Genomic Location: NC_064048.1:4374201...4443023
NR annotation: XP_048578345.1, acetyl-CoA carboxylase-like isoform X3 [Nematostella vectensis]
Species Nematostella vectensis · all data for this species · gene families
| CDS |
| LOC5515660 |
| Transcript |
| rna-XM_048722388.1 |
| Protein |
| XP_048578345.1 |
| UniProt accession | Description |
|---|---|
| P11029 | Acetyl-CoA carboxylase OS=Gallus gallus OX=9031 GN=ACAC PE=1 SV=1 |
| Q5SWU9 | Acetyl-CoA carboxylase 1 OS=Mus musculus OX=10090 GN=Acaca PE=1 SV=1 |
| P11497 | Acetyl-CoA carboxylase 1 OS=Rattus norvegicus OX=10116 GN=Acaca PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002191 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF02786 all species → | CPSase_L_D2 | Carbamoyl-phosphate synthase L chain, ATP binding domain | Domain | Interproscan |
| PF01039 all species → | Carboxyl_trans | Carboxyl transferase domain | Family | Interproscan |
| PF00289 all species → | Biotin_carb_N | Biotin carboxylase, N-terminal domain | Domain | Interproscan |
| PF00364 all species → | Biotin_lipoyl | Biotin-requiring enzyme | Domain | Interproscan |
| PF08326 all species → | ACC_central | Acetyl-CoA carboxylase, central region | Family | Interproscan |
| PF02785 all species → | Biotin_carb_C | Biotin carboxylase C-terminal domain | Domain | Interproscan |
| PF21385 all species → | ACCA_BT | Acetyl-CoA carboxylase, BT domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR005479 all species → | Domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Interproscan |
| IPR049076 all species → | Family | Acetyl-CoA carboxylase | Interproscan |
| IPR034733 all species → | Domain | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | Interproscan |
| IPR029045 all species → | Homologous_superfamily | ClpP/crotonase-like domain superfamily | Interproscan |
| IPR013815 all species → | Homologous_superfamily | ATP-grasp fold, subdomain 1 | Interproscan |
| IPR011762 all species → | Domain | Acetyl-coenzyme A carboxyltransferase, N-terminal | Interproscan |
| IPR005481 all species → | Domain | Biotin carboxylase-like, N-terminal domain | Interproscan |
| IPR011764 all species → | Domain | Biotin carboxylation domain | Interproscan |
| IPR016185 all species → | Homologous_superfamily | Pre-ATP-grasp domain superfamily | Interproscan |
| IPR011053 all species → | Homologous_superfamily | Single hybrid motif | Interproscan |
| IPR011761 all species → | Domain | ATP-grasp fold | Interproscan |
| IPR000089 all species → | Domain | Biotin/lipoyl attachment | Interproscan |
| IPR001882 all species → | Binding_site | Biotin-binding site | Interproscan |
| IPR013537 all species → | Domain | Acetyl-CoA carboxylase, central domain | Interproscan |
| IPR005482 all species → | Domain | Biotin carboxylase, C-terminal | Interproscan |
| IPR011763 all species → | Domain | Acetyl-coenzyme A carboxyltransferase, C-terminal | Interproscan |
| IPR011054 all species → | Homologous_superfamily | Rudiment single hybrid motif | Interproscan |
| IPR049074 all species → | Domain | Acetyl-CoA carboxylase, BT domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45728 all species → | ACETYL-COA CARBOXYLASE, ISOFORM A | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0003989 all species → | Molecular Function | acetyl-CoA carboxylase activity | Interproscan |
| GO:0005739 all species → | Cellular Component | mitochondrion | Interproscan |
| GO:0006633 all species → | Biological Process | fatty acid biosynthetic process | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0016874 all species → | Molecular Function | ligase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11262 | ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 | EC:6.4.1.2 EC:6.3.4.14 EC:2.1.3.15 | Alcoholic liver disease | ko04936 | deepkoala |
Transcript abundance of XP_048578345.1 across 48 RNA-seq samples of Nematostella vectensis. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole 6 week old aboral regenerate · regenerate 96hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 144hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 0hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 2hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate uncut | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 4hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 120hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 36hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 24hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 20hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 16hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 72hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 60hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 48hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 8hpa | 3 | 0 | 0.00 | 0.00 | |
| whole 6 week old aboral regenerate · regenerate 12hpa | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR6320836 | whole 6 week old aboral regenerate · regenerate 96hpa | whole 6 week old aboral regenerate | six weeks | regenerate 96hpa | SRP125570 | 0.00 |
| SRR6320837 | whole 6 week old aboral regenerate · regenerate 96hpa | whole 6 week old aboral regenerate | six weeks | regenerate 96hpa | SRP125570 | 0.00 |
| SRR6320863 | whole 6 week old aboral regenerate · regenerate 96hpa | whole 6 week old aboral regenerate | six weeks | regenerate 96hpa | SRP125570 | 0.00 |
| SRR6320838 | whole 6 week old aboral regenerate · regenerate 144hpa | whole 6 week old aboral regenerate | six weeks | regenerate 144hpa | SRP125570 | 0.00 |
| SRR6320841 | whole 6 week old aboral regenerate · regenerate 144hpa | whole 6 week old aboral regenerate | six weeks | regenerate 144hpa | SRP125570 | 0.00 |
| SRR6320847 | whole 6 week old aboral regenerate · regenerate 144hpa | whole 6 week old aboral regenerate | six weeks | regenerate 144hpa | SRP125570 | 0.00 |
| SRR6320839 | whole 6 week old aboral regenerate · regenerate 0hpa | whole 6 week old aboral regenerate | six weeks | regenerate 0hpa | SRP125570 | 0.00 |
| SRR6320840 | whole 6 week old aboral regenerate · regenerate 0hpa | whole 6 week old aboral regenerate | six weeks | regenerate 0hpa | SRP125570 | 0.00 |
| SRR6320846 | whole 6 week old aboral regenerate · regenerate 0hpa | whole 6 week old aboral regenerate | six weeks | regenerate 0hpa | SRP125570 | 0.00 |
| SRR6320842 | whole 6 week old aboral regenerate · regenerate 2hpa | whole 6 week old aboral regenerate | six weeks | regenerate 2hpa | SRP125570 | 0.00 |
| SRR6320848 | whole 6 week old aboral regenerate · regenerate 2hpa | whole 6 week old aboral regenerate | six weeks | regenerate 2hpa | SRP125570 | 0.00 |
| SRR6320861 | whole 6 week old aboral regenerate · regenerate 2hpa | whole 6 week old aboral regenerate | six weeks | regenerate 2hpa | SRP125570 | 0.00 |
| SRR6320843 | whole 6 week old aboral regenerate · regenerate uncut | whole 6 week old aboral regenerate | six weeks | regenerate uncut | SRP125570 | 0.00 |
| SRR6320844 | whole 6 week old aboral regenerate · regenerate uncut | whole 6 week old aboral regenerate | six weeks | regenerate uncut | SRP125570 | 0.00 |
| SRR6320845 | whole 6 week old aboral regenerate · regenerate uncut | whole 6 week old aboral regenerate | six weeks | regenerate uncut | SRP125570 | 0.00 |
| SRR6320849 | whole 6 week old aboral regenerate · regenerate 4hpa | whole 6 week old aboral regenerate | six weeks | regenerate 4hpa | SRP125570 | 0.00 |
| SRR6320872 | whole 6 week old aboral regenerate · regenerate 4hpa | whole 6 week old aboral regenerate | six weeks | regenerate 4hpa | SRP125570 | 0.00 |
| SRR6320873 | whole 6 week old aboral regenerate · regenerate 4hpa | whole 6 week old aboral regenerate | six weeks | regenerate 4hpa | SRP125570 | 0.00 |
| SRR6320850 | whole 6 week old aboral regenerate · regenerate 120hpa | whole 6 week old aboral regenerate | six weeks | regenerate 120hpa | SRP125570 | 0.00 |
| SRR6320882 | whole 6 week old aboral regenerate · regenerate 120hpa | whole 6 week old aboral regenerate | six weeks | regenerate 120hpa | SRP125570 | 0.00 |
| SRR6320883 | whole 6 week old aboral regenerate · regenerate 120hpa | whole 6 week old aboral regenerate | six weeks | regenerate 120hpa | SRP125570 | 0.00 |
| SRR6320851 | whole 6 week old aboral regenerate · regenerate 36hpa | whole 6 week old aboral regenerate | six weeks | regenerate 36hpa | SRP125570 | 0.00 |
| SRR6320852 | whole 6 week old aboral regenerate · regenerate 36hpa | whole 6 week old aboral regenerate | six weeks | regenerate 36hpa | SRP125570 | 0.00 |
| SRR6320855 | whole 6 week old aboral regenerate · regenerate 36hpa | whole 6 week old aboral regenerate | six weeks | regenerate 36hpa | SRP125570 | 0.00 |
| SRR6320853 | whole 6 week old aboral regenerate · regenerate 24hpa | whole 6 week old aboral regenerate | six weeks | regenerate 24hpa | SRP125570 | 0.00 |
| SRR6320854 | whole 6 week old aboral regenerate · regenerate 24hpa | whole 6 week old aboral regenerate | six weeks | regenerate 24hpa | SRP125570 | 0.00 |
| SRR6320856 | whole 6 week old aboral regenerate · regenerate 24hpa | whole 6 week old aboral regenerate | six weeks | regenerate 24hpa | SRP125570 | 0.00 |
| SRR6320857 | whole 6 week old aboral regenerate · regenerate 20hpa | whole 6 week old aboral regenerate | six weeks | regenerate 20hpa | SRP125570 | 0.00 |
| SRR6320859 | whole 6 week old aboral regenerate · regenerate 20hpa | whole 6 week old aboral regenerate | six weeks | regenerate 20hpa | SRP125570 | 0.00 |
| SRR6320860 | whole 6 week old aboral regenerate · regenerate 20hpa | whole 6 week old aboral regenerate | six weeks | regenerate 20hpa | SRP125570 | 0.00 |
| SRR6320858 | whole 6 week old aboral regenerate · regenerate 16hpa | whole 6 week old aboral regenerate | six weeks | regenerate 16hpa | SRP125570 | 0.00 |
| SRR6320880 | whole 6 week old aboral regenerate · regenerate 16hpa | whole 6 week old aboral regenerate | six weeks | regenerate 16hpa | SRP125570 | 0.00 |
| SRR6320881 | whole 6 week old aboral regenerate · regenerate 16hpa | whole 6 week old aboral regenerate | six weeks | regenerate 16hpa | SRP125570 | 0.00 |
| SRR6320862 | whole 6 week old aboral regenerate · regenerate 72hpa | whole 6 week old aboral regenerate | six weeks | regenerate 72hpa | SRP125570 | 0.00 |
| SRR6320864 | whole 6 week old aboral regenerate · regenerate 72hpa | whole 6 week old aboral regenerate | six weeks | regenerate 72hpa | SRP125570 | 0.00 |
| SRR6320865 | whole 6 week old aboral regenerate · regenerate 72hpa | whole 6 week old aboral regenerate | six weeks | regenerate 72hpa | SRP125570 | 0.00 |
| SRR6320866 | whole 6 week old aboral regenerate · regenerate 60hpa | whole 6 week old aboral regenerate | six weeks | regenerate 60hpa | SRP125570 | 0.00 |
| SRR6320867 | whole 6 week old aboral regenerate · regenerate 60hpa | whole 6 week old aboral regenerate | six weeks | regenerate 60hpa | SRP125570 | 0.00 |
| SRR6320869 | whole 6 week old aboral regenerate · regenerate 60hpa | whole 6 week old aboral regenerate | six weeks | regenerate 60hpa | SRP125570 | 0.00 |
| SRR6320868 | whole 6 week old aboral regenerate · regenerate 48hpa | whole 6 week old aboral regenerate | six weeks | regenerate 48hpa | SRP125570 | 0.00 |
| SRR6320870 | whole 6 week old aboral regenerate · regenerate 48hpa | whole 6 week old aboral regenerate | six weeks | regenerate 48hpa | SRP125570 | 0.00 |
| SRR6320871 | whole 6 week old aboral regenerate · regenerate 48hpa | whole 6 week old aboral regenerate | six weeks | regenerate 48hpa | SRP125570 | 0.00 |
| SRR6320874 | whole 6 week old aboral regenerate · regenerate 8hpa | whole 6 week old aboral regenerate | six weeks | regenerate 8hpa | SRP125570 | 0.00 |
| SRR6320875 | whole 6 week old aboral regenerate · regenerate 8hpa | whole 6 week old aboral regenerate | six weeks | regenerate 8hpa | SRP125570 | 0.00 |
| SRR6320876 | whole 6 week old aboral regenerate · regenerate 8hpa | whole 6 week old aboral regenerate | six weeks | regenerate 8hpa | SRP125570 | 0.00 |
| SRR6320877 | whole 6 week old aboral regenerate · regenerate 12hpa | whole 6 week old aboral regenerate | six weeks | regenerate 12hpa | SRP125570 | 0.00 |
| SRR6320878 | whole 6 week old aboral regenerate · regenerate 12hpa | whole 6 week old aboral regenerate | six weeks | regenerate 12hpa | SRP125570 | 0.00 |
| SRR6320879 | whole 6 week old aboral regenerate · regenerate 12hpa | whole 6 week old aboral regenerate | six weeks | regenerate 12hpa | SRP125570 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (NVECT_TPM,
StringTie quantification over 48 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Nematostella vectensis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 0 | not in this network | - |
| Negatively correlated | 0 | not in this network | - |
This gene has no edge at all in the Nematostella vectensis network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Nematostella vectensis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| NVECT_2month | 2 month animal · Adult tissues/organs | 1,614 | 23 | not in this dataset | – |
| NVECT_bodywall | body wall with mesenteries · 6-8 weeks adults | 11,742 | 13 | not in this dataset | – |
| NVECT_embryo | embryos · 8, 10 and 12 h after fertilisation (deposit labels 8h/10h/12h) | 9,711 | 17 | not in this dataset | – |
| NVECT_gastrula | Blastula-gastrula intermediate · Developmental stages | 49,166 | 27 | not in this dataset | – |
| NVECT_gastruloid | dissociated and reaggregated embryos · 4-48 hpa | 36,550 | 8 | not in this dataset | – |
| NVECT_neoplasm | neoplasm · Adult tissues/organs | 2,532 | 16 | not in this dataset | – |
| NVECT_nervous | Gastrula Cells · nervous system | 16,590 | 27 | unmapped | – |
| NVECT_notch48h | embryos treated 24-48 hpf (DMSO vs LY411575) · 48 hpf | 19,044 | 7 | not in this dataset | – |
| NVECT_tentacle | tentacle · Adult tissues/organs | 7,977 | 19 | not in this dataset | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
| Assay | Sample | Peaks | Region |
|---|
No called peak overlaps this gene in 2 available assays. Either the gene is not near an accessible or marked region in those samples, or it is not represented in the peak caller’s annotation.
Browse the full epigenomic landscape of this species: ChIP-seq · ATAC-seq.
| Sample | Methylation profile |
|---|---|
| Whole_adults | open |
The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |