Genomic Location: sc0000154_pilon:292136...317665
NR annotation: XP_044183135.1, C-1-tetrahydrofolate synthase, cytoplasmic-like [Acropora millepora]
| CDS | |||||
| agem_s0154.g13.t2 | |||||
| Transcript |
| agem_s0154.g13.t2 |
| Protein |
| agem_s0154.g13.t2 |
| Uniprot term | Description |
|---|---|
| P11586 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4 |
| Q922D8 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=4 |
| P27653 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mthfd1 PE=1 SV=3 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00763 | THF_DHG_CYH | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | Domain | Interproscan |
| PF01268 | FTHFS | Formate--tetrahydrofolate ligase | Family | Interproscan |
| PF02882 | THF_DHG_CYH_C | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR020630 | Domain | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | Interproscan |
| IPR020628 | Conserved_site | Formate-tetrahydrofolate ligase, FTHFS, conserved site | Interproscan |
| IPR036291 | Homologous_superfamily | NAD(P)-binding domain superfamily | Interproscan |
| IPR020867 | Conserved_site | Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site | Interproscan |
| IPR027417 | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR000672 | Family | Tetrahydrofolate dehydrogenase/cyclohydrolase | Interproscan |
| IPR046346 | Homologous_superfamily | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Interproscan |
| IPR000559 | Family | Formate-tetrahydrofolate ligase, FTHFS | Interproscan |
| IPR020631 | Domain | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR48099 | C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0004488 | Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | Interproscan |
| GO:0005524 | Molecular Function | ATP binding | Interproscan |
| GO:0003824 | Molecular Function | catalytic activity | Interproscan |
| GO:0004329 | Molecular Function | formate-tetrahydrofolate ligase activity | Interproscan |
| GO:0004477 | Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | Interproscan |
| GO:0005829 | Cellular Component | cytosol | Interproscan |
| GO:0035999 | Biological Process | tetrahydrofolate interconversion | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K00288 | MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase | EC:1.5.1.5 EC:3.5.4.9 EC:6.3.4.3 | Exosome | ko04147 | deepkoala |