Genomic Location: Sc7jCM8_1512:1883915...1935707
NR annotation: XP_020604829.1, acetyl-CoA carboxylase-like isoform X2 [Orbicella faveolata]
Species Orbicella faveolata · all data for this species · gene families
| CDS |
| LOC110043690 |
| Transcript |
| rna-XM_020749172.1 |
| Protein |
| XP_020604831.1 |
| UniProt accession | Description |
|---|---|
| P11029 | Acetyl-CoA carboxylase OS=Gallus gallus OX=9031 GN=ACAC PE=1 SV=1 |
| Q28559 | Acetyl-CoA carboxylase 1 OS=Ovis aries OX=9940 GN=ACACA PE=2 SV=1 |
| Q5SWU9 | Acetyl-CoA carboxylase 1 OS=Mus musculus OX=10090 GN=Acaca PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002191 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF21385 all species → | ACCA_BT | Acetyl-CoA carboxylase, BT domain | Domain | Interproscan |
| PF08326 all species → | ACC_central | Acetyl-CoA carboxylase, central region | Family | Interproscan |
| PF00364 all species → | Biotin_lipoyl | Biotin-requiring enzyme | Domain | Interproscan |
| PF02785 all species → | Biotin_carb_C | Biotin carboxylase C-terminal domain | Domain | Interproscan |
| PF00289 all species → | Biotin_carb_N | Biotin carboxylase, N-terminal domain | Domain | Interproscan |
| PF02786 all species → | CPSase_L_D2 | Carbamoyl-phosphate synthase L chain, ATP binding domain | Domain | Interproscan |
| PF01039 all species → | Carboxyl_trans | Carboxyl transferase domain | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR011763 all species → | Domain | Acetyl-coenzyme A carboxyltransferase, C-terminal | Interproscan |
| IPR005479 all species → | Domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Interproscan |
| IPR016185 all species → | Homologous_superfamily | Pre-ATP-grasp domain superfamily | Interproscan |
| IPR011764 all species → | Domain | Biotin carboxylation domain | Interproscan |
| IPR029045 all species → | Homologous_superfamily | ClpP/crotonase-like domain superfamily | Interproscan |
| IPR005482 all species → | Domain | Biotin carboxylase, C-terminal | Interproscan |
| IPR049074 all species → | Domain | Acetyl-CoA carboxylase, BT domain | Interproscan |
| IPR011054 all species → | Homologous_superfamily | Rudiment single hybrid motif | Interproscan |
| IPR001882 all species → | Binding_site | Biotin-binding site | Interproscan |
| IPR000089 all species → | Domain | Biotin/lipoyl attachment | Interproscan |
| IPR013537 all species → | Domain | Acetyl-CoA carboxylase, central domain | Interproscan |
| IPR049076 all species → | Family | Acetyl-CoA carboxylase | Interproscan |
| IPR013815 all species → | Homologous_superfamily | ATP-grasp fold, subdomain 1 | Interproscan |
| IPR011053 all species → | Homologous_superfamily | Single hybrid motif | Interproscan |
| IPR005481 all species → | Domain | Biotin carboxylase-like, N-terminal domain | Interproscan |
| IPR011762 all species → | Domain | Acetyl-coenzyme A carboxyltransferase, N-terminal | Interproscan |
| IPR034733 all species → | Domain | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | Interproscan |
| IPR011761 all species → | Domain | ATP-grasp fold | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45728 all species → | ACETYL-COA CARBOXYLASE, ISOFORM A | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016874 all species → | Molecular Function | ligase activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0003989 all species → | Molecular Function | acetyl-CoA carboxylase activity | Interproscan |
| GO:0006633 all species → | Biological Process | fatty acid biosynthetic process | Interproscan |
| GO:0005739 all species → | Cellular Component | mitochondrion | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11262 | ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 | EC:6.4.1.2 EC:6.3.4.14 EC:2.1.3.15 | Alcoholic liver disease | ko04936 | deepkoala |
Transcript abundance of XP_020604831.1 across 70 RNA-seq samples of Orbicella faveolata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| holobiont · control.pH_high.temp | 21 | 10 | 24.10 | 83.48 | |
| holobiont · low.pH_high.temp | 19 | 7 | 20.07 | 82.32 | |
| holobiont · low.pH Control.temp | 16 | 9 | 27.48 | 69.38 | |
| holobiont · control.pH Control.temp | 14 | 7 | 19.00 | 59.61 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR22214541 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 83.48 |
| SRR22214502 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 70.71 |
| SRR22214534 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 57.34 |
| SRR22214542 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 54.64 |
| SRR22214498 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 54.39 |
| SRR22214543 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 48.81 |
| SRR22214497 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 45.49 |
| SRR22214538 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 38.34 |
| SRR22214501 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 31.88 |
| SRR22214536 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 20.95 |
| SRR22214496 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214499 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214500 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214531 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214532 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214533 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214537 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214539 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214540 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214544 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214545 | holobiont · control.pH_high.temp | holobiont | not recorded | control.pH_high.temp | SRP406607 | 0.00 |
| SRR22214483 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 82.32 |
| SRR22214478 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 71.32 |
| SRR22214479 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 69.56 |
| SRR22214482 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 57.57 |
| SRR22214476 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 46.77 |
| SRR22214488 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 31.38 |
| SRR22214490 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 22.41 |
| SRR22214472 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214473 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214474 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214475 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214477 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214480 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214484 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214485 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214486 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214487 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214489 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214491 | holobiont · low.pH_high.temp | holobiont | not recorded | low.pH_high.temp | SRP406607 | 0.00 |
| SRR22214522 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 69.38 |
| SRR22214518 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 63.89 |
| SRR22214520 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 61.55 |
| SRR22214521 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 60.07 |
| SRR22214525 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 57.63 |
| SRR22214530 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 38.25 |
| SRR22214529 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 37.52 |
| SRR22214526 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 28.25 |
| SRR22214493 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 23.17 |
| SRR22214494 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214495 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214517 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214519 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214523 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214527 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214528 | holobiont · low.pH Control.temp | holobiont | not recorded | low.pH Control.temp | SRP406607 | 0.00 |
| SRR22214513 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 59.61 |
| SRR22214515 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 54.14 |
| SRR22214514 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 52.83 |
| SRR22214510 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 44.72 |
| SRR22214512 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 32.49 |
| SRR22214504 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 18.09 |
| SRR22214505 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 4.05 |
| SRR22214401 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214503 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214507 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214508 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214509 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214511 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
| SRR22214516 | holobiont · control.pH Control.temp | holobiont | not recorded | control.pH Control.temp | SRP406607 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (OFAVE_TPM,
StringTie quantification over 70 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Orbicella faveolata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 12 | XP_020618345.1 | 0.793415709197875 |
| Negatively correlated | 15 | XP_020627737.1 | -0.454640406855652 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Orbicella faveolata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |