Detailed information of XP_032234036.2 in Nematostella vectensis

Genomic Location: NC_064039.1:15839635...15865064
NR annotation: XP_032234036.2, insulin-degrading enzyme [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P14735Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4
Q24K02Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1
P35559Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0001201 (this species only)

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00675
all species →
Peptidase_M16Insulinase (Peptidase family M16)FamilyInterproscan
PF16187
all species →
Peptidase_M16_MMiddle or third domain of peptidase_M16FamilyInterproscan
PF05193
all species →
Peptidase_M16_CPeptidase M16 inactive domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR011765
all species →
DomainPeptidase M16, N-terminalInterproscan
IPR011249
all species →
Homologous_superfamilyMetalloenzyme, LuxS/M16 peptidase-likeInterproscan
IPR001431
all species →
Binding_sitePeptidase M16, zinc-binding siteInterproscan
IPR032632
all species →
DomainPeptidase M16, middle/third domainInterproscan
IPR007863
all species →
DomainPeptidase M16, C-terminalInterproscan
IPR050626
all species →
FamilyPeptidase M16Interproscan

 PANTHER
PANTHER termDescriptionSource
PTHR43690
all species →
NARDILYSINInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0046872
all species →
Molecular Functionmetal ion bindingInterproscan
GO:0004222
all species →
Molecular Functionmetalloendopeptidase activityInterproscan
GO:0006508
all species →
Biological ProcessproteolysisInterproscan
GO:0005739
all species →
Cellular ComponentmitochondrionInterproscan
GO:0005829
all species →
Cellular ComponentcytosolInterproscan
GO:0043171
all species →
Biological Processpeptide catabolic processInterproscan
GO:0051603
all species →
Biological Processproteolysis involved in protein catabolic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K01408IDE, ide; insulysinEC:3.4.24.56
Peptidases and inhibitorsko01002deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_032234036.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples
43TPM > 0
16Conditions
19.1Max TPM
10.7Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
whole 6 week old aboral regenerate · regenerate 96hpa 3 3 14.98 18.67
whole 6 week old aboral regenerate · regenerate 144hpa 3 3 10.25 14.37
whole 6 week old aboral regenerate · regenerate 0hpa 3 3 7.80 9.18
whole 6 week old aboral regenerate · regenerate 2hpa 3 3 8.67 9.53
whole 6 week old aboral regenerate · regenerate uncut 3 3 8.69 10.10
whole 6 week old aboral regenerate · regenerate 4hpa 3 2 5.80 9.24
whole 6 week old aboral regenerate · regenerate 120hpa 3 3 16.38 19.15
whole 6 week old aboral regenerate · regenerate 36hpa 3 3 14.18 17.41
whole 6 week old aboral regenerate · regenerate 24hpa 3 2 8.33 14.16
whole 6 week old aboral regenerate · regenerate 20hpa 3 3 10.65 11.63
whole 6 week old aboral regenerate · regenerate 16hpa 3 3 10.57 11.85
whole 6 week old aboral regenerate · regenerate 72hpa 3 2 10.02 17.23
whole 6 week old aboral regenerate · regenerate 60hpa 3 3 14.96 16.70
whole 6 week old aboral regenerate · regenerate 48hpa 3 2 9.47 16.58
whole 6 week old aboral regenerate · regenerate 8hpa 3 3 12.95 14.27
whole 6 week old aboral regenerate · regenerate 12hpa 3 2 7.84 11.92

Per sample · hover a bar for the full sample record · show / hide the sample table

Source: CnidoSite RNA-seq expression matrices (NVECT_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

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