Detailed information of FUN_042798-T1 in Siderastrea siderea

Genomic Location: contig_55:4757833...4772574
NR annotation: no NCBI-NR hit recorded
Species Siderastrea siderea · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005034 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF12349
all species →
Sterol-sensingSterol-sensing domain of SREBP cleavage-activationFamilyInterproscan
PF00368
all species →
HMG-CoA_redHydroxymethylglutaryl-coenzyme A reductaseFamilyInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR002202
all species →
FamilyHydroxymethylglutaryl-CoA reductase, class I/IIInterproscan
IPR004816
all species →
FamilyHydroxymethylglutaryl-CoA reductase, metazoanInterproscan
IPR009023
all species →
Homologous_superfamilyHydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamilyInterproscan
IPR000731
all species →
DomainSterol-sensing domainInterproscan
IPR004554
all species →
FamilyHydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal typeInterproscan
IPR023076
all species →
Conserved_siteHydroxymethylglutaryl-CoA reductase, class I/II, conserved siteInterproscan
IPR023074
all species →
Homologous_superfamilyHydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamilyInterproscan
IPR023282
all species →
Homologous_superfamilyHydroxymethylglutaryl-CoA reductase, N-terminalInterproscan
IPR009029
all species →
Homologous_superfamilyHydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamilyInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10572
all species →
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0004420
all species →
Molecular Functionhydroxymethylglutaryl-CoA reductase (NADPH) activityInterproscan
GO:0005778
all species →
Cellular Componentperoxisomal membraneInterproscan
GO:0005789
all species →
Cellular Componentendoplasmic reticulum membraneInterproscan
GO:0008299
all species →
Biological Processisoprenoid biosynthetic processInterproscan
GO:0015936
all species →
Biological Processcoenzyme A metabolic processInterproscan
GO:0016126
all species →
Biological Processsterol biosynthetic processInterproscan
GO:0050661
all species →
Molecular FunctionNADP bindingInterproscan
GO:0005515
all species →
Molecular Functionprotein bindingInterproscan
GO:0016616
all species →
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K00021HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)EC:1.1.1.34
Bile secretionko04976deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of FUN_042798-T1 across 85 RNA-seq samples of Siderastrea siderea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

85Samples
81TPM > 0
7Conditions
1,264.3Max TPM
385.0Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
holobiont · low.pH_high.temp 20 18 320.44 726.22
holobiont · low.pH Control.temp 20 19 510.16 838.22
holobiont · control.pH_high.temp 20 19 338.80 636.33
holobiont · control.pH Control.temp 19 19 479.94 1,264.30
Whole organism 4 4 39.90 45.47
unannotated 1 1 27.99 27.99
live coral tissue/skeleton 1 1 31.62 31.62

Per sample · hover a bar for the full sample record

Show the sample table (85 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR22214414 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 726.22
SRR22214409 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 633.55
SRR22214416 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 575.70
SRR22214404 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 458.86
SRR22214419 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 436.77
SRR22214413 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 367.91
SRR22214421 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 359.00
SRR22214403 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 339.11
SRR22214410 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 317.72
SRR22214423 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 300.27
SRR22214415 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 290.15
SRR22214417 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 286.90
SRR22214406 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 276.79
SRR22214412 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 236.06
SRR22214418 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 232.52
SRR22214420 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 207.87
SRR22214407 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 193.22
SRR22214402 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 170.15
SRR22214405 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214408 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214426 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 838.22
SRR22214431 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 770.28
SRR22214445 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 752.95
SRR22214442 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 701.65
SRR22214432 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 701.39
SRR22214434 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 688.02
SRR22214435 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 687.32
SRR22214439 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 645.05
SRR22214438 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 599.79
SRR22214424 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 581.67
SRR22214440 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 506.29
SRR22214437 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 464.12
SRR22214425 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 417.91
SRR22214441 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 397.64
SRR22214428 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 368.22
SRR22214443 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 362.75
SRR22214436 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 307.08
SRR22214429 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 276.15
SRR22214430 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 136.62
SRR22214427 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214448 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 636.33
SRR22214456 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 573.58
SRR22214446 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 539.92
SRR22214451 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 521.38
SRR22214454 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 496.17
SRR22214453 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 481.71
SRR22214450 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 480.48
SRR22214457 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 456.85
SRR22214465 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 343.72
SRR22214464 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 342.59
SRR22214461 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 334.66
SRR22214467 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 297.54
SRR22214447 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 219.67
SRR22214458 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 216.47
SRR22214463 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 199.72
SRR22214462 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 187.36
SRR22214460 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 182.52
SRR22214459 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 171.89
SRR22214449 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 93.46
SRR22214452 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214455 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 1,264.30
SRR22214546 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 1,089.49
SRR22214524 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 830.99
SRR22214433 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 812.66
SRR22214422 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 562.21
SRR22214481 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 504.94
SRR22214471 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 463.40
SRR22214535 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 461.56
SRR22214444 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 461.35
SRR22214468 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 411.38
SRR22214506 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 338.05
SRR22214469 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 288.60
SRR22214492 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 270.66
SRR22214470 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 270.13
SRR22214547 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 259.89
SRR22214548 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 247.85
SRR22214400 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 224.62
SRR22214466 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 188.75
SRR22214411 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 167.94
SRR14295604 Whole organism Whole organism not recorded not recorded SRP315757 45.47
SRR14295603 Whole organism Whole organism not recorded not recorded SRP315757 43.89
SRR14295600 Whole organism Whole organism not recorded not recorded SRP315757 36.28
SRR14295601 Whole organism Whole organism not recorded not recorded SRP315757 33.96
ERR12861049 unannotated not recorded not recorded not recorded ERP159209 27.99
SRR12454619 live coral tissue/skeleton live coral tissue/skeleton not recorded not recorded SRP277390 31.62

Source: CnidoSite RNA-seq expression matrices (SSIDE_TPM, StringTie quantification over 85 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Siderastrea siderea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated0not in this network-
Negatively correlated387FUN_039284-T1-0.580930816605735

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Siderastrea siderea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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