Genomic Location: sc0000039_pilon:1823916...1848077
NR annotation: XP_029190533.2, E3 ubiquitin-protein ligase HECW2-like isoform X1 [Acropora millepora]
Species Acropora awi · all data for this species · gene families
| CDS |
| aawi_s0039.g186.t1 |
| Transcript |
| aawi_s0039.g186.t1 |
| Protein |
| aawi_s0039.g186.t1 |
| UniProt accession | Description |
|---|---|
| Q9P2P5 | E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens OX=9606 GN=HECW2 PE=1 SV=2 |
| Q6I6G8 | E3 ubiquitin-protein ligase HECW2 OS=Mus musculus OX=10090 GN=Hecw2 PE=1 SV=1 |
| Q76N89 | E3 ubiquitin-protein ligase HECW1 OS=Homo sapiens OX=9606 GN=HECW1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000813 (this species only) · gene tree & orthology |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF18436 all species → | HECW1_helix | Helical box domain of E3 ubiquitin-protein ligase HECW1 | Domain | Interproscan |
| PF16562 all species → | HECW_N | N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 | Domain | Interproscan |
| PF00397 all species → | WW | WW domain | Domain | Interproscan |
| PF00168 all species → | C2 | C2 domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000008 all species → | Domain | C2 domain | Interproscan |
| IPR035892 all species → | Homologous_superfamily | C2 domain superfamily | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR036020 all species → | Homologous_superfamily | WW domain superfamily | Interproscan |
| IPR001202 all species → | Domain | WW domain | Interproscan |
| IPR040524 all species → | Domain | E3 ubiquitin-protein ligase HECW1, helical box domain | Interproscan |
| IPR032348 all species → | Domain | E3 ubiquitin-protein ligase HECW1/2, N-terminal | Interproscan |
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR050409 all species → | Family | E3 ubiquitin-protein ligase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11254 all species → | HECT DOMAIN UBIQUITIN-PROTEIN LIGASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0016567 all species → | Biological Process | protein ubiquitination | Interproscan |
| GO:0048814 all species → | Biological Process | regulation of dendrite morphogenesis | Interproscan |
| GO:0061630 all species → | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:2000650 all species → | Biological Process | negative regulation of sodium ion transmembrane transporter activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K12168 | HECW2; E3 ubiquitin-protein ligase HECW2 | EC:2.3.2.26 | Ubiquitin system | ko04121 | deepkoala |
Genes whose expression across the transcriptome samples of Acropora awi tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Acropora awi, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
