Genomic Location: NC_064034.1:11737891...11754900
NR annotation: XP_032243301.2, histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5517386 |
| Transcript |
| rna-XM_032387411.2 |
| Protein |
| XP_032243302.2 |
| UniProt accession | Description |
|---|---|
| Q8TEK3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3 |
| Q8INR6 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Drosophila melanogaster OX=7227 GN=gpp PE=1 SV=2 |
| Q6AW06 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Caenorhabditis elegans OX=6239 GN=dot-1.1 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0005416 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF08123 all species → | DOT1 | Histone methylation protein DOT1 | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR029063 all species → | Homologous_superfamily | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Interproscan |
| IPR025789 all species → | Domain | Histone-lysine N-methyltransferase DOT1 domain | Interproscan |
| IPR030445 all species → | Family | Histone H3-K79 methyltransferase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR21451 all species → | HISTONE H3 METHYLTRANSFERASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0031151 all species → | Molecular Function | histone H3K79 methyltransferase activity | Interproscan |
| GO:0000077 all species → | Biological Process | DNA damage checkpoint signaling | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006281 all species → | Biological Process | DNA repair | Interproscan |
| GO:0051726 all species → | Biological Process | regulation of cell cycle | Interproscan |
| GO:2000677 all species → | Biological Process | regulation of transcription regulatory region DNA binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11427 | DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase | EC:2.1.1.360 | Chromosome and associated proteins | ko03036 | deepkoala |
Transcript abundance of XP_032243302.2 across 48 RNA-seq samples of Nematostella vectensis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 3 | 20.57 | 23.81 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 3 | 15.42 | 21.27 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 3 | 17.46 | 19.64 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 3 | 21.31 | 23.56 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 3 | 15.36 | 16.91 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 2 | 11.47 | 17.65 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 3 | 21.14 | 23.92 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 3 | 16.41 | 18.97 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 3 | 14.96 | 19.98 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 3 | 15.45 | 18.74 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 3 | 14.94 | 16.79 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 3 | 18.63 | 22.00 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 3 | 18.74 | 21.54 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 2 | 13.05 | 22.48 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 3 | 15.23 | 19.23 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 2 | 8.84 | 17.53 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.