Gene detail

Detailed information of XP_068751689.1 in Montipora capricornis

Genomic Location: chr5:8116373...8145842
NR annotation: XP_044183609.1, peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase-like [Acropora millepora]
Species Montipora capricornis · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

LOC138049344

ATGGCTTCCACGGCTCACGGAAATGCAATCGTTGTGGACGAAGACAGCAAATTTCAGCAGTACATCGATGTGGCGGGTAACCGACTTGTCGTAGTGGATTTTTCGGCTTCTTGGTGTGGTCCATGTCGTATGATGGCCCCCATTTTTGCACAGTTGAGTGTTAAATATTCTGCAGCAATTTTTTTGACAGTTGATACTGACCAGTGCAAGATGACGGCAAAAATTAATGGAATAAGGATGATGCCAACATTCTTCTTTTACAAGAACAGGAAGAAAGTTGATGAAATGTTAGGTGCAGATCCCACTGGGCTGGAAGATAAAATCAACCAGTGGATTGGGGGTGCTGTGGATTCAGTGATTGTCGATCCTAAGAGAGTGGCAGCAGGGCGCAGCTGGGATTGTTTTGAGCAGTTACTAGACAATCCTCCAGATGTTTTTATGGATGTTTCTCAGCTTCTCCTTAAGTTTGCATCCAACATTATCAACAGTCCTGACAACCCAAAGTTCCGCTCCATACGAGTTGGCAACAAGATCTTTCAATCACGTCTTCTCCCTGTTAATGGAGCTGTCGAGTGTCTTTTTACAATGGGATTTAAGGAGCGAGGCAACCAACTTGTTTGTCCGCAAGGCGAATCATTAGAGAACATGCTAATTCTCCAGGATGCATTGATTGATGAAAGGGCCCGTCGCAGTACCAACCAGGAACCGGCCTCTAGACCACAGGGATCACAAGCCCCAGGATGCCCAGAGGAAGCCTTAACTGGCTGTGGACAACCATCAATCATTTCCAGTCTGTCTGCAAGCTCGACAATGGATAACGAAAAGGATTTCCTGCTCAGACTTCAGAGCCTGTTGCAGCATGTCTTACTCTATGAAGATGAAGATTTACAAAGACGAACACGAAACATAATTCCAATAACAGATTTAATGAAGAAGGCCAAAGAGTCCAGTGAAATGACGAAGCGGGGTGGCGAGGCAGGCGTTAGTGAGCAGGATTGTCTTATTTTAGAACTTCTTAACTGGTTCAAAGGTTCATTTTTCAAGTGGGTGGATAAACCGCTCTGCGCGTCTTGTGGTTCCATAACATTCGCCATTGGTGTTGTCCCACCAACGCCAGAGGAAGCTCTGTGGGGTGCTGGAAATGTGGAAAGCTATAAATGTCAGAAGTGCGGCAAGAAAACAAGATTTCCTCGATACAATCACCCAGCAAAACTCTTAGAAACTCGTCAGGGGAGGTGTGGTGAGTGGGCCAACTGCTTCACGCTGATTTGCCGTGCTGTTGGATTCGATTCACGTCACGTGCTTGACTGGACAGATCACGTGTGGACGGAAATATACTCCGAGGCGCAGCAAAGGTGGCTACACTGCGACGCGTGTGAGAACACTTGCGACAAACCGCTGATTTACGAGGCTGGCTGGGGAAAGAAGCTCTCATATATCATAGCTTTCTCTCATGAACAAGTGTTGGATGTGACGTGGCGTTACTCAGCTAAACATGACGAGGTTCGCAAGGCGAGAACGTTAGTTTCAGAGGATTGGCTCGAAAAAGCACTTGCCACATTGACAGAAGAGCGTCAAATAAACTTAAGTGAAGAGAGACGGAAAGTTTTGATGGAGCGCCAAGTGAAGGAATTGGTGGAGTTTTTCACTATAAAAACAGTTCGTGATGGTGAGCTTCAAGGACGAGTCTCGGGTGATTTGGCCTGGAGACTGTTACGAGGAGAAACGAAACCACAACAGGAAGAATATAAACACGATCCATATATTTATAAACCCACGGATGAGGAAATCAAGGAGAAAAGATTAAGATTTTGCTTCAACTGTGTTGTTAACAAGTATCTCAGAGGCTTTGACAGGAAACTTGACATATCGGATTGGCAGTCAAGAGTCGCCGCTTACAACTCAATAACGCGTAAAGTGGAGACGGATTGGAAGATGACGTACTTAGCAAGAACAGAGTCATCTTCATCGGGCTCAATCACTTGGCAGGTTGACTTAACATCATGTGATTTAGTGATTGACAGCGTTACCATAGTAGCGACGAGTGCCACGTTTCAGACAGGCCAGGCGGAATGGAAACTAAGCGGAGACGATGAGAGTCAAAGTGAAATCCTTTCTGGAGGACGGGAATCCACCATTACCTCAGTCCTCAGTGGTTCCAAGACTCTTAAACTCACAGCTACCCTTAGTGGCGGGAAAGGAAACGTTGCCTGGCAACACGCACAGCTGTTTCGCCAACCACTTGACAGCCAGAGCGAATACCCACTCGACGTTGCGATCTTCCTTCGAGAGCCGAGTCGGGACACTCGACTATAA

Transcript

rna-XM_068895588.1

CGCAGTTCCGGTTGCCTGCACTTTACAGACGCCGTCTTCAAAATCTGTCTCTGTTACAGCTCTTTGTCTGTCAACAGACCAAGTTCCGTCCGCTTGTGATTGGAATTTGCAATGTATTCTAAATTGTAGCTTGTTACGGTCAAACGACCGCTACTAAGTTGCTTTCAAACCTTCGCCCACGATCCAAAATGGCTTCCACGGCTCACGGAAATGCAATCGTTGTGGACGAAGACAGCAAATTTCAGCAGTACATCGATGTGGCGGGTAACCGACTTGTCGTAGTGGATTTTTCGGCTTCTTGGTGTGGTCCATGTCGTATGATGGCCCCCATTTTTGCACAGTTGAGTGTTAAATATTCTGCAGCAATTTTTTTGACAGTTGATACTGACCAGTGCAAGATGACGGCAAAAATTAATGGAATAAGGATGATGCCAACATTCTTCTTTTACAAGAACAGGAAGAAAGTTGATGAAATGTTAGGTGCAGATCCCACTGggctggaagataaaatcaacCAGTGGATTGGGGGTGCTGTGGATTCAGTGATTGTCGATCCTAAGAGAGTGGCAGCAGGGCGCAGCTGGGATTGTTTTGAGCAGTTACTAGACAATCCTCCAGATGTTTTTATGGATGTTTCTCAGCTTCTCCTTAAGTTTGCATCCAACATTATCAACAGTCCTGACAACCCAAAGTTCCGCTCCATACGAGTTGGCAACAAGATCTTTCAATCACGTCTTCTCCCTGTTAATGGAGCTGTCGAGTGTCTTTTTACAATGGGATTTAAGGAGCGAGGCAACCAACTTGTTTGTCCGCAAGGCGAATCATTAGAGAACATGCTAATTCTCCAGGATGCATTGATTGATGAAAGGGCCCGTCGCAGTACCAACCAGGAACCGGCCTCTAGACCACAGGGATCACAAGCCCCAGGATGCCCAGAGGAAGCCTTAACTGGCTGTGGACAACCATCAATCATTTCCAGTCTGTCTGCAAGCTCGACAATGGATAACGAAAAGGATTTCCTGCTCAGACTTCAGAGCCTGTTGCAGCATGTCTTACTCTATGAAGATGAAGATTTACAAAGACGAACACGAAACATAATTCCAATAACAGATTTAATGAAGAAGGCCAAAGAGTCCAGTGAAATGACGAAGCGGGGTGGCGAGGCAGGCGTTAGTGAGCAGGATTGTCTTATTTTAGAACTTCTTAACTGGTTCAAAGGTTCATTTTTCAAGTGGGTGGATAAACCGCTCTGCGCGTCTTGTGGTTCCATAACATTCGCCATTGGTGTTGTCCCACCAACGCCAGAGGAAGCTCTGTGGGGTGCTGGAAATGTGGAAAGCTATAAATGTCAGAAGTGCGGCAAGAAAACAAGATTTCCTCGATACAATCACCCAGCAAAACTCTTAGAAACTCGTCAGGGGAGGTGTGGTGAGTGGGCCAACTGCTTCACGCTGATTTGCCGTGCTGTTGGATTCGATTCACGTCACGTGCTTGACTGGACAGATCACGTGTGGACGGAAATATACTCCGAGGCGCAGCAAAGGTGGCTACACTGCGACGCGTGTGAGAACACTTGCGACAAACCGCTGATTTACGAGGCTGGCTGGGGAAAGAAGCTCTCATATATCATAGCTTTCTCTCATGAACAAGTGTTGGATGTGACGTGGCGTTACTCAGCTAAACATGACGAGGTTCGCAAGGCGAGAACGTTAGTTTCAGAGGATTGGCTCGAAAAAGCACTTGCCACATTGACAGAAGAGCGTCAAATAAACTTAAGTGAAGAGAGACGGAAAGTTTTGATGGAGCGCCAAGTGAAGGAATTGGTGGAGTTTTTCACTATAAAAACAGTTCGTGATGGTGAGCTTCAAGGACGAGTCTCGGGTGATTTGGCCTGGAGACTGTTACGAGGAGAAACGAAACCACAACAGGAAGAATATAAACACGATCCATATATTTATAAACCCACGGATGAGGAAATCAAGGAGAAAAGATTAAGATTTTGCTTCAACTGTGTTGTTAACAAGTATCTCAGAGGCTTTGACAGGAAACTTGACATATCGGATTGGCAGTCAAGAGTCGCCGCTTACAACTCAATAACGCGTAAAGTGGAGACGGATTGGAAGATGACGTACTTAGCAAGAACAGAGTCATCTTCATCGGGCTCAATCACTTGGCAGGTTGACTTAACATCATGTGATTTAGTGATTGACAGCGTTACCATAGTAGCGACGAGTGCCACGTTTCAGACAGGCCAGGCGGAATGGAAACTAAGCGGAGACGATGAGAGTCAAAGTGAAATCCTTTCTGGAGGACGGGAATCCACCATTACCTCAGTCCTCAGTGGTTCCAAGACTCTTAAACTCACAGCTACCCTTAGTGGCGGGAAAGGAAACGTTGCCTGGCAACACGCACAGCTGTTTCGCCAACCACTTGACAGCCAGAGCGAATACCCACTCGACGTTGCGATCTTCCTTCGAGAGCCGAGTCGGGACACTCGACTATAACTTTTGCTAGTTGTATAGATTGAATCTTATTAGCAGACCTGACTGCCCTGGGAGGAGGCTCAAACCCGTTTAAACACTCTCAAGAAACTGTACCATCTACGCTACTGTTTCTCGTTACGGTAATTTTATTGACTTATAAAACAGcaataatagaccaa

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q96IV0	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1
Q4R6F3	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Macaca fascicularis OX=9541 GN=NGLY1 PE=2 SV=1
Q9JI78	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Mus musculus OX=10090 GN=Ngly1 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002148 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF01841 all species →	Transglut_core	Transglutaminase-like superfamily	Family	Interproscan
PF09409 all species →	PUB	PUB domain	Domain	Interproscan
PF04721 all species →	PAW	PNGase C-terminal domain, mannose-binding module PAW	Domain	Interproscan
PF00085 all species →	Thioredoxin	Thioredoxin	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR002931 all species →	Domain	Transglutaminase-like	Interproscan
IPR008979 all species →	Homologous_superfamily	Galactose-binding-like domain superfamily	Interproscan
IPR038765 all species →	Homologous_superfamily	Papain-like cysteine peptidase superfamily	Interproscan
IPR018997 all species →	Domain	PUB domain	Interproscan
IPR017937 all species →	Conserved_site	Thioredoxin, conserved site	Interproscan
IPR006588 all species →	Domain	Peptide N glycanase, PAW domain	Interproscan
IPR013766 all species →	Domain	Thioredoxin domain	Interproscan
IPR036339 all species →	Homologous_superfamily	PUB-like domain superfamily	Interproscan
IPR036249 all species →	Homologous_superfamily	Thioredoxin-like superfamily	Interproscan
IPR050883 all species →	Family	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	Interproscan
IPR038680 all species →	Homologous_superfamily	PAW domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12143 all species →	PEPTIDE N-GLYCANASE PNGASE -RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0006516 all species →	Biological Process	glycoprotein catabolic process	Interproscan
GO:0000224 all species →	Molecular Function	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0006515 all species →	Biological Process	protein quality control for misfolded or incompletely synthesized proteins	Interproscan
GO:0006517 all species →	Biological Process	protein deglycosylation	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01456	E3.5.1.52, NGLY1, PNG1; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	EC:3.5.1.52	Protein processing in endoplasmic reticulum	ko04141	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068751689.1 across 36 RNA-seq samples of Montipora capricornis. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples

28TPM > 0

1Conditions

55.4Max TPM

19.1Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	36	28	19.12	55.39

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR27940191	Polyps	Polyps	not recorded	not recorded	SRP199550	55.39
SRR12904783	Polyps	Polyps	not recorded	not recorded	SRP199550	55.27
SRR12904781	Polyps	Polyps	not recorded	not recorded	SRP199550	36.87
SRR12786897	Polyps	Polyps	OA3 day0	not recorded	SRP199550	36.26
SRR12959227	Polyps	Polyps	E3 day3	not recorded	SRP199550	35.67
SRR27940193	Polyps	Polyps	not recorded	not recorded	SRP199550	34.37
SRR12786898	Polyps	Polyps	OA3 day0	not recorded	SRP199550	33.68
SRR12786896	Polyps	Polyps	OA3 day0	not recorded	SRP199550	33.30
SRR12904782	Polyps	Polyps	not recorded	not recorded	SRP199550	31.97
SRR12959229	Polyps	Polyps	E3 day3	not recorded	SRP199550	28.06
SRR12959215	Polyps	Polyps	E3 day9	not recorded	SRP199550	23.15
SRR12959189	Polyps	Polyps	E3 day21	not recorded	SRP199550	22.28
SRR12959188	Polyps	Polyps	E3 day21	not recorded	SRP199550	22.01
SRR12959214	Polyps	Polyps	E3 day9	not recorded	SRP199550	21.56
SRR12959216	Polyps	Polyps	E3 day9	not recorded	SRP199550	21.46
SRR12959190	Polyps	Polyps	E3 day21	not recorded	SRP199550	20.51
SRR12959203	Polyps	Polyps	E3 day15	not recorded	SRP199550	19.37
SRR12959202	Polyps	Polyps	E3 day15	not recorded	SRP199550	18.48
SRR12959201	Polyps	Polyps	E3 day15	not recorded	SRP199550	17.01
SRR12959184	Polyps	Polyps	E3 day0	not recorded	SRP199550	16.61
SRR12959183	Polyps	Polyps	E3 day0	not recorded	SRP199550	16.15
SRR12710857	Polyps	Polyps	OA3 day9	not recorded	SRP199550	15.41
SRR12959182	Polyps	Polyps	E3 day0	not recorded	SRP199550	13.31
SRR12710848	Polyps	Polyps	OA3 day3	not recorded	SRP199550	12.78
SRR12710846	Polyps	Polyps	OA3 day3	not recorded	SRP199550	12.25
SRR12710858	Polyps	Polyps	OA3 day9	not recorded	SRP199550	12.20
SRR12710855	Polyps	Polyps	OA3 day9	not recorded	SRP199550	11.64
SRR12710847	Polyps	Polyps	OA3 day3	not recorded	SRP199550	11.17
SRR12807381	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12849113	Polyps	Polyps	OA3 day0	not recorded	SRP199550	0.00
SRR12927880	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR12959230	Polyps	Polyps	E3 day3	not recorded	SRP199550	0.00
SRR12963484	Polyps	Polyps	E3 day0	not recorded	SRP199550	0.00
SRR27940192	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9129316	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613519	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (MCAPR_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.