Detailed information of XP_032236743.2 in Nematostella vectensis

Genomic Location: NC_064039.1:22647...28476
NR annotation: XP_032236743.2, DNA mismatch repair protein Mlh1 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P40692DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1
Q9JK91DNA mismatch repair protein Mlh1 OS=Mus musculus OX=10090 GN=Mlh1 PE=1 SV=2
P97679DNA mismatch repair protein Mlh1 OS=Rattus norvegicus OX=10116 GN=Mlh1 PE=2 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005246 (this species only)

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF01119
all species →
DNA_mis_repairDNA mismatch repair protein, C-terminal domainFamilyInterproscan
PF16413
all species →
Mlh1_CDNA mismatch repair protein Mlh1 C-terminusDomainInterproscan
PF13589
all species →
HATPase_c_3Histidine kinase-, DNA gyrase B-, and HSP90-like ATPaseDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR038973
all species →
FamilyDNA mismatch repair protein MutL/Mlh/Pms-likeInterproscan
IPR014762
all species →
Conserved_siteDNA mismatch repair, conserved siteInterproscan
IPR002099
all species →
FamilyDNA mismatch repair protein MutL/Mlh/PMSInterproscan
IPR020568
all species →
Homologous_superfamilyRibosomal protein uS5 domain 2-type superfamilyInterproscan
IPR013507
all species →
DomainDNA mismatch repair protein, S5 domain 2-likeInterproscan
IPR032189
all species →
DomainDNA mismatch repair protein Mlh1, C-terminalInterproscan
IPR014721
all species →
Homologous_superfamilySmall ribosomal subunit protein uS5 domain 2-type fold, subgroupInterproscan
IPR036890
all species →
Homologous_superfamilyHistidine kinase/HSP90-like ATPase superfamilyInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10073
all species →
DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTLInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006298
all species →
Biological Processmismatch repairInterproscan
GO:0016887
all species →
Molecular FunctionATP hydrolysis activityInterproscan
GO:0032300
all species →
Cellular Componentmismatch repair complexInterproscan
GO:0032389
all species →
Cellular ComponentMutLalpha complexInterproscan
GO:0140664
all species →
Molecular FunctionATP-dependent DNA damage sensor activityInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan
GO:0030983
all species →
Molecular Functionmismatched DNA bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K08734MLH1; DNA mismatch repair protein MLH1-DNA repair and recombination proteinsko03400deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_032236743.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples
34TPM > 0
16Conditions
3.3Max TPM
1.2Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
whole 6 week old aboral regenerate · regenerate 96hpa 3 1 0.90 2.69
whole 6 week old aboral regenerate · regenerate 144hpa 3 3 1.89 2.79
whole 6 week old aboral regenerate · regenerate 0hpa 3 3 0.88 0.97
whole 6 week old aboral regenerate · regenerate 2hpa 3 3 1.66 2.17
whole 6 week old aboral regenerate · regenerate uncut 3 3 1.34 1.56
whole 6 week old aboral regenerate · regenerate 4hpa 3 1 0.37 1.11
whole 6 week old aboral regenerate · regenerate 120hpa 3 2 1.41 2.27
whole 6 week old aboral regenerate · regenerate 36hpa 3 3 2.09 2.61
whole 6 week old aboral regenerate · regenerate 24hpa 3 2 0.80 1.36
whole 6 week old aboral regenerate · regenerate 20hpa 3 2 0.50 0.80
whole 6 week old aboral regenerate · regenerate 16hpa 3 3 1.15 1.16
whole 6 week old aboral regenerate · regenerate 72hpa 3 2 1.75 3.13
whole 6 week old aboral regenerate · regenerate 60hpa 3 2 1.91 3.31
whole 6 week old aboral regenerate · regenerate 48hpa 3 1 0.77 2.32
whole 6 week old aboral regenerate · regenerate 8hpa 3 2 0.98 1.71
whole 6 week old aboral regenerate · regenerate 12hpa 3 1 0.35 1.04

Per sample · hover a bar for the full sample record · show / hide the sample table

Source: CnidoSite RNA-seq expression matrices (NVECT_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

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