Genomic Location: NC_064037.1:10058997...10081834
NR annotation: XP_001633987.2, pre-mRNA-processing-splicing factor 8 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5513721 |
| Transcript |
| rna-XM_001633937.3 |
| Protein |
| XP_001633987.2 |
| UniProt accession | Description |
|---|---|
| Q6P2Q9 | Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2 |
| Q99PV0 | Pre-mRNA-processing-splicing factor 8 OS=Mus musculus OX=10090 GN=Prpf8 PE=1 SV=2 |
| P34369 | Pre-mRNA-splicing factor 8 homolog OS=Caenorhabditis elegans OX=6239 GN=prp-8 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0004368 (this species only) · gene tree & orthology |
| Ubiquitin family | UBD|Other|Jab_MPN · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF08083 all species → | PROCN | PROCN (NUC071) domain | Domain | Interproscan |
| PF08082 all species → | PRO8NT | PRO8NT (NUC069), PrP8 N-terminal domain | Domain | Interproscan |
| PF10596 all species → | U6-snRNA_bdg | U6-snRNA interacting domain of PrP8 | Domain | Interproscan |
| PF08084 all species → | PROCT | PROCT (NUC072) domain | Domain | Interproscan |
| PF12134 all species → | PRP8_domainIV | PRP8 domain IV core | Domain | Interproscan |
| PF01398 all species → | JAB | JAB1/Mov34/MPN/PAD-1 ubiquitin protease | Family | Interproscan |
| PF10597 all species → | U5_2-snRNA_bdg | U5-snRNA binding site 2 of PrP8 | Domain | Interproscan |
| PF10598 all species → | RRM_4 | RNA recognition motif of the spliceosomal PrP8 | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR012337 all species → | Homologous_superfamily | Ribonuclease H-like superfamily | Interproscan |
| IPR012592 all species → | Domain | PROCN domain | Interproscan |
| IPR043172 all species → | Homologous_superfamily | Prp8 RNase domain IV, palm region | Interproscan |
| IPR021983 all species → | Domain | PRP8 domain IV core | Interproscan |
| IPR043173 all species → | Homologous_superfamily | Prp8 RNase domain IV, fingers region | Interproscan |
| IPR012591 all species → | Domain | PRO8NT domain | Interproscan |
| IPR019580 all species → | Domain | Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding | Interproscan |
| IPR042516 all species → | Homologous_superfamily | Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily | Interproscan |
| IPR027652 all species → | Family | Pre-mRNA-processing-splicing factor 8 | Interproscan |
| IPR012984 all species → | Domain | PROCT domain | Interproscan |
| IPR000555 all species → | Domain | JAB1/MPN/MOV34 metalloenzyme domain | Interproscan |
| IPR019581 all species → | Domain | Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding | Interproscan |
| IPR019582 all species → | Domain | RNA recognition motif, spliceosomal PrP8 | Interproscan |
| IPR037518 all species → | Domain | MPN domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11140 all species → | PRE-MRNA SPLICING FACTOR PRP8 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000398 all species → | Biological Process | mRNA splicing, via spliceosome | Interproscan |
| GO:0017070 all species → | Molecular Function | U6 snRNA binding | Interproscan |
| GO:0000244 all species → | Biological Process | spliceosomal tri-snRNP complex assembly | Interproscan |
| GO:0005681 all species → | Cellular Component | spliceosomal complex | Interproscan |
| GO:0005682 all species → | Cellular Component | U5 snRNP | Interproscan |
| GO:0030619 all species → | Molecular Function | U1 snRNA binding | Interproscan |
| GO:0030620 all species → | Molecular Function | U2 snRNA binding | Interproscan |
| GO:0030623 all species → | Molecular Function | U5 snRNA binding | Interproscan |
| GO:0071013 all species → | Cellular Component | catalytic step 2 spliceosome | Interproscan |
| GO:0097157 all species → | Molecular Function | pre-mRNA intronic binding | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0008233 all species → | Molecular Function | peptidase activity | Interproscan |
| GO:0008237 all species → | Molecular Function | metallopeptidase activity | Interproscan |
| GO:0003723 all species → | Molecular Function | RNA binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K12856 | PRPF8, PRP8; pre-mRNA-processing factor 8 | - | Spliceosome | ko03041 | deepkoala |
Transcript abundance of XP_001633987.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 24.26 | 28.41 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 16.64 | 24.21 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 14.72 | 15.27 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 20.54 | 26.08 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 13.72 | 15.29 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 3 | 23.30 | 27.10 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 3 | 25.06 | 30.20 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 24.63 | 28.10 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 3 | 23.86 | 27.87 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 3 | 23.43 | 26.00 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 18.48 | 20.96 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 3 | 32.60 | 43.14 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 28.67 | 34.81 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 3 | 32.81 | 41.79 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 3 | 20.43 | 21.70 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 3 | 21.14 | 28.23 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.