Genomic Location: NC_064039.1:15839635...15865064
NR annotation: XP_032234036.2, insulin-degrading enzyme [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5509246 |
| Transcript |
| rna-XM_032378145.2 |
| Protein |
| XP_032234036.2 |
| UniProt accession | Description |
|---|---|
| P14735 | Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4 |
| Q24K02 | Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1 |
| P35559 | Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001201 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00675 all species → | Peptidase_M16 | Insulinase (Peptidase family M16) | Family | Interproscan |
| PF16187 all species → | Peptidase_M16_M | Middle or third domain of peptidase_M16 | Family | Interproscan |
| PF05193 all species → | Peptidase_M16_C | Peptidase M16 inactive domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR011765 all species → | Domain | Peptidase M16, N-terminal | Interproscan |
| IPR011249 all species → | Homologous_superfamily | Metalloenzyme, LuxS/M16 peptidase-like | Interproscan |
| IPR001431 all species → | Binding_site | Peptidase M16, zinc-binding site | Interproscan |
| IPR032632 all species → | Domain | Peptidase M16, middle/third domain | Interproscan |
| IPR007863 all species → | Domain | Peptidase M16, C-terminal | Interproscan |
| IPR050626 all species → | Family | Peptidase M16 | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43690 all species → | NARDILYSIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0004222 all species → | Molecular Function | metalloendopeptidase activity | Interproscan |
| GO:0006508 all species → | Biological Process | proteolysis | Interproscan |
| GO:0005739 all species → | Cellular Component | mitochondrion | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0043171 all species → | Biological Process | peptide catabolic process | Interproscan |
| GO:0051603 all species → | Biological Process | proteolysis involved in protein catabolic process | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K01408 | IDE, ide; insulysin | EC:3.4.24.56 | Peptidases and inhibitors | ko01002 | deepkoala |
Transcript abundance of XP_032234036.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 14.98 | 18.67 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 10.25 | 14.37 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 7.80 | 9.18 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 8.67 | 9.53 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 8.69 | 10.10 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 2 | 5.80 | 9.24 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 3 | 16.38 | 19.15 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 14.18 | 17.41 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 2 | 8.33 | 14.16 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 3 | 10.65 | 11.63 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 10.57 | 11.85 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 2 | 10.02 | 17.23 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 14.96 | 16.70 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 2 | 9.47 | 16.58 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 3 | 12.95 | 14.27 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 2 | 7.84 | 11.92 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.