Genomic Location: NC_064044.1:2636284...2694615
NR annotation: XP_032229995.2, E3 ubiquitin-protein ligase UBR5-like isoform X1 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC116613544 |
| Transcript |
| rna-XM_032374104.2 |
| Protein |
| XP_032229995.2 |
| UniProt accession | Description |
|---|---|
| Q80TP3 | E3 ubiquitin-protein ligase UBR5 OS=Mus musculus OX=10090 GN=Ubr5 PE=1 SV=2 |
| O95071 | E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2 |
| Q62671 | E3 ubiquitin-protein ligase UBR5 OS=Rattus norvegicus OX=10116 GN=Ubr5 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002381 (this species only) |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Ubiquitin family | E3|E3 activity|UBR-box · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00658 all species → | PABP | Poly-adenylate binding protein, unique domain | Family | Interproscan |
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF11547 all species → | E3_UbLigase_EDD | E3 ubiquitin ligase EDD | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR003126 all species → | Domain | Zinc finger, UBR-type | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR002004 all species → | Domain | Polyadenylate-binding protein/Hyperplastic disc protein | Interproscan |
| IPR009091 all species → | Homologous_superfamily | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Interproscan |
| IPR024725 all species → | Domain | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain | Interproscan |
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR015940 all species → | Domain | Ubiquitin-associated domain | Interproscan |
| IPR047503 all species → | Domain | E3 ubiquitin-protein ligase UBR5, UBR-box | Interproscan |
| IPR036053 all species → | Homologous_superfamily | PABC (PABP) domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR46276 all species → | E3 UBIQUITIN-PROTEIN LIGASE UBR5 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0003723 all species → | Molecular Function | RNA binding | Interproscan |
| GO:0043130 all species → | Molecular Function | ubiquitin binding | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0034450 all species → | Molecular Function | ubiquitin-ubiquitin ligase activity | Interproscan |
| GO:0090263 all species → | Biological Process | positive regulation of canonical Wnt signaling pathway | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10593 | EDD1, UBR5; E3 ubiquitin-protein ligase EDD1 | EC:2.3.2.26 | Ubiquitin system | ko04121 | deepkoala |
Transcript abundance of XP_032229995.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 9.86 | 12.69 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 5.62 | 7.50 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 5.97 | 6.99 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 6.61 | 9.05 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 4.30 | 5.58 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 2 | 7.54 | 13.02 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 2 | 5.42 | 8.76 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 10.46 | 11.29 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 3 | 9.76 | 11.65 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 3 | 10.62 | 11.31 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 7.39 | 8.58 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 3 | 11.68 | 16.20 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 9.08 | 9.86 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 3 | 13.37 | 17.23 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 3 | 7.42 | 8.75 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 2 | 5.19 | 8.63 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.