Detailed information of XP_068762622.1 in Montipora capricornis

Genomic Location: chr8:51001211...51044057
NR annotation: CAH3137439.1, unnamed protein product [Pocillopora meandrina]
Species Montipora capricornis · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
O70157DNA topoisomerase 3-alpha OS=Mus musculus OX=10090 GN=Top3a PE=2 SV=1
Q13472DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1
Q9NG98DNA topoisomerase 3-alpha OS=Drosophila melanogaster OX=7227 GN=Top3alpha PE=2 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003217 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF01751
all species →
ToprimToprim domainFamilyInterproscan
PF01396
all species →
zf-C4_TopoisomTopoisomerase DNA binding C4 zinc fingerDomainInterproscan
PF01131
all species →
Topoisom_bacDNA topoisomeraseFamilyInterproscan
PF06839
all species →
zf-GRFGRF zinc fingerDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR003602
all species →
DomainDNA topoisomerase, type IA, DNA-binding domainInterproscan
IPR010666
all species →
DomainZinc finger, GRF-typeInterproscan
IPR006171
all species →
DomainTOPRIM domainInterproscan
IPR013825
all species →
Homologous_superfamilyDNA topoisomerase, type IA, central region, subdomain 2Interproscan
IPR013826
all species →
Homologous_superfamilyDNA topoisomerase, type IA, central region, subdomain 3Interproscan
IPR003601
all species →
DomainDNA topoisomerase, type IA, domain 2Interproscan
IPR034144
all species →
DomainDNA topoisomerase 3-like, TOPRIM domainInterproscan
IPR013497
all species →
DomainDNA topoisomerase, type IA, centralInterproscan
IPR013824
all species →
Homologous_superfamilyDNA topoisomerase, type IA, central region, subdomain 1Interproscan
IPR013498
all species →
DomainDNA topoisomerase, type IA, zn fingerInterproscan
IPR000380
all species →
FamilyDNA topoisomerase, type IAInterproscan
IPR023405
all species →
Homologous_superfamilyDNA topoisomerase, type IA, core domainInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11390
all species →
PROKARYOTIC DNA TOPOISOMERASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0003677
all species →
Molecular FunctionDNA bindingInterproscan
GO:0003916
all species →
Molecular FunctionDNA topoisomerase activityInterproscan
GO:0006265
all species →
Biological ProcessDNA topological changeInterproscan
GO:0008270
all species →
Molecular Functionzinc ion bindingInterproscan
GO:0005694
all species →
Cellular ComponentchromosomeInterproscan
GO:0003917
all species →
Molecular FunctionDNA topoisomerase type I (single strand cut, ATP-independent) activityInterproscan
GO:0005634
all species →
Cellular ComponentnucleusInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K03165TOP3; DNA topoisomerase IIIEC:5.6.2.1
DNA repair and recombination proteinsko03400deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_068762622.1 across 36 RNA-seq samples of Montipora capricornis. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

36Samples
0TPM > 0
1Conditions
0.0Max TPM
0.0Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Polyps 36 0 0.00 0.00

Per sample · hover a bar for the full sample record

Show the sample table (36 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR12710846 Polyps Polyps OA3 day3 not recorded SRP199550 0.00
SRR12710847 Polyps Polyps OA3 day3 not recorded SRP199550 0.00
SRR12710848 Polyps Polyps OA3 day3 not recorded SRP199550 0.00
SRR12710855 Polyps Polyps OA3 day9 not recorded SRP199550 0.00
SRR12710857 Polyps Polyps OA3 day9 not recorded SRP199550 0.00
SRR12710858 Polyps Polyps OA3 day9 not recorded SRP199550 0.00
SRR12786896 Polyps Polyps OA3 day0 not recorded SRP199550 0.00
SRR12786897 Polyps Polyps OA3 day0 not recorded SRP199550 0.00
SRR12786898 Polyps Polyps OA3 day0 not recorded SRP199550 0.00
SRR12807381 Polyps Polyps OA3 day0 not recorded SRP199550 0.00
SRR12849113 Polyps Polyps OA3 day0 not recorded SRP199550 0.00
SRR12904781 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR12904782 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR12904783 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR12927880 Polyps Polyps E3 day0 not recorded SRP199550 0.00
SRR12959182 Polyps Polyps E3 day0 not recorded SRP199550 0.00
SRR12959183 Polyps Polyps E3 day0 not recorded SRP199550 0.00
SRR12959184 Polyps Polyps E3 day0 not recorded SRP199550 0.00
SRR12959188 Polyps Polyps E3 day21 not recorded SRP199550 0.00
SRR12959189 Polyps Polyps E3 day21 not recorded SRP199550 0.00
SRR12959190 Polyps Polyps E3 day21 not recorded SRP199550 0.00
SRR12959201 Polyps Polyps E3 day15 not recorded SRP199550 0.00
SRR12959202 Polyps Polyps E3 day15 not recorded SRP199550 0.00
SRR12959203 Polyps Polyps E3 day15 not recorded SRP199550 0.00
SRR12959214 Polyps Polyps E3 day9 not recorded SRP199550 0.00
SRR12959215 Polyps Polyps E3 day9 not recorded SRP199550 0.00
SRR12959216 Polyps Polyps E3 day9 not recorded SRP199550 0.00
SRR12959227 Polyps Polyps E3 day3 not recorded SRP199550 0.00
SRR12959229 Polyps Polyps E3 day3 not recorded SRP199550 0.00
SRR12959230 Polyps Polyps E3 day3 not recorded SRP199550 0.00
SRR12963484 Polyps Polyps E3 day0 not recorded SRP199550 0.00
SRR27940191 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR27940192 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR27940193 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9129316 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9613519 Polyps Polyps not recorded not recorded SRP199550 0.00

Source: CnidoSite RNA-seq expression matrices (MCAPR_TPM, StringTie quantification over 36 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Montipora capricornis tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated0not in this network-
Negatively correlated0not in this network-

This gene has no edge at all in the Montipora capricornis network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Montipora capricornis, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.no expression matrix
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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