Gene detail

Detailed information of XP_068732925.1 in Montipora capricornis

Genomic Location: chr2:58460417...58471920
NR annotation: XP_029182099.2, disintegrin and metalloproteinase domain-containing protein 10-like [Acropora millepora]
Species Montipora capricornis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

LOC138029120

ATGGTCGTTAAATTTAGTTTTGTTGTTTTCTTTCTATTGACCGTTGCCTTTCGATCTGAGGCTGCTGTCGGGAGACAGCTAGGAAAATTTATCAAGCACTACGAGCCACTTTACTACGACATTGACTCTCTTCACAGTGTACACCGCAGAGCCGTTGAAAGTAGTAGCGATGCAAACTTCGCTTTCTCTGCTTTCGGAAAATTTCATCGCCTGAACTTGCGACCTGACAGAGAAATATTTACAGGGGATGCTAAAATCCTATCTGGAGATGGAAAGCCTTTCCCGTTTGATCGAGATGCCATTGTGAGGGGGTATGTTGAGGGCGCTACCAATTCTGATGTCTATGGTGTTATCGACAAGAAAGATGGATTCCACGGGAAAATATTGAGTGGAACAGAAAACTATTACGTCGACCCTTCCTCGTGGTACTTTGATGAAAAGCAGGACTTCCCCTCAGTTATTTACAAAGATACAGACCTTGAATATAATCACGCTTATGCCGACATCAAACAACGAATTCCAGCCGACATGCATCCTGAACGAGTCCGCCGCTCTTCAAAGAACGAGGGAAGCCGCGTCCGAAGGCAAACTCCAGAAGTGCTCGAGAAAAATGCCTGCACGCTTGGTCTTTACGCTGATAATTTTTTCACTGAGTTATTTGGTGGTAAAACAAATGCCATCCTGCAGCTAGTCAAGCAGGTACAAGCAGCACAGATAATATATATGAACGCGTTCAACAACTCGGATTACTATTTTCCCAAAGGTATAACATTTCGCGTTAGCACTGTTGTTGTGTTCAATAAAACCGATCCTTTGCCCAGTGGTCTCCCTGCCCAAGTTAAAGACTCAAACGTCGGCGTTGATACATTATTGGATTATTTCTCAAGCATGAATCATGACACAGTTTGCGAGGCTTTCTTATTTACTAATCGCGATTTTGAAGGAGGAATTTTAGGCCTTGCGTGGATTGGTTCCAGTGATGAAGGGCAAGCAGGAGGAATCTGCGATAAATTTTCCGATTATGGAGGAGGCAGAAAAAGAAGTTACAATACTGGAACTGTCACAATGACTTTGTACGGACGATTTACCCCACCGAGAATTTCCGAAATTACTTTCGTCCACGAGCTTGGACATGGGTTTGGATCTGAGCATGATCCCTCCGGTAATTCTGATTGTGTTCCTGGAGGTCTTGAAGGAAATTACATCATGTTTGACAAAGCAACATCTGGTGTCAGAGCCAACAATGATAGATTCTCAAAGTGTAGCAAAGATCAGATCAAAAAGAATGTTGACTTCAAGCGTCCAAAGTACAGTGGTTGCTTTAAAAAGGGTGATGAACCCATTTGTGGAAACAAGATTGTGGAGGAAAATGAACAGTGTGACTGTGGTGATGAAAATACTTGTACGGAAAAATGTTGCATTCCAGCTGGCAGGGATCGTGCGTGCAAGCTGGTATTGGAGCCTGGTATATTATGTAGCCCAAGCCAAGGTCCTTGTTGTACAGAACAATGCAGATATGCCGGTCGCGACAGAATTTGTTCCAAATCAACAGATTGCACTAAAAACCAAACTTGCAGTGGCTTGTCCTTCAGTTGCAATACCCCTGAACCTGTGCGAAATGAGACATTGTGTGACCAAGGCCGGCGTGTGTGCTATGCTGGGCAATGCTCGGTGTCAGTGTGTGCAAAGTATAACATGGAATCATGTTCCTGTACTGTCAATTCTGAACTTTGTGACTTGTGTTGCAAGCAAGATGGGGTGTGTACTCCCTCAAGCAAGCTGGCATTGTTCCCACCAGAACTGAAAGGCCTAAAGCTTGTTCCAGGAACACCTTGTGATAACATGAATGGGTACTGTGATGTGTTTGCAGTGTGCCGTCGGGTCGACGCGCATGGTCCCTTAATCCGACTCACAACAAAAATCTTTACTGGTGAAGGCCTCAAGGAAACAGTTGAGAAGTATTGGTGGGCGATATTGCTTGGTACTATTGCCTTTGCTGTGATCGTCGCGCTCATGGTGTTCCTGTGCGCTCGCTACACACCAAGCAGTAATCCGCACAAAGAGGCCCAGAAACCAGCCAAGACACTGCCAGGTCGTAAGAGGAGACCCCCATCGCAACATCCCTACTACCAACAGGGAATGGAAATGCAGCAACGAGCATGA

Transcript

rna-XM_068876824.1

GCCTACAGACTGATATTGCAACTCCTTTGACTGTTCGTTTGTAAGCACCATGGTCGttaaatttagttttgttgttttctttctattGACCGTTGCCTTTCGATCTGAGGCTGCTGTCGGGAGACAGCTAGGAAAATTTATCAAGCACTACGAGCCACTTTACTACGACATTGACTCTCTTCACAGTGTACACCGCAGAGCCGTTGAAAGTAGTAGCGATGCAAACTTCGCTTTCTCTGCTTTCGGAAAATTTCATCGCCTGAACTTGCGACCTGACAGAGAAATATTTACAGGGGATGCTAAAATCCTATCTGGAGATGGAAAGCCTTTCCCGTTTGATCGAGATGCCATTGTGAGGGGGTATGTTGAGGGCGCTACCAATTCTGATGTCTATGGTGTTATCGACAAGAAAGATGGATTCCACGGGAAAATATTGAGTGGAACAGAAAACTATTACGTCGACCCTTCCTCGTGGTACTTTGATGAAAAGCAGGACTTCCCCTCAGTTATTTACAAAGATACAGACCTTGAATATAATCACGCTTATGCCGACATCAAACAACGAATTCCAGCCGACATGCATCCTGAACGAGTCCGCCGCTCTTCAAAGAACGAGGGAAGCCGCGTCCGAAGGCAAACTCCAGAAGTGCTCGAGAAAAATGCCTGCACGCTTGGTCTTTACGCTGATAATTTTTTCACTGAGTTATTTGGTGGTAAAACAAATGCCATCCTGCAGCTAGTCAAGCAGGTACAAGCAGCACAGATAATATATATGAACGCGTTCAACAACTCGGATTACTATTTTCCCAAAGGTATAACATTTCGCGTTAGCACTGTTGTTGTGTTCAATAAAACCGATCCTTTGCCCAGTGGTCTCCCTGCCCAAGTTAAAGACTCAAACGTCGGCGTTGATACATTATTGGATTATTTCTCAAGCATGAATCATGACACAGTTTGCGAGGCTTTCTTATTTACTAATCGCGATTTTGAAGGAGGAATTTTAGGCCTTGCGTGGATTGGTTCCAGTGATGAAGGGCAAGCAGGAGGAATCTGCGATAAATTTTCCGATTATGGAGGAGGCAGAAAAAGAAGTTACAATACTGGAACTGTCACAATGACTTTGTACGGACGATTTACCCCACCGAGAATTTCCGAAATTACTTTCGTCCACGAGCTTGGACATGGGTTTGGATCTGAGcaTGATCCCTCCGGTAATTCTGATTGTGTTCCTGGAGGTCTTGAAGGAAATTACATCATGTTTGACAAAGCAACATCTGGTGTCAGAGCCAACAATGATAGATTCTCAAAGTGTAGCAAAGATCAGATCAAAAAGAATGTTGACTTCAAGCGTCCAAAGTACAGTGGTTGCTTTAAAAAGGGTGATGAACCCATTTGTGGAAACAAGATTGTGGAGGAAAATGAACAGTGTGACTGTGGTGATGAAAATACTTGTACGGAAAAATGTTGCATTCCAGCTGGCAGGGATCGTGCGTGCAAGCTGGTATTGGAGCCTGGTATATTATGTAGCCCAAGCCAAGGTCCTTgttgtacagaacaatgcagatATGCCGGTCGCGACAGAATTTGTTCCAAATCAACAGATTGCACTAAAAACCAAACTTGCAGTGGCTTGTCCTTCAGTTGCAATACCCCTGAACCTGTGCGAAATGAGACATTGTGTGACCAAGGCCGGCGTGTGTGCTATGCTGGGCAATGCTCGGTGTCAGTGTGTGCAAAGTATAACATGGAATCATGTTCCTGTACTGTCAATTCTGAACTTTGTGACTTGTGTTGCAAGCAAGATGGGGTGTGTACTCCCTCAAGCAAGCTGGCATTGttccCACCAGAACTGAAAGGCCTAAAGCTTGTTCCAGGAACACCTTGTGATAACATGAATGGGTACTGTGATGTGTTTGCAGTGTGCCGTCGGGTCGACGCGCATGGTCCCTTAATCCGACTCACAACAAAAATCTTTACTGGTGAAGGCCTCAAGGAAACAGTTGAGAAGTATTGGTGGGCGATATTGCTTGGTACTATTGCCTTTGCTGTGATCGTCGCGCTCATGGTGTTCCTGTGCGCTCGCTACACACCAAGCAGTAATCCGCACAAAGAGGCCCAGAAACCAGCCAAGACACTGCCAGGTCGTAAGAGGAGACCCCCATCGCAACATCCCTACTACCAACAGGGAATGGAAATGCAGCAACGAGCATGAAATTAGTGGTGACCAGATGCAGCTGCAACAACAGTTCCAAATATATTGGCGTTCACGCAGTCCCCACGCATTGAACATGAGATGTCTTCGTAATGAAGAGAGTGTGAGCAAAATGTGTAAACATGAAAGTGCTATTTGTAAT

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O77633	Disintegrin and metalloproteinase domain-containing protein 10 OS=Sus scrofa OX=9823 GN=ADAM10 PE=2 SV=2
Q10741	Disintegrin and metalloproteinase domain-containing protein 10 OS=Bos taurus OX=9913 GN=ADAM10 PE=1 SV=1
O35598	Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus OX=10090 GN=Adam10 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000651 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF13688 all species →	Reprolysin_5	Metallo-peptidase family M12	Family	Interproscan
PF21299 all species →	ADAM10_Cys-rich	ADAM10, cysteine-rich domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001762 all species →	Domain	Disintegrin domain	Interproscan
IPR051489 all species →	Family	Disintegrin and Metalloproteinase Domain-Containing	Interproscan
IPR024079 all species →	Homologous_superfamily	Metallopeptidase, catalytic domain superfamily	Interproscan
IPR036436 all species →	Homologous_superfamily	Disintegrin domain superfamily	Interproscan
IPR049038 all species →	Domain	ADAM10, cysteine-rich domain	Interproscan
IPR001590 all species →	Domain	Peptidase M12B, ADAM/reprolysin	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR45702 all species →	ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004222 all species →	Molecular Function	metalloendopeptidase activity	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006509 all species →	Biological Process	membrane protein ectodomain proteolysis	Interproscan
GO:0007219 all species →	Biological Process	Notch signaling pathway	Interproscan
GO:0008237 all species →	Molecular Function	metallopeptidase activity	Interproscan
GO:0006508 all species →	Biological Process	proteolysis	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K06704	ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10	EC:3.4.24.81	CD molecules	ko04090	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068732925.1 across 36 RNA-seq samples of Montipora capricornis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples

30TPM > 0

1Conditions

106.7Max TPM

23.1Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	36	30	23.07	106.72

Per sample · hover a bar for the full sample record

Show the sample table (36 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR27940192	Polyps	Polyps	not recorded	not recorded	SRP199550	106.72
SRR12904783	Polyps	Polyps	not recorded	not recorded	SRP199550	80.59
SRR27940191	Polyps	Polyps	not recorded	not recorded	SRP199550	79.72
SRR27940193	Polyps	Polyps	not recorded	not recorded	SRP199550	44.92
SRR12904781	Polyps	Polyps	not recorded	not recorded	SRP199550	43.33
SRR12904782	Polyps	Polyps	not recorded	not recorded	SRP199550	41.95
SRR12786896	Polyps	Polyps	OA3 day0	not recorded	SRP199550	40.93
SRR12786897	Polyps	Polyps	OA3 day0	not recorded	SRP199550	35.68
SRR12786898	Polyps	Polyps	OA3 day0	not recorded	SRP199550	35.41
SRR12959202	Polyps	Polyps	E3 day15	not recorded	SRP199550	26.89
SRR12959201	Polyps	Polyps	E3 day15	not recorded	SRP199550	26.16
SRR12959203	Polyps	Polyps	E3 day15	not recorded	SRP199550	25.98
SRR12959229	Polyps	Polyps	E3 day3	not recorded	SRP199550	24.86
SRR12959214	Polyps	Polyps	E3 day9	not recorded	SRP199550	20.45
SRR12959183	Polyps	Polyps	E3 day0	not recorded	SRP199550	19.81
SRR12959215	Polyps	Polyps	E3 day9	not recorded	SRP199550	18.87
SRR12959216	Polyps	Polyps	E3 day9	not recorded	SRP199550	18.35
SRR12959182	Polyps	Polyps	E3 day0	not recorded	SRP199550	17.85
SRR12959184	Polyps	Polyps	E3 day0	not recorded	SRP199550	15.01
SRR12959188	Polyps	Polyps	E3 day21	not recorded	SRP199550	12.44
SRR12959190	Polyps	Polyps	E3 day21	not recorded	SRP199550	11.53
SRR12959230	Polyps	Polyps	E3 day3	not recorded	SRP199550	10.67
SRR12959189	Polyps	Polyps	E3 day21	not recorded	SRP199550	10.66
SRR12959227	Polyps	Polyps	E3 day3	not recorded	SRP199550	10.17
SRR12710858	Polyps	Polyps	OA3 day9	not recorded	SRP199550	9.33
SRR12710857	Polyps	Polyps	OA3 day9	not recorded	SRP199550	8.94
SRR12710855	Polyps	Polyps	OA3 day9	not recorded	SRP199550	8.84
SRR12710846	Polyps	Polyps	OA3 day3	not recorded	SRP199550	8.58
SRR12710848	Polyps	Polyps	OA3 day3	not recorded	SRP199550	8.42
SRR12710847	Polyps	Polyps	OA3 day3	not recorded	SRP199550	7.33
SRR12807381	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12849113	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12927880	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR12963484	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR9129316	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613519	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (MCAPR_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capricornis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	48	XP_068737822.1	0.989362701634357
Negatively correlated	3	XP_068725808.1	-0.304496767541572

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capricornis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →