Detailed information of XP_020625866.1 in Orbicella faveolata

Genomic Location: Sc7jCM8_371:495718...524542
NR annotation: XP_020625866.1, ras GTPase-activating-like protein IQGAP1 [Orbicella faveolata]
Species Orbicella faveolata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P46940Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1
Q9JKF1Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus OX=10090 GN=Iqgap1 PE=1 SV=2
Q13576Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0002232 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF03836
all species →
RasGAP_CRasGAP C-terminusFamilyInterproscan
PF00616
all species →
RasGAPGTPase-activator protein for Ras-like GTPaseFamilyInterproscan
PF00612
all species →
IQIQ calmodulin-binding motifMotifInterproscan
PF00307
all species →
CHCalponin homology (CH) domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR001936
all species →
DomainRas GTPase-activating domainInterproscan
IPR000593
all species →
DomainRasGAP protein, C-terminalInterproscan
IPR001202
all species →
DomainWW domainInterproscan
IPR036872
all species →
Homologous_superfamilyCH domain superfamilyInterproscan
IPR008936
all species →
Homologous_superfamilyRho GTPase activation proteinInterproscan
IPR036020
all species →
Homologous_superfamilyWW domain superfamilyInterproscan
IPR023152
all species →
Conserved_siteRas GTPase-activating protein, conserved siteInterproscan
IPR001715
all species →
DomainCalponin homology domainInterproscan
IPR027417
all species →
Homologous_superfamilyP-loop containing nucleoside triphosphate hydrolaseInterproscan
IPR000048
all species →
Binding_siteIQ motif, EF-hand binding siteInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR14149
all species →
RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIFInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0043087
all species →
Biological Processregulation of GTPase activityInterproscan
GO:0005515
all species →
Molecular Functionprotein bindingInterproscan
GO:0005096
all species →
Molecular FunctionGTPase activator activityInterproscan
GO:0005516
all species →
Molecular Functioncalmodulin bindingInterproscan
GO:0005938
all species →
Cellular Componentcell cortexInterproscan
GO:0051015
all species →
Molecular Functionactin filament bindingInterproscan
GO:1903479
all species →
Biological Processmitotic actomyosin contractile ring assembly actin filament organizationInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
No KEGG orthology assignment for XP_020625866.1.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_020625866.1 across 70 RNA-seq samples of Orbicella faveolata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

70Samples
33TPM > 0
4Conditions
93.0Max TPM
10.3Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
holobiont · control.pH_high.temp 21 11 12.87 93.02
holobiont · low.pH_high.temp 19 6 6.16 49.66
holobiont · low.pH Control.temp 16 10 11.48 28.01
holobiont · control.pH Control.temp 14 6 10.50 38.82

Per sample · hover a bar for the full sample record

Show the sample table (70 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR22214540 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 93.02
SRR22214543 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 25.06
SRR22214532 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 24.51
SRR22214542 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 23.36
SRR22214501 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 23.22
SRR22214533 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 21.43
SRR22214502 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 15.13
SRR22214541 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 12.82
SRR22214497 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 12.61
SRR22214498 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 11.75
SRR22214534 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 7.40
SRR22214496 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214499 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214500 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214531 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214536 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214537 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214538 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214539 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214544 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214545 holobiont · control.pH_high.temp holobiont not recorded control.pH_high.temp SRP406607 0.00
SRR22214488 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 49.66
SRR22214485 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 22.40
SRR22214476 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 20.23
SRR22214479 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 17.24
SRR22214482 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 6.95
SRR22214490 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.48
SRR22214472 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214473 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214474 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214475 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214477 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214478 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214480 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214483 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214484 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214486 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214487 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214489 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214491 holobiont · low.pH_high.temp holobiont not recorded low.pH_high.temp SRP406607 0.00
SRR22214525 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 28.01
SRR22214521 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 23.40
SRR22214520 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 22.59
SRR22214494 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 18.22
SRR22214529 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 18.21
SRR22214522 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 17.55
SRR22214493 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 16.79
SRR22214526 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 16.71
SRR22214517 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 12.34
SRR22214518 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 9.88
SRR22214495 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214519 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214523 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214527 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214528 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214530 holobiont · low.pH Control.temp holobiont not recorded low.pH Control.temp SRP406607 0.00
SRR22214512 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 38.82
SRR22214504 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 27.70
SRR22214510 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 26.21
SRR22214507 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 23.59
SRR22214505 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 15.97
SRR22214514 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 14.67
SRR22214401 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214503 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214508 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214509 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214511 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214513 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214515 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00
SRR22214516 holobiont · control.pH Control.temp holobiont not recorded control.pH Control.temp SRP406607 0.00

Source: CnidoSite RNA-seq expression matrices (OFAVE_TPM, StringTie quantification over 70 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Orbicella faveolata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated4XP_020603361.10.796236040130534
Negatively correlated3XP_020619949.1-0.390894046090811

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Orbicella faveolata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
TOP