Gene detail

Detailed information of XP_068688616.1 in Montipora foliosa

Genomic Location: chr14:5274816...5298333
NR annotation: XP_029196378.2, molybdenum cofactor biosynthesis protein 1-like [Acropora millepora]
Species Montipora foliosa · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

rna-XM_068832515.1

AGACCCCAGACGGGGACGTACCAACACCGGATAATGGCGGCAACCCGAAGTTCTCTTCGTCCACTTTGTCTTAATACCAAGGCACGTTGTAAATTTTTACATGTTGCTTGCTCTTTATTGGGACAACAGCATACAAGAACTGCGGAAGAATATGGTGCCTTAGATGTTGAGCAACCAAGACGGAGACTGTACTTCAAGGATAACGACGTAAAACCTCTTTCAGAATTCCTGTCAGATAAATTTGGAAGACACCACACGTATCTTAGGATTTCATTAACGGAACGCTGCAATTTAAGATGTCAATACTGTATGCCGGAGGAAGGTGTGCAACTTTCACAAAACAATGAACTATTAACAACAGAAGAAATCATAACATTGGCCAAACTGTTTGTCAAAGAAGGTGTTGACAAGATAAGACTGACTGGTGGTGAACCATTGATTCGAAAAGATATTGTCGAGCTTTGTGcgGAACTAAGTCGATTAGATGGTCTTCAAACATTGGCTATGACAACTAATGCAGTTACTTTGAAAAGGAAGTTGCCACAACTGCGAAAAGCGGGACTAAAGTCTATCAACATTAGTCTTGACACTCTGGAGCCACAAAAATTTGAATTCCTCACAAGAAGAAAGGGGTGGCACAAAGTCATGGAGTCCATAGATTGTGCATTAGAACTTGGATTTCACCCGTTAAAGCTGAATTGTGTTGTAATGAGAGGTCTGAATGAAGATGAAGTCTGCAACTTTGTGGCTCTGACGCAAGATAAGCCTCTCGATGTACGGTTTTTGGAATACATGCCCTTCGATGgaaacaaATGGAACTTCAAGAAATTGGTATCTTACACTGAAATATTGGACAGAATATCGCAAAGATGGCCGGATGTTGCAAAATTATCGAACCACCCGAATGATACTTCTAAGGCATACAAAGTTCCTGGTTTTGCTGGCCAGATCGGATTTGTTACTTCCATGAGCGAGCATTTCTGTGGAGGCTGTAACAGACTTCGAATTACAGCAGATGGCAATTTAAAGGTCTGCTTGTTTGGAAATGCTGAAGTGTCATTACGAGATGCCCTCAGAGCAGGGACAAACGAAGAAGAAATGTTAGAGATTATCGGCGGCGCCgtaaagaggaagaaaaagcaTCACGCTGGAATGTTCAACATTGTGAAACAGAAGAACCGGCCAATGATCCTGATTGGTGGATGACGCATTGCTGTGGCATTGCAAAACTTGCCATTTTCTGCAAAGGAGTCTTTTTTAGAAACTTGCATTTGAGCGCGTAGTTCGAAGCTCAATTGCttgttttgtaaatattttataaaCAGACTCCAATCTAAATCTGCATATTAACATGTATGAGGAGCCTTTAACTacgagcgaacaacagccctatattcctgtcacggcgttttaacagaccgatttatttagattgaatttcccgcaaatAACACTCCCGGGGAGTGGGGGTACTCCTTATAATGGGGTACCTTTTTCACGCTTCGGGTATATGAAAGAGTAGGGATTTCACGAGTCGAAGTATATGAAAGGGTAGGGAAATCTGTCATTTTGGTATTTAAAAGGGCCTTTCATTAATATATTTCAAACACACGTACCTTATAATTGTTCTGTTTTAATTTATTGAACACTgcatgacaatgacaatggaaggtatacgaaaggggtatcttttctgccaaaaatggtatataaaaggGTAAAGGGTCGGACCTCGGGGCGGAGCCgctaatttccctttcgtaaacaagcgatgccattttcgacggtcgatgccattcttagtaaccaagccatTTTATTCGGGTAGCTTTTGATATAGTGTTAGGATTAGCTTCATTTCAATATGTTAAAATAGCCGAAGGGGGTCCGTCGTTTCGGTAGTGTAGAGGTTAAGTGCATGTGTCCTCAAGTCATTGAACCGAGTTCGATACCGTTCAAAAAACTTttcctaaatttttttttttttctgatcttTTTCCAAGGTTTTtccgcagtttttttttttaattctaagtgacataccCTGCTAATCTAGTCttagattaagtatttttatcctcatttgcaaacgaaaattgttttaagtctcgtccaaatggcatcgcttgtttacggaAGTGAAAATTGCGGCGGAGTCACCCCGTATAAAACGTTTTTTAGTGACCCCTCTTTCCCCGGGAGACTCCCTAGGGAACccaatgaccaatcacaagaaccAAATTTGACGTCATAGcctcaccgaaccggaactgcctttggtTTCTTCGGAAAAGGTAGTCAAAAAATTggttggtctgtaaaaatgccgtgggTCCCTTGTGTGTCTAAATGTGGTTTATCTAAACTGGTTGacgtcaggaacccatgacccggagcctacaactctactgtgttggtgtaacggcgttttcacagaccgatttatttttagattgaatttcctgcgaatgagactcccacaggagcccgatgaccaattacaaggaattacgctgacgtcataggctcaccgaaccggaactgcctttgttttttgacctaattcgcgggaagggctagtctaaaaatgaacctacttgtgaaaacgccgtttcacagacgctgtatggaacttgcacgctccagatgggctcctcgTGACGTAATGTACATAAGTgctcctaataataataataataataataaaaatatattccttttg

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q1JQD7	Molybdenum cofactor biosynthesis protein 1 OS=Bos taurus OX=9913 GN=MOCS1 PE=2 SV=2
Q5RKZ7	Molybdenum cofactor biosynthesis protein 1 OS=Mus musculus OX=10090 GN=Mocs1 PE=1 SV=2
Q9NZB8	Molybdenum cofactor biosynthesis protein 1 OS=Homo sapiens OX=9606 GN=MOCS1 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001789 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF13353 all species →	Fer4_12	4Fe-4S single cluster domain	Domain	Interproscan
PF04055 all species →	Radical_SAM	Radical SAM superfamily	Domain	Interproscan
PF06463 all species →	Mob_synth_C	Molybdenum Cofactor Synthesis C	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR050105 all species →	Family	Molybdenum cofactor biosynthesis MoaA/MoaC	Interproscan
IPR006638 all species →	Domain	Elp3/MiaA/NifB-like, radical SAM core domain	Interproscan
IPR013483 all species →	Family	Molybdenum cofactor biosynthesis protein A	Interproscan
IPR007197 all species →	Domain	Radical SAM	Interproscan
IPR000385 all species →	Conserved_site	MoaA/NifB/PqqE, iron-sulphur binding, conserved site	Interproscan
IPR010505 all species →	Domain	Molybdenum cofactor biosynthesis protein A-like, twitch domain	Interproscan
IPR013785 all species →	Homologous_superfamily	Aldolase-type TIM barrel	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR22960 all species →	MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0006777 all species →	Biological Process	Mo-molybdopterin cofactor biosynthetic process	Interproscan
GO:0061798 all species →	Molecular Function	GTP 3',8'-cyclase activity	Interproscan
GO:0061799 all species →	Molecular Function	cyclic pyranopterin monophosphate synthase activity	Interproscan
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0051536 all species →	Molecular Function	iron-sulfur cluster binding	Interproscan
GO:0046872 all species →	Molecular Function	metal ion binding	Interproscan
GO:0051539 all species →	Molecular Function	4 iron, 4 sulfur cluster binding	Interproscan
GO:0019008 all species →	Cellular Component	obsolete molybdopterin synthase complex	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K20967	MOCS1; GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase	EC:4.1.99.22 EC:4.6.1.17	Folate biosynthesis	ko00790	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068688616.1 across 36 RNA-seq samples of Montipora foliosa. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples

28TPM > 0

1Conditions

29.1Max TPM

12.0Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	36	28	12.02	29.15

Per sample · hover a bar for the full sample record

Show the sample table (36 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR12959211	Polyps	Polyps	E4 day9	not recorded	SRP199550	29.15
SRR12710845	Polyps	Polyps	OA4 day3	not recorded	SRP199550	27.77
SRR12959200	Polyps	Polyps	E4 day15	not recorded	SRP199550	19.90
SRR12904780	Polyps	Polyps	not recorded	not recorded	SRP199550	19.77
SRR27940180	Polyps	Polyps	not recorded	not recorded	SRP199550	19.61
SRR12959226	Polyps	Polyps	E4 day3	not recorded	SRP199550	19.47
SRR12959225	Polyps	Polyps	E4 day3	not recorded	SRP199550	18.92
SRR12786895	Polyps	Polyps	OA4 day0	not recorded	SRP199550	18.05
SRR12959237	Polyps	Polyps	E4 day0	not recorded	SRP199550	18.04
SRR12786904	Polyps	Polyps	OA4 day0	not recorded	SRP199550	17.86
SRR12959199	Polyps	Polyps	E4 day15	not recorded	SRP199550	17.82
SRR27940179	Polyps	Polyps	not recorded	not recorded	SRP199550	17.59
SRR12904792	Polyps	Polyps	not recorded	not recorded	SRP199550	17.59
SRR12959181	Polyps	Polyps	E4 day0	not recorded	SRP199550	17.15
SRR12959224	Polyps	Polyps	E4 day3	not recorded	SRP199550	17.09
SRR12959198	Polyps	Polyps	E4 day15	not recorded	SRP199550	16.83
SRR12904791	Polyps	Polyps	not recorded	not recorded	SRP199550	15.87
SRR27940177	Polyps	Polyps	not recorded	not recorded	SRP199550	15.76
SRR12959238	Polyps	Polyps	E4 day0	not recorded	SRP199550	15.62
SRR12959212	Polyps	Polyps	E4 day9	not recorded	SRP199550	12.70
SRR12959213	Polyps	Polyps	E4 day9	not recorded	SRP199550	11.77
SRR12710853	Polyps	Polyps	OA4 day9	not recorded	SRP199550	9.84
SRR12710852	Polyps	Polyps	OA4 day9	not recorded	SRP199550	9.31
SRR12710865	Polyps	Polyps	OA4 day3	not recorded	SRP199550	9.26
SRR12710866	Polyps	Polyps	OA4 day3	not recorded	SRP199550	7.79
SRR12959186	Polyps	Polyps	E4 day21	not recorded	SRP199550	5.71
SRR12959187	Polyps	Polyps	E4 day21	not recorded	SRP199550	3.84
SRR12959185	Polyps	Polyps	E4 day21	not recorded	SRP199550	2.65
SRR12710854	Polyps	Polyps	OA4 day9	not recorded	SRP199550	0.00
SRR12786903	Polyps	Polyps	OA4 day0	not recorded	SRP199550	0.00
SRR12807380	Polyps	Polyps	OA4 day0	not recorded	SRP199550	0.00
SRR12849112	Polyps	Polyps	OA4 day0	not recorded	SRP199550	0.00
SRR12927879	Polyps	Polyps	E4 day0	not recorded	SRP199550	0.00
SRR12963483	Polyps	Polyps	E4 day0	not recorded	SRP199550	0.00
SRR9129315	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613518	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (MFOLI_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora foliosa tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	46	XP_068670778.1	0.961235516863359
Negatively correlated	3	XP_068710420.1	-0.405913526845024

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora foliosa, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →