Gene detail

Detailed information of XP_032235848.2 in Nematostella vectensis

Genomic Location: NC_064040.1:12139271...12151785
NR annotation: XP_032235848.2, sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

LOC116617326

ATGTCTTCCCTCTCTGCGGTTGTGTTCCTAGTACTCTGGCTTCACATGGCATTCCTTGCGGATGCATGTCCGCCGAGACCTCCGCCCATCTGCAGGTGGACCACATGCTACAATGTCTGGAATGGCTGGTATCCTTCTGGTATATCTCCAGGGAGATGTGTCTGGCAATACAGAACCACAAGGACAATAACGTACCATCACTCTCGTAGGGGAGGATGCCCAAGTTCGCAAAGATGCTACAGCAATCATCAGCGACGGGTTATGTGTTCCTGTCGTTATGCCTACCACTGCCCATTACGTCATTGGTCTGGATGGGGAGGGGTCTCTCAGGGCACATGCAGACGACAGAGCCGATATAGAGATTACAATGAACACGTCAGCTATATACATAGAGCACACAGTTGTAGCGGGGTCCGGAGGTACTGCGGCTCAAGACAGTATCAACACAGGCAATGGTGCTCGTGCCGTCATGCGTACAGTTGCCCGCTGCAGCAGTGGTCTGGTTGGTCAGGTACCATCCCTCAGGGACACTGTAATGGTCAGACAAGATACCGTTATTATCGCGAACATGTCAGGTATATTCAACAGTCCAATTGCCATGGAGTTAGTCAGACGTGTGGCAGCGGACACCACGAGAACAGAAGATACTGTTCGTGTCGTTACGCGCATTGCTCCCTGGGTGGGTGGAGCTCATGGAGTGACACACCATCATCCGTCAATCAACACCACTGCGCATCTCAAAAGCGTTCCCGCCGTTACTCGCTGACGTGGAAATATGACATGAGGTTGAACAACTGCCAGGGGGTGGTCCCGCAGTCCTGCCCTTCGACCCAACACGAGACTCGAGAGAAAATCGTCAAGTGTCTTCCTCTGGCTCTTCCTCAAAATGGGGCCTGGGACCGAGACGAATGCAGTAAGATAGCGCAAGTCTGTAAGGCCACGTGTATGATCACGTGTGACGAGGCCAACGGGTTCAAAGCCGAGGGCGCTACCATACGAAGCTGCGGTGCTACTGGACAGTGGTCGACACCTTGGAACACTTATTGCAAAGATATTCTCCCACCATCACTTAAATGCCCTGATAGTATCGTCAGCAAAACCGACCCTGGTAAACCGACCGCAAGAATCACTATCCCCTCTCCTGAGGCGGTCGATAATAGCGGAGATGCGCCTGTGATTACTCACGATGTTGGAGTTGCTGTAAAGGATTTCCCGATCAGCGGCAAGCCCCATGTTGTCAGGTACACTGCCAGAGACAAGGCGGGAAACGCGGCCGTGTGCTCTCTCTACATTACGGTGAAAGACAAGGAACGACCTAAAGTCACCTTCTGCCCGGATGACATCCACATCGAGACAAACAAAAACAGTGAGCGGGTCACGTGGTTGTACCCGACATTTGTTGACAACAGCCTGCCGCCGGACCAGCCCATAAGGGTCACCAGTAATAGGAACCCTGGGGTGCGGTTCCACTGGGGCAAATATCAGGTCAAGTATACGGCGTTTGACCAGGCCAACAATAACGCCACGTGCGAGTTCTACGTACAAGTGAGCCCCGTAAAGTGCCCGCTGTTTGATCCGCCACAACACGGCACGCGTGCATGTAACAAAAAGACGCAAGGCGCCAATGGCATCTCACACGAGCTCGTGTGTAGCGTGCAGTGCAAGACTGGTTATGCCTTCGCTGAATTCACCCCGTCATCTGTATACATGTGCCAATCAGACGGCAAGTGGTATAGGATGATCCACGGCTTCCCAGTACCTGTATTTGATCAGAAGAAAAGACCTTGGCCTGACTGTGCACCAAAGACGGGTGTCACATCTACCGCAAAGTCCTTCACGTTCTACACCGGCTCCTGCATCGGCAACCACAGCATGACACTGGATCAGATTCGGCAGAACTTCCTCCATGCGATCAGGCAAAGCATGATGGCGAACGTGCTGTTGTGTCAGGAGAGCCAAGGAGTCGACTGCGTGGTAGAAAACGTCAAAGTCTACTGTGGAGCACGTTCAAAGCGCAGTGGCAGTGACGAGCCACAGAGAGTGATAACCTTCGACTTTGTAATAAACGACAAGAAACCGCAGGGTGACCGCGCAAAAGAAGCCACAAAACTACAGTCGATGATGAAGGAGCTCGATATGGCAGAAAGCTACATCAAGACCAGTTTCCCCTCGAACGCGCACATGCCTACCCTTAAAATTGAAGCATCCGGAAGCTCTTTGTTTTGTCCACCGAAAAGCGCCCTTGTGGTTCCTGAAGGATCTGGGTCTGAATTACAGAAAGCGATATGTGTTGAATGCCCCGTGGGTACATTCTACGACGAGGCTACCAGGAACTGCAGCATATGTCCCGTGGGCACGTATCAGGACGAGATGGGACAGACCAAGTGCAAAGAGTGCCCATTGGGTACACTTACCATAGAGGCGGGAGCGCGCAACGCGACAATGTGTTACGACACTTGTGAGCCCGGCGAGTACCGCCATATTGGAAATGCAGGCGCGGCTACCTGTTTGGCGTGTCCACTAGGGACGTACCAGCCCAAGGCCTTCTCGGCTTCGTGCATAAAATGCCCGGATGTGAGAACCACCGCTCGAGTTGGTTCGACGTCACTGAGTGATTGCAAGTGA

Transcript

rna-XM_032379957.2

CGGCAATGGCAGAAAGCAATGAGAATTTAAAGATCTAGGCGTGAAATGCACTCTATcttatacatttcagccgttttcctcTTAACTATGTCGTAAAAACACCACGTTTCGCAGTCTTGTGTGGTTCTCTAAGGCAGGAACAAGCTCTTCGACATATCTTTGGCTATTTGGAACTCTAAGAACGAGTTTCTCGCAATTAGTTACTTGGTGCTAGTTAGCATTGAGTGCCAAGATAAAAGAGATTTTGTGGTCATATTTTTCTTCACTACGCCGTGCTAAAATTCTGACTGAAGTTTACTTGATAACTCGTGGGAATTTATAGTAATGGCAGCCGGATGTTTCTGATTACACGAAACTCTAATTTACCCAGCCTAAACCAACAAAAATGAATTACTCTATATTATAACCCGTTATGTGTAGACCGTCTAGTCCGAGGGTTAAGGTTTAATTGCGAGGATGTCTTCCCTCTCTGCGGTTGTGTTCCTAGTACTCTGGCTTCACATGGCATTCCTTGCGGATGCATGTCCGCCGAGACCTCCGCCCATCTGCAGGTGGACCACATGCTACAATGTCTGGAATGGCTGGTATCCTTCTGGTATATCTCCAGGGAGATGTGTCTGGCAATACAGAACCACAAGGACAATAACGTACCATCACTCTCGTAGGGGAGGATGCCCAAGTTCGCAAAGATGCTACAGCAATCATCAGCGACGGGTTATGTGTTCCTGTCGTTATGCCTACCACTGCCCATTACGTCATTGGTCTGGATGGGGAGGGGTCTCTCAGGGCACATGCAGACGACAGAGCCGATATAGAGATTACAATGAACACGTCAGCTATATACATAGAGCACACAGTTGTAGCGGGGTCCGGAGGTACTGCGGCTCAAGACAGTATCAACACAGGCAATGGTGCTCGTGCCGTCATGCGTACAGTTGCCCGCTGCAGCAGTGGTCTGGTTGGTCAGGTACCATCCCTCAGGGACACTGTAATGGTCAGACAAGATACCGTTATTATCGCGAACATGTCAGGTATATTCAACAGTCCAATTGCCATGGAGTTAGTCAGACGTGTGGCAGCGGACACCACGAGAACAGAAGATACTgTTCGTGTCGTTACGCGCATTGCTCCCTGGGTGGGTGGAGCTCATGGAGTGACACACCATCATCCGTCAATCAACACCACTGCGCATCTCAAAAGCGTTCCCGCCGTTACTCGCTGACGTGGAAATATGACATGAGGTTGAACAACTGCCAGGGGGTGGTCCCGCAGTCCTGCCCTTCGACCCAACACGAGACTCGAGAGAAAATCGTCAAGTGTCTTCCTCTGGCTCTTCCTCAAAATGGGGCCTGGGACCGAGACGAATGCAGTAAGATAGCGCAAGTCTGTAAGGCCACGTGTATGATCACGTGTGACGAGGCCAACGGGTTCAAAGCCGAGGGCGCTACCATACGAAGCTGCGGTGCTACTGGACAGTGGTCGACACCTTGGAACACTTATTGCAAAGatattCTCCCACCATCACTTAAATGCCCTGATAGTATCGTCAGCAAAACCGACCCTGGTAAACCGACCGCAAGAATCACTATCCCCTCTCCTGAGGCGGTCGATAATAGCGGAGATGCGCCTGTGATTACTCACGATGTTGGAGTTGCTGTAAAGGATTTCCCGATCAGCGGCAAGCCCCATGTTGTCAGGTACACTGCCAGAGACAAGGCGGGAAACGCGGCCGTGTGCTCTCTCTACATTACGGTGAAAGACAAGGAACGACCTAAAGTCACCTTCTGCCCGGATGACATCCACATCGagacaaacaaaaacagtgaGCGGGTCACGTGGTTGTACCCGACATTTGTTGACAACAGCCTGCCGCCGGACCAGCCCATAAGGGTCACCAGTAATAGGAACCCTGGGGTGCGGTTCCACTGGGGCAAATATCAGGTCAAGTATACGGCGTTTGACCAGGCCAACAATAACGCCACGTGCGAGTTCTACGTACAAGTGAGCCCCGTAAAGTGCCCGCTGTTTGATCCGCCACAACACGGCACGCGTGCATGTAACAAAAAGACGCAAGGCGCCAATGGCATCTCACACGAGCTCGTGTGTAGCGTGCAGTGCAAGACTGGTTATGCCTTCGCTGAATTCACCCCGTCATCTGTATACATGTGCCAATCAGACGGCAAGTGGTATAGGATGATCCACGGCTTCCCAGTACCTGTATTTGATCAGAAGAAAAGACCTTGGCCTGACTGTGCACCAAAGACGGGTGTCACATCTACCGCAAAGTCCTTCACGTTCTACACCGGCTCCTGCATCGGCAACCACAGCATGACACTGGATCAGATTCGGCAGAACTTCCTCCATGCGATCAGGCAAAGCATGATGGCGAACGTGCTGTTGTGTCAGGAGAGCCAAGGAGTCGACTGCGTGGTAGAAAACGTCAAAGTCTACTGTGGAGCACGTTCAAAGCGCAGTGGCAGTGACGAGCCACAGAGAGTGATAACCTTCGACTTTGTAATAAACGACAAGAAACCGCAGGGTGACCGCGCAAAAGAAGCCACAAAACTACAGTCGATGATGAAGGAGCTCGATATGGCAGAAAGCTACATCAAGACCAGTTTCCCCTCGAACGCGCACATGCCTACCCTTAAAATTGAAGCATCCGGAAGCTCTTTGTTTTGTCCACCGAAAAGCGCCCTTGTGGTTCCTGAAGGATCTGGGTCTGAATTACAGAAAGCGATATGTGttgaATGCCCCGTGGGTACATTCTACGACGAGGCTACCAGGAACTGCAGCATATGTCCCGTGGGCACGTATCAGGACGAGATGGGACAGACCAAGTGCAAAGAGTGCCCATTGGGTACACTTACCATAGAGGCGGGAGCGCGCAACGCGACAATGTGTTACGACACTTGTGAGCCCGGCGAGTACCGCCATATTGGAAATGCAGGCGCGGCTACCTGTTTGGCGTGTCCACTAGGGACGTACCAGCCCAAGGCCTTCTCGGCTTCGTGCATAAAATGCCCGGATGTGAGAACCACCGCTCGAGTTGGTTCGACGTCACTGAGTGATTGCAAGTGAACTGGTGTTGATCTGACAGTTCCTTTAAAATAAACGGATTTAGAAAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q4LDE5	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001683 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF07699 all species →	Ephrin_rec_like	Tyrosine-protein kinase ephrin type A/B receptor-like	Domain	Interproscan
PF02494 all species →	HYR	HYR domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR011641 all species →	Domain	Tyrosine-protein kinase ephrin type A/B receptor-like	Interproscan
IPR003410 all species →	Domain	HYR domain	Interproscan
IPR035976 all species →	Homologous_superfamily	Sushi/SCR/CCP superfamily	Interproscan
IPR009030 all species →	Homologous_superfamily	Growth factor receptor cysteine-rich domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR24273 all species →	FI04643P-RELATED	Interproscan

Gene Ontology

No Gene Ontology signature was detected for XP_032235848.2. This gene does have a gene model — the search simply returned no hit.

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

No KEGG orthology assignment for XP_032235848.2.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_032235848.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples

37TPM > 0

16Conditions

10.3Max TPM

4.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
whole 6 week old aboral regenerate · regenerate 96hpa	3	2	3.53	5.92
whole 6 week old aboral regenerate · regenerate 144hpa	3	3	4.79	6.13
whole 6 week old aboral regenerate · regenerate 0hpa	3	3	8.20	10.32
whole 6 week old aboral regenerate · regenerate 2hpa	3	3	8.50	9.66
whole 6 week old aboral regenerate · regenerate uncut	3	3	4.69	7.01
whole 6 week old aboral regenerate · regenerate 4hpa	3	1	1.65	4.95
whole 6 week old aboral regenerate · regenerate 120hpa	3	2	3.24	5.06
whole 6 week old aboral regenerate · regenerate 36hpa	3	3	4.93	6.31
whole 6 week old aboral regenerate · regenerate 24hpa	3	2	3.56	5.95
whole 6 week old aboral regenerate · regenerate 20hpa	3	2	4.64	7.49
whole 6 week old aboral regenerate · regenerate 16hpa	3	3	8.04	8.72
whole 6 week old aboral regenerate · regenerate 72hpa	3	2	2.75	5.17
whole 6 week old aboral regenerate · regenerate 60hpa	3	3	6.48	7.96
whole 6 week old aboral regenerate · regenerate 48hpa	3	1	1.51	4.52
whole 6 week old aboral regenerate · regenerate 8hpa	3	2	4.83	7.42
whole 6 week old aboral regenerate · regenerate 12hpa	3	2	5.59	9.35

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6320836	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	5.92
SRR6320863	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	4.66
SRR6320837	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	0.00
SRR6320847	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	6.13
SRR6320841	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	4.28
SRR6320838	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	3.94
SRR6320840	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	10.32
SRR6320846	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	7.97
SRR6320839	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	6.32
SRR6320848	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	9.66
SRR6320842	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	8.24
SRR6320861	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	7.59
SRR6320845	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	7.01
SRR6320843	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	4.21
SRR6320844	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	2.84
SRR6320872	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	4.95
SRR6320849	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	0.00
SRR6320873	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	0.00
SRR6320883	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	5.06
SRR6320882	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	4.65
SRR6320850	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	0.00
SRR6320851	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	6.31
SRR6320855	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	4.56
SRR6320852	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	3.90
SRR6320854	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	5.95
SRR6320853	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	4.74
SRR6320856	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	0.00
SRR6320860	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	7.49
SRR6320857	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	6.42
SRR6320859	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	0.00
SRR6320881	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	8.72
SRR6320858	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	8.58
SRR6320880	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	6.80
SRR6320862	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	5.17
SRR6320865	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	3.09
SRR6320864	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	0.00
SRR6320869	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	7.96
SRR6320867	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	6.50
SRR6320866	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	4.97
SRR6320870	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	4.52
SRR6320868	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	0.00
SRR6320871	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	0.00
SRR6320875	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	7.42
SRR6320874	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	7.06
SRR6320876	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	0.00
SRR6320879	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	9.35
SRR6320877	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	7.43
SRR6320878	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	0.00

Source: CnidoSite RNA-seq expression matrices (NVECT_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.