Gene detail

Detailed information of ENSSYXP00000041770.1 in Micromussa lordhowensis

Genomic Location: chr5:561917...587848
NR annotation: XP_020621594.1, peripheral plasma membrane protein CASK-like isoform X2 [Orbicella faveolata]
Species Micromussa lordhowensis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSSYXT00000043995

ATGGAGGACGGTTTTCCAGCTCGGTTCGACCTTCAAGAGCAAATCGGAAAAGGGACCTTCAGTGTCATTCGACGATGCTTCGACAAGAGGAGCGATCGAGTGTGTGCGGTGAAAATTGTGGACCTTGCGAAGATGTCATCTTCCAGTGGTCTTACAGAGGAAGATTTACAAAGGGAGGCCCGCATTTGTCAGAAGTTGCGCCATCCACATATCgTGGAAATTATAGGAGCTTACTCAATGGATGGCTATATTTACATGGTGTTTGAGTACATGGATGGTGcagatttgtgttttgaaatagTGAATCGTGTTCACGCAGGTTTTGTTTACAGTGAAGCTGTAGCAAGTCACTACCTCAGACAAGTTCTGGAAGCAGTGTCTTTCTGTCATGAAAATGACATTATTCACCGTGACCTCAAGCCTCACAACATTCTATTATCAAGTAAGGAGAATTCAGCTCCAATCAAGATCGCTGACTTTGGTGTCGCTACAGAAATTGGGGAAGAAGGATACGTCACAAGTGGTCGCATAGGAACACCACATTTTATGTCGCCAGAGGTAATAAACAGGGAACAGTATGGGAAACCTGTGGATGTTTGGGGATGTGGTGTAATCCTCTTTATTCTTGTGAGTGGATCCTTCCCGTTCCATGGCACAGGAGAAAAAGTATATGACTCTATCAAGAAAGGCATCCCCACGATGAGAGCCAAAATTTGGGACAATATTTCTGATGAAGCAAAAGATTTAGTGAAGCAGATGCTGACACATGATCAGAATGACAGACTGACAGCACGGGAAGCACTTCAGCATCCATGGCTAAGTAATCGCAATGTGCCTCAGAGAATGCATCTTCAAGACTCAGTAGATGAAATGAAGAAGTTTAATGCAAGAAGAAAATTGAAGGATGATGTTTTCGAGTATGAGGATGATGACTTGTCGGCTTCAGGCGCTATTGGCCAGCTTCTTGACTCACTGGAGGAGATCCAAGTTCTTACTGGAGCGAACGACGACGATGTAAACTTTTTACAAAGCTTTTTCGAACATCAAACGCTGCAAGCTTTACTTGAGGTCTACGATAGAAGTCAGGAATGGACAGATGAAAATCGGACTTGTCCGTCAACGTCCTCTCCGAGCGCTGTACAAGACGCAAAAGAGGTGGTTGAACTGATCGAGTTTCGGGCAGAAGACGACGACGATTGTTACGAGTTACAAAATATCTTGTCGGACCCTCATGTCATGGCAATGTTGCAATCACACGATGAGGTCCTGAGAAACACTTCATCAGGTGAAGAAGTCAATCCATATCAGCCCGAGAATACAACTCAGTACAGCAGCAGGATGGATGACTCTGTAGGAGATCGACCGGAAAAACTAACGCGTGTTCGACTTGTCCAATTTCACAAGAACCTCAACGAACCTATGGGCATCACTCTTAAGCTAAATGAAGAGGCAAGATGTATTGTGGCTCGGATCATGCATGGCGGAATGATTCACAGACAAGGCACGCTACATCCAGGAGACGAAATCAGGGAAATCAATGGAGTAAACGTAGCGGATAAATCAGTGGAAAATCTTCAAGCCATTTTGCGTGACGCAAGTGGAAACGTGACGTTCAAAATCGTACCAAGCTCAAGAAATGTCACGCAAGTTTCTGAGGTGTTCGTGCGGGCGCTGTTTGATTACGACCCCAGAGGGGATGACCTAATTCCGTGCCAGCAGGCTGGGTTATCCTTCACGTGTGGGGATATTATTCAAGTGGTGAGCAAAACTGACCCATATTGGTGGCAGGCTATGAAAGCTGATGATAAAGACGGTTTTGCTGGACTCGCTCCCTCGCCCGAGTTACAGGAATGGTTAGTATTCCGAGACTTTGCCGAGTTCTTCCGATTAAAATCGTATGCTGTCGGAATTGAGTCGGCAAATACAACATGCATCTGGTtcaacaagaagaagaagagtgGACGGGATAAATACGTCGCCAAGCATAACGCAGtgttCGATCAGCTTGATCTGGTTACTTACGAAGAAGTGGTTAAGCTTGATTACTTCAAACGAAAGACTCTTGTTCTTCTTGGGGCCCATGGTGTCGGAAGAAGGCATATAAAAAACACGCTCATCAATAAATACCCCGAAAGATTTTCTTACCCGATTCCTCATACAACACGAGAACCAAAAGACGGTGAAGAAGACGGAAAGAATTATTTCTTCGTCTCCGCCGAGGACATGTTATTGGACATAGAAGCCAACAAGTACCTGGAGTATGGAACTCACCAGGGGGCCATGTATGGCACCAAACTCGACACGATAAGGGACAATCTCAACCAGGGCCTTACAGCCATACTCGACGTGGAACCTCAGgcGCTCAAGGTTCTTCGGACGGCCGAATTCTCTCCGTATGTCGTCTTCATCTCGGCGCCAACTATTGTGGGAAACGACAGCATGAAAGGGTCGTCCACGCCAAATGGAGATCTTGCTGACGAAAGTCTTCAGCGGCTTGCCAAAGACTCGGACTCACTCCGCCAGTCTTACGGACACTTGTTCGATCTGACAATTGTCAACAACGATATCGACGACACCATACGGCTGCTGGAGGACGATCTCGAACGTCTCCGCAGAACACCGCAGTGGGTACCCGTGTCGTGGGTGTACTAA

Transcript

ENSSYXT00000043995

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O14936	Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3
O70589	Peripheral plasma membrane protein CASK OS=Mus musculus OX=10090 GN=Cask PE=1 SV=2
Q62915	Peripheral plasma membrane protein CASK OS=Rattus norvegicus OX=10116 GN=Cask PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000786 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00018 all species →	SH3_1	SH3 domain	Domain	Interproscan
PF00069 all species →	Pkinase	Protein kinase domain	Domain	Interproscan
PF00595 all species →	PDZ	PDZ domain	Domain	Interproscan
PF02828 all species →	L27	L27 domain	Domain	Interproscan
PF00625 all species →	Guanylate_kin	Guanylate kinase	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001452 all species →	Domain	SH3 domain	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR036034 all species →	Homologous_superfamily	PDZ superfamily	Interproscan
IPR001478 all species →	Domain	PDZ domain	Interproscan
IPR020590 all species →	Conserved_site	Guanylate kinase, conserved site	Interproscan
IPR017441 all species →	Binding_site	Protein kinase, ATP binding site	Interproscan
IPR036892 all species →	Homologous_superfamily	L27 domain superfamily	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR008271 all species →	Active_site	Serine/threonine-protein kinase, active site	Interproscan
IPR008145 all species →	Domain	Guanylate kinase/L-type calcium channel beta subunit	Interproscan
IPR036028 all species →	Homologous_superfamily	SH3-like domain superfamily	Interproscan
IPR050716 all species →	Family	Membrane-associated guanylate kinase	Interproscan
IPR004172 all species →	Domain	L27 domain	Interproscan
IPR008144 all species →	Domain	Guanylate kinase-like domain	Interproscan
IPR014775 all species →	Domain	L27 domain, C-terminal	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR23122 all species →	MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0005102 all species →	Molecular Function	signaling receptor binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0005911 all species →	Cellular Component	cell-cell junction	Interproscan
GO:0034613 all species →	Biological Process	protein localization	Interproscan
GO:0046928 all species →	Biological Process	regulation of neurotransmitter secretion	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K06103	CASK; calcium/calmodulin-dependent serine protein kinase	EC:2.7.11.1	Cilium and associated proteins	ko03037	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Micromussa lordhowensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Micromussa lordhowensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →