Gene detail

Detailed information of XP_066927387.1 in Clytia hemisphaerica

Genomic Location: NW_027104185.1:346353...364078
NR annotation: XP_012560801.1, sodium/potassium-transporting ATPase subunit alpha-like [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_066927387.1

ATGGCTGACGAAGGAAAAGAAGAACTAACGAAAAATGAAGCAGAAACGCCTCAAGATCCTGCTGTAGAAGCGCCAACTGTAGAAAACGATAACACAGAACAAAAGGGGGATGGAGATGATACAAGTAATAGCAGTTATATTGTGGCAGTTAAATCCAACACAAACTCTAAAGCTGAAGGTGACAAAAAAGATGCCGCAATTTCTAAAAAGAACAAGAAAACAAAAAAGAAAGATGACTTAAATGACTTAAAGAAAGAACTTGAGCTAACTTGTCATAGTGAAAATTTGGATGATCTTATTGCTCAATATGAAACAAACCTTACAACCGGTCTGACTAAAGAGATTGCTGCTCGAAACCTTGAACGTGATGGCCCAAATGCTCTCTCCCCTCCAAAACAAACACCTGAATGGATCAAATTTTGTAAACAATTATTTGGGGGGTTTTCAATGTTACTTTGGGTTGGTGCAATCCTTTGTTTCTTTGCTTATGGTATTCGAACAGTCAGAGAGGATGATCCGAGTCAAGATGAGTTATATCTTGGAATTGTACTTGCTGTTGTTGTCATTATTACTGGTTGTTTCTCTTATTATCAAGAAGCCAAAAGTTCAAAGATCATGGAAAGTTTTAAGAAGATGATCCCACAGGAGGCTACAGTATTACGTGATGGGGCAAAGATTCAAATCAATGCGGAAGAATGTACCATTGGAGACATAGTATTTGTTAAGTTTGGTGACCGTATCCCTGCGGATATTCGTGTTATCGAGTCAATGGGTTTCAAGGTTGACAACTCTTCATTGACTGGTGAATCTGAACCACAATCTAGAAACAGTGAATGTACTTCAGAGAATCCTTTGGAAACCAAAAACTTGGCTTTCTTTTCCACAAACGCTGTTGAAGGTACTGCGACTGGTATGGTCGTTAACATTGGTGATAACACTGTCATGGGACGTATTGCCAACTTGGCTTCTGGTCTCGGCGCTGGTAAAACGCCTATTGCTCTTGAATTGGAACATTTTATTCATATCATTACTGGAGTTGCAGTGTTCCTTGGTGTGACATTCCTCATCATTTCACTTGCTATGGATTACCATTGGTTAGAAGCGATCATCTTTTTGATTGGTATTATTGTAGCTAACGTCCCTGAAGGTCTACTTGCCACTGTCACAGTATGTTTAACATTGACAGCAAAGAAAATGGCAGCCAAGAATTGTTTAGTCAAACATTTGGAAGCTGTAGAAACCCTGGGAAGTACTTCTGTTATTTGCTCAGATAAAACTGGAACATTGACACAAAATCGTATGACTGTTGCACACATGTGGTTTGACAAGATGATTATTGAAGCTGACACGACTGAAGATCAATCAGGACTTTCACATGACAAAGGTTCATCTACATGGAAAGCCCTTGCCAAAATTGGTGGTCTGTGCAATCGTGCCGAGTTCAAAGAAGGACAGGAAGATTTACCCATATTAAGGAAAGAGTGTAACGGTGATGCTTCAGAGACTGCTATTTTGAAATTTGTTGAACTGTCTGTCGGCAATGTTATGGATATGCGTTCTAAGAATGGAAAGGTTGTTGAAATCCCATTCAATTCAACCAACAAATATCAAGTATCTATCCACAAACAAGAAGATGAGAAAGACCCCCGATATCTTTTGGTTATGAAAGGTGCTCCTGAACGAATTCTAGACAGATGTTCAACAATCTTGCTCCAAGGTGAAGAGAAACCATTGGATGATGAAATGAAGGACGCATTCAATGATGCATATCTTCAACTTGGTGGTCTTGGTGAACGCGTCTTGGGATTCTGCCATTACTATCTTCCTGCTGAAAACTTTCCTGAAGGATTCGAGTTTCAAACAGATGATCCATGTAATTTCCCACTTGATAACCTATGTTTCGTTGGTTTGATGAGTATGATTGATCCTCCAAGAGCTGCTGTGCCCGATGCTGTCAGCAAGTGCCGAAGTGCAGGAATCAAGGTCATCATGGTTACAGGTGATCATCCAATCACAGCAAAAGCTATCGCCAAAGGTGTCGGCATCATCTCCGAAGGAAATGAGACTGTTGAAGACATTGCTCAACGCTTGAATATTCCTGTTGAAGAAGTCAATCCTCGTGATGCACACGCTGCTGTTGTCCATGGAACTCAACTGAAAGACTTGTCAGCGGAGGACATTGACGACATTTTGAAATACCACACTGAAATTGTGTTTGCCAGGACTTCACCACAACAAAAATTGATCATTGTTGAAGGATGTCAACGTCAAGGAGCTATCGTTGCTGTCACCGGAGATGGTGTTAATGATTCGCCTGCTTTGAAGAAAGCTGATATCGGTGTTGCTATGGGGATTGCTGGCTCAGACGTTTCAAAACAAGCAGCTGACATGATCTTATTGGATGACAATTTCGCTTCCATTGTCACCGGAGTTGAAGAAGGACGTCTCATTTTTGACAATCTCAAAAAATCAATTGCTTACACCTTAACCAGTAACATTCCAGAGATCTCGCCGTTCTTGATGTTTATTTTGCTCAGTATTCCACTCCCTCTTGGTACTGTCACCATTCTGTGCATCGATTTAGGCACTGACTTGATACCCGCCATTTCTCTTGCTTACGAGAAGGCTGAGACTGACATCATGAAACGTAAACCACGTGACCCTATACGTGATAAATTGGTGAATGAACGTTTGATCAGTTTGGCGTACGGTCAAATTGGTATGATCCAGGCTATTGCTGGTTTTTTCACCTACTTTGTGATCATGGCTGAGAATGGTTTCTTGCCATCCTTCCTAATGGGTATCCGATCCCAATGGGATGACAAAAACAATAATTCAGTCATCGATTCTTACGGTAGCGAATGGACGTACTCTCAACGCAAAGATTTGGAGTTGACTTGTCACACAGCTTTCTTTACTACCATCGTTGTTGTCCAATGGGCTGACGTCATCATCTCCAAAACAAGACGTCTCTCCGTATTTACGCAAGGAATGACAAACTGGATGTTGAATTTTGGTTTGGTTTTCGAAACTTTATTAGCTGCCTTCTTGCAATACACACCAGGTTTGAGTACTGGCTTACGTTTACGCCCATTGAACGCCTCGTGGTGGTTCTGTGGTGTCCCTTTTTCCTTGTTGATCTGGATTTATGATGAAATCAGAAGATATTTGTTAAGAAAGTATCCTGGAGGATGGGTGGAGCAAGAGACATATTATTAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P35317	Sodium/potassium-transporting ATPase subunit alpha OS=Hydra vulgaris OX=6087 PE=2 SV=1
P13637	Sodium/potassium-transporting ATPase subunit alpha-3 OS=Homo sapiens OX=9606 GN=ATP1A3 PE=1 SV=3
Q6PIC6	Sodium/potassium-transporting ATPase subunit alpha-3 OS=Mus musculus OX=10090 GN=Atp1a3 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001595 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00689 all species →	Cation_ATPase_C	Cation transporting ATPase, C-terminus	Family	Interproscan
PF00122 all species →	E1-E2_ATPase	E1-E2 ATPase	Family	Interproscan
PF13246 all species →	Cation_ATPase	Cation transport ATPase (P-type)	Family	Interproscan
PF00702 all species →	Hydrolase	haloacid dehalogenase-like hydrolase	Domain	Interproscan
PF00690 all species →	Cation_ATPase_N	Cation transporter/ATPase, N-terminus	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR023299 all species →	Homologous_superfamily	P-type ATPase, cytoplasmic domain N	Interproscan
IPR004014 all species →	Domain	Cation-transporting P-type ATPase, N-terminal	Interproscan
IPR023214 all species →	Homologous_superfamily	HAD superfamily	Interproscan
IPR006068 all species →	Domain	Cation-transporting P-type ATPase, C-terminal	Interproscan
IPR018303 all species →	PTM	P-type ATPase, phosphorylation site	Interproscan
IPR050510 all species →	Family	Cation transport ATPase (P-type)	Interproscan
IPR023298 all species →	Homologous_superfamily	P-type ATPase, transmembrane domain superfamily	Interproscan
IPR001757 all species →	Family	P-type ATPase	Interproscan
IPR036412 all species →	Homologous_superfamily	HAD-like superfamily	Interproscan
IPR005775 all species →	Family	P-type ATPase subfamily IIC, subunit alpha	Interproscan
IPR044492 all species →	Domain	P-type ATPase, haloacid dehalogenase domain	Interproscan
IPR008250 all species →	Homologous_superfamily	P-type ATPase, A domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR43294 all species →	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0000166 all species →	Molecular Function	nucleotide binding	Interproscan
GO:0005391 all species →	Molecular Function	P-type sodium:potassium-exchanging transporter activity	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006883 all species →	Biological Process	intracellular sodium ion homeostasis	Interproscan
GO:0019829 all species →	Molecular Function	ATPase-coupled monoatomic cation transmembrane transporter activity	Interproscan
GO:0030007 all species →	Biological Process	intracellular potassium ion homeostasis	Interproscan
GO:0036376 all species →	Biological Process	sodium ion export across plasma membrane	Interproscan
GO:1902600 all species →	Biological Process	proton transmembrane transport	Interproscan
GO:1990573 all species →	Biological Process	potassium ion import across plasma membrane	Interproscan
GO:0005215 all species →	Molecular Function	transporter activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0016020 all species →	Cellular Component	membrane	Interproscan
GO:0016887 all species →	Molecular Function	ATP hydrolysis activity	Interproscan
GO:0006813 all species →	Biological Process	potassium ion transport	Interproscan
GO:0008556 all species →	Molecular Function	P-type potassium transmembrane transporter activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01539	ATP1A; sodium/potassium-transporting ATPase subunit alpha	EC:7.2.2.13	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_066927387.1 across 40 RNA-seq samples of Clytia hemisphaerica. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

40Samples

40TPM > 0

16Conditions

51.7Max TPM

22.3Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Mature medusa	5	5	13.84	18.04
medusa · Experiment Condition A1	4	4	22.00	22.84
medusa · Experiment Condition A2	4	4	47.05	51.73
medusa · Experiment Condition A3	4	4	35.59	44.08
Early gastrula	2	2	7.17	7.29
Planula 24hpf	2	2	14.65	15.97
Planula 48hpf	2	2	21.77	29.23
Planula 72hpf	2	2	21.97	23.14
Primary polyp	2	2	21.86	22.47
Gastrozooid	2	2	11.08	13.16
Gonozooid	2	2	20.60	22.22
Stolon	2	2	25.02	32.83
Baby medusa	2	2	16.45	16.50
medusa · Experiment Condition B1	2	2	2.61	2.98
medusa · Experiment Condition B2	2	2	34.04	34.44
Mixed	1	1	10.35	10.35

Per sample · hover a bar for the full sample record

Show the sample table (40 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR2816251	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	18.04
ERR2816250	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	16.37
ERR2862245	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	12.50
ERR2816249	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	12.38
ERR2816248	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	9.93
ERR3299475	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	22.84
ERR3299477	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	22.36
ERR3299476	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	22.31
ERR3299478	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	20.50
ERR3299479	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	51.73
ERR3299480	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	47.78
ERR3299481	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	44.86
ERR3299482	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	43.85
ERR3299485	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	44.08
ERR3299486	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	39.87
ERR3299484	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	30.22
ERR3299483	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	28.20
ERR2816230	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	7.29
ERR2816231	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	7.05
ERR2816233	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	15.97
ERR2816232	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	13.32
ERR2816234	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	29.23
ERR2816235	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	14.31
ERR2816236	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	23.14
ERR2816237	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	20.80
ERR2816238	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	22.47
ERR2816239	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	21.25
ERR2816241	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	13.16
ERR2816240	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	9.00
ERR2816242	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	22.22
ERR2816243	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	18.97
ERR2816245	Stolon	not recorded	Stolon	not recorded	ERP110164	32.83
ERR2816244	Stolon	not recorded	Stolon	not recorded	ERP110164	17.21
ERR2816246	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	16.50
ERR2816247	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	16.40
ERR3299472	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	2.98
ERR3299471	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	2.23
ERR3299474	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	34.44
ERR3299473	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	33.64
ERR2862244	Mixed	not recorded	Mixed	not recorded	ERP110164	10.35

Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM, StringTie quantification over 40 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	10	XP_066929893.1	0.902936602676794
Negatively correlated	35	XP_066933085.1	-0.774959226871724

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →