Genomic Location: NC_064047.1:9135446...9149821
NR annotation: XP_032234831.2, trifunctional purine biosynthetic protein adenosine-3 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5509911 |
| Transcript |
| rna-XM_032378940.2 |
| Protein |
| XP_032234831.2 |
| UniProt accession | Description |
|---|---|
| P21872 | Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus OX=9031 GN=GART PE=1 SV=1 |
| Q64737 | Trifunctional purine biosynthetic protein adenosine-3 OS=Mus musculus OX=10090 GN=Gart PE=1 SV=3 |
| P22102 | Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002861 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00551 all species → | Formyl_trans_N | Formyl transferase | Domain | Interproscan |
| PF02843 all species → | GARS_C | Phosphoribosylglycinamide synthetase, C domain | Domain | Interproscan |
| PF00586 all species → | AIRS | AIR synthase related protein, N-terminal domain | Domain | Interproscan |
| PF02769 all species → | AIRS_C | AIR synthase related protein, C-terminal domain | Domain | Interproscan |
| PF01071 all species → | GARS_A | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain | Domain | Interproscan |
| PF02844 all species → | GARS_N | Phosphoribosylglycinamide synthetase, N domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR011054 all species → | Homologous_superfamily | Rudiment single hybrid motif | Interproscan |
| IPR001555 all species → | Active_site | Phosphoribosylglycinamide formyltransferase, active site | Interproscan |
| IPR011761 all species → | Domain | ATP-grasp fold | Interproscan |
| IPR004733 all species → | Family | Phosphoribosylformylglycinamidine cyclo-ligase | Interproscan |
| IPR036921 all species → | Homologous_superfamily | PurM-like, N-terminal domain superfamily | Interproscan |
| IPR037123 all species → | Homologous_superfamily | Phosphoribosylglycinamide synthetase, C-domain superfamily | Interproscan |
| IPR020560 all species → | Domain | Phosphoribosylglycinamide synthetase, C-domain | Interproscan |
| IPR004607 all species → | Family | Phosphoribosylglycinamide formyltransferase | Interproscan |
| IPR000115 all species → | Family | Phosphoribosylglycinamide synthetase | Interproscan |
| IPR036477 all species → | Homologous_superfamily | Formyl transferase, N-terminal domain superfamily | Interproscan |
| IPR036676 all species → | Homologous_superfamily | PurM-like, C-terminal domain superfamily | Interproscan |
| IPR013815 all species → | Homologous_superfamily | ATP-grasp fold, subdomain 1 | Interproscan |
| IPR002376 all species → | Domain | Formyl transferase, N-terminal | Interproscan |
| IPR016185 all species → | Homologous_superfamily | Pre-ATP-grasp domain superfamily | Interproscan |
| IPR016188 all species → | Domain | PurM-like, N-terminal domain | Interproscan |
| IPR010918 all species → | Domain | PurM-like, C-terminal domain | Interproscan |
| IPR020561 all species → | Domain | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain | Interproscan |
| IPR020559 all species → | Conserved_site | Phosphoribosylglycinamide synthetase, conserved site | Interproscan |
| IPR020562 all species → | Domain | Phosphoribosylglycinamide synthetase, N-terminal | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10520 all species → | TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0004641 all species → | Molecular Function | phosphoribosylformylglycinamidine cyclo-ligase activity | Interproscan |
| GO:0006189 all species → | Biological Process | 'de novo' IMP biosynthetic process | Interproscan |
| GO:0004637 all species → | Molecular Function | phosphoribosylamine-glycine ligase activity | Interproscan |
| GO:0009113 all species → | Biological Process | purine nucleobase biosynthetic process | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0006164 all species → | Biological Process | purine nucleotide biosynthetic process | Interproscan |
| GO:0046084 all species → | Biological Process | adenine biosynthetic process | Interproscan |
| GO:0004644 all species → | Molecular Function | phosphoribosylglycinamide formyltransferase activity | Interproscan |
| GO:0009058 all species → | Biological Process | biosynthetic process | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11787 | GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase | EC:6.3.4.13 EC:2.1.2.2 EC:6.3.3.1 | Antifolate resistance | ko01523 | deepkoala |
Transcript abundance of XP_032234831.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 5.18 | 6.04 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 3.40 | 4.16 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 1.53 | 1.73 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 3.53 | 4.30 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 2.16 | 2.59 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 1 | 1.64 | 4.91 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 2 | 2.82 | 4.59 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 8.79 | 9.82 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 3 | 6.92 | 8.12 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 2 | 3.84 | 6.17 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 3.50 | 4.07 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 2 | 4.33 | 6.65 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 7.56 | 10.05 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 2 | 6.31 | 9.92 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 2 | 2.75 | 4.31 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 1 | 1.15 | 3.46 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.