Gene detail

Detailed information of ENSSYXP00000031080.1 in Micromussa lordhowensis

Genomic Location: chr8:7834147...7842628
NR annotation: XP_020612582.1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X2 [Orbicella faveolata]
Species Micromussa lordhowensis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSSYXT00000032678

ggaaaaatcaatctAACTCTGGAAaggtcctggaaatttgtttgtgAAAAAGGGTGCAAACCCTGATTTACTCTCTGAATGTTTCTCttggattgtttttttttttctgaatgcCATTCTATAGTGGATGTTAACACAAGTGAGCAATAACTATGGGTTATTGACCTGGTGTGAAGTCAAGATACGATGTGGatatggaaaatacaccactcagGCCCCAGATGTAGTTTCGTATGAAATTTGTAAGTGGTGTATTTTGCAGTAAAACTCTTGCGTCTTATATTACAGTCATGTAGCACATGGATTTCATTGTTTGCAGGTTTCTAGAGGCAAGACATAAAGACcactacaaaatatacaactTGTGTTCAGAAAGACACTATGATCCTGCCAAGTTTAACAACAGAGTCACTGCATATCCTTTTGATCACCACAATGCTCCTCCATTTGAGCTGATTGAGCCCTTCTGTGAAGATGTGGATAATTTTCTGAGTGAAAATGAGAAGAATGTAGCTTTTATCCACTGCAAATCTGGCAAGGGAAGAACAGGAGTAATGATTTGTGCCTACCTGCTTCATAAACATCACTTTAACGACAGTAATGAGGCCTTGAAGTATTACGGAGATGCAAGGACAAGAAATGCCAAAGGTGTTACCATTCCCAGTCAGCGGAGATATGTCCTGTACTACAATCATGTGCTAAGACAGGACTTACAATACACACCGACCATGGTGCTACTCAAGCGCTTTGAGATGCTCTCCAGGAACACGTTCCAAAACTCCACTTTCAATCCATATTACATTATTTGGCAGCAGAAAGTTAAGTTGTACCAATCCAAAGTTGATGAGgGAAAGAAATCTGTTAATGGGTTTTTATTTGAGCCAAGCCAACCAGTTTCAATTTGTGGTGATATCAGGGTAGAATTTTTCAACAAGGACATGTTCAAAAAGGAGAGAATGTTCCAGTTTTGGTTTAACACATACTTCATAAGTCAACAAGCTACTGATGTGGAACAACTTTTTGAGGATGAGCCAACCCTTAGAATAGTAAAGCTTGATCCTGATTTGTGCTATTTTGATGTTGGCAAGGAAGATCTTGACAAGGCACACAAAGATGCCAAGGAAAAGATTTACAACAAAGATTTTAAGGTTCGAGTCACGTTTTCGGAGGCCGATTCTGTTGCTCCATCATCAAGTGCATCATTACCAAGGAAATCTGAAGTAGTTAAACCAAGGCATAAAAAGAGTCGCTCCATGGATTCATTTGACCGAGAAGATATGGCCAGCATTAATAATGAAGAAGATAACTTTTCCGATACTGATAATGAGGAACAGTGGGAAGAGGAATCAATGTTGGCAGTAACGCAAACGACATATGTTTGAGAAAGAAACAATTGAATGGAAATTGCCAGTGTTGAGAATAGTGTCCTTTTgccttattgttttagtattaatctacatgtacacaatGTACTAACTAGTTGTTGAAAATGTTAACTAAATTTCCTTCACAGACACTtagaaaacgcaaagaagcggctcCCAGCGCACACTgccacgctactcactatctacaacagaatagatagtgagtagtgtagccaatcagagaacggcagaACGgcgtgatagaatgctagtagatttatactaatcgCTGATAGATTAGGTGCACTCATGCTCTTCAAACTGAATCAGAAATGTTTTTAGATGTATCTGTATGTCATTATAAttgtcatcattgtcatcaccaccatcatcatcattgttgtTGTCAccgttatcattatcatcagcTCTCTTCACTTTAGTAGGCACACCATGCCATATATCTTGTACATGTTTGTGAATGTAAACGTAGACCTCAGTAATAAGGCATAGTTCTTTGATCAGTTTTTTGCTgggaaattgaaatttaaagGGGTGGAACAAGTTGAGTTCCTTACcaattacattaaaatacttttctagctatgttataatagcAGACAAGATATGGCAAGACCATAGTCTTCATTTTATAGACTGGAGTATGTTATGCAGTTTATCACAAAGAATGGTTTTTCTGGGTTTCGATAAGTTTTTGTAATGATGATCAATTCATCTGCGTTATAAGATGAAGagtttaattaaaaacataattaaATGAATTTTTGTTACACTGTGGGAGAAATATTGTTGATTTATCAGATtgataactacttattaaccaagagtgaggACTTTACGGGAAATTCTCAGAccaagaccttgccgtattgactgaGCGATAGTGAGGTCAATACGCCAAGGCCGAGGTTGGAGATTTTCCCATTGAACGTCGAGGTTAAAAAGCTGTTTATtgtatggctttttgctttgttttttccAGGCCCATTATCG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Canis lupus familiaris OX=9615 GN=PTEN PE=2 SV=1
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1
O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Mus musculus OX=10090 GN=Pten PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001472 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF10409 all species →	PTEN_C2	C2 domain of PTEN tumour-suppressor protein	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR029021 all species →	Homologous_superfamily	Protein-tyrosine phosphatase-like	Interproscan
IPR014020 all species →	Domain	Tensin phosphatase, C2 domain	Interproscan
IPR000387 all species →	Domain	Tyrosine-specific protein phosphatases domain	Interproscan
IPR016130 all species →	Active_site	Protein-tyrosine phosphatase, active site	Interproscan
IPR051281 all species →	Family	Dual-specificity lipid and protein phosphatase	Interproscan
IPR029023 all species →	Domain	Tensin-type phosphatase domain	Interproscan
IPR003595 all species →	Domain	Protein-tyrosine phosphatase, catalytic	Interproscan
IPR035892 all species →	Homologous_superfamily	C2 domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12305 all species →	PHOSPHATASE WITH HOMOLOGY TO TENSIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0016311 all species →	Biological Process	dephosphorylation	Interproscan
GO:0004725 all species →	Molecular Function	protein tyrosine phosphatase activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006470 all species →	Biological Process	protein dephosphorylation	Interproscan
GO:0008285 all species →	Biological Process	negative regulation of cell population proliferation	Interproscan
GO:0014065 all species →	Biological Process	obsolete phosphatidylinositol 3-kinase signaling	Interproscan
GO:0016314 all species →	Molecular Function	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Interproscan
GO:0042995 all species →	Cellular Component	cell projection	Interproscan
GO:0046856 all species →	Biological Process	phosphatidylinositol dephosphorylation	Interproscan
GO:0048870 all species →	Biological Process	cell motility	Interproscan
GO:0051896 all species →	Biological Process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01110	PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	EC:3.1.3.16 EC:3.1.3.48 EC:3.1.3.67	Protein phosphatases and associated proteins	ko01009	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Micromussa lordhowensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Micromussa lordhowensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →