Gene detail

Detailed information of KAK2572860.1 in Acropora cervicornis

Genomic Location: JARQWQ010000003.1:2111114...2119637
NR annotation: XP_029212880.2, NAD-dependent protein deacetylase sirtuin-1-like [Acropora millepora]
Species abbreviation ACERV · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

KAK2572860.1

ATGGCGGACAACGAAGAGAGAGAATTTGCCAAAATAAAACGAGCTCGTTTGTCATCAGAAACTTCTCCTCGCCAAAGTAAGGTCTTCATCGATTTTAATGGTACCGAAGAGAGCAAATGTGACTCTCTTTTAAACGGAATTGGATCAGAACTCAGTGTCTCTCTCGACAATGGATCGTTCGCAACTGAGTCACGTGAACAACATGGTGGCCTCACATCTCACGATAGATTGGAAAGTGACGACTTTCCCACCTGTTTCAGTGTGGAGGATGACGTAGACAACCTAGATGAACACCATTTTCAGCCAATAGCAGGGCCAATGGGATGGATTCAAAGGCAGATGAATCTTGGAATTGATCCTGAAGATATTTTGGCTTATATGGTTCCCCATGCTCAAATGCCTCCTGAAGTTGACAAAGCAAGCTTGTGGAAAATCATTATTGATATCCTCACAGAACCCAATCCAAGACAAAAGCTGGATCACATGAACACCCTGGATGATGTAGTGGAGCTTCTCAGGGGATCCAAGAATATTGTTGTGTTAACGGGAGCTGGGGTATCAGTATCTTGTGGTATTCCAGACTTCCGATCTCGTGATGGTGTTTATGCCAAACTAAGCATTGAATACCCCGATCTCCCAGATCCTCAAGCCATGTTTGATATTGAATACTTTTCTCAGAATCCACGGCCATTCTTCAAGTTTGCAAAGGAAATCTATCCAGGACAGTTTCAGCCCTCACTAAGTCATCACTTTATCAAGCAGTTGGAGAGTAAAGGTCAACTCTTACAAAATTACTCTCAAAATATTGACACCCTGGAACAAATCGCTGGTATAACAAGAGTCATCCAGTGTCATGGTTCTTTTTCTACTGCATCGTGTACAAATTGCAAACATCAAGTGTCCTGTGAAGTCATTAGAGAAGATATCTTTAAGCAGATCATACCACGCTGCCCAAAGTGTCCACAGGATGGAAGCTGTTTTTCAATCATGAAACCTGATATTGTGTTCTTTGGTGAAAGTCTTCCCTCACAGTTTTATCACAACCTAGACAATGATTCAGAAAAGGCTGATCTTCTGATTGTTATAGGATCTTCATTAAAGGTCAGACCTGTTGCTTTGATCCCAAGTCATATACCACCCGAGGTCCCTCAAATTTTGATCAACCGAGAGCCACTCAGACACATGAGATTTGATGTTGAGTTACTGGGTGATTGTGATGTCATAGTCTCAGAGTTGTGCCAGCGATTGGGTGGTGAATGGCTCAACCTGTTAAATGGGTGTGCTGAGATTCCTTGTGTGGAAACGTGGCCTCTGTCAGCAGAAGAGCAGAATTCTGGAGCAGTGGATAATCCTGCAGGGAAAAGCAATGACTGCAGCAATTATCAGATTTCAGAAAATGGATGTAGCAAAGTAGCTAGTGCAGCAAGTGAAAGTACCCTTTCATCAGAACCTTTGAGCAGTTTTAGAGAAAGACATGTGACTGTTGGTGAAAGCAGTGGCTGTGAAGAGACTGTGGACAGCTCATCTCGTGATCAGCCCAGGGCATTCATTGCTGAAAGTTCCACTGAGCATGAAACAGAGAGTGAAGAAGGTTCCTCCAAATTTGTGTTCTTGCCTCCAAGCCGTTACATTTTCTATGGAGCAGAACTGATGGAATCTCCCCTCCCCTCTCCTCAAAGCAACATACCAGGGTACCCTGATAGCAACAGTGAGGAGAGCGACAGTGATAGTCTTGGAGAAATTGATGATGACAGTGAAGTGGCTTCCGGTGATAAACCCTACAATGTAATAATTGGAAATTTGATCAGCCAGGGTTGTGAACGAAGTGAGGGATGTGAACAAGATGACTGGAAAGTATCCAACCCCATTGTGAACAATCCCGGGTCAGCTATCAACACTTTTGGCAATGAGAGCAACAGTGACGATGGTTTTGGTGAAGGTGATGGAGATGTGGACAAATCTGAGGCAACAGTAAGAACCGGCTCCAAGAGGAAGGCTTTGTCTCTTATTCTTGGTGAGCTGAACAACTACAGGTATGAAAGTGAAGAAAACAGGCGAATGTCTGGCTCAGAGGACCCCGGCACTGTGGGCTCATTTGCAAGCGTGACCAGTGATCTTGATTTCGCATCAAGTTCAGAACCACTATTTGCAGATCAACCATTCAGTGCCATTACCTTGGACACAACGTTAAAGAAGCAGGCTTACGTGGATTCTGACAATCTGCAACAGGTGGAAGATGCAAGCAAAGATAACAATGATACCACGAACACAGGCAGTGTTGGCCCATCTGGATCTGAACAGTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q923E4	NAD-dependent protein deacetylase sirtuin-1 OS=Mus musculus OX=10090 GN=Sirt1 PE=1 SV=2
A0A0G2JZ79	NAD-dependent protein deacetylase sirtuin-1 OS=Rattus norvegicus OX=10116 GN=Sirt1 PE=3 SV=2
Q96EB6	NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0005877 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02146 all species →	SIR2	Sir2 family	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR003000 all species →	Family	Sirtuin family	Interproscan
IPR050134 all species →	Family	NAD-dependent sirtuin protein deacylases	Interproscan
IPR026590 all species →	Domain	Sirtuin family, catalytic core domain	Interproscan
IPR026591 all species →	Homologous_superfamily	Sirtuin, catalytic core small domain superfamily	Interproscan
IPR029035 all species →	Homologous_superfamily	DHS-like NAD/FAD-binding domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11085 all species →	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0070403 all species →	Molecular Function	NAD+ binding	Interproscan
GO:0002039 all species →	Molecular Function	p53 binding	Interproscan
GO:0003714 all species →	Molecular Function	transcription corepressor activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005637 all species →	Cellular Component	nuclear inner membrane	Interproscan
GO:0005654 all species →	Cellular Component	nucleoplasm	Interproscan
GO:0017136 all species →	Molecular Function	histone deacetylase activity, NAD-dependent	Interproscan
GO:0033553 all species →	Cellular Component	rDNA heterochromatin	Interproscan
GO:0045892 all species →	Biological Process	negative regulation of DNA-templated transcription	Interproscan
GO:0070932 all species →	Biological Process	obsolete histone H3 deacetylation	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11411	SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1	EC:2.3.1.286	Mitochondrial biogenesis	ko03029	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.