Gene detail

Detailed information of ENSVBPP00000023643.1 in Meandrina meandrites

Genomic Location: chr2:38355030...38395600
NR annotation: PFX34909.1, Protein unc-13-like B [Stylophora pistillata]
Species Meandrina meandrites · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSVBPT00000024651

ATGCCAATTTTAAGTGTGCTTGAAAAAGCGAGTTCATTTGTTCGTGTGATTCTTCAAAATGTCACCTTGGAGACAGAAGTTTGCAAAGGAATCTCTCCAACATGGGAACAAGAATTTGTCTTTGAGACCAACCGTCTGGACCAGACACTCTGTTTTCAACTGTGGGAGAAAGGATTCTTCAAGGACAACCTGCTAGGAAGTGCATGGATTCCGTTGATGCAGATCCATCATTCAAATGTGGATGGGAGTGGTGCGTGGGTTCAGCTGAGCAATGAATCATCCAAAGGCCTAGTGTCTTCAGGCCACCTGTTGCTTGTAGACACTCGGTTCGAACTGCCATCAGGGCTTTCAGAAGAAGAGGCTCTAGCCCTCCAAAATAAACTGGATTCATTTTACACCATCATGAATCAGGAAATGGAAGTCTTAAAGGAGCAAGCCAGGAAAGTACAAAGAGAGAAGGATATAAAGAACTTTAATGATGAATTAGACAGTGCGTACACAAGTGATGCAGCCATGTACAATCCATATTTGGACTCAGACCCAGAAACAAATGACCAAGATTCCGATGACATTCCTGATGGACGTTTCAGTGACAGCGAAGCTGACAGAGACAGACTGATGATCAATTACACAGATCATTTTGAAACTAGTGGACGCACCTCTGATGACATCCGTGAAGAACTGgaagaagaagtggaagaaGACAGTATGTTGCAAACATCTGTTTTGCCTGAGAGCCAGCAAGGAGAAGAGGAAGATTATTTCTTGGAAGAATTTGAGTCAAGCGTGGAGGTAACTGAAATCTTTGATGATGATGCAGTCATCACTGAAATAGATGCAGAAAAAATGGAATTAACATTAAAGAAACCAGAGGAAGGCGATgaaactgatgatgatgataacgaCAGCCCAGACAAAAATGGTCCTCTGCGACGAAAGGGAGGCTTCAGAGTATCTCCAGGAACCACACGGAAATCATCttggAATGCAAAAACTAAAGCACTTCTCAATTCTGCAAATTCTGGCTCCCTGATAAGGAAAAGAAGGCCCTCGATTCCTATTAAACTTCATGTTTATAAGAAGACACTCCAGGCACTTATTTATCCCATATCAGATACTACACCTCACAGATTTGAGATCTGGTCAACTCAAGTACCAGCCTATTGCTATGAGTGTGAAGGTCTTCTCTGGGGTCTGGCCAGACAGGGGCTTAAATGCAAAGAGTGTGGAGTCAAGTGTCATGAGAGGTGCAAGGACTTGTTGAATGCTGATTGTTTGCAACGTGCTGCCGAGAAATCAGCCAAACACGGTACAGATGACAAAACACATTCCATCATTGTTGCAGCTATGAAGGGGCGAATGGAAACCCGAGAAGCGACTAGACCTGAAATATTTGAACAAATCAGTGAAGTGTTCCATATGGAGCCAAAAACACATGCTGGACACATGAAAGCCGTCAAAAACTTGATCCTTGATGGAACATCAAAGTGGTTGGCAAAAATATTCATCACAGTTGTGAGTGCACAAGGACTCATTGCCAAAGATAAAACAGGTACAAGTGACCCTTATGTGACAGTTCAGATCGgcagaacaaagaaaagaacGAAGACCATTCCTCATGAGCTGAATCCAGAGTGGAATGAGACCTTTCCATTCGAGTGTCACAACTCTTCTGATAGAATCAAAGTGCGTGTTTGGGATGAGGATGATGATATCAAAGCTAGAGTAAGATCAAAACTTATCAGAGAGCCTGATGATTTCCTTGGACAGACGATCATTGAAGTGCGGACACTCAGTGGGGAGATGGATGTGTGGTACAATCTAGAAAAAAGAACAGACAGATCAGCTGTGTCTGGTGCAATACGTCTCAGAATCAGTATTGAgatcaaaggagaagagaaggTCGTGCCATATCACCAGCAATACACCTGCCTACATGAGAATATCTTTCATTTCTTATGTGAAAAGAACAGTGGTCAAGTTCCGCTTCCAGTGTCTAGCTCAaGAGAAGATCCATGGAAAGTGTTTTTCCCACAACCAGCTCTTGAAATAGTGAATGAGTTTGCCATGCGATATGGAATTGAAAGTATCTATCAAGCGATGACCCACCTGTCATGCCTCACAGCTTGTTACATGTGTCCAGGTGTCCCAGCTGTCATCAGCAGTTTGCTTGCAAACATCAATGCTTTCTTCTCTCACACCACAGCAAACTCTGCCACGTCAGCTTCACACAGATTCACCTCCACAAACTTTGGGAGTGAAAAGTTTGTGAAGATTGTAGATCATCTTTACAACACATTGAGAATTGACATCGCAAACTACAGGACAAACTTTCCCTCATCCAGCGCTGAGAAGCTGGTTGATTTAAAGTCCTCTGTTGATCTGTTAACAAGTGTCACCTTTTTCAGAATGAAGGTCCTCAGTCAGCGACCCACCAGGACAGCAGAAATTGTGCGCGAGTGTGTTAAGAATTGCATGAAAGGAAGCTATGCATATCTCTACGCAAACTGTGCTGAGTTGTATGACAGAGAGCTTGCTACAGAAAGCTCATCATTAGATCCAAATGTTACACAAGCTGGTCCTAAGAGCCTGGACTTTTGGCCAAAACTGATTTCACTGGTCGTGTCTGTGATTGAGGAAGACAAGAGTATCTATACACAAGTTCTTAACCAGTTTCCAACTGAGCTGAATGTAGGAGAAGTCAGTGCACAAGTGTTTTGGAATATGTTCTGTTCAGACCTGCAGGAAATGTTAAAAGAACACAGCTTGCGGCAACAGTCTCGATGGAGTAGTGCTGATTATATGAACCTTCACTTCAAGGTCAAGTGGTTTTACAATGAGTTTGTCAGTCATTGTCCAGAACACAAAGGCAAAGTGCCAGAGTATCCAAGCTGGTTTGAGCCATTTGTTTCCCAGTGGCTGACTGAAAATGACGAAGTTTCTATGGAATTCATGATTGGAGCACTTGAAAGAGACAAGAGAGATGGGTTTCCTACCAGTTCACCTCACACTTTGTTCTCAAATTCAGTGGTTGACATATTCTGCTCACTGAATCAGAGCTTTGAGATTGTTCGGAAACTTGACTGTCCAGATCCAGAAATCCAGACTCGCTACGTCATCAAGTTTACCATAACTGTACAGAATGTTTTGCTTCAATATGCTGAGAAAATCATCAAAGAATTCAGTACTTGGTGTGAGCAGGGGAAAACAGCCTGCATTCTGATGAACAACATACAACAACTACGAGTTCAACTAGAGAAGCTTTATGAAACAATGGGCGGAGGAGAAAAGCTTTCCCCAGAGTGCAGTGAAGTGTTCAAAGAGCTGCAAGTCAAACTCAATCTTACTCTTGATGAACTGTGTGTTGTATTTGTTCAAAGCCTTGATTCCAAAATACAAGAAAGTGTAAAAGGTGTTGGAAACTTGTTGTTCAAGATTAAAAGCACTGGAACCTTTAATCCTGCTTTGCCTAGTAGTAAAGTGGTGATTCAAAATGACTCAGAGTCAATTCTCCAACCACTGCTGGGAATTCTCGAAGGAAGCTTGGAACTTTTTTACAATGCTTGTGAAAAAACAGTGCTAAAAAGATTACTTAAGGAACTGTGGAAGATTGTCATGGTCAGTATTGAGAAGATTATTGTTCTGCCACCTCTACCAGATATCAAGGAGATGGGAGGAATAACGGGACAATCAGATTCAAGAAACATGAGTCTAAAACAGTGCGCGGTGCTGGAATCTGCGCTTGTAAGGATAAAGGATTACTTCCATGCCTCTGGCAATGGACTGAAGAAGACGTACTTGGACAAGTGTATACACTGCCAGTCTCTCAAATCAGCATTATCTCTGTACACACAGACCACTGATACACTTATTAAAGAATTTGTCAAGAGTCAGACTTCACAAGAGGATCCAGGAGTTGATGACCCAGTGGGGGAGGTGTCAGTGCAAGTGGATCTGTTCACCCACCCTGGGACAGGAGAACACAAGGTTACTGTTAAAGTTGTCGCTGCCAAAGACTTGAGATGGCAATCACCTGGGATGTTCCGTCCTTTTGTAGAAGTGAACATTGTGGGTCCCAGTCTCAATGGGAAGCGACGTAAATATTCAACGAGGTCGAAAAACAACAACTGGTCTCCAACGTACAACgaaacatttttctttATCCTAGGCAACGAAGATGACCTCGACTCTTACGAGCTTCAGATATGTGCCAAAGATTACTGTTTTGCTCGTTCGGACAACCTCGTAGGCATGACAGTACTGCATCTGAAGAACATTGCCGAGATGGGCTCGTGCGCGTGTACGCCAGCTCTTGGTCGTTACATCCAAATGGACTCGAAGGGATGGACTATTCTGAAGATCCTTTCACAAAGAATGAACGATGAAGTTGCTCGTGAGTTTGTACTGCTCAAAAATAACAGTCGATCTGAGGGATTTGATTGA

Transcript

ENSVBPT00000024651

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9Z1N9	Protein unc-13 homolog B OS=Mus musculus OX=10090 GN=Unc13b PE=1 SV=2
O14795	Protein unc-13 homolog B OS=Homo sapiens OX=9606 GN=UNC13B PE=1 SV=2
Q62769	Protein unc-13 homolog B OS=Rattus norvegicus OX=10116 GN=Unc13b PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002183 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF06292 all species →	MUN	MUN domain	Repeat	Interproscan
PF00130 all species →	C1_1	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain	Interproscan
PF00168 all species →	C2	C2 domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR035892 all species →	Homologous_superfamily	C2 domain superfamily	Interproscan
IPR037302 all species →	Domain	Protein Unc-13, C2B domain	Interproscan
IPR000008 all species →	Domain	C2 domain	Interproscan
IPR010439 all species →	Domain	MUN domain	Interproscan
IPR002219 all species →	Domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Interproscan
IPR046349 all species →	Homologous_superfamily	C1-like domain superfamily	Interproscan
IPR014770 all species →	Domain	Munc13 homology 1	Interproscan
IPR027080 all species →	Family	Protein Unc-13	Interproscan
IPR014772 all species →	Domain	Mammalian uncoordinated homology 13, domain 2	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR10480 all species →	PROTEIN UNC-13 HOMOLOG	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005509 all species →	Molecular Function	calcium ion binding	Interproscan
GO:0005543 all species →	Molecular Function	phospholipid binding	Interproscan
GO:0005516 all species →	Molecular Function	calmodulin binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0007268 all species →	Biological Process	chemical synaptic transmission	Interproscan
GO:0007528 all species →	Biological Process	neuromuscular junction development	Interproscan
GO:0016081 all species →	Biological Process	synaptic vesicle docking	Interproscan
GO:0016082 all species →	Biological Process	synaptic vesicle priming	Interproscan
GO:0016188 all species →	Biological Process	synaptic vesicle maturation	Interproscan
GO:0017075 all species →	Molecular Function	syntaxin-1 binding	Interproscan
GO:0019992 all species →	Molecular Function	diacylglycerol binding	Interproscan
GO:0030672 all species →	Cellular Component	synaptic vesicle membrane	Interproscan
GO:0031594 all species →	Cellular Component	neuromuscular junction	Interproscan
GO:0035249 all species →	Biological Process	synaptic transmission, glutamatergic	Interproscan
GO:0042734 all species →	Cellular Component	presynaptic membrane	Interproscan
GO:0043195 all species →	Cellular Component	terminal bouton	Interproscan
GO:0061789 all species →	Biological Process	dense core granule priming	Interproscan
GO:0098831 all species →	Cellular Component	presynaptic active zone cytoplasmic component	Interproscan
GO:0099525 all species →	Biological Process	presynaptic dense core vesicle exocytosis	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K15293	UNC13A_B_C, MUNC13; protein unc-13 A/B/C	-	Membrane trafficking	ko04131	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Meandrina meandrites tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Meandrina meandrites, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →