Gene detail

Detailed information of XP_066932623.1 in Clytia hemisphaerica

Genomic Location: NW_027104420.1:536094...547597
NR annotation: XP_047141447.1, cytoplasmic tyrosine-protein kinase BMX isoform X1 [Hydra vulgaris]
Species Clytia hemisphaerica · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P42680	Tyrosine-protein kinase Tec OS=Homo sapiens OX=9606 GN=TEC PE=1 SV=2
Q08881	Tyrosine-protein kinase ITK/TSK OS=Homo sapiens OX=9606 GN=ITK PE=1 SV=1
Q03526	Tyrosine-protein kinase ITK/TSK OS=Mus musculus OX=10090 GN=Itk PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000425 (this species only) · gene tree & orthology
Ubiquitin family	UBD\|Other\|SH3 · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00018 all species →	SH3_1	SH3 domain	Domain	Interproscan
PF00169 all species →	PH	PH domain	Domain	Interproscan
PF00779 all species →	BTK	BTK motif	Motif	Interproscan
PF07714 all species →	PK_Tyr_Ser-Thr	Protein tyrosine and serine/threonine kinase	Domain	Interproscan
PF00017 all species →	SH2	SH2 domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001452 all species →	Domain	SH3 domain	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR036860 all species →	Homologous_superfamily	SH2 domain superfamily	Interproscan
IPR001562 all species →	Conserved_site	Zinc finger, Btk motif	Interproscan
IPR001245 all species →	Domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	Interproscan
IPR017441 all species →	Binding_site	Protein kinase, ATP binding site	Interproscan
IPR000980 all species →	Domain	SH2 domain	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR020635 all species →	Domain	Tyrosine-protein kinase, catalytic domain	Interproscan
IPR001849 all species →	Domain	Pleckstrin homology domain	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan
IPR050198 all species →	Family	Non-receptor tyrosine kinases involved in cell signaling	Interproscan
IPR008266 all species →	Active_site	Tyrosine-protein kinase, active site	Interproscan
IPR036028 all species →	Homologous_superfamily	SH3-like domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR24418 all species →	TYROSINE-PROTEIN KINASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0035556 all species →	Biological Process	intracellular signal transduction	Interproscan
GO:0004713 all species →	Molecular Function	protein tyrosine kinase activity	Interproscan
GO:0004715 all species →	Molecular Function	non-membrane spanning protein tyrosine kinase activity	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

No KEGG orthology assignment for XP_066932623.1.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_066932623.1 across 40 RNA-seq samples of Clytia hemisphaerica. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

40Samples

40TPM > 0

16Conditions

31.6Max TPM

17.2Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Mature medusa	5	5	12.99	18.12
medusa · Experiment Condition A1	4	4	10.88	11.28
medusa · Experiment Condition A2	4	4	18.90	19.52
medusa · Experiment Condition A3	4	4	29.17	31.60
Early gastrula	2	2	25.80	27.54
Planula 24hpf	2	2	24.81	26.07
Planula 48hpf	2	2	19.04	20.48
Planula 72hpf	2	2	15.69	18.98
Primary polyp	2	2	15.04	15.92
Gastrozooid	2	2	15.36	17.82
Gonozooid	2	2	15.32	15.67
Stolon	2	2	10.95	11.08
Baby medusa	2	2	14.19	14.77
medusa · Experiment Condition B1	2	2	17.45	19.14
medusa · Experiment Condition B2	2	2	13.37	13.90
Mixed	1	1	13.78	13.78

Per sample · hover a bar for the full sample record

Show the sample table (40 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR2816251	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	18.12
ERR2816250	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	13.48
ERR2862245	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	12.27
ERR2816249	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	11.48
ERR2816248	Mature medusa	not recorded	Mature medusa	not recorded	ERP110164	9.58
ERR3299476	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	11.28
ERR3299478	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	11.08
ERR3299475	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	10.76
ERR3299477	medusa · Experiment Condition A1	not recorded	medusa	Experiment Condition A1	ERP115020	10.42
ERR3299481	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	19.52
ERR3299479	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	19.44
ERR3299480	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	18.50
ERR3299482	medusa · Experiment Condition A2	not recorded	medusa	Experiment Condition A2	ERP115020	18.15
ERR3299483	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	31.60
ERR3299485	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	30.71
ERR3299484	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	28.69
ERR3299486	medusa · Experiment Condition A3	not recorded	medusa	Experiment Condition A3	ERP115020	25.70
ERR2816230	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	27.54
ERR2816231	Early gastrula	not recorded	Early gastrula	not recorded	ERP110164	24.07
ERR2816233	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	26.07
ERR2816232	Planula 24hpf	not recorded	Planula 24hpf	not recorded	ERP110164	23.56
ERR2816235	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	20.48
ERR2816234	Planula 48hpf	not recorded	Planula 48hpf	not recorded	ERP110164	17.60
ERR2816236	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	18.98
ERR2816237	Planula 72hpf	not recorded	Planula 72hpf	not recorded	ERP110164	12.40
ERR2816238	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	15.92
ERR2816239	Primary polyp	not recorded	Primary polyp	not recorded	ERP110164	14.16
ERR2816241	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	17.82
ERR2816240	Gastrozooid	not recorded	Gastrozooid	not recorded	ERP110164	12.90
ERR2816242	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	15.67
ERR2816243	Gonozooid	not recorded	Gonozooid	not recorded	ERP110164	14.97
ERR2816245	Stolon	not recorded	Stolon	not recorded	ERP110164	11.08
ERR2816244	Stolon	not recorded	Stolon	not recorded	ERP110164	10.82
ERR2816246	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	14.77
ERR2816247	Baby medusa	not recorded	Baby medusa	not recorded	ERP110164	13.61
ERR3299472	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	19.14
ERR3299471	medusa · Experiment Condition B1	not recorded	medusa	Experiment Condition B1	ERP115020	15.76
ERR3299474	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	13.90
ERR3299473	medusa · Experiment Condition B2	not recorded	medusa	Experiment Condition B2	ERP115020	12.84
ERR2862244	Mixed	not recorded	Mixed	not recorded	ERP110164	13.78

Source: CnidoSite RNA-seq expression matrices (CHEMI_TPM, StringTie quantification over 40 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Clytia hemisphaerica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	23	XP_066917418.1	0.944139455572939
Negatively correlated	18	XP_066913177.1	-0.863865506247202

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Clytia hemisphaerica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →