Detailed information of XP_066920851.1 in Clytia hemisphaerica

Genomic Location: NW_027103855.1:1140147...1218436
NR annotation: XP_047126593.1, cytoplasmic dynein 2 heavy chain 1 [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q9JJ79Cytoplasmic dynein 2 heavy chain 1 OS=Rattus norvegicus OX=10116 GN=Dync2h1 PE=1 SV=1
Q27802Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla OX=7673 GN=DYH1B PE=2 SV=2
Q45VK7Cytoplasmic dynein 2 heavy chain 1 OS=Mus musculus OX=10090 GN=Dync2h1 PE=1 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0002128 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF21264
all species →
DYNC2H1_AAA_domCytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domainDomainInterproscan
PF03028
all species →
Dynein_heavyDynein heavy chain region D6 P-loop domain DomainInterproscan
PF12780
all species →
AAA_8P-loop containing dynein motor region D4DomainInterproscan
PF08393
all species →
DHC_N2Dynein heavy chain, N-terminal region 2FamilyInterproscan
PF18199
all species →
Dynein_CDynein heavy chain C-terminal domainDomainInterproscan
PF18198
all species →
AAA_lid_11Dynein heavy chain AAA lid domainDomainInterproscan
PF08385
all species →
DHC_N1Dynein heavy chain, N-terminal region 1FamilyInterproscan
PF12775
all species →
AAA_7P-loop containing dynein motor regionDomainInterproscan
PF12774
all species →
AAA_6Hydrolytic ATP binding site of dynein motor regionDomainInterproscan
PF12781
all species →
AAA_9ATP-binding dynein motor regionDomainInterproscan
PF12777
all species →
MTMicrotubule-binding stalk of dynein motorDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR027417
all species →
Homologous_superfamilyP-loop containing nucleoside triphosphate hydrolaseInterproscan
IPR049400
all species →
DomainCytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domainInterproscan
IPR042222
all species →
Homologous_superfamilyDynein heavy chain, domain 2, N-terminalInterproscan
IPR004273
all species →
DomainDynein heavy chain region D6 P-loop domainInterproscan
IPR042219
all species →
Homologous_superfamilyDynein heavy chain AAA lid domain superfamilyInterproscan
IPR024317
all species →
DomainDynein heavy chain, AAA module D4Interproscan
IPR013602
all species →
DomainDynein heavy chain, linkerInterproscan
IPR043160
all species →
Homologous_superfamilyDynein heavy chain, C-terminal domain, barrel regionInterproscan
IPR026983
all species →
FamilyDynein heavy chainInterproscan
IPR041228
all species →
DomainDynein heavy chain, C-terminal domainInterproscan
IPR042228
all species →
Homologous_superfamilyDynein heavy chain, linker, subdomain 3Interproscan
IPR041658
all species →
DomainDynein heavy chain AAA lid domainInterproscan
IPR013594
all species →
DomainDynein heavy chain, tailInterproscan
IPR035699
all species →
DomainDynein heavy chain, hydrolytic ATP-binding dynein motor regionInterproscan
IPR035706
all species →
DomainDynein heavy chain, ATP-binding dynein motor regionInterproscan
IPR043157
all species →
Homologous_superfamilyDynein heavy chain, AAA1 domain, small subdomainInterproscan
IPR024743
all species →
DomainDynein heavy chain, coiled coil stalkInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10676
all species →
DYNEIN HEAVY CHAIN FAMILY PROTEINInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0007018
all species →
Biological Processmicrotubule-based movementInterproscan
GO:0008569
all species →
Molecular Functionminus-end-directed microtubule motor activityInterproscan
GO:0030286
all species →
Cellular Componentdynein complexInterproscan
GO:0005868
all species →
Cellular Componentcytoplasmic dynein complexInterproscan
GO:0005930
all species →
Cellular ComponentaxonemeInterproscan
GO:0035721
all species →
Biological Processintraciliary retrograde transportInterproscan
GO:0045505
all species →
Molecular Functiondynein intermediate chain bindingInterproscan
GO:0051959
all species →
Molecular Functiondynein light intermediate chain bindingInterproscan
GO:0060271
all species →
Biological Processcilium assemblyInterproscan
GO:0060294
all species →
Biological Processcilium movement involved in cell motilityInterproscan
GO:0097729
all species →
Cellular Component9+2 motile ciliumInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K10414DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain-Cytoskeleton proteinsko04812deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_066920851.1 across 40 RNA-seq samples of Clytia hemisphaerica. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

40Samples
40TPM > 0
16Conditions
56.8Max TPM
16.2Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Mature medusa 5 5 20.86 48.48
medusa · Experiment Condition A1 4 4 10.06 10.58
medusa · Experiment Condition A2 4 4 22.74 23.97
medusa · Experiment Condition A3 4 4 51.70 56.80
Early gastrula 2 2 18.60 19.60
Planula 24hpf 2 2 11.24 12.23
Planula 48hpf 2 2 9.72 10.15
Planula 72hpf 2 2 10.86 12.45
Primary polyp 2 2 6.22 6.52
Gastrozooid 2 2 8.35 9.19
Gonozooid 2 2 3.95 4.15
Stolon 2 2 5.35 6.48
Baby medusa 2 2 5.60 5.94
medusa · Experiment Condition B1 2 2 4.00 4.08
medusa · Experiment Condition B2 2 2 9.73 10.38
Mixed 1 1 18.90 18.90

Per sample · hover a bar for the full sample record

Show the sample table (40 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
ERR2816250 Mature medusa not recorded Mature medusa not recorded ERP110164 48.48
ERR2816251 Mature medusa not recorded Mature medusa not recorded ERP110164 34.65
ERR2862245 Mature medusa not recorded Mature medusa not recorded ERP110164 10.67
ERR2816249 Mature medusa not recorded Mature medusa not recorded ERP110164 6.33
ERR2816248 Mature medusa not recorded Mature medusa not recorded ERP110164 4.19
ERR3299478 medusa · Experiment Condition A1 not recorded medusa Experiment Condition A1 ERP115020 10.58
ERR3299475 medusa · Experiment Condition A1 not recorded medusa Experiment Condition A1 ERP115020 10.12
ERR3299477 medusa · Experiment Condition A1 not recorded medusa Experiment Condition A1 ERP115020 9.88
ERR3299476 medusa · Experiment Condition A1 not recorded medusa Experiment Condition A1 ERP115020 9.65
ERR3299481 medusa · Experiment Condition A2 not recorded medusa Experiment Condition A2 ERP115020 23.97
ERR3299482 medusa · Experiment Condition A2 not recorded medusa Experiment Condition A2 ERP115020 23.94
ERR3299479 medusa · Experiment Condition A2 not recorded medusa Experiment Condition A2 ERP115020 21.54
ERR3299480 medusa · Experiment Condition A2 not recorded medusa Experiment Condition A2 ERP115020 21.49
ERR3299486 medusa · Experiment Condition A3 not recorded medusa Experiment Condition A3 ERP115020 56.80
ERR3299485 medusa · Experiment Condition A3 not recorded medusa Experiment Condition A3 ERP115020 55.98
ERR3299484 medusa · Experiment Condition A3 not recorded medusa Experiment Condition A3 ERP115020 47.34
ERR3299483 medusa · Experiment Condition A3 not recorded medusa Experiment Condition A3 ERP115020 46.67
ERR2816230 Early gastrula not recorded Early gastrula not recorded ERP110164 19.60
ERR2816231 Early gastrula not recorded Early gastrula not recorded ERP110164 17.60
ERR2816233 Planula 24hpf not recorded Planula 24hpf not recorded ERP110164 12.23
ERR2816232 Planula 24hpf not recorded Planula 24hpf not recorded ERP110164 10.26
ERR2816234 Planula 48hpf not recorded Planula 48hpf not recorded ERP110164 10.15
ERR2816235 Planula 48hpf not recorded Planula 48hpf not recorded ERP110164 9.28
ERR2816237 Planula 72hpf not recorded Planula 72hpf not recorded ERP110164 12.45
ERR2816236 Planula 72hpf not recorded Planula 72hpf not recorded ERP110164 9.26
ERR2816239 Primary polyp not recorded Primary polyp not recorded ERP110164 6.52
ERR2816238 Primary polyp not recorded Primary polyp not recorded ERP110164 5.92
ERR2816241 Gastrozooid not recorded Gastrozooid not recorded ERP110164 9.19
ERR2816240 Gastrozooid not recorded Gastrozooid not recorded ERP110164 7.52
ERR2816243 Gonozooid not recorded Gonozooid not recorded ERP110164 4.15
ERR2816242 Gonozooid not recorded Gonozooid not recorded ERP110164 3.75
ERR2816245 Stolon not recorded Stolon not recorded ERP110164 6.48
ERR2816244 Stolon not recorded Stolon not recorded ERP110164 4.22
ERR2816246 Baby medusa not recorded Baby medusa not recorded ERP110164 5.94
ERR2816247 Baby medusa not recorded Baby medusa not recorded ERP110164 5.27
ERR3299472 medusa · Experiment Condition B1 not recorded medusa Experiment Condition B1 ERP115020 4.08
ERR3299471 medusa · Experiment Condition B1 not recorded medusa Experiment Condition B1 ERP115020 3.93
ERR3299473 medusa · Experiment Condition B2 not recorded medusa Experiment Condition B2 ERP115020 10.38
ERR3299474 medusa · Experiment Condition B2 not recorded medusa Experiment Condition B2 ERP115020 9.08
ERR2862244 Mixed not recorded Mixed not recorded ERP110164 18.90

Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM, StringTie quantification over 40 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated17XP_066928895.10.951746209405521
Negatively correlated12XP_066928023.1-0.811282289194812

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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