Gene detail

Detailed information of XP_068750149.1 in Montipora capricornis

Genomic Location: chr4:50429835...50448508
NR annotation: XP_015771220.1, PREDICTED: signal peptide peptidase-like 3 [Acropora digitifera]
Species Montipora capricornis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

rna-XM_068894048.1

AGAAGGCTTTGTTTCTGGTACTAAAAATCACAACAAACTAAGCCGTTTTTGCTCAAGTCTGTCTCTCTAACGTTTAGAAAAGCAGAAATTTAAGCCAAAATACCTCGCTTTAGACCGTCTTGTAGACCTTAATTTCCTGATACGTACAAGGAGCCAATGGAGAGCTGTATTAAAGCTTTTTACTTGAAGAATGATCATTAATTTGTGAGCAGGAATGGAGGAAGTTCCAGTAGAAGGAGAAACTCTGTGGATCTACACATTTGCAGATAGCTCGAGATTGTTGACTATTATTATATCAATCTTGCTGATTATCTATGGGAGTTTCAGGGCATCAGGATTAGATGCTGCATTTGATGCTTCTGAGGATGGGGATGGAGAACAGAACTATAATTCCTCTCCTTTTACAAGACTTATGGATGGGTTCCAGACAATCAACACAGCTCAAGCTGTCTTTCTTCCAGTTGGGGCTTCCTTCTCTCTTCTTGTGATGTTCTTCTTTTTTGACACTCTGCAGTTTTTCTTTGCGCTTTGCACCGCTGCTTTGGCCACTGTggctttttcctttgttcttctACCTGTCTGCCAATTTCTGACAAGACCCTGCTGTGGAAGTAACAATCAAAAATTTTATGTTGGCTTCTGTGGCCGATTCACGCCAGCCGAAGCCATGGCACTTGTATGTTCTGCAGTATTAGTGATGATCTGGATTGTGACAGGACATTGGGTGCTCATGGACGCACTTGCCATGGGATTGTGTGTTTCCATGATTGCCTATATCCGACTACCAAGCCTTAAAGTGTCTACTCTTCTGTTAATAGGTCTTTTAATTTATGATGTGTTTTGGgttttcttttcaagttacatATTTAAAGCAAATGTCATGGTTCATGTAGCCACACAACGGGCTGCAAACCCTGTTTCTTATGTGGCAAATAAGTTAAAAATGAATTCTGTAGGAAATCTCTCTCCTCAAATATCTCTTCCTGGAAAGTTGATTTTTCCAAGCATGAATGACAGAGGCAGATTTTCCATGTTAGGACTTGGAGATATTGTCATGCCAGGGCTTCTGTTGTGTTTTGTTATGAGATATGACAACTACAAAAAGCAAGCCGCAGTCGCCACTGACACAGAACATTCAAAGATAACTTATTTTCATTGCTCACTTATTGGATATATTGTAGGTTTAATGACTGCCACTTTGGCGTCTGAAGTTTACAAAGCAGCTCAACCAGCTTTGCTTTACCTTGTTCCTTTCACACTGCTTCCAATCCTAGTTATGGCTTATCTTAAGGGCGATCTACGGAAGATGTGGCAGGACCCTTTTGTGGCAGCAAGCTCTAAGCTTAAGTTTATGGAAGTATGATACGAGTTCAAACAAGTCGAAGACAGGTGCTTTAGTGGACTCCTAAAAAACTGTTCTTCATCTTCAACCACAATTACAGTTGAAAACTGACGTTGTATTAGTACTGGAGAGTTATTGCAGATGTTTCAAATCATAACTTACAGAAGAAGAGGATGACGCTGCTTCAAACATACATGAATTGTACAAATGGTAGAGGAAAAAGCACTGAAACCTCAAGAAaagagaacaataattattattctgcaGCTTTTTTGGTGCAGTCCTATGCCGTCATTTTCAAACGTAAACAGTTAGAGAAACAGCATTCCAAAGAAAAACATTCCATAACTTCATTTAAATCTTTTCTTCTGTGAGGGATTTACTTCATTTTTAGTACCCAATCTGGCGGTTATGAGGATAAAGAGTGTTGTGCGCAAGTGACACCCCGAAGGAGATGCCCAACTTTCATGATCCTCAAAGGCTGaggccttgcaaacaataaatTTTTTCCACTCTGATCAGAACAGGTAGAATTTATGAATGGGCAAATGGTGGAAATCTTAGGTATTGTAAATGAAATTTATTCTTATTTAAGTTTTTAGTTAAGAGGATGTAATTTTATGAAAAGCAACCATCATCATTTCTTCAAAAAACGGATAATTTACTTCACTTAGTTGTCTTGTGAGccttggtttgtttttttctaaaaatccACAAGCAGACAAAAAAGACTTCTTCAGTTTCAGGTTACAGTGATGATCAGTGATAAATGATATTAGTGTATGACAAGGAGGATGCAATAAGTATAATATACACTTAAACTCAAGAGTGATGCTGTAAATAGCTAGAGCTCTTACTTGACAACATAAACCCATCCGTTTTGTTGATCAAAGTCACCACCACACCCTTGCAAAGTTCTGTCCAGATAAAACTGGTGGACATTTCAGACCAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q8TCT6	Signal peptide peptidase-like 3 OS=Homo sapiens OX=9606 GN=SPPL3 PE=1 SV=2
Q9CUS9	Signal peptide peptidase-like 3 OS=Mus musculus OX=10090 GN=Sppl3 PE=1 SV=3
Q7G7C7	Signal peptide peptidase-like 1 OS=Oryza sativa subsp. japonica OX=39947 GN=SPPL1 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0006858 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF04258 all species →	Peptidase_A22B	Signal peptide peptidase	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR006639 all species →	Family	Presenilin/signal peptide peptidase	Interproscan
IPR007369 all species →	Family	Peptidase A22B, signal peptide peptidase	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12174 all species →	SIGNAL PEPTIDE PEPTIDASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0016020 all species →	Cellular Component	membrane	Interproscan
GO:0042500 all species →	Molecular Function	aspartic endopeptidase activity, intramembrane cleaving	Interproscan
GO:0006465 all species →	Biological Process	signal peptide processing	Interproscan
GO:0030660 all species →	Cellular Component	Golgi-associated vesicle membrane	Interproscan
GO:0033619 all species →	Biological Process	membrane protein proteolysis	Interproscan
GO:0071458 all species →	Cellular Component	obsolete integral component of cytoplasmic side of endoplasmic reticulum membrane	Interproscan
GO:0071556 all species →	Cellular Component	obsolete integral component of lumenal side of endoplasmic reticulum membrane	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K09598	SPPL3; signal peptide peptidase-like 3	EC:3.4.23.-	Peptidases and inhibitors	ko01002	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068750149.1 across 36 RNA-seq samples of Montipora capricornis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples

28TPM > 0

1Conditions

43.8Max TPM

20.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	36	28	20.75	43.77

Per sample · hover a bar for the full sample record

Show the sample table (36 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR27940191	Polyps	Polyps	not recorded	not recorded	SRP199550	43.77
SRR12904783	Polyps	Polyps	not recorded	not recorded	SRP199550	43.41
SRR12786896	Polyps	Polyps	OA3 day0	not recorded	SRP199550	42.06
SRR12786898	Polyps	Polyps	OA3 day0	not recorded	SRP199550	41.45
SRR12786897	Polyps	Polyps	OA3 day0	not recorded	SRP199550	39.71
SRR12959229	Polyps	Polyps	E3 day3	not recorded	SRP199550	39.24
SRR12904782	Polyps	Polyps	not recorded	not recorded	SRP199550	37.84
SRR12904781	Polyps	Polyps	not recorded	not recorded	SRP199550	35.56
SRR27940193	Polyps	Polyps	not recorded	not recorded	SRP199550	33.88
SRR12959183	Polyps	Polyps	E3 day0	not recorded	SRP199550	29.92
SRR12959184	Polyps	Polyps	E3 day0	not recorded	SRP199550	29.18
SRR12959182	Polyps	Polyps	E3 day0	not recorded	SRP199550	27.26
SRR12959216	Polyps	Polyps	E3 day9	not recorded	SRP199550	26.73
SRR12959215	Polyps	Polyps	E3 day9	not recorded	SRP199550	26.31
SRR12959202	Polyps	Polyps	E3 day15	not recorded	SRP199550	25.54
SRR12959227	Polyps	Polyps	E3 day3	not recorded	SRP199550	25.29
SRR12959203	Polyps	Polyps	E3 day15	not recorded	SRP199550	24.38
SRR12959201	Polyps	Polyps	E3 day15	not recorded	SRP199550	23.87
SRR12959214	Polyps	Polyps	E3 day9	not recorded	SRP199550	20.65
SRR12959190	Polyps	Polyps	E3 day21	not recorded	SRP199550	16.63
SRR12959188	Polyps	Polyps	E3 day21	not recorded	SRP199550	16.49
SRR12710848	Polyps	Polyps	OA3 day3	not recorded	SRP199550	16.16
SRR12959189	Polyps	Polyps	E3 day21	not recorded	SRP199550	15.69
SRR12710846	Polyps	Polyps	OA3 day3	not recorded	SRP199550	15.35
SRR12710847	Polyps	Polyps	OA3 day3	not recorded	SRP199550	14.30
SRR12710857	Polyps	Polyps	OA3 day9	not recorded	SRP199550	13.27
SRR12710858	Polyps	Polyps	OA3 day9	not recorded	SRP199550	11.82
SRR12710855	Polyps	Polyps	OA3 day9	not recorded	SRP199550	11.38
SRR12807381	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12849113	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12927880	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR12959230	Polyps	Polyps	E3 day3	not recorded	SRP199550	0.00
SRR12963484	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR27940192	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9129316	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613519	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (MCAPR_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capricornis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	34	XP_068759356.1	0.977044486762816
Negatively correlated	3	XP_068724527.1	-0.42882366972211

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capricornis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →