Genomic Location: NC_064044.1:11723742...11730662
NR annotation: XP_032219094.2, hydroxymethylglutaryl-CoA lyase, mitochondrial [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5518609 |
| Transcript |
| rna-XM_032363203.2 |
| Protein |
| XP_032219094.2 |
| UniProt accession | Description |
|---|---|
| P35915 | Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Gallus gallus OX=9031 GN=HMGCL PE=1 SV=1 |
| Q8JZS7 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic OS=Mus musculus OX=10090 GN=Hmgcll1 PE=2 SV=1 |
| P97519 | Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Hmgcl PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003337 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00682 all species → | HMGL-like | HMGL-like | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR043594 all species → | Family | HMG-CoA lyase | Interproscan |
| IPR000891 all species → | Domain | Pyruvate carboxyltransferase | Interproscan |
| IPR013785 all species → | Homologous_superfamily | Aldolase-type TIM barrel | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR42738 all species → | HYDROXYMETHYLGLUTARYL-COA LYASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004419 all species → | Molecular Function | hydroxymethylglutaryl-CoA lyase activity | Interproscan |
| GO:0006552 all species → | Biological Process | L-leucine catabolic process | Interproscan |
| GO:0016833 all species → | Molecular Function | oxo-acid-lyase activity | Interproscan |
| GO:0046951 all species → | Biological Process | ketone body biosynthetic process | Interproscan |
| GO:0003824 all species → | Molecular Function | catalytic activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K01640 | HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase | EC:4.1.3.4 | Peroxisome | ko04146 | deepkoala |
Transcript abundance of XP_032219094.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 9.29 | 14.45 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 5.33 | 7.47 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 5.37 | 5.55 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 4.75 | 6.30 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 3.71 | 4.43 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 1 | 1.50 | 4.50 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 2 | 4.58 | 8.35 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 7.41 | 10.12 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 2 | 3.93 | 7.37 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 2 | 3.10 | 4.78 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 4.62 | 5.95 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 2 | 3.99 | 6.97 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 2 | 4.75 | 7.25 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 2 | 5.83 | 9.29 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 2 | 3.43 | 5.94 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 1 | 1.54 | 4.61 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
