Gene detail

Detailed information of XP_074618310.1 in Acropora palmata

Genomic Location: NC_133884.1:23816230...23835172
NR annotation: UBR69922.1, NF-kB [Acropora cervicornis]
Species Acropora palmata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_074618310.1

ATGGCAACTAACTCAGAACAGCAGGTTAATGCTACACTTACCGATAGTCTTTTGATGGATGTCTTGAATCCAGGATATCTCCCTGATATCTCGGCATTGCAGGTGCCCACTGGCAGTTATCAAGGCCCTTATTTAGAAATTTTGGAGCAACCCAAACAGAGAGGGTTTCGCTTCCGTTACCCATGTGAGGGTCCTTCCCATGGAGGTTTACCTGGAGAGTACTCTGAAAAAGGCAAAAAGTCATACCCATCTGTGCAGCTATGCAACTATAAAGGGCCTGCACGCATCGTCGTATCACTGGTTACTTGTGATGAAAATCCAATGCCTCACGCTCATAGTTTGATTGGCAAGAATGCATCCAGTGGGGTTGTTACAGTACAGATTGGACCTGAACAGGGGATGACAGCAAGTTTCCCAAATCTTGGTATTCAACATGTTACAAAGAAAAATGTGGGCTACGTGTTGATGGACAGATACCTCAAAATGCAGATGTTACACACAGCCACTTTGAATGCGCTGACAACTGATCCTAGAGTCTTTGATATCGGGGCAATGGTAGATGAAGCAACAGCTGATGGCGACCGAGGAGAATTTGACAAACAGATTGCAGATACCATTGCTGAGGAGGAAGCATCAAAGGTTCGAAGTTTGGTAGAGAAACAGAAAAATTCCATGAATCTAAGTGTTGTGCGGCTGTGCTTTCAAGCCTACCTTCCAGATGATAATGGCTGTTTTACAAAAGCCCTGCCTCCTTGCTTCTCTCGAAGCGTGTATGACTCAAAGGCACCATCAGCTGCAAATTTGAAGATTTGTCGTATGGATCGCAATTCTGGTTGTGTGACAGGAAATGATGAAGTTTACCTTCTTTGTGACAAGGTTCAGAAAGATGATATAGCTGTTGTGTTCTATGAGATAGATGAAAATGGCAAGAGAAGTTGGGAAGGCCTAGGGCTTTTTGCGCCCACAGATGTTCACCGTCAGGTTGCCATTGTGTTCAAAACACCTGCTTACTGGAATATTGCTGTTGAGAGACCAGTCAAAGTGCATCTCGAATTGAGGCGAAAGTCTGATGATGAAACAAGTGACCCTGTGGAATTCACATACCAACCACAAATGTTTGATAAAGAGCAAATTGGTTCTAAACGAAGAAAAAAGATCCCTCATTTCTCGGATTATTTTAAAGATGGCAGCGGTGGTGGGGACCCCCCTACAGCAGGTGGAGGAGGGGGAGGAGGGTTTAGTTTCCCTACTTTCATGTTTCCAGGATTATTGTCCTTTCAGCAAAACCCAGGCACATCTCAGTCCTCTTATCAAGGAGGTGCTGGTACATCTCAAGAGGGCGAAGCCAATGAATCTGGACAAAGGCAGGACAAAGAGCTGTCGCTCACGGAATTGGCATGGAATGTTGCAGCGATTTGTGCTGCTGCGGTACGGGATTATGCTGCCTCCGGTGACATGAGATACCTCCTTGCTGTTCAACGGCATCTGACAGCAGTTCAAGATGATAATGGAGATACGGCGCTTCATCTTGCTGTCATTAATTCGCAACAAGAGGTCATCCATTGCCTCGTCGATGTCATGGCTGGTCTTCCAGAGTCTTTTGTCAATGAATATAACTTCTTGAGACAAACCCCCTTACACCTTGCTGTCATTACAAAACAACCACGTGCTCTGGACTGTCTCATAAAGGCCGGTGCGAATCCCAGGTTACGTGATCGCCACGGCAACACCGCTGTTCACATTGCTTGCAGCTATGGTGATGCTACCTCTCTTAAAGCTCTGTTGCATTACGATGTTTCAAAAATGGTGCTGAACTGGCAGAACTACCAAGGCCTCACGCCGGTTCATCTAGCGGTTTTGTGTGGCAGTAAAGATGTTCTGAAACTTTTGCGCTCGGCTGGGGCTAACATGAGTTCTCAGGATGGAACAAGTGGAAAGACTCCTCTCCACCTGTCAGTTGAACAAGATAATTTATCGCTTTCTGGTTTTCTTATCTTGGAGGCAAACTGTGATGTGGATGCGAGTACATTCGATGGCAATACCCCTCTTCACCTTGCTGCTGGACTCGGTCTCAAAGGACACACGGCGCTTCTGGTGGCTGCAGGAGCAGATACAACCTTCCCTAACAGTGAAGACGAAACTGCTTTTGACTTGGCTAATGTGGCTGAGGTCCAGGAAATTTTGGATGAAGATGAAGCACCGAGTGCTGACCCCGTTGAAGAGTTAGAAACTGGTGTGATTAGTATCAGGCTTGGTAAAGGTGATCTGGACCAACTTGATCCATACGTTCGAAGAAAAATGGCGCAGAGGCTTGATCCCAGTACCGGAGCAGACTGGCGTGATTTAGCCAGGAGACTGGGGCTAGGGACACTTGCCAACGCCTTCGCTATCCAGTCCAGTCCAACTGTCCAGGTGTTGGCTCATTTTGAGGCAGCGGATGGTACCATGGAGAAATTGCGTGAAGTCTTGTATGACATGCGCAGAGGCGATGTGTTAGAAATACTTGACCAGGAAAGCAGACACGACTCCGGCTTCGACTCGGGATTTGGGTCTCAATCTCTCTCGATAAACCGGTCAGAAGGTGGCACATCGTCCGGGGCTCACAGCTCTGATGTCGCATCCAGGTCTTCGTTAAGCAAAGATTTCCATAAATTGGAGTCTTCGCAAGAGTCTGCAAAAACTCGCCCACTACTACAACAACAGCATGTGTTTTAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q04861	Nuclear factor NF-kappa-B p105 subunit OS=Gallus gallus OX=9031 GN=NFKB1 PE=2 SV=2
P19838	Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2
Q6F3J0	Nuclear factor NF-kappa-B p105 subunit OS=Canis lupus familiaris OX=9615 GN=NFKB1 PE=2 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000719 (this species only) · gene tree & orthology
Transcription factor family	RHD · all TF in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00023 all species →	Ank	Ankyrin repeat	Repeat	Interproscan
PF12796 all species →	Ank_2	Ankyrin repeats (3 copies)	Repeat	Interproscan
PF16179 all species →	RHD_dimer	Rel homology dimerisation domain	Domain	Interproscan
PF00531 all species →	Death	Death domain	Domain	Interproscan
PF00554 all species →	RHD_DNA_bind	Rel homology DNA-binding domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR037059 all species →	Homologous_superfamily	Rel homology domain (RHD), DNA-binding domain superfamily	Interproscan
IPR014756 all species →	Homologous_superfamily	Immunoglobulin E-set	Interproscan
IPR013783 all species →	Homologous_superfamily	Immunoglobulin-like fold	Interproscan
IPR030492 all species →	Conserved_site	Rel homology domain, conserved site	Interproscan
IPR011029 all species →	Homologous_superfamily	Death-like domain superfamily	Interproscan
IPR002110 all species →	Repeat	Ankyrin repeat	Interproscan
IPR011539 all species →	Domain	Rel homology domain, DNA-binding domain	Interproscan
IPR033926 all species →	Domain	NFkappaB IPT domain	Interproscan
IPR032397 all species →	Domain	Rel homology dimerisation domain	Interproscan
IPR008967 all species →	Homologous_superfamily	p53-like transcription factor, DNA-binding domain superfamily	Interproscan
IPR000451 all species →	Family	NF-kappa-B/Dorsal	Interproscan
IPR000488 all species →	Domain	Death domain	Interproscan
IPR036770 all species →	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	Interproscan
IPR002909 all species →	Domain	IPT domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR24169 all species →	NUCLEAR FACTOR NF-KAPPA-B PROTEIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0003677 all species →	Molecular Function	DNA binding	Interproscan
GO:0003700 all species →	Molecular Function	DNA-binding transcription factor activity	Interproscan
GO:0006355 all species →	Biological Process	regulation of DNA-templated transcription	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0000978 all species →	Molecular Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Interproscan
GO:0000981 all species →	Molecular Function	DNA-binding transcription factor activity, RNA polymerase II-specific	Interproscan
GO:0007165 all species →	Biological Process	signal transduction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K02580	NFKB1; nuclear factor NF-kappa-B p105 subunit	-	Transcription factors	ko03000	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_074618310.1 across 84 RNA-seq samples of Acropora palmata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

84Samples

81TPM > 0

2Conditions

123.7Max TPM

59.4Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
all_coral_tissue · exposed	46	44	56.25	123.71
all_coral_tissue · baseline	38	37	63.18	93.46

Per sample · hover a bar for the full sample record

Show the sample table (84 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR8800039	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	123.71
SRR8800075	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	122.76
SRR8800105	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	88.86
SRR8800068	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	87.20
SRR8800077	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	84.89
SRR8800044	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	83.63
SRR8800097	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	82.77
SRR8800099	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	78.70
SRR8800093	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	73.30
SRR8800051	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	72.86
SRR8800080	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	70.07
SRR8800036	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	69.16
SRR8800079	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	69.15
SRR8800056	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	68.11
SRR8800100	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	66.87
SRR8800092	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	66.20
SRR8800038	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	64.22
SRR8800053	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	62.76
SRR8800060	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	58.36
SRR8800045	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	58.07
SRR8800063	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	57.42
SRR8800083	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	57.29
SRR8800028	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	56.42
SRR8800107	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	55.97
SRR8800034	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	55.25
SRR8800071	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	54.93
SRR8800073	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	52.69
SRR8800086	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	52.10
SRR8800047	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	51.14
SRR8800061	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	44.40
SRR8800058	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	44.33
SRR8800065	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	42.70
SRR8800040	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	42.47
SRR8800091	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	42.20
SRR8800095	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	38.85
SRR8800033	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	38.80
SRR8800088	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	38.76
SRR8800062	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	36.87
SRR8800094	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	35.39
SRR8800026	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	35.33
SRR8800027	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	30.22
SRR8800029	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	26.11
SRR8800087	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	24.33
SRR8800089	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	21.69
SRR8800042	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800066	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800074	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	93.46
SRR8800043	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	88.56
SRR8800106	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	87.59
SRR8800069	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	84.91
SRR8800101	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	84.26
SRR8800057	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	83.83
SRR8800041	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	80.63
SRR8800082	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	79.27
SRR8800096	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	78.31
SRR8800098	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	77.25
SRR8800035	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	75.96
SRR8800081	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	75.86
SRR8800049	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	73.64
SRR8800048	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	73.52
SRR8800067	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	73.38
SRR8800078	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	73.20
SRR8800055	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	71.62
SRR8800037	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	69.27
SRR8800076	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	68.48
SRR8800108	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	67.37
SRR8800059	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	66.41
SRR8800072	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	66.40
SRR8800050	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	65.49
SRR8800109	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	64.75
SRR8800102	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	57.01
SRR8800032	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	52.77
SRR8800031	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	52.44
SRR8800103	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	51.08
SRR8800084	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	50.30
SRR8800104	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	50.23
SRR8800070	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	45.92
SRR8800064	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	43.38
SRR8800054	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	40.43
SRR8800030	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	35.81
SRR8800085	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	34.46
SRR8800090	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	33.57
SRR8800046	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	29.99
SRR8800052	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00

Source: CnidoSite RNA-seq expression matrices (APALM_TPM, StringTie quantification over 84 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora palmata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	23	XP_074630833.1	0.860930127102545
Negatively correlated	4	XP_074637659.1	-0.666466554763855

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora palmata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

DNA methylation (bisulphite samples)

Sample	Methylation profile
Polyp_Underside_Control_2	open
Polyp_Underside_Control_3	open
Polyp_Underside_Treatment_1	open
Polyp_Upperside_Control_1	open
Polyp_Upperside_Treatment_3	open
Polyp_Upperside_Treatment_4	open

The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →