Detailed information of XP_020612806.1 in Orbicella faveolata

Genomic Location: Sc7jCM8_2259:1462171...1479799
NR annotation: XP_020612806.1, signal transducer and activator of transcription 5B-like isoform X1 [Orbicella faveolata]
Species Orbicella faveolata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P52632Signal transducer and activator of transcription 5B OS=Rattus norvegicus OX=10116 GN=Stat5b PE=1 SV=1
P42232Signal transducer and activator of transcription 5B OS=Mus musculus OX=10090 GN=Stat5b PE=1 SV=1
P51692Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003311 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF01017
all species →
STAT_alphaSTAT protein, all-alpha domainFamilyInterproscan
PF21354
all species →
STAT_linkerSignal transducer and activator of transcription, linker domainDomainInterproscan
PF02864
all species →
STAT_bindSTAT protein, DNA binding domainDomainInterproscan
PF00017
all species →
SH2SH2 domainDomainInterproscan
PF02865
all species →
STAT_intSTAT protein, protein interaction domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR013800
all species →
DomainSTAT transcription factor, all-alpha domainInterproscan
IPR001217
all species →
FamilyTranscription factor STATInterproscan
IPR000980
all species →
DomainSH2 domainInterproscan
IPR036535
all species →
Homologous_superfamilySTAT transcription factor, N-terminal domain superfamilyInterproscan
IPR036860
all species →
Homologous_superfamilySH2 domain superfamilyInterproscan
IPR048988
all species →
DomainSignal transducer and activator of transcription, linker domainInterproscan
IPR013801
all species →
DomainSTAT transcription factor, DNA-bindingInterproscan
IPR013799
all species →
DomainSTAT transcription factor, protein interactionInterproscan
IPR008967
all species →
Homologous_superfamilyp53-like transcription factor, DNA-binding domain superfamilyInterproscan
IPR012345
all species →
Homologous_superfamilySTAT transcription factor, DNA-binding, N-terminalInterproscan
IPR015988
all species →
Homologous_superfamilySTAT transcription factor, coiled coilInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11801
all species →
SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTIONInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006355
all species →
Biological Processregulation of DNA-templated transcriptionInterproscan
GO:0007165
all species →
Biological Processsignal transductionInterproscan
GO:0000978
all species →
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA bindingInterproscan
GO:0000981
all species →
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specificInterproscan
GO:0003700
all species →
Molecular FunctionDNA-binding transcription factor activityInterproscan
GO:0006357
all species →
Biological Processregulation of transcription by RNA polymerase IIInterproscan
GO:0006952
all species →
Biological Processdefense responseInterproscan
GO:0007259
all species →
Biological Processcell surface receptor signaling pathway via JAK-STATInterproscan
GO:0042127
all species →
Biological Processregulation of cell population proliferationInterproscan
GO:0003677
all species →
Molecular FunctionDNA bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K11224STAT5B; signal transducer and activator of transcription 5B-Transcription factorsko03000deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_020612806.1 across 70 RNA-seq samples of Orbicella faveolata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

70Samples
4TPM > 0
4Conditions
8.7Max TPM
0.3Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
holobiont · control.pH_high.temp 21 1 0.10 2.06
holobiont · low.pH_high.temp 19 0 0.00 0.00
holobiont · low.pH Control.temp 16 2 0.58 4.73
holobiont · control.pH Control.temp 14 1 0.62 8.68

Per sample · hover a bar for the full sample record

Show the sample table (70 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR22214542 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 2.06
SRR22214496 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214497 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214498 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214499 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214500 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214501 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214502 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214531 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214532 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214533 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214534 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214536 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214537 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214538 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214539 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214540 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214541 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214543 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214544 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214545 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214472 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214473 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214474 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214475 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214476 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214477 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214478 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214479 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214480 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214482 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214483 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214484 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214485 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214486 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214487 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214488 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214489 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214490 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214491 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214525 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 4.73
SRR22214529 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 4.53
SRR22214493 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214494 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214495 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214517 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214518 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214519 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214520 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214521 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214522 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214523 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214526 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214527 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214528 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214530 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214515 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 8.68
SRR22214401 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214503 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214504 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214505 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214507 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214508 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214509 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214510 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214511 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214512 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214513 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214514 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214516 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00

Source: CnidoSite RNA-seq expression matrices (OFAVE_TPM, StringTie quantification over 70 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Orbicella faveolata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated17XP_020609829.10.878013996530463
Negatively correlated3XP_020619700.1-0.18250398941585

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Orbicella faveolata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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