Gene detail

Detailed information of acyt_s0380.g4.t1 in Acropora cytherea

Genomic Location: sc0000380_pilon:29207...66675
NR annotation: XP_044162737.1, apoptosis-resistant E3 ubiquitin protein ligase 1-like isoform X1 [Acropora millepora]
Species Acropora cytherea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

acyt_s0380.g4.t1

ATGCTTGGAAAGATCGCTGTTTATACCATTGGTTTAGCATTCATATTTTATCGCGTACAAGTGTACCTTACTTCGAGGCAAGAAAAACTTGATTTGCATGTATTCTTGGAGGAAAATGAGCTTTCGGAATATGAAGCCAAGTTGCACAAATTCGGTATTCACTCAAAAGCTATCTTTGCAAGACTTGATGTTCACAAGTTTCTTGCACAATACAGTTCCTTTTGGGGATTTTTCCGATTTAATTCAGAGAAAGAGAAACTGGAATTGGCTTCACAGAAAGCTGAACAAGAAGTGCTGCTCTTGTCACACTTGCAGAATTTAAGAATAGATGCTAAATACTTCAGAAAGCTGTTATCCCATGGGATAAATAGCATAGAACAGTTCCAAGAGAATTTGGATTCAGTTGTGCTGAGGAAGATCTTTGAATATGACGATCTCCTCAAGTTACAAGATGCAGCTCCAAGAAAAGATGAACAATTTACTGATTCGTTTCCTGTGAGAAGTGCATTAACTATCTTTTCTTTTTCCTGGTGGACTTTCAAATCTGTTTGTAAAATGATTTTTTTCATCCTAAGCTTTGTTCTGAGCATAGTGTTTGCTTGGGGTGGAATTTCTCACTTGCAAAAAAAAAGCAGGCAAAGTCAAACCTCAATCTTGAAGTACATGTTTGGTTCAACATTGGAACCCAAGTTCACATTAGTGACATGGGAGAAGACAGATCCATATGTGGTTGGGGAGTCAATCATATTTTTCATTCATTTTTACCGAATGAATCTTTTTCCATATCCAGTATCACCGGATGATCCCATCTTGATTGAAATCATGCACAAAGACACACTTGTTGCATGTTCACGTGAATATGGGGGTGAAAATTGGGGAAGAAACAACACCATGAAAGTGTCTTTTACTGTGAGGGAGGCAGGTACCTACAGAATTTCAATTCTTGCCAGAGGGATGCCAATAAGAGGGAGCCCATTCAAAAAAGACTTTTTACCTGGAACAATTGACCCATCCAAGTGTGTCATTTTAGAAGGTGGATCTCTGCTCGAAGTTCAGAAGAATATTTACACACCTCTTACTGTTGAGGCACGAGACAAATTTGGCAACATCTGCCCACTGTCAGTTCAAGATGTAAAATCATATACAGTTGAAGTCACTGAGATTGGGAGCATCGTTAAGGTAGATCCCGAATTGGTGATCTTTCATGATGATGATGGAAAGAACAATGTCCTTTGCATCAAGTTGGATTGGGAAGGTTGTTTCAGTGCTGTGGTCAAATATAATGGTGTTCCAGTCAGCCAGGGACAATTCACTGTTATCTCTCTAAACTCAGAAGAAGCTAAACAGGTTGATGAGAACATAAAAAAGCAATGTTGGAATGTCTGGTACGAAGCATACCTTCTCAGACATGCAGAATCAAGCCAGACAAATGGATCTTCGCTTTCTTCTGGTACTCCTCCCTGGATGATAATTCAACCGCTAGTTAATTTTGACAACACAGTTAATGGAGGTGCCTGTAAAAAGCCAAGTAGAGTCTATTGCTACATTTCCAAGAAGCATTTATCCATAAAAGAATTCTACATCAAGATTATTCCTCGCAGATTGTATGGATTTCGTGTTCGGCCATCAACTAAGATAATTCTGCACCCCCTTGATCTCAACATGGAACACCCAACTTTCACTGTTGATGATGGTTACCAGTCTCCTGTGACTATCATGTGCAAGGAAAGAAATGTCTTGGTTGCAACATTCTCAAGACTTCTCCTCAGGAAAATTGGTGGATCAGAAAGTTTCAACGATAAAAAAGATTTCTTTTATCGTGAACTAGTGGCCCATCTTGGTCGTAAAGGAGGCGAAGTGATGTTGAAGATTGATCGACAAAAGATTTTAGAGACTTCTTATCAGGCTACTGTCAGGACGCTATATTTCAGTGATTGGCTGCGTCTCTTTACAATAAAATTCAAAGATGAATTAGGCGTTGACTGGGGTGGCCTGCGTCGCGAATGGTTTGAATTGTTATGCAAGGCTTTATTTTCTCATGAAAGTGGTTTCTTCACTCGATTTAATGAAGATGATCCACAAGCCCTGGTTCACCCTAATTCTAGAAGACCTCTCAGTAAGAAGCTGAAGTTTTACGAGTTCGCTGGTCGAGTTGTTGGAAAATGTTTGTACGAATCGGCTTTGGGTTCATCTCGGAGACTGAATGTTAAAGCCCGTTTTAGCAGATCATTTCTGGCTCAACTGCTTGGACTTCGCGTCTGCTACAAGTATTTCGAAAGCGACGATAAGGATCTCTATCGCAGCAAGATAAAGTACATCGAGGAGACAGACCCAGAAGACCTGGCACTAGTCTTTGCTGAAGAGGAGTGTGATGAGCATGGGCGCCTACAGAAGACAGTAGACTTGAAGCCTGGTGGCAGACACATTCCGGTGACAGAATCAAACAAGATGGAATATTTGGATCTCCTGGCACAGTATCGTTTATCCTCCTCTTGCAAGCAAGAAATTGAAGCTTTTGCAAAAGGTTTGAATGAATTTGTTCCAGAAAACCTTCTAAGCGTCTTTGATGAATACGAATTGGAGCTATTAATGTGTGGAACAGGAGATATAAGCGTGTCCGATTTGAGACAGCATCACAACGTTATTGACAGCGGATCATCATTTAGAAAGAGTCTGGACTGGTTTTGGACTATCGTGACAAGTTTCACGCAGGATGAACTTGCTCGTCTAGTGCAGTTTATTACAGGCTCCTCACAGCTCCCCCCTGGGGGATTCGCTGAACTCTCACCCCAGATCCAGATTTCCTCAGCTCCCACTACAGATGCACTTCCATCAGCTCACACGTGTTTCAACCAACTTTGTTTACCGTCGTACTCATCGTTTACCGAGATGCAGAAGAAACTGGTACTCGCTATAAACGAGCGAAGTGAAGGATTCTCCATGGTTTGA

Transcript

acyt_s0380.g4.t1

TAGGAAGTAAATGAAAGATTCTGACTAAGAACTAGCTATGATTGGAAGAATTTTTTACTGTGCTTTTATTTTGCGTTGACATTTTTCATCCAACGAGGTTTTATCCAGGTAACACGGAAACTCAAATTCTCCATTACAAGTTAGAGCACTTTAAAGAGGTGCAAGATGCTTGGAAAGATCGCTGTTTATACCATTGGTTTAGCATTCATATTTTATCGCGTACAAGTGTACCTTACTTCGAGGCAAGAAAAACTTGATTTGCATGTATTCTTGGAGGAAAATGAGCTTTCGGAATATGAAGCCAAGTTGCACAAATTCGGTATTCACTCAAAAGCTATCTTTGCAAGACTTGATGTTCACAAGTTTCTTGCACAATACAGTTCCTTTTGGGGATTTTTCCGATTTAATTCAGAGAAAGAGAAACTGGAATTGGCTTCACAGAAAGCTGAACAAGAAGTGCTGCTCTTGTCACACTTGCAGAATTTAAGAATAGATGCTAAATACTTCAGAAAGCTGTTATCCCATGGGATAAATAGCATAGAACAGTTCCAAGAGAATTTGGATTCAGTTGTGCTGAGGAAGATCTTTGAATATGACGATCTCCTCAAGTTACAAGATGCAGCTCCAAGAAAAGATGAACAATTTACTGATTCGTTTCCTGTGAGAAGTGCATTAACTATCTTTTCTTTTTCCTGGTGGACTTTCAAATCTGTTTGTAAAATGATTTTTTTCATCCTAAGCTTTGTTCTGAGCATAGTGTTTGCTTGGGGTGGAATTTCTCACTTGCAAAAAAAAAGCAGGCAAAGTCAAACCTCAATCTTGAAGTACATGTTTGGTTCAACATTGGAACCCAAGTTCACATTAGTGACATGGGAGAAGACAGATCCATATGTGGTTGGGGAGTCAATCATATTTTTCATTCATTTTTACCGAATGAATCTTTTTCCATATCCAGTATCACCGGATGATCCCATCTTGATTGAAATCATGCACAAAGACACACTTGTTGCATGTTCACGTGAATATGGGGGTGAAAATTGGGGAAGAAACAACACCATGAAAGTGTCTTTTACTGTGAGGGAGGCAGGTACCTACAGAATTTCAATTCTTGCCAGAGGGATGCCAATAAGAGGGAGCCCATTCAAAAAAGACTTTTTACCTGGAACAATTGACCCATCCAAGTGTGTCATTTTAGAAGGTGGATCTCTGCTCGAAGTTCAGAAGAATATTTACACACCTCTTACTGTTGAGGCACGAGACAAATTTGGCAACATCTGCCCACTGTCAGTTCAAGATGTAAAATCATATACAGTTGAAGTCACTGAGATTGGGAGCATCGTTAAGGTAGATCCCGAATTGGTGATCTTTCATGATGATGATGGAAAGAACAATGTCCTTTGCATCAAGTTGGATTGGGAAGGTTGTTTCAGTGCTGTGGTCAAATATAATGGTGTTCCAGTCAGCCAGGGACAATTCACTGTTATCTCTCTAAACTCAGAAGAAGCTAAACAGGTTGATGAGAACATAAAAAAGCAATGTTGGAATGTCTGGTACGAAGCATACCTTCTCAGACATGCAGAATCAAGCCAGACAAATGGATCTTCGCTTTCTTCTGGTACTCCTCCCTGGATGATAATTCAACCGCTAGTTAATTTTGACAACACAGTTAATGGAGGTGCCTGTAAAAAGCCAAGTAGAGTCTATTGCTACATTTCCAAGAAGCATTTATCCATAAAAGAATTCTACATCAAGATTATTCCTCGCAGATTGTATGGATTTCGTGTTCGGCCATCAACTAAGATAATTCTGCACCCCCTTGATCTCAACATGGAACACCCAACTTTCACTGTTGATGATGGTTACCAGTCTCCTGTGACTATCATGTGCAAGGAAAGAAATGTCTTGGTTGCAACATTCTCAAGACTTCTCCTCAGGAAAATTGGTGGATCAGAAAGTTTCAACGATAAAAAAGATTTCTTTTATCGTGAACTAGTGGCCCATCTTGGTCGTAAAGGAGGCGAAGTGATGTTGAAGATTGATCGACAAAAGATTTTAGAGACTTCTTATCAGGCTACTGTCAGGACGCTATATTTCAGTGATTGGCTGCGTCTCTTTACAATAAAATTCAAAGATGAATTAGGCGTTGACTGGGGTGGCCTGCGTCGCGAATGGTTTGAATTGTTATGCAAGGCTTTATTTTCTCATGAAAGTGGTTTCTTCACTCGATTTAATGAAGATGATCCACAAGCCCTGGTTCACCCTAATTCTAGAAGACCTCTCAGTAAGAAGCTGAAGTTTTACGAGTTCGCTGGTCGAGTTGTTGGAAAATGTTTGTACGAATCGGCTTTGGGTTCATCTCGGAGACTGAATGTTAAAGCCCGTTTTAGCAGATCATTTCTGGCTCAACTGCTTGGACTTCGCGTCTGCTACAAGTATTTCGAAAGCGACGATAAGGATCTCTATCGCAGCAAGATAAAGTACATCGAGGAGACAGACCCAGAAGACCTGGCACTAGTCTTTGCTGAAGAGGAGTGTGATGAGCATGGGCGCCTACAGAAGACAGTAGACTTGAAGCCTGGTGGCAGACACATTCCGGTGACAGAATCAAACAAGATGGAATATTTGGATCTCCTGGCACAGTATCGTTTATCCTCCTCTTGCAAGCAAGAAATTGAAGCTTTTGCAAAAGGTTTGAATGAATTTGTTCCAGAAAACCTTCTAAGCGTCTTTGATGAATACGAATTGGAGCTATTAATGTGTGGAACAGGAGATATAAGCGTGTCCGATTTGAGACAGCATCACAACGTTATTGACAGCGGATCATCATTTAGAAAGAGTCTGGACTGGTTTTGGACTATCGTGACAAGTTTCACGCAGGATGAACTTGCTCGTCTAGTGCAGTTTATTACAGGCTCCTCACAGCTCCCCCCTGGGGGATTCGCTGAACTCTCACCCCAGATCCAGATTTCCTCAGCTCCCACTACAGATGCACTTCCATCAGCTCACACGTGTTTCAACCAACTTTGTTTACCGTCGTACTCATCGTTTACCGAGATGCAGAAGAAACTGGTACTCGCTATAAACGAGCGAAGTGAAGGATTCTCCATGGTTTGAATCCAAGAATTTTATAAGAAGGAAAGATTTTTGGCATTAACCTAAAGAACGAAGCTAGTGTTGGGTTCACCGATCAGTCCGAAACAATAACAAAAAGAACTCTTTTCTCTTGTTGCTTCAAAGTTAGTCCGTTTAACGGACTAAGTTTGAAATCGATTTCAAAGAAATGCATTTGCATAGAAACCTTAGCTCATCAAAAATCGTCATTTTGTTTGATCGTCAAGGCATATCTGTTGTAAAATATATTTAACTGTAATTTCAGTAGTTAGCTCTTGAAACTTGGAGAAGTTTAGTACAATATCTGTTTTTTAAGATGTGGCCActgtttctcgaaagtcccgaaacttttacggtgcatttcggatgacgtaattctctttgtatcttcaaaAcgcaggggcctcgaggcacgaaactttattatttatttcaatctttatcccctttacaagatatgaaaagaccagctttacagagttagggggtcggagttttacaaagggcttttcggacccgaagagttttcgggattttcctgaaacgggacacaggcctCAGCTGTTCAAGGGTTGAATAGTGCTAGCCACTGGATAAGAACTACCAAAGCCTatggagttatttagtggaaagtagtatccaccctttgaacaactgggaccagTAGTTTTTTAATTG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O15033	Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens OX=9606 GN=AREL1 PE=1 SV=3
Q8CHG5	Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Mus musculus OX=10090 GN=Arel1 PE=1 SV=2
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002618 (this species only) · gene tree & orthology
Ubiquitin family	E3\|E3 activity\|HECT · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00632 all species →	HECT	HECT-domain (ubiquitin-transferase)	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR035983 all species →	Homologous_superfamily	HECT, E3 ligase catalytic domain	Interproscan
IPR014756 all species →	Homologous_superfamily	Immunoglobulin E-set	Interproscan
IPR013783 all species →	Homologous_superfamily	Immunoglobulin-like fold	Interproscan
IPR017868 all species →	Repeat	Filamin/ABP280 repeat-like	Interproscan
IPR050409 all species →	Family	E3 ubiquitin-protein ligase	Interproscan
IPR000569 all species →	Domain	HECT domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11254 all species →	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004842 all species →	Molecular Function	ubiquitin-protein transferase activity	Interproscan
GO:0000209 all species →	Biological Process	protein polyubiquitination	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0016567 all species →	Biological Process	protein ubiquitination	Interproscan
GO:0043066 all species →	Biological Process	negative regulation of apoptotic process	Interproscan
GO:0061630 all species →	Molecular Function	ubiquitin protein ligase activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K22370	AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1	EC:2.3.2.26	Ubiquitin system	ko04121	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora cytherea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora cytherea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →