Gene detail

Detailed information of XP_066923275.1 in Clytia hemisphaerica

Genomic Location: NW_027103974.1:192041...203991
NR annotation: XP_002164134.1, histone acetyltransferase KAT6A isoform X1 [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_066923275.1

ATGACTGACCATCAAGAAACTATACCATGGGTGCTGGCAGCAATTGCCAAAGTAAAAGGCCAAAAACAACAGCCAAATGAAGACAGAATCTCCACTGTCCTCCTTCAATCTTATGGCCTTGAAAAAGATGAAGCTTTGCATCATTTGCAGCTATGCGTGGATGAAGGTTTGGTTACAGTGGCTATGGCTAAAAATGGAAAGAACTCTTACAGAAATGCCAAAGCAACACCTGGAATCAAAGGCCCACCTATTAACCATGTACAGCTGAAGAAAACTTTGGATGAGATTTTGGCCAACCCTATAAGAGATCAAGGCATGACTATTGAGGAAATTGAACACAGTCTACGAACAAAAAAATCTCTGGAAGGAGATTTAGAAAATGCAGATTTTGTGAATCAATTTCGAGCAGCATTGAAGTATGGAATGGCAAAAAACAGATATTTGAAAGAAGGAAAATACTACGTTATCAATAAATTTCCACCAAGGCATCCAAGGAAGAAGAAGGAACCACAGGAGAATGGCAATGCTGAAGATTCCATTAACCAAGAAGAAGAAGAGGAGGATGAAGACATTACTGCTGAAGAAAAAGCAATGCTGAAGGAAATATGTGGCTTTTGTAAAGGTGGTCCGGAGAAAAATAAATATGGAGAAGATGAAGATTTGTTATCTTGTATGGATTGTGGCAACAGCGGGCATCCAACATGTATGCAATATTCTAAAGAATTGACAGTAAGAGTCAGATTAGAACCATGGCAATGTATGGAGTGTAAAAAGTGTACTGTGTGCAAAGACATCGGTGAAGCGGCTAATTTATTGTTTTGTGATGCGTGCGATAAAGGATACCACATGGAATGTTTATCACCACCTCTAGATGACATGCCAATAGGGAGTTGGATTTGTGATAACTGTGTGGCTGAAAGGAATGGCAAACGAAAGCGTCCACAGAGCAATGTTCCTGCAACATTACTGCAACATGACGATTATATAACATTCAAAACACCTACTGGCAAGAAGGGTTCGCAGAAGAGGAAAGGACCTGCCACTGAGAATGACGAAGAAACAATCACTCATATTAAAGGATGTCCAACCCCTGGATGTGATGGCACTGGTCATTCCCAAAATAAATACCCAAATCATCGAAGTGCACAATTCTGTCCGCTGGTTCCACGCAAGAAGAAAGGTCAAAAGGAAGGAAACAACGAAGAAGAAGAAGACATGATTTCCGAAACAACACCAGCTAGACTCCCAGGAGTCACCGAGAAGGATGAGCAGATGTTTAAGAATGCACGCGAGAAAGCCAACTCCTACTTGACGTCTAATAATGAACCAGCTGATCCCAACAACGTGCGATGTCCACCAAAAATCGAATTCGGAAGATACGAAATAGAAACATGGTACTCTTCACCTTACCCTCAAGAATATGCCAGTGCACCAAAACTATACTTATGTGAATTCTGCTTGAAGTACATGAAAACAAGAACTATATTGAAACGACATCTGATGAAATGCAACTGGACGCATCCACCGGCAAACGAAATTTATCGTAAAGACAGTCTCTCCGTGTTCGAAGTCGACGGCGCTGTTAGCAAGATTTATTGTCAGAACTTGTGTTTATTGGCGAAACTGTTTTTGGATCACAAAACGTTATACTATGACGTGGAACCCTTCTTATTTTACGTGCTCACTCGAAACGATAATACTGGCAGTCATCTCATCGGATATTTCTCTAAGGAGAAAGCATGCCAACAGAAGAACAATGTTTCTTGTATCATGACGATGCCACAATATCAACGTCAAGGATATGGACGTTTTCTCATCGACTTCAGTTACCTGCTATCGAGGAAAGAAGGACAAGCTGGCTCACCGGAGAAACCTCTCAGCGATTTAGGGCTAATCACGTATCGAAATTATTGGAAGAATGTCATCGCTGAGTATTTGTACGAACACATGAATGATAAAGCAGTCACTATTAAAGCAATCAGTCAAGCGACGGGAATGGATCCTCACGATATTGCGTCCACTCTTCAATCATTAGAAGTTGTCCAAGTTCGGAACGGAAAAGTGACGATAGTGATAAACGAGAGAGTCATAGCTGACCACATGGCTAAACTGAAGCAACAGAAACGAGTACCTATCGATGAGGAAGCTCTCAGGTGGACACCCCTCGTTCAATCAGGCAATCCTGCACAAATTATGAAAGACGCCGCAATGTCTTCTTCTGAAGACGAAGAAGATGATGACGATGAGAATGAAGAAGAAACCGAAAATGCCGGTGCCGAAGATAAAGATGTCGACGTTGTCATGGAAAACGGCGACGTCACCGAACAAACGAAACAAAATGGCGACGTCGCTGACGAGAAAACTGATTCGGGAGAGGAGAAACAAGTGAATGGGGTGAAGGATGAAAAAGAGGCTACTACGAACGAAAGCGAGGCTACGGAAAATAACGGTGATGACATCGAAATGAAAGAAGTTGACGAGAAAATGGGTAATGAAAATGTAGAAAAAGACTCCTTAGAAGAAGAAAAATCTGAAGAATCGTCTAAAAACAATGAAAATGAAACCCCTGTTGATGGACAGGATGATGTTGATAAAGTAACGACAGAATCGGATGAGCAAATCACTGAAGAGACATCGACTGAAATTTCATCAAAAGATGAAGAAGAGAAATCGACTGACAAAGAAGAAGCGTCATCCAAAACTGAAGATAAAGGGGAATCTTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5TKR9	Histone acetyltransferase KAT6A OS=Rattus norvegicus OX=10116 GN=Kat6a PE=1 SV=2
Q8BZ21	Histone acetyltransferase KAT6A OS=Mus musculus OX=10090 GN=Kat6a PE=1 SV=2
Q92794	Histone acetyltransferase KAT6A OS=Homo sapiens OX=9606 GN=KAT6A PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000832 (this species only) · gene tree & orthology
Transcription factor family	zf-C2HC · all TF in this species
Ubiquitin family	E3\|E3 activity RING\|PHD · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF17772 all species →	zf-MYST	MYST family zinc finger domain	Domain	Interproscan
PF00628 all species →	PHD	PHD-finger	Domain	Interproscan
PF01530 all species →	zf-C2HC	Zinc finger, C2HC type	Family	Interproscan
PF21524 all species →	SAMD1_WH	SAM domain-containing protein 1, WH domain	Domain	Interproscan
PF01853 all species →	MOZ_SAS	MOZ/SAS family	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR013083 all species →	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	Interproscan
IPR050603 all species →	Family	MYST family histone acetyltransferases	Interproscan
IPR040706 all species →	Domain	MYST, zinc finger domain	Interproscan
IPR019787 all species →	Domain	Zinc finger, PHD-finger	Interproscan
IPR048589 all species →	Domain	SAM domain-containing protein 1-like, WH domain	Interproscan
IPR036388 all species →	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	Interproscan
IPR002717 all species →	Domain	Histone acetyltransferase domain, MYST-type	Interproscan
IPR011011 all species →	Homologous_superfamily	Zinc finger, FYVE/PHD-type	Interproscan
IPR001965 all species →	Domain	Zinc finger, PHD-type	Interproscan
IPR002515 all species →	Repeat	Zinc finger, C2H2C-type	Interproscan
IPR016181 all species →	Homologous_superfamily	Acyl-CoA N-acyltransferase	Interproscan
IPR036060 all species →	Homologous_superfamily	Zinc finger, C2H2C-type superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR10615 all species →	HISTONE ACETYLTRANSFERASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0000790 all species →	Cellular Component	chromatin	Interproscan
GO:0003712 all species →	Molecular Function	transcription coregulator activity	Interproscan
GO:0004402 all species →	Molecular Function	histone acetyltransferase activity	Interproscan
GO:0045892 all species →	Biological Process	negative regulation of DNA-templated transcription	Interproscan
GO:0045944 all species →	Biological Process	positive regulation of transcription by RNA polymerase II	Interproscan
GO:0070776 all species →	Cellular Component	MOZ/MORF histone acetyltransferase complex	Interproscan
GO:0003677 all species →	Molecular Function	DNA binding	Interproscan
GO:0006355 all species →	Biological Process	regulation of DNA-templated transcription	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0008270 all species →	Molecular Function	zinc ion binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11378	SAS3; histone acetyltransferase SAS3	EC:2.3.1.48	Chromosome and associated proteins	ko03036	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_066923275.1 across 40 RNA-seq samples of Clytia hemisphaerica. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

40Samples

40TPM > 0

16Conditions

144.1Max TPM

43.0Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Mature medusa	5	5	57.00	69.44
medusa · Experiment Condition A1	4	4	29.73	31.08
medusa · Experiment Condition A2	4	4	21.53	23.89
medusa · Experiment Condition A3	4	4	15.84	17.03
Early gastrula	2	2	134.59	144.11
Planula 24hpf	2	2	87.69	88.51
Planula 48hpf	2	2	48.26	54.83
Planula 72hpf	2	2	36.73	40.79
Primary polyp	2	2	37.72	40.29
Gastrozooid	2	2	23.94	24.09
Gonozooid	2	2	46.94	50.57
Stolon	2	2	41.44	44.93
Baby medusa	2	2	39.44	41.97
medusa · Experiment Condition B1	2	2	24.60	24.71
medusa · Experiment Condition B2	2	2	32.95	33.88
Mixed	1	1	56.67	56.67

Per sample · hover a bar for the full sample record

Show the sample table (40 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR2862245	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	69.44
ERR2816250	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	59.82
ERR2816251	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	56.18
ERR2816249	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	51.11
ERR2816248	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	48.44
ERR3299476	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	31.08
ERR3299475	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	30.89
ERR3299478	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	28.84
ERR3299477	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	28.12
ERR3299479	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	23.89
ERR3299480	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	23.14
ERR3299482	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	19.91
ERR3299481	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	19.18
ERR3299483	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	17.03
ERR3299484	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	16.67
ERR3299485	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	15.08
ERR3299486	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	14.61
ERR2816230	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	144.11
ERR2816231	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	125.07
ERR2816233	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	88.51
ERR2816232	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	86.88
ERR2816235	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	54.83
ERR2816234	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	41.69
ERR2816236	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	40.79
ERR2816237	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	32.67
ERR2816239	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	40.29
ERR2816238	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	35.15
ERR2816240	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	24.09
ERR2816241	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	23.78
ERR2816243	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	50.57
ERR2816242	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	43.31
ERR2816245	Stolon	not recorded	Stolon	not recorded	ERP110164	44.93
ERR2816244	Stolon	not recorded	Stolon	not recorded	ERP110164	37.95
ERR2816247	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	41.97
ERR2816246	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	36.91
ERR3299472	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	24.71
ERR3299471	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	24.48
ERR3299473	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	33.88
ERR3299474	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	32.02
ERR2862244	Mixed	not recorded	Mixed	not recorded	ERP110164	56.67

Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM, StringTie quantification over 40 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	43	XP_066911465.1	0.980444866520291
Negatively correlated	3	XP_066924414.1	-0.805973668784329

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →