Detailed information of XP_020623447.1 in Orbicella faveolata

Genomic Location: Sc7jCM8_3154:3118829...3150924
NR annotation: XP_020623447.1, CAD protein-like isoform X2 [Orbicella faveolata]
Species Orbicella faveolata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q91437Multifunctional protein CAD OS=Squalus acanthias OX=7797 GN=CAD PE=2 SV=1
P08955Multifunctional protein CAD OS=Mesocricetus auratus OX=10036 GN=CAD PE=1 SV=4
B2RQC6Multifunctional protein CAD OS=Mus musculus OX=10090 GN=Cad PE=1 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0001105 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF02729
all species →
OTCace_NAspartate/ornithine carbamoyltransferase, carbamoyl-P binding domainDomainInterproscan
PF02787
all species →
CPSase_L_D3Carbamoyl-phosphate synthetase large chain, oligomerisation domainDomainInterproscan
PF01979
all species →
Amidohydro_1Amidohydrolase familyDomainInterproscan
PF00117
all species →
GATaseGlutamine amidotransferase class-IDomainInterproscan
PF02142
all species →
MGSMGS-like domainDomainInterproscan
PF02786
all species →
CPSase_L_D2Carbamoyl-phosphate synthase L chain, ATP binding domainDomainInterproscan
PF00185
all species →
OTCaceAspartate/ornithine carbamoyltransferase, Asp/Orn binding domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR006132
all species →
DomainAspartate/ornithine carbamoyltransferase, carbamoyl-P bindingInterproscan
IPR005479
all species →
DomainCarbamoyl-phosphate synthetase large subunit-like, ATP-binding domainInterproscan
IPR036897
all species →
Homologous_superfamilyCarbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamilyInterproscan
IPR011761
all species →
DomainATP-grasp foldInterproscan
IPR005480
all species →
DomainCarbamoyl-phosphate synthetase, large subunit oligomerisation domainInterproscan
IPR013815
all species →
Homologous_superfamilyATP-grasp fold, subdomain 1Interproscan
IPR006680
all species →
DomainAmidohydrolase-relatedInterproscan
IPR036901
all species →
Homologous_superfamilyAspartate/ornithine carbamoyltransferase superfamilyInterproscan
IPR005483
all species →
DomainCarbamoyl-phosphate synthase large subunit, CPSase domainInterproscan
IPR011607
all species →
DomainMethylglyoxal synthase-like domainInterproscan
IPR006130
all species →
FamilyAspartate/ornithine carbamoyltransferaseInterproscan
IPR002082
all species →
FamilyAspartate carbamoyltransferaseInterproscan
IPR017926
all species →
DomainGlutamine amidotransferaseInterproscan
IPR029062
all species →
Homologous_superfamilyClass I glutamine amidotransferase-likeInterproscan
IPR036914
all species →
Homologous_superfamilyMethylglyoxal synthase-like domain superfamilyInterproscan
IPR016185
all species →
Homologous_superfamilyPre-ATP-grasp domain superfamilyInterproscan
IPR032466
all species →
Homologous_superfamilyMetal-dependent hydrolaseInterproscan
IPR002195
all species →
Conserved_siteDihydroorotase, conserved siteInterproscan
IPR006131
all species →
DomainAspartate/ornithine carbamoyltransferase, Asp/Orn-binding domainInterproscan
IPR006275
all species →
FamilyCarbamoyl-phosphate synthase, large subunitInterproscan
IPR011059
all species →
Homologous_superfamilyMetal-dependent hydrolase, composite domain superfamilyInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11405
all species →
CARBAMOYLTRANSFERASE FAMILY MEMBERInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006520
all species →
Biological Processamino acid metabolic processInterproscan
GO:0016743
all species →
Molecular Functioncarboxyl- or carbamoyltransferase activityInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan
GO:0046872
all species →
Molecular Functionmetal ion bindingInterproscan
GO:0016787
all species →
Molecular Functionhydrolase activityInterproscan
GO:0016597
all species →
Molecular Functionamino acid bindingInterproscan
GO:0004070
all species →
Molecular Functionaspartate carbamoyltransferase activityInterproscan
GO:0004088
all species →
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activityInterproscan
GO:0004151
all species →
Molecular Functiondihydroorotase activityInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0005829
all species →
Cellular ComponentcytosolInterproscan
GO:0006207
all species →
Biological Process'de novo' pyrimidine nucleobase biosynthetic processInterproscan
GO:0006228
all species →
Biological ProcessUTP biosynthetic processInterproscan
GO:0006541
all species →
Biological Processglutamine metabolic processInterproscan
GO:0006807
all species →
Biological Processobsolete nitrogen compound metabolic processInterproscan
GO:0019240
all species →
Biological Processcitrulline biosynthetic processInterproscan
GO:0016812
all species →
Molecular Functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidesInterproscan
GO:0016810
all species →
Molecular Functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bondsInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K11540CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotaseEC:6.3.5.5
EC:2.1.3.2
EC:3.5.2.3
Peptidases and inhibitorsko01002deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_020623447.1 across 70 RNA-seq samples of Orbicella faveolata. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

70Samples
0TPM > 0
4Conditions
0.0Max TPM
0.0Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
holobiont · control.pH_high.temp 21 0 0.00 0.00
holobiont · low.pH_high.temp 19 0 0.00 0.00
holobiont · low.pH Control.temp 16 0 0.00 0.00
holobiont · control.pH Control.temp 14 0 0.00 0.00

Per sample · hover a bar for the full sample record

Show the sample table (70 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR22214496 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214497 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214498 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214499 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214500 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214501 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214502 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214531 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214532 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214533 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214534 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214536 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214537 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214538 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214539 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214540 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214541 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214542 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214543 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214544 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214545 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214472 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214473 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214474 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214475 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214476 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214477 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214478 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214479 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214480 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214482 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214483 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214484 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214485 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214486 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214487 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214488 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214489 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214490 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214491 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214493 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214494 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214495 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214517 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214518 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214519 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214520 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214521 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214522 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214523 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214525 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214526 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214527 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214528 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214529 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214530 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214401 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214503 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214504 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214505 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214507 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214508 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214509 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214510 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214511 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214512 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214513 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214514 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214515 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214516 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00

Source: CnidoSite RNA-seq expression matrices (OFAVE_TPM, StringTie quantification over 70 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Orbicella faveolata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated0not in this network-
Negatively correlated0not in this network-

This gene has no edge at all in the Orbicella faveolata network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Orbicella faveolata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.no expression matrix
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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