Gene detail

Detailed information of ENSVBPP00000027607.1 in Meandrina meandrites

Genomic Location: chr5:18050710...18104432
NR annotation: XP_020605533.1, ADAM 17-like protease [Orbicella faveolata]
Species Meandrina meandrites · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSVBPT00000028788

aggaaatctttgtaTAAGATTGGAGATTCATTGAGACATTATGAAACATTACACACAGATGACATTTTACATGGCTTTCACAAAAGACACATCAGTAAGCAAGAAAAGATTGTTTCCTTCACAACATTGGATAGACATTTCAGACTTCATCTGACTCCACACAGTGAACTCTTTGCTGAAAATTTTCATGCTTATTCAATTGGAGAAGATAATCAAAGGAGAGAAGTGACAGTGGAAAAGGAGGGCTTTTATAGGGGTTATGCTGAAGGTGACCCGTCATCCCGTGCAAGTGTTCATGTGGACCATGGAGGAGTCATGACAGCTACCATAGCAACAAAAGATGACATTTATATCATTGAGCCAGCTTGGCGGCACATTGGAGAGTCTAGCAATCAACATATGATTTCATACCGACATTCTGATGTGAAATCAAATATAACAAGCCCTCAACCGGATCCCGCAGAGAAGAAAAGATTTAGCTTTTGTGGTCATGATTCTGACCATTCTACTGTGCTTTACACAAAAGATGGCAAAGGTGAGCTCGTTTCACCAGACATGCCATCTAAGAGAAAGAGGCGAGCACTTCCAACACAAGTAAGGTGTGCTCTTGCTTTGGTGGCTGACTTCAGATTTTTCCAAGAAATGGGTGGAGGTTCCAAGAAGCAAACCATCAATTATATGaTTGGTGTGATAGACAGAGTGGATGGCATTTTTCAAAACACGGAATGGTCAAGTGAATACAAAGGATATGGATTTGAAATTGAAGAAGTTATAGTTCACGAACAATCCACCCCAGGTGAACACTATAACAAGGAGACGGTTGGCAATGAACCATGGTCTATCAAGTCACTTCTGAATgTATTCAGCCAAAACAGTGAATGGGAAAAGTACTGTCTGGCACATTTGTTCACATACCAAGACTTTGCTGATGGTGTCATTGGACTTGCTTATGTTGCCAACCCCAATACAAATGCTGTTGGAGGAATTTGTACTAAAACATACTTCACAAATAAGAAGACGTTGTACCTGAACACTGGGCTGAGTAGCAGCATTAATTGGGGAAGAAAGTTGCTTACAGAAGAGGCAGACATTGTTACTGCTCATGGACACAATTTTGGCAGTGAACACGATCCAGACACAACCGAGTGTGCACCCGCAGAGTCTGATGGAGGCAAATATATCATGTATCCTGCTTCTGTAAGTGGTCAGTGGGAAAACAACAAGCTTTTCTCTCCATGCAGCAAGCGCAGGATTGTTAATGTTTTAAGATCCAAGTCAGGTTGTTTCAAAGAACCAAGGAATGAGATTTGCGGTAActacaagaaagaaaaggaTGAAGAGTGTGATCCAGGTGGTGGCATAACACCTCAGGACAGCTTGTGTTGTACTAGCGAGTGCAAACTGAAAACTACAGCTCTGTGCAGTGATGGCTATGATTCGCCATGCTGCAAGGACTGCTTGTATACCAATACTACAGGCATTAAGTGTCGTGATGCTGACCCAACTACCTGTAAAGACTTCACGTTCTGTGACGGTACAATGCCGCAGTGTCCTCCAGCGCCGAGCATGACTGATGGAAACAGCTGTATTGACAGAGGAACCTGCAAAGGCGGAGAGTGTAAGCCATTCTGCACCGCTAAGGACCTGAAGCCATGTAAATGCTCCAAGGTTGAAGATGCTTGTAAAGTTTGCTGCAAAGGCCTGGAACCTAACAGCATTTGTACTCCATATATAAACAACGATACTGGCACAACAATGGATATTCTTGACGGGCGATCTTGTCAAGGCGAAGGGCAGCAGGGAACTTGTGTACAGGGCAAATGCGAGAAAACAACCCAAGACTTGATAGAGAGATTCTGGACTTTTTTGACGTCATTGGACAGCAATATAGTTGCTCAGTTTATGAAGGACAACCTGGCTGGCACAGTTGTGGTGTTTTCATTACTAATTTGGATTCCTGCGAGCTGTTATGTCAATCGGATTGACAAGAAACGTGACAAGAGAGAATCTCTTGAAGCAGAATGGAGAGATCCCAAGAATACTCAACTGCTGCGTCAACCAAAGCCAACAAACAAGGGAAAGTTTATCTACAGGCAAGACTCGATAAGCAGGTCATCAAAAGCCGACAAGCCTTTCAAAATAAAGCCGAAGAACATTAAGACGCACAGGATGCCACAACTTGAGTACACTGTTCAACGTGAAAgtaacttgtaa

Transcript

ENSVBPT00000028788

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9VAC5	ADAM 17-like protease OS=Drosophila melanogaster OX=7227 GN=Tace PE=2 SV=2
P78536	Disintegrin and metalloproteinase domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ADAM17 PE=1 SV=1
Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17 OS=Rattus norvegicus OX=10116 GN=Adam17 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000651 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF13574 all species →	Reprolysin_2	Metallo-peptidase family M12B Reprolysin-like	Domain	Interproscan
PF16698 all species →	ADAM17_MPD	Membrane-proximal domain, switch, for ADAM17	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001762 all species →	Domain	Disintegrin domain	Interproscan
IPR001590 all species →	Domain	Peptidase M12B, ADAM/reprolysin	Interproscan
IPR032029 all species →	Domain	ADAM17, membrane-proximal domain	Interproscan
IPR036436 all species →	Homologous_superfamily	Disintegrin domain superfamily	Interproscan
IPR024079 all species →	Homologous_superfamily	Metallopeptidase, catalytic domain superfamily	Interproscan
IPR051489 all species →	Family	Disintegrin and Metalloproteinase Domain-Containing	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR45702 all species →	ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004222 all species →	Molecular Function	metalloendopeptidase activity	Interproscan
GO:0006508 all species →	Biological Process	proteolysis	Interproscan
GO:0008237 all species →	Molecular Function	metallopeptidase activity	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006509 all species →	Biological Process	membrane protein ectodomain proteolysis	Interproscan
GO:0007219 all species →	Biological Process	Notch signaling pathway	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K06059	ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17	EC:3.4.24.86	CD molecules	ko04090	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Meandrina meandrites tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Meandrina meandrites, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →