Genomic Location: NW_027103855.1:1140147...1218436
NR annotation: XP_047126593.1, cytoplasmic dynein 2 heavy chain 1 [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families
| CDS |
| XP_066920851.1 |
| Protein |
| XP_066920851.1 |
| UniProt accession | Description |
|---|---|
| Q9JJ79 | Cytoplasmic dynein 2 heavy chain 1 OS=Rattus norvegicus OX=10116 GN=Dync2h1 PE=1 SV=1 |
| Q27802 | Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla OX=7673 GN=DYH1B PE=2 SV=2 |
| Q45VK7 | Cytoplasmic dynein 2 heavy chain 1 OS=Mus musculus OX=10090 GN=Dync2h1 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002128 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF21264 all species → | DYNC2H1_AAA_dom | Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain | Domain | Interproscan |
| PF03028 all species → | Dynein_heavy | Dynein heavy chain region D6 P-loop domain | Domain | Interproscan |
| PF12780 all species → | AAA_8 | P-loop containing dynein motor region D4 | Domain | Interproscan |
| PF08393 all species → | DHC_N2 | Dynein heavy chain, N-terminal region 2 | Family | Interproscan |
| PF18199 all species → | Dynein_C | Dynein heavy chain C-terminal domain | Domain | Interproscan |
| PF18198 all species → | AAA_lid_11 | Dynein heavy chain AAA lid domain | Domain | Interproscan |
| PF08385 all species → | DHC_N1 | Dynein heavy chain, N-terminal region 1 | Family | Interproscan |
| PF12775 all species → | AAA_7 | P-loop containing dynein motor region | Domain | Interproscan |
| PF12774 all species → | AAA_6 | Hydrolytic ATP binding site of dynein motor region | Domain | Interproscan |
| PF12781 all species → | AAA_9 | ATP-binding dynein motor region | Domain | Interproscan |
| PF12777 all species → | MT | Microtubule-binding stalk of dynein motor | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR027417 all species → | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR049400 all species → | Domain | Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain | Interproscan |
| IPR042222 all species → | Homologous_superfamily | Dynein heavy chain, domain 2, N-terminal | Interproscan |
| IPR004273 all species → | Domain | Dynein heavy chain region D6 P-loop domain | Interproscan |
| IPR042219 all species → | Homologous_superfamily | Dynein heavy chain AAA lid domain superfamily | Interproscan |
| IPR024317 all species → | Domain | Dynein heavy chain, AAA module D4 | Interproscan |
| IPR013602 all species → | Domain | Dynein heavy chain, linker | Interproscan |
| IPR043160 all species → | Homologous_superfamily | Dynein heavy chain, C-terminal domain, barrel region | Interproscan |
| IPR026983 all species → | Family | Dynein heavy chain | Interproscan |
| IPR041228 all species → | Domain | Dynein heavy chain, C-terminal domain | Interproscan |
| IPR042228 all species → | Homologous_superfamily | Dynein heavy chain, linker, subdomain 3 | Interproscan |
| IPR041658 all species → | Domain | Dynein heavy chain AAA lid domain | Interproscan |
| IPR013594 all species → | Domain | Dynein heavy chain, tail | Interproscan |
| IPR035699 all species → | Domain | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Interproscan |
| IPR035706 all species → | Domain | Dynein heavy chain, ATP-binding dynein motor region | Interproscan |
| IPR043157 all species → | Homologous_superfamily | Dynein heavy chain, AAA1 domain, small subdomain | Interproscan |
| IPR024743 all species → | Domain | Dynein heavy chain, coiled coil stalk | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10676 all species → | DYNEIN HEAVY CHAIN FAMILY PROTEIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0007018 all species → | Biological Process | microtubule-based movement | Interproscan |
| GO:0008569 all species → | Molecular Function | minus-end-directed microtubule motor activity | Interproscan |
| GO:0030286 all species → | Cellular Component | dynein complex | Interproscan |
| GO:0005868 all species → | Cellular Component | cytoplasmic dynein complex | Interproscan |
| GO:0005930 all species → | Cellular Component | axoneme | Interproscan |
| GO:0035721 all species → | Biological Process | intraciliary retrograde transport | Interproscan |
| GO:0045505 all species → | Molecular Function | dynein intermediate chain binding | Interproscan |
| GO:0051959 all species → | Molecular Function | dynein light intermediate chain binding | Interproscan |
| GO:0060271 all species → | Biological Process | cilium assembly | Interproscan |
| GO:0060294 all species → | Biological Process | cilium movement involved in cell motility | Interproscan |
| GO:0097729 all species → | Cellular Component | 9+2 motile cilium | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10414 | DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain | - | Cytoskeleton proteins | ko04812 | deepkoala |
Transcript abundance of XP_066920851.1 across 40 RNA-seq samples of Clytia hemisphaerica. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Mature medusa | 5 | 5 | 20.86 | 48.48 | |
| medusa · Experiment Condition A1 | 4 | 4 | 10.06 | 10.58 | |
| medusa · Experiment Condition A2 | 4 | 4 | 22.74 | 23.97 | |
| medusa · Experiment Condition A3 | 4 | 4 | 51.70 | 56.80 | |
| Early gastrula | 2 | 2 | 18.60 | 19.60 | |
| Planula 24hpf | 2 | 2 | 11.24 | 12.23 | |
| Planula 48hpf | 2 | 2 | 9.72 | 10.15 | |
| Planula 72hpf | 2 | 2 | 10.86 | 12.45 | |
| Primary polyp | 2 | 2 | 6.22 | 6.52 | |
| Gastrozooid | 2 | 2 | 8.35 | 9.19 | |
| Gonozooid | 2 | 2 | 3.95 | 4.15 | |
| Stolon | 2 | 2 | 5.35 | 6.48 | |
| Baby medusa | 2 | 2 | 5.60 | 5.94 | |
| medusa · Experiment Condition B1 | 2 | 2 | 4.00 | 4.08 | |
| medusa · Experiment Condition B2 | 2 | 2 | 9.73 | 10.38 | |
| Mixed | 1 | 1 | 18.90 | 18.90 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR2816250 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 48.48 |
| ERR2816251 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 34.65 |
| ERR2862245 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 10.67 |
| ERR2816249 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 6.33 |
| ERR2816248 | Mature medusa | not recorded | Mature medusa | not recorded | ERP110164 | 4.19 |
| ERR3299478 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 10.58 |
| ERR3299475 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 10.12 |
| ERR3299477 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 9.88 |
| ERR3299476 | medusa · Experiment Condition A1 | not recorded | medusa | Experiment Condition A1 | ERP115020 | 9.65 |
| ERR3299481 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 23.97 |
| ERR3299482 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 23.94 |
| ERR3299479 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 21.54 |
| ERR3299480 | medusa · Experiment Condition A2 | not recorded | medusa | Experiment Condition A2 | ERP115020 | 21.49 |
| ERR3299486 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 56.80 |
| ERR3299485 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 55.98 |
| ERR3299484 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 47.34 |
| ERR3299483 | medusa · Experiment Condition A3 | not recorded | medusa | Experiment Condition A3 | ERP115020 | 46.67 |
| ERR2816230 | Early gastrula | not recorded | Early gastrula | not recorded | ERP110164 | 19.60 |
| ERR2816231 | Early gastrula | not recorded | Early gastrula | not recorded | ERP110164 | 17.60 |
| ERR2816233 | Planula 24hpf | not recorded | Planula 24hpf | not recorded | ERP110164 | 12.23 |
| ERR2816232 | Planula 24hpf | not recorded | Planula 24hpf | not recorded | ERP110164 | 10.26 |
| ERR2816234 | Planula 48hpf | not recorded | Planula 48hpf | not recorded | ERP110164 | 10.15 |
| ERR2816235 | Planula 48hpf | not recorded | Planula 48hpf | not recorded | ERP110164 | 9.28 |
| ERR2816237 | Planula 72hpf | not recorded | Planula 72hpf | not recorded | ERP110164 | 12.45 |
| ERR2816236 | Planula 72hpf | not recorded | Planula 72hpf | not recorded | ERP110164 | 9.26 |
| ERR2816239 | Primary polyp | not recorded | Primary polyp | not recorded | ERP110164 | 6.52 |
| ERR2816238 | Primary polyp | not recorded | Primary polyp | not recorded | ERP110164 | 5.92 |
| ERR2816241 | Gastrozooid | not recorded | Gastrozooid | not recorded | ERP110164 | 9.19 |
| ERR2816240 | Gastrozooid | not recorded | Gastrozooid | not recorded | ERP110164 | 7.52 |
| ERR2816243 | Gonozooid | not recorded | Gonozooid | not recorded | ERP110164 | 4.15 |
| ERR2816242 | Gonozooid | not recorded | Gonozooid | not recorded | ERP110164 | 3.75 |
| ERR2816245 | Stolon | not recorded | Stolon | not recorded | ERP110164 | 6.48 |
| ERR2816244 | Stolon | not recorded | Stolon | not recorded | ERP110164 | 4.22 |
| ERR2816246 | Baby medusa | not recorded | Baby medusa | not recorded | ERP110164 | 5.94 |
| ERR2816247 | Baby medusa | not recorded | Baby medusa | not recorded | ERP110164 | 5.27 |
| ERR3299472 | medusa · Experiment Condition B1 | not recorded | medusa | Experiment Condition B1 | ERP115020 | 4.08 |
| ERR3299471 | medusa · Experiment Condition B1 | not recorded | medusa | Experiment Condition B1 | ERP115020 | 3.93 |
| ERR3299473 | medusa · Experiment Condition B2 | not recorded | medusa | Experiment Condition B2 | ERP115020 | 10.38 |
| ERR3299474 | medusa · Experiment Condition B2 | not recorded | medusa | Experiment Condition B2 | ERP115020 | 9.08 |
| ERR2862244 | Mixed | not recorded | Mixed | not recorded | ERP110164 | 18.90 |
Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM,
StringTie quantification over 40 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 17 | XP_066928895.1 | 0.951746209405521 |
| Negatively correlated | 12 | XP_066928023.1 | -0.811282289194812 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |