Genomic Location: chr13:8773179...8802130
NR annotation: XP_020614938.1, DNA topoisomerase 2-alpha-like [Orbicella faveolata]
Species Micromussa lordhowensis · all data for this species · gene families
| CDS |
| ENSSYXT00000020581 |
| Transcript |
| ENSSYXT00000020581 |
| Protein |
| ENSSYXP00000019527.1 |
| UniProt accession | Description |
|---|---|
| P41515 | DNA topoisomerase 2-alpha OS=Cricetulus griseus OX=10029 GN=TOP2A PE=2 SV=1 |
| O42131 | DNA topoisomerase 2-beta OS=Gallus gallus OX=9031 GN=TOP2B PE=2 SV=1 |
| O46374 | DNA topoisomerase 2-alpha OS=Sus scrofa OX=9823 GN=TOP2A PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002381 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00204 all species → | DNA_gyraseB | DNA gyrase B | Domain | Interproscan |
| PF16898 all species → | TOPRIM_C | C-terminal associated domain of TOPRIM | Family | Interproscan |
| PF02518 all species → | HATPase_c | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | Domain | Interproscan |
| PF00521 all species → | DNA_topoisoIV | DNA gyrase/topoisomerase IV, subunit A | Family | Interproscan |
| PF01751 all species → | Toprim | Toprim domain | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001154 all species → | Family | DNA topoisomerase II, eukaryotic-type | Interproscan |
| IPR013758 all species → | Homologous_superfamily | DNA topoisomerase, type IIA, domain A, alpha-beta | Interproscan |
| IPR018522 all species → | Conserved_site | DNA topoisomerase, type IIA, conserved site | Interproscan |
| IPR013757 all species → | Homologous_superfamily | DNA topoisomerase, type IIA, alpha-helical domain superfamily | Interproscan |
| IPR036890 all species → | Homologous_superfamily | Histidine kinase/HSP90-like ATPase superfamily | Interproscan |
| IPR013506 all species → | Domain | DNA topoisomerase, type IIA, subunit B, domain 2 | Interproscan |
| IPR014721 all species → | Homologous_superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Interproscan |
| IPR020568 all species → | Homologous_superfamily | Ribosomal protein uS5 domain 2-type superfamily | Interproscan |
| IPR013759 all species → | Homologous_superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | Interproscan |
| IPR031660 all species → | Domain | C-terminal associated domain of TOPRIM | Interproscan |
| IPR003594 all species → | Domain | Histidine kinase/HSP90-like ATPase | Interproscan |
| IPR002205 all species → | Domain | DNA topoisomerase, type IIA, domain A | Interproscan |
| IPR006171 all species → | Domain | TOPRIM domain | Interproscan |
| IPR013760 all species → | Homologous_superfamily | DNA topoisomerase, type IIA-like domain superfamily | Interproscan |
| IPR050634 all species → | Family | DNA Topoisomerase II Enzyme | Interproscan |
| IPR034157 all species → | Domain | DNA topoisomerase 2, TOPRIM domain | Interproscan |
| IPR001241 all species → | Family | DNA topoisomerase, type IIA | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10169 all species → | DNA TOPOISOMERASE/GYRASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| GO:0003918 all species → | Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0006265 all species → | Biological Process | DNA topological change | Interproscan |
| GO:0006259 all species → | Biological Process | DNA metabolic process | Interproscan |
| GO:0000712 all species → | Biological Process | resolution of meiotic recombination intermediates | Interproscan |
| GO:0000819 all species → | Biological Process | sister chromatid segregation | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K03164 | TOP2; DNA topoisomerase II | EC:5.6.2.2 | Chromosome and associated proteins | ko03036 | deepkoala |
Genes whose expression across the transcriptome samples of Micromussa lordhowensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Micromussa lordhowensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |