Gene detail

Detailed information of XP_032240819.2 in Nematostella vectensis

Genomic Location: NC_064041.1:6896820...6912917
NR annotation: XP_032240819.2, folylpolyglutamate synthase, mitochondrial [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

rna-XM_032384928.2

CAAGTCTCCCATCCTCCATTTACATTTGGTAATCAGCCTGTAAGCTACAAAGTAGGGGCCCAAAGTTCAAAAGTTTATGGTTGTCAGGAAAATTCTGAGGCATCCAAGCTTACGTTGCCTTAACTTGACGACTATTTCGCCTAGTTTGCTAGCTTTCATGTCGGAACAACGAGGCTATGAGGATGCCGTGAAAGCGCTAAACACTCTGCAGACAAATGCTCAAGTTCTAGCTCAGATCCGTAAGGAGCGTGGCAGATTAAGAAGGGATAATCTTGTCGAGATGCGACGGTTTGTCGAGCGAGCCGGTGTATCGATGGAACAATTAGATGAGTTGTCAGTGATTCATGTCAGTGGAACCAAGGGTAAAGGATCTACATGTGCTTTCACAGAGAGCATTTTGAGGAATTGTGGATTTAAAACTGGATTTTACAGCTCCCCACATTTGATAGAAGTCAGAGAGAGAATCAGGATTAATGGAAAACCTCTAGCAAAGAATTTGTTtgcaaagtatttttttaagtgtTGGGACAACCTTCAATCTTCAAAGACAGAGGAAAATCAAAAGATGCCAGCCTATTTCAGGTTTCTTACATTAATGGCTTTCTATGTATTCCTCCATGAACAGGTCGATGTTGCCATCCTTGAAGTAGGAATTGGGGGTGCCTATGACTCAACCAACATCATTAGAAAGCCTGTGGTGTGTGGGGTGACCTCACTTGGAATGGACCATGTACAGGTGCTTGGGGGATCCCTGGAGAGCATTGCTCTGCACAAGGCTGGGATATTTAAGCCAAATGTTCCAGCATTCACTGTACCTCAAGATGAAAGTGCTTTGCAAGTGGTTGCTGAAAAAGCTAGTGAATTGCAGACTTCTTTACATGTTGTTCCTTCTCTAGATGACTATCCAGGCAAACGACCAGAACTTGGTATTGATGGTGAACACCAAGGTATAAACGCTTCCACTGCAATACAGCTGAGCCGAACATGGATACAAAAGCATGAACAGAGAACAAATAGCAATGCAGAAACTGAAGCCAGCAACGAACAAAACGCAGAGGATGACTCAGAAACAAAAGCCCCTAAAAAACCAAGACTTTCAATCCCAGTCGCAGAAACTTTTGAGATCCCTGATTCATTCCGAGAAGGTCTTCGAAATACTCGTTGGTGGGGACGTAATCAGATGATTGTGCTTCcaaaaatcacattttataTAGATGGAGCACATACACCTCGAAGCATAGAGGCTTGCATCAAGTGGTTCTTACTCAGAGCTGACGATGAACGAGAGAAAACATCaggCAGTACTGCGCGTGTTCTTCTGTTCAATTTGACAGGAGATCGGGACCCGCACGGAATTCTCAGGCCGCTGATCGATTGCAAGTTTGATCATGCTGTGTTTTCTCCTAACACTGTTAGCCTGGATAGCATGGGTGAAAGCACGGACCTGACGAACTTCACCGTAACACGTGACAGCCAGCTTCGTCACTGCGTGGAAAACCAACGTTGCTGGATGGCTCTAAGAGGTGCTGGCTTCCAGTCCCACGCGGACGAGGAAGACCACTTGATTCAGAACGGGCTAGATGACGGACCTTACTCGACCATATTTCCCTGCGTTGCGCAGGCGCTGAGGTGGATAACCGCTGGCCGGGATCCGCGCATCCCGACTAACGGCAACAACGGGATAGCTGTTCCGGAGACTCTAACCCAGGCCACGCGCCTCCAAGTCCTGGTGACTGGGAGCCTGCACTTGGTCGGCACTGCGCTTAAGGTTCTGGGTAGTGACATCACAGGGGAAATGTAGACACCTGAACTTCGGAACCGGACCCTCGGGTCCAGGCGAACTCGGGAAGCCATCTCGCCCGTCGTTTCCGGATTGCCCTGGTGTTCCAGGAACACCTGAAACTCACAGATTTCCGTTCTTTCCATCTTGGCCACAGGGAAAGCAACCCTGAAAAAATTTTGATTGCAAAGTTTTATTGCTCGCCCATCTACACGATAAATATTCCGATCCGTCCAATTTTCTTGGCAAAACCCCCATCGAGCAAGTTCTAAGCAAAAGAGCTATCGTGgcgaagacaaaaaaaataaggccTACCAGTTCTAGTATATCGTCCACTTTTTTCGACTGTTGACTGTCGTGGACTCGTTCCCTCGCTGCTCTATCTGCTCTTCGAATTAACGTTTTGATAAGTTTCGCTTTGCATGCGTAAATGCTAGATTTACTTGAaacaatgtgtagttccagaaaatatccatacccccccccctccattgaggggattggaaattccgtgggggggggggggggggtaaaatgcccctttttccttaacagttactgtattttatttccagggggttggaaattccagaggggtggtgggtctgtgtatggatattttctggaactacacaatgtaTAAAGTAGTCTTAAAggccgacttctccctaaaaacgaggagaattcatactttgaacatttgaaaactgcacttcaagcctcatatctcgaagacgaatccataacaacaacaaaaaagcctttttgatatgttggtttacataacataaggaacctctatgcaaaaattcaagcttaccgaagttaaccagaccttattttgggaaaacttgccatagGGGCGGATTCCGGAGTTtcagaaggggggggggggggaagagggGGAATTTTTTAAAGTTCTTTTAAGGGGAACTAAAGTTTAAAAAGGTCCTACGGGGATAACCAGAACTCGATGCTCTTAGAGCATGTACTTGGGCTTTATTGTAGAGATAACCAAAGGTTATTTTCAGCTTGCAACATTGGCTTGTCGCATTATTTTTccatgtggggggggggggggggaggggggaggtgtTACCTTTGAGAAACCACCTTCCATGGAATCGCCAGTGCGATTAATTATACAGTACGATCAATTATACaacattttgcgttgaaagtTATAAACATCGTAAAGTTGCTATGAGTTATGTAGATTTCAATGGTGGGGGGAAAGGGGTGCAAcaagatggtcacgtgatctgtaaATCCACGACGTCACAAAAGCGAAAATATCCACATCtcataattaaaaaataaatagaaccA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q05932	Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3
Q924L9	Folylpolyglutamate synthase, mitochondrial OS=Cricetulus griseus OX=10029 GN=FPGS PE=2 SV=1
A6H751	Folylpolyglutamate synthase, mitochondrial OS=Bos taurus OX=9913 GN=FPGS PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002827 (this species only)

Pfam domain

No Pfam domain signature was detected for XP_032240819.2. This gene does have a gene model — the search simply returned no hit.

InterPro

InterPro term	Type	Description	Source
IPR023600 all species →	Family	Folylpolyglutamate synthase, eukaryota	Interproscan
IPR036565 all species →	Homologous_superfamily	Mur-like, catalytic domain superfamily	Interproscan
IPR001645 all species →	Family	Folylpolyglutamate synthetase	Interproscan
IPR036615 all species →	Homologous_superfamily	Mur ligase, C-terminal domain superfamily	Interproscan
IPR018109 all species →	Conserved_site	Folylpolyglutamate synthetase, conserved site	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11136 all species →	FOLYLPOLYGLUTAMATE SYNTHASE-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004326 all species →	Molecular Function	tetrahydrofolylpolyglutamate synthase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0009396 all species →	Biological Process	folic acid-containing compound biosynthetic process	Interproscan
GO:0009058 all species →	Biological Process	biosynthetic process	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0046901 all species →	Biological Process	tetrahydrofolylpolyglutamate biosynthetic process	Interproscan
GO:0016881 all species →	Molecular Function	acid-amino acid ligase activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01930	FPGS; folylpolyglutamate synthase	EC:6.3.2.17	Antifolate resistance	ko01523	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_032240819.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

48Samples

40TPM > 0

16Conditions

15.8Max TPM

5.5Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
whole 6 week old aboral regenerate · regenerate 96hpa	3	3	6.73	7.18
whole 6 week old aboral regenerate · regenerate 144hpa	3	3	4.99	6.72
whole 6 week old aboral regenerate · regenerate 0hpa	3	3	6.50	7.80
whole 6 week old aboral regenerate · regenerate 2hpa	3	3	7.64	8.89
whole 6 week old aboral regenerate · regenerate uncut	3	3	5.05	5.43
whole 6 week old aboral regenerate · regenerate 4hpa	3	2	5.38	8.65
whole 6 week old aboral regenerate · regenerate 120hpa	3	3	7.18	7.45
whole 6 week old aboral regenerate · regenerate 36hpa	3	3	6.14	6.65
whole 6 week old aboral regenerate · regenerate 24hpa	3	3	5.81	6.19
whole 6 week old aboral regenerate · regenerate 20hpa	3	2	3.79	5.80
whole 6 week old aboral regenerate · regenerate 16hpa	3	3	5.27	5.80
whole 6 week old aboral regenerate · regenerate 72hpa	3	3	10.20	15.84
whole 6 week old aboral regenerate · regenerate 60hpa	3	2	4.43	6.67
whole 6 week old aboral regenerate · regenerate 48hpa	3	1	2.76	8.28
whole 6 week old aboral regenerate · regenerate 8hpa	3	2	4.65	7.02
whole 6 week old aboral regenerate · regenerate 12hpa	3	1	1.97	5.90

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6320863	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	7.18
SRR6320836	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	7.13
SRR6320837	whole 6 week old aboral regenerate · regenerate 96hpa	whole 6 week old aboral regenerate	six weeks	regenerate 96hpa	SRP125570	5.88
SRR6320847	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	6.72
SRR6320841	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	4.65
SRR6320838	whole 6 week old aboral regenerate · regenerate 144hpa	whole 6 week old aboral regenerate	six weeks	regenerate 144hpa	SRP125570	3.60
SRR6320846	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	7.80
SRR6320839	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	5.90
SRR6320840	whole 6 week old aboral regenerate · regenerate 0hpa	whole 6 week old aboral regenerate	six weeks	regenerate 0hpa	SRP125570	5.80
SRR6320861	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	8.89
SRR6320842	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	8.41
SRR6320848	whole 6 week old aboral regenerate · regenerate 2hpa	whole 6 week old aboral regenerate	six weeks	regenerate 2hpa	SRP125570	5.62
SRR6320843	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	5.43
SRR6320844	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	5.35
SRR6320845	whole 6 week old aboral regenerate · regenerate uncut	whole 6 week old aboral regenerate	six weeks	regenerate uncut	SRP125570	4.38
SRR6320873	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	8.65
SRR6320872	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	7.50
SRR6320849	whole 6 week old aboral regenerate · regenerate 4hpa	whole 6 week old aboral regenerate	six weeks	regenerate 4hpa	SRP125570	0.00
SRR6320850	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	7.45
SRR6320882	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	7.35
SRR6320883	whole 6 week old aboral regenerate · regenerate 120hpa	whole 6 week old aboral regenerate	six weeks	regenerate 120hpa	SRP125570	6.76
SRR6320851	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	6.65
SRR6320855	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	6.36
SRR6320852	whole 6 week old aboral regenerate · regenerate 36hpa	whole 6 week old aboral regenerate	six weeks	regenerate 36hpa	SRP125570	5.39
SRR6320854	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	6.19
SRR6320853	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	5.81
SRR6320856	whole 6 week old aboral regenerate · regenerate 24hpa	whole 6 week old aboral regenerate	six weeks	regenerate 24hpa	SRP125570	5.43
SRR6320857	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	5.80
SRR6320860	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	5.59
SRR6320859	whole 6 week old aboral regenerate · regenerate 20hpa	whole 6 week old aboral regenerate	six weeks	regenerate 20hpa	SRP125570	0.00
SRR6320880	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	5.80
SRR6320881	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	5.73
SRR6320858	whole 6 week old aboral regenerate · regenerate 16hpa	whole 6 week old aboral regenerate	six weeks	regenerate 16hpa	SRP125570	4.28
SRR6320864	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	15.84
SRR6320862	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	7.78
SRR6320865	whole 6 week old aboral regenerate · regenerate 72hpa	whole 6 week old aboral regenerate	six weeks	regenerate 72hpa	SRP125570	6.99
SRR6320867	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	6.67
SRR6320866	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	6.60
SRR6320869	whole 6 week old aboral regenerate · regenerate 60hpa	whole 6 week old aboral regenerate	six weeks	regenerate 60hpa	SRP125570	0.00
SRR6320870	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	8.28
SRR6320868	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	0.00
SRR6320871	whole 6 week old aboral regenerate · regenerate 48hpa	whole 6 week old aboral regenerate	six weeks	regenerate 48hpa	SRP125570	0.00
SRR6320875	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	7.02
SRR6320874	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	6.92
SRR6320876	whole 6 week old aboral regenerate · regenerate 8hpa	whole 6 week old aboral regenerate	six weeks	regenerate 8hpa	SRP125570	0.00
SRR6320877	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	5.90
SRR6320878	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	0.00
SRR6320879	whole 6 week old aboral regenerate · regenerate 12hpa	whole 6 week old aboral regenerate	six weeks	regenerate 12hpa	SRP125570	0.00

Source: CnidoSite RNA-seq expression matrices (NVECT_TPM, StringTie quantification over 48 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.