Genomic Location: NC_064034.1:892884...943173
NR annotation: XP_032242082.2, E3 ubiquitin-protein ligase HUWE1 isoform X1 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC116620378 |
| Transcript |
| rna-XM_032386191.2 |
| Protein |
| XP_032242082.2 |
| UniProt accession | Description |
|---|---|
| Q7Z6Z7 | E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3 |
| Q7TMY8 | E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus OX=10090 GN=Huwe1 PE=1 SV=5 |
| P51593 | E3 ubiquitin-protein ligase HUWE1 OS=Rattus norvegicus OX=10116 GN=Huwe1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002420 (this species only) |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Ubiquitin family | UBD|Alpha-Helix|UBM · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00627 all species → | UBA | UBA/TS-N domain | Domain | Interproscan |
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF06025 all species → | DUF913 | Domain of Unknown Function (DUF913) | Family | Interproscan |
| PF06012 all species → | DUF908 | Domain of Unknown Function (DUF908) | Family | Interproscan |
| PF02825 all species → | WWE | WWE domain | Family | Interproscan |
| PF14377 all species → | UBM | Ubiquitin binding region | Motif | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR015940 all species → | Domain | Ubiquitin-associated domain | Interproscan |
| IPR009060 all species → | Homologous_superfamily | UBA-like superfamily | Interproscan |
| IPR018123 all species → | Domain | WWE domain, subgroup | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR037197 all species → | Homologous_superfamily | WWE domain superfamily | Interproscan |
| IPR004170 all species → | Domain | WWE domain | Interproscan |
| IPR041918 all species → | Domain | HUWE1, UBA domain | Interproscan |
| IPR050409 all species → | Family | E3 ubiquitin-protein ligase | Interproscan |
| IPR010314 all species → | Domain | E3 ubiquitin ligase, domain of unknown function DUF913 | Interproscan |
| IPR010309 all species → | Domain | E3 ubiquitin ligase, domain of unknown function DUF908 | Interproscan |
| IPR025527 all species → | Conserved_site | HUWE1/REV1, ubiquitin-binding motif | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11254 all species → | HECT DOMAIN UBIQUITIN-PROTEIN LIGASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0016567 all species → | Biological Process | protein ubiquitination | Interproscan |
| GO:0061630 all species → | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10592 | HUWE1, MULE, ARF-BP1, TOM1; E3 ubiquitin-protein ligase HUWE1 | EC:2.3.2.26 | Ubiquitin system | ko04121 | deepkoala |
Transcript abundance of XP_032242082.2 across 48 RNA-seq samples of Nematostella vectensis. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 0 | 0.00 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
