Gene detail

Detailed information of XP_031551845.1 in Actinia tenebrosa

Genomic Location: NW_022258659.1:5478...37310
NR annotation: XP_031551845.1, C-1-tetrahydrofolate synthase, cytoplasmic-like [Actinia tenebrosa]
Species Actinia tenebrosa · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_031551845.1

ATGGCGACGGAAGGCAAAAGACTGTCTGGTAAACAGATTTCGGGAGAAATCCGAAAACAGTTGCAAGAAGATGTGTCGAACATTCAAGCTGAACATCCAAATTTCAAACCAGGATTGGCAATTGTTCAGATTGGTGGACGTAGTGATTCTACTGTTTATATCAATGCCAAAATTAAAGCCGCAGAGGAGATAGGAATGATGGCTAGACATGTGAACCTGCCCAGAACCTGTACACAACAAGATGTTCTAAAAGCAGTAGATGAGCTCAATAAAGATAGCACAATTCATGGTATTATTGTCCAGCTTCCACCAGACTGTGATAACCCAGTGGATCCAGCCATCGTTACTAATGCTGTCATCCCTGAGAAAGATGTTGACGGGTTAAATGACATCAATGCTGGACGTCTGGCCAGGGGGGAGCTTGATAGTTGCATYGTTCCATGTACTCCCAGGGGTTGCCTGGAACTGATCAAGAGGACAGGCTAACTGGATCAAGCCAGGTGCAGTTGTGATTGATTGTGGCATCAATGTTATACCAGATGCAACCAAGAAAAGTGGTACTCGTCTGGTTGGTGATGTTGATTTTCATGGAGCTCAAATGAAAGCCAGCTGGATAACTCCTGTACCTGGAGGTGTCGGTCCGATGACAGTTGCCATGCTTATGATGAACACAGTGGAYGGCGCAAAGAAAGCTCTTCATCAACAAAAGTGACATAGAAATATCAAAGGCTCAGTATCCAAAGGATATAGCACAGCTGGCCAGTGAAATTGGAGTCAAGAAATCTGAGTTGGAGTTGTATGGGAACAAGAAAGCTAAAGTATCCCTGAATGTCCTGGAAAGACTCAAAGATGTTGAAAATGGAAAATACATTGTGGTGGCTGGTATCACRCCCACACCATTTGGAGAAGGAAAGAGCACCACTACAGTAGGACTATCACAAGCCATGGGAGCACACCTGAAGAAGAACTGCTTTACCTGCATCAGACAACCATCTCAAGGACCTACATTTGGAATAAAAGGTGGTGCCGCTGGTGGAGGGTACTCTCAAGTCATTCCAATGGAAGAGTTCAACCTTCATCTGACGGGTGACATTCATGCCATTACTGCTGCAAACAACTTGCTTGCTGCTGCCATCGATACAAGAATCTTCCATGAAGCCACTCAGAAGGATGAGGCTTTGTTCAACCGTCTTGTTCCTGAGAAGAAAGGCAAGAGAACGTTCTCTAACGTGATGCTTAAAAGACTAAAGTTATGGACACCAATGACCGATTCTTGAGGAAGATCACTATAGGACAGTCACCAACAGAGAAGAATATGACCAGAGAGACCCAGTTTGATATAACAGTTGCCAGCGAGATCATGGCTATTCTGGCTCTAACAACTGATATCAAAGACATGAGAAAAAGGCTKGGTGATATTGTAGTCGCAAGCAACAAGGAAGGAGATCCCATTACTGCTGATGATTTGGGTATTGGAGGAGCCTTGACTGTCCTMATGAAAGAGACTATTAAACCCAACTTGATGCAGACCCTTGAGGGTACCCCAGTGTTTGTACATGCTGGACCGTTTGCTAACATCGCTCATGGAAACTCATCCATATTAGCAGACAAGATAGCATTGAAGCTTGTGGGTCCTGAAGGATTTGTCTTTACAGAGTGTGGTTTTGGTGCAGATATTGGGATGGAGAAGTTCTTTGATATCAAGTGCCGATACAGTGGACTCAAGCCTCATGCAGCCATCATTGTAGCAACTGTAAGGGCACTCAAAATGCACGGCGGAGGCCCAAAGGTCGTGGCTGGACAACCTTTAGCAGAAGAATACACAACAGAGAATCTAGATTTRATACGAAAAGGAATGTGCAACCTGTCTAAACAAATCGAGAATGCAAGACTGTTTGGTGTTCAGGCTATTGTTGCTGTTAACCGATTCCATACTGATACAGATAACGAGGTGGCTTTAGTGATTGAACTGTCTAAAGCAGCAGGAGCATTTGATGCCAAGGAGTGCACACACTGGGCTAATGGAGGTTCTGGTGCGGTAGAGCTAGCTGAAGTCGTTATCAAAGCTCTGGAACAACCTGTGCAGTTTAATTTCCTGTATGACCTACAGTTGCCGGTTGAAGAGAAGATACGTATTATTGCACAGAAAGTGTATGGATCTGATGATATCGAGCTCTCCCCTGAAGCGCAGGAAAGAATTGAACGTTATAAAAAGCAGGGATTCAACGATCTTCCTATCTGTGTGGCCAAGACTCATCTCTCCTTGTCCCATAAACCTGAACTAAAAGGAGTTCCTGAAGGAATCATTCTTCCAATCAGAGATGTTCGTGCCAGTGTTGGGGCTGGATTCCTGTACCCACTAGTAGGAACAATGAGCACCATGCCTGGATTACCCACAAGACCTTGCTTCTATGACATTGACCTTGACCTTGACACAGAAGAAGTTATTGGTTTATTCTAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P11586	C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4
P27653	C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mthfd1 PE=1 SV=3
Q922D8	C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=4

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001689 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00763 all species →	THF_DHG_CYH	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Domain	Interproscan
PF02882 all species →	THF_DHG_CYH_C	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Domain	Interproscan
PF01268 all species →	FTHFS	Formate--tetrahydrofolate ligase	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR020867 all species →	Conserved_site	Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR000672 all species →	Family	Tetrahydrofolate dehydrogenase/cyclohydrolase	Interproscan
IPR020630 all species →	Domain	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Interproscan
IPR000559 all species →	Family	Formate-tetrahydrofolate ligase, FTHFS	Interproscan
IPR046346 all species →	Homologous_superfamily	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Interproscan
IPR036291 all species →	Homologous_superfamily	NAD(P)-binding domain superfamily	Interproscan
IPR020628 all species →	Conserved_site	Formate-tetrahydrofolate ligase, FTHFS, conserved site	Interproscan
IPR020631 all species →	Domain	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR48099 all species →	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0004488 all species →	Molecular Function	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Interproscan
GO:0004329 all species →	Molecular Function	formate-tetrahydrofolate ligase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0004477 all species →	Molecular Function	methenyltetrahydrofolate cyclohydrolase activity	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0035999 all species →	Biological Process	tetrahydrofolate interconversion	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K00288	MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase	EC:1.5.1.5 EC:3.5.4.9 EC:6.3.4.3	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.