGAAAACTTTGAGAAAGCTTACATTGATGCCACCAGAGAGTTCTACAAGACTCAAGCTTCTGCATACCTCCAGGAAAATGGAGTTCAAAACTACATGAAATACGCTGAAACAAAActaaaggaagaagaagagagaGCTAATAGATATTTAGAGACCAGAAAAGGCTGCAACTCTGTCAGTGCATTGACAGAATGTTGTGTGAATGTTTTAGTCGGTGATTTCAAAGAAACCATCCTTGCTGAGTGTCCAGGGATGATCGCTGATAACGAAACAGAAAAATTACTCCTGATGTTCAAACTAATGGATCGAGTTCCGGGTGGCGTAGACCCAATGATTCAAAGTCTAGAGTCATATATTGTAACGACAGGTCTGGATGATATGATGGCAGCAGCCGAGACCATCACCATGGATTCAGAGAAATATGTCGAGCAGTTGTTAGGCCTGTTTAACAGGTTTAGTACACTGGTAAAAGAAGCATTTAATGATGATCCACGTTTCTTGACCTCTAGAGACAAGGCATTCAAGTCAGTAGTCAATGATATAACAATATTCAAGTTAGAACTACCTAGTAAATCCAAACTTGGGGGTGGCCTGTCAGTCAAACCTCAACCAGAGTCAAGATGTCCAGAACTTCTTGCCAATTACTGCGACATGTTGCTAAGGAAAACACCGTATAGCAAAAAGCTGACGTCAGATGAGATTGAAGCCAAGCTAAAAGATGTGTTATTGGTTCTGAAATACGTGGTTAATAAAGATGTCTTCATGAGGTATCATAAGGCGCATTTAACAAGACGACTCATTCTGGACACATCAGCTGACAGTGAAATGGAAGAGAATATGGTAGAATGGCTCAGGGATGTTGGAATGCCTGCCGACTACATCAATAAATTAGCTCGTATGTTCCAGGACATTAAAGTCAGTGAAGACTTGAACCAGGAATTTAAAAAGAATTACAAGACAAAAGGTGACGTCGCAGATTCTATTAATATCAAGATACTAAACGCGGGAGCCTGGTCGCGAGCCTCTGAAAGGATTCCTGTTTCTTTGCCTACAGATTTAGAGGACTGTATCCCAGAAGTAGAAGAATTTTACCGTAAAAACCACAGCGGACGGAAACTGCAATGGCATCACTTAATGTCTAATGGAGTTATAACGTTTGCTAACAAGATTGGCAAGTTCGATCTAGAAGTAACAACATTTCAAATGTCTGTTCTCTTCGCGTGGAACGAACGACCGCAAGAAAAGATATCATTTGAAAACCTGAGGTTAGCGACCGAATTACCTGATTCTGAATTACGAAAAACATTATGGTCAATGGTAGCTTTATCAAAACTCAAGCGTCAAGTACTCCTCTGCGACTCACCAGTTCGTTCACCCAAGGATTTCACTGACGCCTCTATGTTCCGGGTGAACCAGGAATTCGCTCTGATtaaaaATGGGAAAGTACAAAAACGAGGTAAAGTGAATCTGATTGGAAGACTTCAGCTATCGACTGAGAAAACAAagcaagaagaaaatgaagggATTGTGGCTCTAAGAATTCTAAGAATACagGAAGCGATTGTTAAAATTATGAAAATGAGAAAGCGAATCACAAACGCTGCGCTCCAAACAGAACTGGTGGAAATCCTGAAAAACATGTTTATaccacaaaagaaaatgataaaagaaCAGATAGAATGGCTGATAGAACATAAGTACTTAAAGAGAGACGAAGAAGACATCAATACCTTTATATATCTCGTCTAACAGACCGAAGATTATGGAACACGAGGCTGCTTGGGCTGGGCAAGTTGAAGGAAGGCTACTACTATGTGTAAGACATCTAGAAAATGAATCTATTATTTGTTTATGGGAAGCGTCCTGTAGAGTAATTCTCAAACGCTTTCATTGTAATAAGGAGCACGATAATTTGTGCTGCAAATGGGCTCAATCCTTAGAACTGCTaaatatgtgagtagagttgttggTTGGTTGTCAGACTCCTGTGCTTCTATGTTTCTGttattcctcttcctcttcctgcAAGAAGCGACACTTTCATATTCCATTTCAGCAAGGTCTACTAAGTGCTACCCTGacaaaataagaatattttattctatatCTTTTTAATAGGATAATGTGCGTGTATTTTTTTGGTTGCAATTGTATTTGCTTATTGATTGGTTTAGAGTGGAAGCCATTTAAGTGTCGGGGTAGCCTGAATGGCTTCCGTGTAATTGATTTGTATGTATTTCGTAcggcttctgattggtttagaGTGGAACCCATTTAAATGTCAGGGTAGCCTGAATGGCTTCCGTGTCATTGATTGGTAAGATTTTGTAcggcttctgattggttcaaagtttttttttgaagatGCCACAGGAAAAAAGAATATTCTGCATGTTACAGGCAAATTCATTCAATAAATTTGGGGGAAatattacgcccaagctaagGTCACTAATTTAAGTTAAATTTGAATATTAGAAATTAAACGCAATTTCTTTACAATTTAAGCCACCACCAAAAATTTGGAAAATTCTCGCAATTCAgtttttggaatgttggtctCACTAGTGATTGGTCGGAatgtcagccaatcagaaaattttaaatttcatgAAATTTCGCGCCAAAATTGTAAAACGCGAGCGCgcacaaaccaaaaaaaaccgaaacatttttgtaatttttggcTAACAAGAATATATTGTAATAGCAATAATATAAGAAAATGTTCATCTTCCTTAAAAGAAT

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9JJ31	Cullin-5 OS=Rattus norvegicus OX=10116 GN=Cul5 PE=1 SV=3
Q93034	Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4
Q5RB36	Cullin-5 OS=Pongo abelii OX=9601 GN=CUL5 PE=2 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000557 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00888 all species →	Cullin	Cullin family	Repeat	Interproscan
PF10557 all species →	Cullin_Nedd8	Cullin protein neddylation domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR016159 all species →	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	Interproscan
IPR001373 all species →	Domain	Cullin, N-terminal	Interproscan
IPR019559 all species →	Domain	Cullin protein, neddylation domain	Interproscan
IPR036388 all species →	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	Interproscan
IPR016158 all species →	Domain	Cullin homology domain	Interproscan
IPR036390 all species →	Homologous_superfamily	Winged helix DNA-binding domain superfamily	Interproscan
IPR036317 all species →	Homologous_superfamily	Cullin homology domain superfamily	Interproscan
IPR045093 all species →	Family	Cullin	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11932 all species →	CULLIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0006511 all species →	Biological Process	ubiquitin-dependent protein catabolic process	Interproscan
GO:0031625 all species →	Molecular Function	ubiquitin protein ligase binding	Interproscan
GO:0016567 all species →	Biological Process	protein ubiquitination	Interproscan
GO:0019005 all species →	Cellular Component	SCF ubiquitin ligase complex	Interproscan
GO:0030674 all species →	Molecular Function	protein-macromolecule adaptor activity	Interproscan
GO:0031146 all species →	Biological Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Interproscan
GO:0031461 all species →	Cellular Component	cullin-RING ubiquitin ligase complex	Interproscan
GO:0031466 all species →	Cellular Component	Cul5-RING ubiquitin ligase complex	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K10612	CUL5; cullin 5	-	DNA repair and recombination proteins	ko03400	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Actinia mediterranea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Actinia mediterranea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →