Genomic Location: NC_064034.1:17300400...17315423
NR annotation: XP_032232152.2, dihydropyrimidine dehydrogenase [NADP(+)] [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5507598 |
| Transcript |
| rna-XM_032376261.2 |
| Protein |
| XP_032232152.2 |
| UniProt accession | Description |
|---|---|
| Q8CHR6 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus musculus OX=10090 GN=Dpyd PE=1 SV=1 |
| O89000 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Rattus norvegicus OX=10116 GN=Dpyd PE=2 SV=1 |
| Q12882 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003103 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF07992 all species → | Pyr_redox_2 | Pyridine nucleotide-disulphide oxidoreductase | Domain | Interproscan |
| PF01180 all species → | DHO_dh | Dihydroorotate dehydrogenase | Domain | Interproscan |
| PF14691 all species → | Fer4_20 | Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster | Domain | Interproscan |
| PF14697 all species → | Fer4_21 | 4Fe-4S dicluster domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR017896 all species → | Domain | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Interproscan |
| IPR017900 all species → | Conserved_site | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | Interproscan |
| IPR023753 all species → | Domain | FAD/NAD(P)-binding domain | Interproscan |
| IPR009051 all species → | Homologous_superfamily | Alpha-helical ferredoxin | Interproscan |
| IPR036188 all species → | Homologous_superfamily | FAD/NAD(P)-binding domain superfamily | Interproscan |
| IPR005720 all species → | Domain | Dihydroorotate dehydrogenase, catalytic | Interproscan |
| IPR001295 all species → | Conserved_site | Dihydroorotate dehydrogenase, conserved site | Interproscan |
| IPR028261 all species → | Domain | Dihydroprymidine dehydrogenase domain II | Interproscan |
| IPR013785 all species → | Homologous_superfamily | Aldolase-type TIM barrel | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43073 all species → | DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0002058 all species → | Molecular Function | uracil binding | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0006210 all species → | Biological Process | thymine catabolic process | Interproscan |
| GO:0006212 all species → | Biological Process | uracil catabolic process | Interproscan |
| GO:0017113 all species → | Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | Interproscan |
| GO:0050661 all species → | Molecular Function | NADP binding | Interproscan |
| GO:0051536 all species → | Molecular Function | iron-sulfur cluster binding | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0016627 all species → | Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors | Interproscan |
| GO:0006207 all species → | Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K00207 | DPYD; dihydropyrimidine dehydrogenase (NADP+) | EC:1.3.1.2 | Drug metabolism - other enzymes | ko00983 | deepkoala |
Transcript abundance of XP_032232152.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 142.11 | 160.77 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 111.50 | 142.16 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 132.05 | 135.17 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 133.25 | 137.56 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 112.38 | 114.85 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 3 | 122.48 | 133.00 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 3 | 146.63 | 161.48 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 108.05 | 116.90 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 3 | 89.52 | 98.05 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 3 | 87.46 | 89.61 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 93.54 | 102.95 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 3 | 145.05 | 164.79 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 129.10 | 140.00 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 3 | 122.49 | 133.83 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 3 | 122.15 | 133.72 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 3 | 116.50 | 148.32 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.