Detailed information of XP_032232152.2 in Nematostella vectensis

Genomic Location: NC_064034.1:17300400...17315423
NR annotation: XP_032232152.2, dihydropyrimidine dehydrogenase [NADP(+)] [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q8CHR6Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus musculus OX=10090 GN=Dpyd PE=1 SV=1
O89000Dihydropyrimidine dehydrogenase [NADP(+)] OS=Rattus norvegicus OX=10116 GN=Dpyd PE=2 SV=1
Q12882Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003103 (this species only)

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF07992
all species →
Pyr_redox_2Pyridine nucleotide-disulphide oxidoreductaseDomainInterproscan
PF01180
all species →
DHO_dhDihydroorotate dehydrogenaseDomainInterproscan
PF14691
all species →
Fer4_20Dihydroprymidine dehydrogenase domain II, 4Fe-4S clusterDomainInterproscan
PF14697
all species →
Fer4_214Fe-4S dicluster domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR017896
all species →
Domain4Fe-4S ferredoxin-type, iron-sulphur binding domainInterproscan
IPR017900
all species →
Conserved_site4Fe-4S ferredoxin, iron-sulphur binding, conserved siteInterproscan
IPR023753
all species →
DomainFAD/NAD(P)-binding domainInterproscan
IPR009051
all species →
Homologous_superfamilyAlpha-helical ferredoxinInterproscan
IPR036188
all species →
Homologous_superfamilyFAD/NAD(P)-binding domain superfamilyInterproscan
IPR005720
all species →
DomainDihydroorotate dehydrogenase, catalyticInterproscan
IPR001295
all species →
Conserved_siteDihydroorotate dehydrogenase, conserved siteInterproscan
IPR028261
all species →
DomainDihydroprymidine dehydrogenase domain IIInterproscan
IPR013785
all species →
Homologous_superfamilyAldolase-type TIM barrelInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR43073
all species →
DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]Interproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0016491
all species →
Molecular Functionoxidoreductase activityInterproscan
GO:0002058
all species →
Molecular Functionuracil bindingInterproscan
GO:0005829
all species →
Cellular ComponentcytosolInterproscan
GO:0006210
all species →
Biological Processthymine catabolic processInterproscan
GO:0006212
all species →
Biological Processuracil catabolic processInterproscan
GO:0017113
all species →
Molecular Functiondihydropyrimidine dehydrogenase (NADP+) activityInterproscan
GO:0050661
all species →
Molecular FunctionNADP bindingInterproscan
GO:0051536
all species →
Molecular Functioniron-sulfur cluster bindingInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0016627
all species →
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donorsInterproscan
GO:0006207
all species →
Biological Process'de novo' pyrimidine nucleobase biosynthetic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K00207DPYD; dihydropyrimidine dehydrogenase (NADP+)EC:1.3.1.2
Drug metabolism - other enzymesko00983deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_032232152.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples
48TPM > 0
16Conditions
164.8Max TPM
119.6Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
whole 6 week old aboral regenerate · regenerate 96hpa 3 3 142.11 160.77
whole 6 week old aboral regenerate · regenerate 144hpa 3 3 111.50 142.16
whole 6 week old aboral regenerate · regenerate 0hpa 3 3 132.05 135.17
whole 6 week old aboral regenerate · regenerate 2hpa 3 3 133.25 137.56
whole 6 week old aboral regenerate · regenerate uncut 3 3 112.38 114.85
whole 6 week old aboral regenerate · regenerate 4hpa 3 3 122.48 133.00
whole 6 week old aboral regenerate · regenerate 120hpa 3 3 146.63 161.48
whole 6 week old aboral regenerate · regenerate 36hpa 3 3 108.05 116.90
whole 6 week old aboral regenerate · regenerate 24hpa 3 3 89.52 98.05
whole 6 week old aboral regenerate · regenerate 20hpa 3 3 87.46 89.61
whole 6 week old aboral regenerate · regenerate 16hpa 3 3 93.54 102.95
whole 6 week old aboral regenerate · regenerate 72hpa 3 3 145.05 164.79
whole 6 week old aboral regenerate · regenerate 60hpa 3 3 129.10 140.00
whole 6 week old aboral regenerate · regenerate 48hpa 3 3 122.49 133.83
whole 6 week old aboral regenerate · regenerate 8hpa 3 3 122.15 133.72
whole 6 week old aboral regenerate · regenerate 12hpa 3 3 116.50 148.32

Per sample · hover a bar for the full sample record · show / hide the sample table

Source: CnidoSite RNA-seq expression matrices (NVECT_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

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