Gene detail

Detailed information of ENSSYXP00000007212.1 in Micromussa lordhowensis

Genomic Location: chr3:7952380...7972581
NR annotation: XP_020615185.1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like [Orbicella faveolata]
Species Micromussa lordhowensis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSSYXT00000007556

ATGTCACACAGTGGTATTTACAGTCTTTTTTACTACCATGGAAGGCAATGTTCTTGCCGTCCGGTTGAAGTGTTGTTAGTTTGTATCACTGGAACAGTTTGTTTGTTAAGTTTGAATATCTACGATGCGACACACTCCACAAGTGCACAAAGCGAAAATTCCGGCGAAAAGatttctttACCAGCTGGCTTACATGTTGGTCCTACAAGTTACTTCTTTGCACTTGTATGTATTTATCTTCAATGTAAAAAGCTTATCCATCAAGGATCTTCATATATATTAGGATTTGTGTCTGTGTTTGCTATCTTTTCCTGCGTAGTTTTCAGTTCCATTGTTGCCAATTTATATGGTAGAGATTTTTGGATTGTAAGgGAAGCTTTACCATATTTCTTTCTTCTGAGTGACTTCAATACTGCTAGCTCATTAGTGAGACACACTCTTCAGTCTCCAACATATGATGCAGTGCCTAGCAGGATAGCTGAGAGTATTGCTTGCTTGGGTCCAACTGTCACTCTAAATACTCTTGTGGGAACTTTGGTTATTGGGATTGGAACCCTTTCAGGCGTCATGGAGTTGGAGACCATTTGTCAGTTTGGTTGTTTGTCTCTGGTTACCCATTATGTGATCTTCATGACCTTCTTTCCAGCCTGTCTATCATTGTTTTTAGAGCTGTGCACAGGACAGGGTCACAGTAAACCAAGATGGCAATTAGAGACTACAGATGTCCCAGTGGATGAACTTGAACCCAACCCTGTGGTACAGGGTGTCAAGCTTATAATGTCCACAGGTCTGATGTTAATTCATGTGCACCGATGGTTAATGGTTAAAGGAGATGGCGATGAAAATGTTCATGATGCCTCATTTGAGGAAAGCGGGTTTAAAAGgtttttagaGGGAAACACTGAACAGATTGTAGTGGTAGTGTTTGCTCTTGGCCTAGCAATTAGATACTTGTTAATGGACAATGAGGACAGAATTTATGATCATGTTGAGCACAAGCAAAAAACAATATCCCAAGATCGCAAAGCATTCATTACTGTGGGACTCACTGACCAAGTTGAAGGATCTGACCAAGCCTGTTCAAGCCAAGTGACAAATAGACAAGGAACTTCTGCTCTATTCCTAAAAAATACATGTGAAAAAAGAATGGCTTCAAAAAAGGTTACTAGAACAAGGTCTGATTTCAGTCGTCTGCCAAGAATAGAGTCAGTCGATGAGGCATTTGAAAAAGACTCCACTGATGTTGATGTGAAAACAAAGGTGTTAGATAGAAGAAGAACAGTAAGCGAAGGTGACTGTGCTAATGATTGCCAAATAAGTGATGATAATCAACATCCTCAAGAGCTTCCAAGAGTAGACAGCAGTCCACCAAGAATGGAACACAAAGAACGGAGCTTAGAAGAGTGcaagctgattttgaagcaatcaGATGGAGTGTTTAGCTTGAACGATAAGGAAATACAGATGTTAGTTGAATCTAAAGCCATTCCTGGGCATCAGCTTGAAAAGGTTTTAAAAGATTCAGCAAGGGCTGTAAGGATCAGacGCAGTGTCATATCAAAGAAACTTCCAGCAGCTGCAGATTTGGTTGATCTCCCTTGTGATCACTATGATTACTCTGATGTTGTGGGAGCTTGTTGTGAAAATGTCATTGGTTACATGCCTGTTCCTGTGGGTGTTGCTGGACCTCTTTTGCTTAATGGAGAAAACTATcatgttcccatggcaaccacAGAAGGATGTCTTGTAGCAAGTACTAATCGAGGATGCCGAGCTCTGCTgCTGAGTGGTGGTGTAAGAAGCTCTGTGTTTGGTGATGGCATGACACGAGGACCTGTTGTAAGATTTCCTTCAGCATTACTTGCCAGtgatGTTAAAATGTGGTTAGAAGAGGAGAAAAATTTCATGGAAATGAAACAAGTGTTTGACAGTACAAGCAGATTTGCAAGATTACAGTCTGTGAAAGGTGTGGTAGCTGGTCGCTTGTTATTCATCAGATTCGTAGCAACCACTGGTGATGCTATGGGCATGAACATGGTGTCGAAGGGAACAGAGAAAGCCCTGTCCTGCTTGCATGGTCACTTCCCTACTATGGAGGTGTTAAGTTTGAGTGGAAATGTTTGTACAGATAAAAAGGCAGCGGCGATAAACTGGATTGAAGGCAGAGGGAAGTCTGTTGTGTGTGAGGCTATTGTACCAGGACACATTGTGCACAAGGTATTGAAGACAACAGTGTTTGCGCTTACAGAACTCAATGTCAGCAAAAATCTTGTTGGTTCCGCCATGGCTGGAGCCATTGGAGGATTTAATGCTCATGCTGCTAACATAGTGACAGCAATATTCATAGCCACAGGCCAGGATCCTGCACAGTGTGTTTCTAGTGGCAACTGTATCACTTTATTAGAGCCTTGCGGACCTACTAAAGAAGACTTGTACATCAGCTGTACAATGCCGTCATTGGAGGTTGGAACGGTTGGAGGGGGGACTGTTCTTGGTCCTCAGTCAGCCTGTCTTAAGATGCTTGGTGTTGGTGGAGCCAGCAAATCGGAGCCAGGCAAGAATTCAACAAAATTCGCACAAATTGTGTGCAGCACAGTCCTTGCTGGAGAGTTGTCATTACTTTCAGCTCTTGCTTCAGGTGATCTGGTGAAAAGTCACTTAACACTTAACAGgTCGACAGTAAATCTCTTAGCAGAAGATGCCAGCAAAAATTGTGCAGTGTTATAG

Transcript

ENSSYXT00000007556

CCCCTCAGCTGTTTCGTCATTTTGGCTTAgcaaccaggcagacgttgccTGTCACATAAATTATCATGCAAGAAAGTAGGGAGTAGAAATTTCTTCGGCTTTCGAATTTTATACGTGTCAGACTTTGCCATGTCACACAGTGGTATTTACAGTCTTTTTTACTACCATGGAAGGCAATGTTCTTGCCGTCCGGTTGAAGTGTTGTTAGTTTGTATCACTGGAACAGTTTGTTTGTTAAGTTTGAATATCTACGATGCGACACACTCCACAAGTGCACAAAGCGAAAATTCCGGCGAAAAGatttctttACCAGCTGGCTTACATGTTGGTCCTACAAGTTACTTCTTTGCACTTGTATGTATTTATCTTCAATGTAAAAAGCTTATCCATCAAGGATCTTCATATATATTAGGATTTGTGTCTGTGTTTGCTATCTTTTCCTGCGTAGTTTTCAGTTCCATTGTTGCCAATTTATATGGTAGAGATTTTTGGATTGTAAGgGAAGCTTTACCATATTTCTTTCTTCTGAGTGACTTCAATACTGCTAGCTCATTAGTGAGACACACTCTTCAGTCTCCAACATATGATGCAGTGCCTAGCAGGATAGCTGAGAGTATTGCTTGCTTGGGTCCAACTGTCACTCTAAATACTCTTGTGGGAACTTTGGTTATTGGGATTGGAACCCTTTCAGGCGTCATGGAGTTGGAGACCATTTGTCAGTTTGGTTGTTTGTCTCTGGTTACCCATTATGTGATCTTCATGACCTTCTTTCCAGCCTGTCTATCATTGTTTTTAGAGCTGTGCACAGGACAGGGTCACAGTAAACCAAGATGGCAATTAGAGACTACAGATGTCCCAGTGGATGAACTTGAACCCAACCCTGTGGTACAGGGTGTCAAGCTTATAATGTCCACAGGTCTGATGTTAATTCATGTGCACCGATGGTTAATGGTTAAAGGAGATGGCGATGAAAATGTTCATGATGCCTCATTTGAGGAAAGCGGGTTTAAAAGgtttttagaGGGAAACACTGAACAGATTGTAGTGGTAGTGTTTGCTCTTGGCCTAGCAATTAGATACTTGTTAATGGACAATGAGGACAGAATTTATGATCATGTTGAGCACAAGCAAAAAACAATATCCCAAGATCGCAAAGCATTCATTACTGTGGGACTCACTGACCAAGTTGAAGGATCTGACCAAGCCTGTTCAAGCCAAGTGACAAATAGACAAGGAACTTCTGCTCTATTCCTAAAAAATACATGTGAAAAAAGAATGGCTTCAAAAAAGGTTACTAGAACAAGGTCTGATTTCAGTCGTCTGCCAAGAATAGAGTCAGTCGATGAGGCATTTGAAAAAGACTCCACTGATGTTGATGTGAAAACAAAGGTGTTAGATAGAAGAAGAACAGTAAGCGAAGGTGACTGTGCTAATGATTGCCAAATAAGTGATGATAATCAACATCCTCAAGAGCTTCCAAGAGTAGACAGCAGTCCACCAAGAATGGAACACAAAGAACGGAGCTTAGAAGAGTGcaagctgattttgaagcaatcaGATGGAGTGTTTAGCTTGAACGATAAGGAAATACAGATGTTAGTTGAATCTAAAGCCATTCCTGGGCATCAGCTTGAAAAGGTTTTAAAAGATTCAGCAAGGGCTGTAAGGATCAGacGCAGTGTCATATCAAAGAAACTTCCAGCAGCTGCAGATTTGGTTGATCTCCCTTGTGATCACTATGATTACTCTGATGTTGTGGGAGCTTGTTGTGAAAATGTCATTGGTTACATGCCTGTTCCTGTGGGTGTTGCTGGACCTCTTTTGCTTAATGGAGAAAACTATcatgttcccatggcaaccacAGAAGGATGTCTTGTAGCAAGTACTAATCGAGGATGCCGAGCTCTGCTgCTGAGTGGTGGTGTAAGAAGCTCTGTGTTTGGTGATGGCATGACACGAGGACCTGTTGTAAGATTTCCTTCAGCATTACTTGCCAGtgatGTTAAAATGTGGTTAGAAGAGGAGAAAAATTTCATGGAAATGAAACAAGTGTTTGACAGTACAAGCAGATTTGCAAGATTACAGTCTGTGAAAGGTGTGGTAGCTGGTCGCTTGTTATTCATCAGATTCGTAGCAACCACTGGTGATGCTATGGGCATGAACATGGTGTCGAAGGGAACAGAGAAAGCCCTGTCCTGCTTGCATGGTCACTTCCCTACTATGGAGGTGTTAAGTTTGAGTGGAAATGTTTGTACAGATAAAAAGGCAGCGGCGATAAACTGGATTGAAGGCAGAGGGAAGTCTGTTGTGTGTGAGGCTATTGTACCAGGACACATTGTGCACAAGGTATTGAAGACAACAGTGTTTGCGCTTACAGAACTCAATGTCAGCAAAAATCTTGTTGGTTCCGCCATGGCTGGAGCCATTGGAGGATTTAATGCTCATGCTGCTAACATAGTGACAGCAATATTCATAGCCACAGGCCAGGATCCTGCACAGTGTGTTTCTAGTGGCAACTGTATCACTTTATTAGAGCCTTGCGGACCTACTAAAGAAGACTTGTACATCAGCTGTACAATGCCGTCATTGGAGGTTGGAACGGTTGGAGGGGGGACTGTTCTTGGTCCTCAGTCAGCCTGTCTTAAGATGCTTGGTGTTGGTGGAGCCAGCAAATCGGAGCCAGGCAAGAATTCAACAAAATTCGCACAAATTGTGTGCAGCACAGTCCTTGCTGGAGAGTTGTCATTACTTTCAGCTCTTGCTTCAGGTGATCTGGTGAAAAGTCACTTAACACTTAACAGgTCGACAGTAAATCTCTTAGCAGAAGATGCCAGCAAAAATTGTGCAGTGTTATAGGAGGCCTAGCCACAACTCGATTTTCATTACCACCAAGGGTTAGCAAATGTTGCTGGAAATTACGACAACTGCGAGGCAGTTACTAACGGATCTTCTCGATGTTGCCAACAATTTATCGTCATCCGCATTACACTGATGCCTCATTCTGCCCGAGCTAGAAGCAAGTCGACAAGTTTTACGATAGAAGCCACTGTTTGAGAGCTTCCATTTAATAGTGACACACTGAGGCTTCATTTGCCTGATTCTCACACGGTCTGAGGTCGCACGATCTCAGGAGGGAGTGAGCGAGTGACCTCGGACCGTCTGAGATTCAGATCAGGCTAAGGCTTCGTGTGTAGGCTTAAAAAGTCAGAAGATAGCCGAGACGAGCAGTGACTGAAATCTGTCAATCAGAATGCGGTCATCTTAGATCAATGAAGTCCTATAATCAGTCTTTTATTAACCAGCTTGCGTGGCCCTAGCCTCATCACGCAGTCTTTCCTCTGGAACGTCTTTTGGAGAGATTGCGTGACGTGCCCAAAGGACATCTTCTTAGGAGACTACTcggcccggggggggggggggggggaggagtgccagaaaaattgggtgggggtgtgcgacccgcttcccaaaacccttaccctatttatgatcaaaatctgcgatttttcctaccctatttatgacttgaCCAAATatttgatgtcctatttatgaccgtagCGGCTGGCACAGTTTCCTTATCGATAAcaatgaaaaagtagcttcttccaacAAACATACCCTGTTCAAGACGAGAGCAAAaagcataccctatttatgactaaaatagctgaaaaaccacaccctttggggccgcacatacctatatagcccatataagagagcaccccccccccccccccctgggctACTCGGATACCGTTCTGTGAGAAGCTTTTCTGTGCGGGCCTTGCTATACTT

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
A7Z064	3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Bos taurus OX=9913 GN=HMGCR PE=2 SV=2
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens OX=9606 GN=HMGCR PE=1 SV=1
Q1W675	3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Sus scrofa OX=9823 GN=HMGCR PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0005034 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00368 all species →	HMG-CoA_red	Hydroxymethylglutaryl-coenzyme A reductase	Family	Interproscan
PF12349 all species →	Sterol-sensing	Sterol-sensing domain of SREBP cleavage-activation	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR023076 all species →	Conserved_site	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	Interproscan
IPR009023 all species →	Homologous_superfamily	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily	Interproscan
IPR002202 all species →	Family	Hydroxymethylglutaryl-CoA reductase, class I/II	Interproscan
IPR004816 all species →	Family	Hydroxymethylglutaryl-CoA reductase, metazoan	Interproscan
IPR004554 all species →	Family	Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type	Interproscan
IPR023282 all species →	Homologous_superfamily	Hydroxymethylglutaryl-CoA reductase, N-terminal	Interproscan
IPR000731 all species →	Domain	Sterol-sensing domain	Interproscan
IPR023074 all species →	Homologous_superfamily	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily	Interproscan
IPR009029 all species →	Homologous_superfamily	Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR10572 all species →	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004420 all species →	Molecular Function	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Interproscan
GO:0015936 all species →	Biological Process	coenzyme A metabolic process	Interproscan
GO:0005789 all species →	Cellular Component	endoplasmic reticulum membrane	Interproscan
GO:0008299 all species →	Biological Process	isoprenoid biosynthetic process	Interproscan
GO:0050661 all species →	Molecular Function	NADP binding	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0005778 all species →	Cellular Component	peroxisomal membrane	Interproscan
GO:0016126 all species →	Biological Process	sterol biosynthetic process	Interproscan
GO:0016616 all species →	Molecular Function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K00021	HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)	EC:1.1.1.34	Bile secretion	ko04976	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Micromussa lordhowensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Micromussa lordhowensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →