Gene detail

Detailed information of XP_068731699.1 in Montipora capricornis

Genomic Location: chr12:2243600...2255485
NR annotation: XP_044162837.1, fumarate hydratase, mitochondrial-like [Acropora millepora]
Species Montipora capricornis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

rna-XM_068875598.1

GTGTGCTTCACCGCTGTTCACCTGAAACCATTTAAACTGTTAACACTCTACAGGTCACAGTTTGTTCCTTTCAGGGCATGGCGTTGCGGCTGGGAGCTGTGTTACGAACATTCAGCAGAAATCCTCGGCTTGTACCTTATCGTGGAAAACTATATTCTGGCTCTGTGGTGTTGTCACGAACAATGGCGACCCGGAAGGAAACAGACAGCTTTGGAGAAATAGAAGTGCCAGCGGACAAGTATTATGGTGCCCAAACTGCAAGATCAAAATTGAATTTTCCAATTGGTGATGAGAGTGAGCACATGCCAGCTCCTGTAATCCGTGCATTTGGTATCCTAAAAAAAGCTGCAGCTGAGGTTAACAAGGAATTTGGTTTGGACGAAAATGTTGCCAATAATATAATGAAAGCTGCAGATGAGGTGATATCTGGTAAATTAAAGAACAATTTTCCTCTCGTGGTTTGGCAAACAGGCTCAGGTACACAGTCTAACATGAACGTAAATGAGGTCATCAGTAACCGCGCCATTGAGCTGATGGGTGGTCAGATGGGATCCAAGAAACCTGTTCACCCCAATGACCATGTGAATAAAAGCCAGAGCTCCAATGACACATTTCCAACTGCGATGCACATTGCAGCAGCACTTGAGGTGCAGGAGCGTCTGCTACCAGGGTTGAAAAAGCTGCATGGTGCACTTCAATCCAAGGCTGTTGAGTTTAAAGATCTCGTTAAGATTGGTCGAACGCACACACAGGATGCTACACCAGTCACTTTGGGCCAGGAATTTAGTGGTTATGTACAACAAGTTAAGTATGGCATCTCCAGAGTGGAAGGTACCCTGGGGCGAGTCTATGAACTTGCTATCGGCGGTACAGCGGTCGGCACAGGGCTCAACACAAGGATTGGCTTTGCTGAGAAGATGGCTGCTAAGATTGCCGAGTACACAAATCTACCATTTACGAGtGCCCCAAACAAGTTTGAAGCCCTTGCTGCCCATGATGCCATGGTGGAGTTACATGGAACACTGAATGTCATTGCCTGCAGTTTGATGAAGATCGCCAATGACATCAGGTTTCTCGGCTCCGGTCCTCGCTGCGGATTGGGTGAACTCTCTTTACCCGAAAACGAACCAGGAAGCAGCATTATGCCAGGGAAGGTGAACCCGACCCAATGTGAGGCCATCACCATGGTTGCAGCTCAAGTCATAGGAAATCAAACCGCTGTGTCAGTGGGCGGAAGTAACGGTCACTTCGAACTGAATGTCTTCAAGCCCATGATCATCAGGAATGTTCTTCAATCAACGCGTCTTATTGGTGATGCTTGCGTCGCATTCACAGATAACTGCGTGGTCGGAATCGAAGCCAATGTGGACAGAATTAATAAGCTGCGAGATGAGTCACTTATGCTGGTGACGGCGCTCAACCCTCACATTGGATATGATAACGCTGCAAAGATTGCAAAGAAGGCGCACAAAGAAGGCACGACATTAAAGGAAGCTGCGATAAGCTTGGGGTTATTAACGGAAGAACAGTTTGCTGAGTGGGTGAAACCTGAAGACATGCTGGGGCCAAAGTGATCTCAAGGTTGTTGGACAAAGGTCGTTttttattccagaaaaaaaaagaacgaaaacaaactaaaacgGTGCTTCTATTTTAGCTCAGAGAGAGTTGCAGACTAATGCGTTTTAAACGAAATTGCGCGAGTTCGAACTCAACGTTACTCTCCCCAGCTTAAGTGCACCCGGCCTTACATAACGAGGGCATTATTGACGACATCTATTGTTAGTTGATTAACCATCCAGGGCCGAGTTTTTCGAAGTATAGTTAAGAATTGTCGTGGCATTTAACGCGTGTTTGCGCTGACTTAGCTTCGACCAACCCTGGCTAGAGCTTTATTGGCTACCAAACTGAAGCGTGATTTTGTCTCAGAGGTCGGCGGATTTGAATGACAGAaggaatgtttgtaaacaggtgtctttcttATAGAAAGCACATTTTGTTGTCTTTAGCATGGCGAGGGAGAACATTTAATTCTTCCTTAAAGGAATTTTACATACCAAAGCAGACGACACATACTTCCCGCAAGCCCGGTTGTAGAACTAGCAATTGCCTGTTTCAAAATACGTTACGTTAGGTGTACTTCAAGCTGGACACGCAAATAAGGTGTTGGCAAAGACATACAAATAAAATTTCTGGAACGCTGGCCA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P10173	Fumarate hydratase, mitochondrial OS=Sus scrofa OX=9823 GN=FH PE=1 SV=2
P97807	Fumarate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Fh PE=1 SV=3
P14408	Fumarate hydratase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Fh PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0003293 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00206 all species →	Lyase_1	Lyase	Domain	Interproscan
PF10415 all species →	FumaraseC_C	Fumarase C C-terminus	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR005677 all species →	Family	Fumarate hydratase, class II	Interproscan
IPR008948 all species →	Homologous_superfamily	L-Aspartase-like	Interproscan
IPR000362 all species →	Family	Fumarate lyase family	Interproscan
IPR020557 all species →	Conserved_site	Fumarate lyase, conserved site	Interproscan
IPR024083 all species →	Homologous_superfamily	Fumarase/histidase, N-terminal	Interproscan
IPR022761 all species →	Domain	Fumarate lyase, N-terminal	Interproscan
IPR018951 all species →	Domain	Fumarase C, C-terminal	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11444 all species →	ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004333 all species →	Molecular Function	fumarate hydratase activity	Interproscan
GO:0006106 all species →	Biological Process	fumarate metabolic process	Interproscan
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0006099 all species →	Biological Process	tricarboxylic acid cycle	Interproscan
GO:0006108 all species →	Biological Process	malate metabolic process	Interproscan
GO:0016829 all species →	Molecular Function	lyase activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01679	E4.2.1.2B, fumC, FH; fumarate hydratase, class II	EC:4.2.1.2	Cushing syndrome	ko04934	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068731699.1 across 36 RNA-seq samples of Montipora capricornis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples

30TPM > 0

1Conditions

92.2Max TPM

45.3Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	36	30	45.34	92.17

Per sample · hover a bar for the full sample record

Show the sample table (36 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR12959227	Polyps	Polyps	E3 day3	not recorded	SRP199550	92.17
SRR27940191	Polyps	Polyps	not recorded	not recorded	SRP199550	88.79
SRR12904783	Polyps	Polyps	not recorded	not recorded	SRP199550	88.70
SRR27940192	Polyps	Polyps	not recorded	not recorded	SRP199550	80.47
SRR12959201	Polyps	Polyps	E3 day15	not recorded	SRP199550	64.95
SRR12959203	Polyps	Polyps	E3 day15	not recorded	SRP199550	63.72
SRR27940193	Polyps	Polyps	not recorded	not recorded	SRP199550	63.67
SRR12904782	Polyps	Polyps	not recorded	not recorded	SRP199550	63.10
SRR12904781	Polyps	Polyps	not recorded	not recorded	SRP199550	62.14
SRR12959202	Polyps	Polyps	E3 day15	not recorded	SRP199550	61.33
SRR12959184	Polyps	Polyps	E3 day0	not recorded	SRP199550	58.13
SRR12959183	Polyps	Polyps	E3 day0	not recorded	SRP199550	57.91
SRR12959214	Polyps	Polyps	E3 day9	not recorded	SRP199550	56.22
SRR12959230	Polyps	Polyps	E3 day3	not recorded	SRP199550	56.20
SRR12786897	Polyps	Polyps	OA3 day0	not recorded	SRP199550	53.59
SRR12959182	Polyps	Polyps	E3 day0	not recorded	SRP199550	53.11
SRR12959215	Polyps	Polyps	E3 day9	not recorded	SRP199550	52.69
SRR12959216	Polyps	Polyps	E3 day9	not recorded	SRP199550	52.39
SRR12786896	Polyps	Polyps	OA3 day0	not recorded	SRP199550	49.53
SRR12786898	Polyps	Polyps	OA3 day0	not recorded	SRP199550	49.30
SRR12710857	Polyps	Polyps	OA3 day9	not recorded	SRP199550	48.53
SRR12710858	Polyps	Polyps	OA3 day9	not recorded	SRP199550	46.44
SRR12710855	Polyps	Polyps	OA3 day9	not recorded	SRP199550	45.76
SRR12959188	Polyps	Polyps	E3 day21	not recorded	SRP199550	44.06
SRR12959190	Polyps	Polyps	E3 day21	not recorded	SRP199550	36.94
SRR12959229	Polyps	Polyps	E3 day3	not recorded	SRP199550	35.88
SRR12959189	Polyps	Polyps	E3 day21	not recorded	SRP199550	35.03
SRR12710846	Polyps	Polyps	OA3 day3	not recorded	SRP199550	24.26
SRR12710847	Polyps	Polyps	OA3 day3	not recorded	SRP199550	24.13
SRR12710848	Polyps	Polyps	OA3 day3	not recorded	SRP199550	23.07
SRR12807381	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12849113	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12927880	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR12963484	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR9129316	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613519	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (MCAPR_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capricornis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	26	XP_068716640.1	0.957320439606814
Negatively correlated	3	XP_068724527.1	-0.526484797532386

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capricornis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →