Gene detail

Detailed information of XP_074628577.1 in Acropora palmata

Genomic Location: NC_133888.1:5625870...5649065
NR annotation: XP_044183833.1, eIF-2-alpha kinase GCN2-like [Acropora millepora]
Species Acropora palmata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_074628577.1

ATGGAGGAAACGTGTAAAGAAAGACAAGAAAATGAGCTCCAAGCTATTCAAGCAATTTACATGGATGATTTTCAAGACCTGCGTGAGAAGCGTGAAGACCCACCAAAAGTTTGTTTGAATTTGACCCCACTCCAAAGTGTTGTAGGTAAAGAAGTTTATGCCAGAGTGGACTTGATTGTGCAGTACACCAAACACTATCCCAATAAGAGCCCAAAGCTGTCTTTGAGCAATGCAAAAGGGATCTCAAATGAGGATGTGAGTGAACTGCAGAAAGAGCTGCAACAAATGGCTGCTGAACTGGTTGGTGAGGTAATGGTTCTGAACCTTGCACACCATGTGCAAACGTTTCTTCACACACGCAACAAACCACAGCTGTCATTCTATGAAAAGATGATGGTGAACAAGAAAGAGGAAGAAGAGAGGCTCCAGGCAGCAGAACAAGAAAAGCGGCTAATGGAGTTTGAGGCCAAAAAGGAAAGAGAGGAAAATGAGAAAAGGGAAATAGAAGAGGTACTTCAAAGAAGAGAAGAAGCAGTGAAAGAAAGCAGGAGACGTAGAGTAATTACAGAACAGAATTCCAAAACTAACCCATCACAACTGAGTGCAAACACCAATAATACAGATCTCAGCCAGGCAAAGGAATCATCACCTCTTCAGAGGAAAGCCTCTGGAAATTCCCTCGCACTTTGTCAACATCCGACAGCTTCGCCCAAGAAAACAGATGCGATAAAAGTAGCTCCCGCAAGGAGTATCTTGAGACGGCGGAGAAGTTCAGAATGTATAGGAGACGAAGTATCGTTCTCGGGGACTCAAGTGATCACTTTCAAATCCAAGAGTAAACGAGTAGTACACGCTGGAAAATGTCTTGGTCAAGGTTCATCCGGGTCACGTGTCTTCAGCGCCATGGATATTTCTCTTGGAGAGCTGGTTGTGGTTTGTGAATGGAGTTTGTCTTCACAGCAGGGTGGAGCCAAGCGCTCTCTTCTCAGCAATGACAATCAACAACTGGACTCGCATGGAGGGCTCATGAAACAGGTTTGCAGTATCGAACAAGAGATTGTGTCTGGTCTTGTCAACAGAGTTAGTCATCCGAATTTAACCCACTACTTAGCTGTGAACGTTCAGGAAACTGTCCCATTTGTTAAAGTTCAGGTTCTCGTTGAGTATGTTGGCGGTGGGGATCTAAGTCTTCGTCTCAGAAGTGGTGGTCTCCCGGTACGAGAGCTACGGGAATACACGCAACAACTCGTGGAAGCGATAACTTATCTGCATGGCAAACATGTTGTGCACAAAGACCTGAGGCTGACAAGTTGTCGCTTCGACTCTGGTGGGAATCTAAGGCTGGCAGACTACAGTGTAGGCAAAAGATATATCCTCCTAAAGTTACGTCAAGAGAAAAATTTGGAGGTGCGGAACAGGCTGGATAACTGCTTGTACGCTGTCAAGCGCATTCCTCTGAAACCTAAAAGCGTTCAGTTTACCAAGAAAATTACTCGTGAAGTCCAGCTTATCTCCCGTTTAAATCACGAAAATGTTGTCAGATATTACAACGCGTGGATTGAAAGTTCTGAAGAACAATCCAGCAGTAGTAATTCCACAGATACAGACAGCGCTTCCAAAAATAAACCCGTGGAGGACAGTCTCTTAGAGCTCAACAAAATCGAGGCGCCAAGTTTAAGACCAGACAGACAGAGCGGTCTCGAGTCCTGGTGGAGGGACGGTGAGGAATCGAGCAAAGATGGATCGGATTCATCGTCCAGTGGATCGCAGGATTCTGTTCGCAGTCCACAGAAAAGTCACAGCACATCGTTTTTCAGCAGCAAGTCGAAGTCTTCTGAGAGAATTGTGTTTGATACCGCAAAAATTGACGAATCCGTTCTTCAATTTGGTGATCTTATGGATACAGAGTCAGAAGACTCAGAGGAAGGAGAAGACTGGCAAGAAACTGAAAGCGACTCGAGCTTGGAGGTCAAAGGGCTACAGTATCTGTACATTCAGATGGAATACTGCGAAAAAAGCACGTTGAGGAACCTTATTGACGAGGGCTTGCACCAGGACGAGGAGTGCGTGTGGAGGCTCTTCAGAGAGATAGTTGAAGGACTGGCCCACATTCATACCCAGGGTATCATCATTCATCGAGATCTGAAGCCCGTTAATTTGTTCCTTGACTCCCACGGTCGAGTTAAAATAGGCGACTTTGGCTTAGCAACCACCCACAGTATTATGCGTGTTGGCATGGGAACCGATACACCGGAAAACAATGACAATTCCCAGTCCTCAAAAAGCAGTGCCTCCGCCAAAGAAAGCGTGACGGGTAAAGTTGGTACGTTTCTGTACGTAGCGCCTGAGCTGGGCAAACGAGGCAACTTAAGGGCCAAGTACAGTCCGAAAGTAGATCTTTACAGTTTGGGCATTATTTTCTTCGAGATGTGCTTTCGACCGCTCACGACATCCATGGAAAGGGTTGAAGTCCTTGGCAATTTAAGAACGGAGCGCACAATCTTTCCAGGCGAATTCGATCAAAAACAACTCGCCAAGCAAACCACTGTTCTCAAATGGCTACTAAAACACAACCCCGAGGAACGTCCTTCATCTCAGGAACTCCTGCAAAGTCAATACATTCCACCCAAGATTGAAGACGGCCAGCTCGATGAAGTACTTGAGCACACGCTCGCGTCCACGAACTCCACGCGCTACCAGCGTCTAATGAAAGCTGTGTTCTCGCAACATGTGTACCCCGTTCGTGAGGTAACCTACGATGTTGAGTTTTACACGAGGCAAGTTTTTCCAAGAACGATTCTTGCGCAACAGATGGTTCACGAAAGCGTGAAGTCGGTGTTCGTGCGGCATGGCGCGTTGCGCGTGAGAACACCTTTACTGGCGCCGCGCACGAAGCTTTTTGAAGAATTGGAACTCGCAGTGAGTCTGATGGATCACAGTGGGGCACTTGTCATGCTACCGTACGATTTGAGAATTCCCTTTGCGCGTTACGTTGCACGGAAGGGAGTTCTTCAAATGAAGAGGTTTGATGTTGGCTGTGTATATCGTGTTAACAGATTCCTGGGAGCTCATCCCAGAGAAATTTACGAGTGCGTTTTCGACATCATCACGAGCACAACCGAAGATCTTGTTCCCGACGCCGAAGTCTTACTCGTTGTCGCCGAAATTATCAGGGAATTTCCATGTCTGGACAATCGGGATTATTACATTAGAATCAACCACACTGGTCTCATGAAATCGTTTTTGTCGTCGCATTGCGTCTCAGATGAAAGACAATCCGAGCTGATCTCCATTCTGCAAGAACCTCTGGGCGAAAAAGAGAGAAACGACCAGATCAGTTCGTTTGTTGAGAACTTGCAAATAAGTGAGCATAATGCGACGGCTCTGTGTGAGTTTTTAAATTTCAATGGGCCCGTCAATAAACTCCGCGAACATTTGATTGCGACGAGGAAGCGAAAATCGTGGATTGGGCAAACTGCCAGACAAGCTTTTTCAGATCTCGAGAAGATCACTTCACATGCTAAAAAATTTGTAATATCTTTGCCAGTTGTCGTAAACACGTCCATGGTTTACAACTTTCAACATTTCTCGGGACTGATTTTCCAGTTTGTAGCCGCTGATAGTCGGAAGCGGAAACGAGGAGGGGTCGATATTCTTGCCGCAGGGGGGAGATATGATAAGCTGATAGGTCAGTTTCGGCGTGTTGCTGACACCTCTTGTGGCGTGGGGGTCAGCATCGCCATCGAGAAAATAGTCTCGGCCCTTGTGGAAGATCAAGAGGCTTTTGTGCCCTGCCAGTACGATGTCTTTGTCTGTTCAACTGGTTCCAAGCCCTTGCAAGAAGAGAGCATGCACATTGCACGTGATTTATGGAATGCAGGTATCAAGGCTACAATTTCGTACGGTGCAATACTTCTGGAAGAGGCGCAGGAAGTTTGCAAAAGGGAAGGAATTCAACACATGGTGGTGCTAAAAGACCTAGATCCTGGTTTTGTTAGGGTTCGATCGCTGGACAGGGAGAGGGTTTCCGAATCGCGTGTCCAAATCTCTGAGCTTGTGGACCACCTTCACGGCAAGTGCTCGGGAAAGCCTGAAGTCGCCGAATGCAATGCGCCCCCTAGCAACAAGTGCCAAGGAACACAGGGCAGCAATGAGCCAAGTTCTATTATTGCGCCAGAGATAAAAGTTTCTTTTAATACTCAGGAAAAGATGGCTTGGAATACGAAAAGAAGATATGAAAGCGTGATGGTGGCAAAGATTAAACCTCTCTTTGCTCAATTCAGTTCCAAAAACGCAGTAGAAGTGATAGGGGTTGACTTACCTGGCTCCGTGTTGCGCAATATGTCAGCCATCCTTGATCTCGACGCTAACAAAGACGCTTTCGACGCCAGCGTAGCAACAATCGAAGATAAGATTCCGCGACACAGGAGATACATCGAACGTGTTTGCGAAGAAATCAGGGAACTTAAGGTTATAAAGAAAGTACCCATGGTTTTTGTGTACAGCGTGAAAGATGACATCTTCAAAACTTTTTTCTAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9P2K8	eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3
Q9QZ05	eIF-2-alpha kinase GCN2 OS=Mus musculus OX=10090 GN=Eif2ak4 PE=1 SV=2
D4A7V9	eIF-2-alpha kinase GCN2 OS=Rattus norvegicus OX=10116 GN=Eif2ak4 PE=3 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002825 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF05773 all species →	RWD	RWD domain	Domain	Interproscan
PF13393 all species →	tRNA-synt_His	Histidyl-tRNA synthetase	Domain	Interproscan
PF00069 all species →	Pkinase	Protein kinase domain	Domain	Interproscan
PF12745 all species →	HGTP_anticodon2	Anticodon binding domain of tRNAs	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR036621 all species →	Homologous_superfamily	Anticodon-binding domain superfamily	Interproscan
IPR045864 all species →	Homologous_superfamily	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Interproscan
IPR050339 all species →	Family	Cell Cycle and Stress Response Kinase	Interproscan
IPR016135 all species →	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	Interproscan
IPR006575 all species →	Domain	RWD domain	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR041715 all species →	Domain	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR008271 all species →	Active_site	Serine/threonine-protein kinase, active site	Interproscan
IPR024435 all species →	Domain	Histidyl tRNA synthetase-related domain	Interproscan
IPR016255 all species →	Family	eIF-2-alpha kinase Gcn2	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11042 all species →	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0004694 all species →	Molecular Function	eukaryotic translation initiation factor 2alpha kinase activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0000077 all species →	Biological Process	DNA damage checkpoint signaling	Interproscan
GO:0010998 all species →	Biological Process	regulation of translational initiation by eIF2 alpha phosphorylation	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K16196	EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4	EC:2.7.11.1	Protein kinases	ko01001	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_074628577.1 across 84 RNA-seq samples of Acropora palmata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

84Samples

69TPM > 0

2Conditions

39.1Max TPM

7.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
all_coral_tissue · exposed	46	39	7.93	39.10
all_coral_tissue · baseline	38	30	7.60	26.23

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR8800066	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	39.10
SRR8800097	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	31.37
SRR8800105	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	30.68
SRR8800068	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	29.22
SRR8800077	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	28.94
SRR8800099	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	26.80
SRR8800100	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	25.58
SRR8800051	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	23.07
SRR8800056	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	22.68
SRR8800071	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	20.13
SRR8800038	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	16.98
SRR8800053	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	14.70
SRR8800094	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	7.55
SRR8800029	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	7.00
SRR8800036	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	3.61
SRR8800080	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	3.56
SRR8800093	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	3.37
SRR8800045	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	3.02
SRR8800083	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	2.69
SRR8800073	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	2.25
SRR8800079	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	2.07
SRR8800034	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.83
SRR8800047	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.47
SRR8800044	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.45
SRR8800063	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.42
SRR8800088	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.41
SRR8800091	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.26
SRR8800065	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.25
SRR8800060	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.25
SRR8800095	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.22
SRR8800058	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.20
SRR8800033	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.15
SRR8800040	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	1.06
SRR8800062	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.92
SRR8800107	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.85
SRR8800089	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.79
SRR8800087	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.71
SRR8800027	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.70
SRR8800026	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.65
SRR8800028	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800039	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800042	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800061	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800075	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800086	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800092	all_coral_tissue · exposed	all_coral_tissue	not recorded	exposed	SRP189781	0.00
SRR8800078	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	26.23
SRR8800106	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	24.50
SRR8800067	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	23.38
SRR8800096	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	23.35
SRR8800069	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	23.30
SRR8800072	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	23.05
SRR8800057	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	22.94
SRR8800052	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	21.95
SRR8800098	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	21.73
SRR8800101	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	19.13
SRR8800050	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	13.73
SRR8800103	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	9.44
SRR8800043	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	3.54
SRR8800041	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	3.30
SRR8800048	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.68
SRR8800076	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.66
SRR8800049	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.54
SRR8800109	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.54
SRR8800037	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.49
SRR8800074	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.28
SRR8800081	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.04
SRR8800032	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	2.02
SRR8800102	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.69
SRR8800104	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.69
SRR8800064	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.22
SRR8800055	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.20
SRR8800084	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.19
SRR8800070	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.17
SRR8800059	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	1.12
SRR8800085	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.88
SRR8800030	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800031	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800035	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800046	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800054	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800082	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800090	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00
SRR8800108	all_coral_tissue · baseline	all_coral_tissue	not recorded	baseline	SRP189781	0.00

Source: CnidoSite RNA-seq expression matrices (APALM_TPM, StringTie quantification over 84 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.