Genomic Location: NW_027103768.1:221285...227222
NR annotation: XP_012566929.2, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families
| CDS |
| XP_066918369.1 |
| Protein |
| XP_066918369.1 |
| UniProt accession | Description |
|---|---|
| Q6XPS3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2 |
| Q4R6N0 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Macaca fascicularis OX=9541 GN=TPTE2 PE=2 SV=1 |
| P56180 | Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001472 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00520 all species → | Ion_trans | Ion transport protein | Family | Interproscan |
| PF10409 all species → | PTEN_C2 | C2 domain of PTEN tumour-suppressor protein | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR035892 all species → | Homologous_superfamily | C2 domain superfamily | Interproscan |
| IPR005821 all species → | Domain | Ion transport domain | Interproscan |
| IPR016130 all species → | Active_site | Protein-tyrosine phosphatase, active site | Interproscan |
| IPR029021 all species → | Homologous_superfamily | Protein-tyrosine phosphatase-like | Interproscan |
| IPR051281 all species → | Family | Dual-specificity lipid and protein phosphatase | Interproscan |
| IPR000387 all species → | Domain | Tyrosine-specific protein phosphatases domain | Interproscan |
| IPR014020 all species → | Domain | Tensin phosphatase, C2 domain | Interproscan |
| IPR045102 all species → | Domain | TPTE, protein tyrosine phosphatase-like catalytic domain | Interproscan |
| IPR027359 all species → | Homologous_superfamily | Voltage-dependent channel domain superfamily | Interproscan |
| IPR029023 all species → | Domain | Tensin-type phosphatase domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR12305 all species → | PHOSPHATASE WITH HOMOLOGY TO TENSIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005216 all species → | Molecular Function | monoatomic ion channel activity | Interproscan |
| GO:0006811 all species → | Biological Process | monoatomic ion transport | Interproscan |
| GO:0016020 all species → | Cellular Component | membrane | Interproscan |
| GO:0055085 all species → | Biological Process | transmembrane transport | Interproscan |
| GO:0016311 all species → | Biological Process | dephosphorylation | Interproscan |
| GO:0004725 all species → | Molecular Function | protein tyrosine phosphatase activity | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0006470 all species → | Biological Process | protein dephosphorylation | Interproscan |
| GO:0008285 all species → | Biological Process | negative regulation of cell population proliferation | Interproscan |
| GO:0014065 all species → | Biological Process | obsolete phosphatidylinositol 3-kinase signaling | Interproscan |
| GO:0016314 all species → | Molecular Function | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | Interproscan |
| GO:0042995 all species → | Cellular Component | cell projection | Interproscan |
| GO:0046856 all species → | Biological Process | phosphatidylinositol dephosphorylation | Interproscan |
| GO:0048870 all species → | Biological Process | cell motility | Interproscan |
| GO:0051896 all species → | Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K18079 | TPTE, TPIP; PTEN homologous phosphatase | - | Protein phosphatases and associated proteins | ko01009 | deepkoala |
Transcript abundance of XP_066918369.1 across 40 RNA-seq samples of Clytia hemisphaerica. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Mature medusa | 5 | 0 | 0.00 | 0.00 | |
| medusa · Experiment Condition A1 | 4 | 0 | 0.00 | 0.00 | |
| medusa · Experiment Condition A2 | 4 | 0 | 0.00 | 0.00 | |
| medusa · Experiment Condition A3 | 4 | 0 | 0.00 | 0.00 | |
| Early gastrula | 2 | 0 | 0.00 | 0.00 | |
| Planula 24hpf | 2 | 0 | 0.00 | 0.00 | |
| Planula 48hpf | 2 | 0 | 0.00 | 0.00 | |
| Planula 72hpf | 2 | 0 | 0.00 | 0.00 | |
| Primary polyp | 2 | 0 | 0.00 | 0.00 | |
| Gastrozooid | 2 | 0 | 0.00 | 0.00 | |
| Gonozooid | 2 | 0 | 0.00 | 0.00 | |
| Stolon | 2 | 0 | 0.00 | 0.00 | |
| Baby medusa | 2 | 0 | 0.00 | 0.00 | |
| medusa · Experiment Condition B1 | 2 | 0 | 0.00 | 0.00 | |
| medusa · Experiment Condition B2 | 2 | 0 | 0.00 | 0.00 | |
| Mixed | 1 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR2816248 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 0.00 |
| ERR2816249 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 0.00 |
| ERR2816250 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 0.00 |
| ERR2816251 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 0.00 |
| ERR2862245 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 0.00 |
| ERR3299475 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 0.00 |
| ERR3299476 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 0.00 |
| ERR3299477 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 0.00 |
| ERR3299478 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 0.00 |
| ERR3299479 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 0.00 |
| ERR3299480 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 0.00 |
| ERR3299481 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 0.00 |
| ERR3299482 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 0.00 |
| ERR3299483 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 0.00 |
| ERR3299484 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 0.00 |
| ERR3299485 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 0.00 |
| ERR3299486 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 0.00 |
| ERR2816230 | Early gastrula | not recorded | Early gastrula | not recorded | ERP110164 | 0.00 |
| ERR2816231 | Early gastrula | not recorded | Early gastrula | not recorded | ERP110164 | 0.00 |
| ERR2816232 | Planula 24hpf | not recorded | Planula 24hpf | not recorded | ERP110164 | 0.00 |
| ERR2816233 | Planula 24hpf | not recorded | Planula 24hpf | not recorded | ERP110164 | 0.00 |
| ERR2816234 | Planula 48hpf | not recorded | Planula 48hpf | not recorded | ERP110164 | 0.00 |
| ERR2816235 | Planula 48hpf | not recorded | Planula 48hpf | not recorded | ERP110164 | 0.00 |
| ERR2816236 | Planula 72hpf | not recorded | Planula 72hpf | not recorded | ERP110164 | 0.00 |
| ERR2816237 | Planula 72hpf | not recorded | Planula 72hpf | not recorded | ERP110164 | 0.00 |
| ERR2816238 | Primary polyp | not recorded | Primary polyp | not recorded | ERP110164 | 0.00 |
| ERR2816239 | Primary polyp | not recorded | Primary polyp | not recorded | ERP110164 | 0.00 |
| ERR2816240 | Gastrozooid | not recorded | Gastrozooid | not recorded | ERP110164 | 0.00 |
| ERR2816241 | Gastrozooid | not recorded | Gastrozooid | not recorded | ERP110164 | 0.00 |
| ERR2816242 | Gonozooid | not recorded | Gonozooid | not recorded | ERP110164 | 0.00 |
| ERR2816243 | Gonozooid | not recorded | Gonozooid | not recorded | ERP110164 | 0.00 |
| ERR2816244 | Stolon | not recorded | Stolon | not recorded | ERP110164 | 0.00 |
| ERR2816245 | Stolon | not recorded | Stolon | not recorded | ERP110164 | 0.00 |
| ERR2816246 | Baby medusa | not recorded | Baby medusa | not recorded | ERP110164 | 0.00 |
| ERR2816247 | Baby medusa | not recorded | Baby medusa | not recorded | ERP110164 | 0.00 |
| ERR3299471 | medusa · Experiment Condition B1 | not recorded | medusa | Experiment Condition B1 | ERP115020 | 0.00 |
| ERR3299472 | medusa · Experiment Condition B1 | not recorded | medusa | Experiment Condition B1 | ERP115020 | 0.00 |
| ERR3299473 | medusa · Experiment Condition B2 | not recorded | medusa | Experiment Condition B2 | ERP115020 | 0.00 |
| ERR3299474 | medusa · Experiment Condition B2 | not recorded | medusa | Experiment Condition B2 | ERP115020 | 0.00 |
| ERR2862244 | Mixed | not recorded | Mixed | not recorded | ERP110164 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM,
StringTie quantification over 40 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 0 | not in this network | - |
| Negatively correlated | 0 | not in this network | - |
This gene has no edge at all in the Clytia hemisphaerica network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
