Gene detail

Detailed information of amic_s0016.g48.t1 in Acropora microphthalma

Genomic Location: sc0000016_pilon:939742...964623
NR annotation: XP_029179252.1, tyrosine-protein kinase SRK2-like isoform X1 [Acropora millepora]
Species Acropora microphthalma · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

amic_s0016.g48.t1

ATCAGCAAGGATCAGCACTAGTTCCTTCCGGTTGAGTAGAATATTTACATGTCGTGTCAACCCACGACTTTTAAAAGCATTTGACATGGGTATCATTAGAACTCCGTCTTGTTGGGATTTATTTAATTGAAAAAGCCATCAAGTTAATTGTCGCCAATATGTATTTCGATCAAGGAGAGCAAAGAGAGCTGAAGGTGGCTGTGATGTGGAAACGAGCCCAAGGAAAAAAGAAGGTCCTCAGCTCAGTGAACTGGAAAGAGCGAGTGTTTGTACTCACACCGAAAACTCTGAACTATTTTGAAGGCAATTATGAGAAACGTGGCAAATGCAGAGGAAGCATCGCTTTAAGTTCAGTTAAAGCTGTGGAGTGTGTAGATGACACAGTGTTTGACCAAGATAAAAGAAACTGCTTTCAAGTTGTTTATGATGATTTGGTTCTCTATATCAGCGCAAACGGTGACGAGGAAAGGAAAGATTGGGTTGAAGCTATTCAAGATGAATGCCGTGGTAACAAATTTCTCCTTAAAGAATACCATCCTGGAATATTTGTAAACAAATGGACATGTTGTGGTGGCGGTGAGAAGTCAACTCAAGGTTGCAAGAGTTCCTTTGCTTCACTAGAAAATAATGGCTACCAAGGTGGAAGCTACACGCAATCTTCAACATTTATAGCGTCTCAACCATTGCCACCAATTCCTTCTGCTAATCAAGCAGTTGTGGCACCTCAACCCCACAAGGAAACTATGAAAGAACCTGAAAAGAAAGCAACTGAGACTGTAGTGGCCATCTGTGACTTCTTTGGTGCCGAGCAGGGTGACTTATCACTCACTAAGGGAGAGCAATTAACTGTTATTGAAAAACAGTCTGATCATTGGTGGATAGCAAAGAATTCAAGTGGTGAACAGGGATTCATCCCAAGTAATTATGTTAGAAGACAGGGATTGGAAAGTGAAAGCTGGTTCCAACCAGAAATGTCTCGGCAAATGTCTGAGGATGCTCTAAAAGAGGAGGGAAAAGAAGGTTGTTTTTTAGTGCGTAATTCAAGCCGGGAAGGAATGTACACGTTGTCAGTTTTGCATGGTGATCATGTGCGTCATTATCACATCAAAGATGAAGACGGACAGTTATATATATCAGACAGACACAGATATCCAACAGTTTCCGAACTCATCAACTACCATCAACATAACAGTGGAGGTCTGGTCACAAGACTACGACAACCTCCATCGTTTGGTGCAGCACCAGTGGCAGCGTTTGGACATGATATATGGGAAATACCCAGGGCGGAGATAGTTCTTGGGAAGGAGCTTGGTACCGGCCAGTTTGGGACTGTGAGACAAGGAACATGGCGTCGAAGCATTGCAGTTGCAGTCAAATTAATGAAAGAAGGTGCAATGTCCGAGGACGATTTTATCGATGAAGCCAAAGTTATGACGCAATTCCATCACCCCCATCTTGTACAGCTGTTCGGAGTTTGCAGTGAAAAACCAATATATATCATTACTGAATTTATGAGCCAGGGATGTCTTTTGCACTATTTACGCAAGAACCAACCGCGGCTCAAATTTGGCGGCAAGAAACTGCCTCATTGGAGATAAAAATATCGTCAAAGTTGCTGATTTTGGGTTAGCAAGATATGTCATAGATGATGAATACACAGCATCAGAGGGCACAAAATTCCCCATTAAATGGGCGTCGCCTGAAGTCATTCTGTACACCAAATTCAGCAGCAAATCAGATATCTGGGCTTTTGGAATCTTGACATGGGAAATATACAGTGGCGGAAAGCAACCATACCCTGCGATAAACAACACCGAGGTCGTGCAAAAGGTCCTCAATGGTTACAGACTTGAAAAACCTCAAAGGTGCCCAGATGATATGTACAGGATGGTAACTAAGTGTTGGCAAACGGAACCGGAGCATAGACCGAACTTTGCATCTGTCAAAAAAAGTGTCAGTGACTTTTTGGGTGAAGATTATGATGAGACCTTTGAATAAGAGTGCTGCACTGTTAACTAGCCACAGAGAACTCAACAAGACAGAACTACATAAAATAATGTGAAAGAAAAATTGTGGTATGTCATAATCCCTGAGAAGTAAACGGGATCTGGCAGTTAAAAGTTATGTAAATGGCGATATTTTCATCTCTGCTAGGAAACTGAAAAGGCTATTTTCTTATTTGTTTCCACTTTTCAGGACTTATCATTTCTGCATGTAGTTTCATAGTGTAATAGTGGTTCAAGTATAGTTCTTAGTGTCGCTAAATTTGTGCTCTTGGGTTTGCTTCAAGAACAGAATGAGCTTGGATTTGTCGTAAAACTAACTTAAGCGGTTGTGTTTTTTGCGTAATATTTTGAATTCTATAATTACGAATTAAGACAACATGTGGTGTTGTTAAAGGGCTGAGAACAGTACGGTATTGGAGATTATTTTGATATGGCTTATTGGTTTATACATATTCTATTTTTTGTAAACATTTGCCAGTAAAAGGAAGAAAAGGGAAGGCTCTTTAAAAGCCGCACTGCCAAGAATTAAGCCGGGCTTTTAATATTAGGGCTTTTGGCCTTTTGTAAAGAGCCACTTGAACCAGAAATATCCTCGACCTTCAGGCAACCCGATTTTTTGCCGGTAATAATTGATACTGGGAAGTTGCGTTAGGTTCCTTCATTTCTTTCGTCGAGGAATGTTAGAACGCTTCATCGTTGAACTTGCAGTTAAATTATCAGAAAGTAAGCAGCTGGAGTACTATAGTGAGGCGTCGGCCGCAAGCAGAACTCTCATTCAACTTTTTTAAGATCAGTAGTGCTATTTTTTTTTTGCTATTAGGCAAAAATTAAGTTGCCCACCTCGACATCAGGCGTGagttattcaaagttggataacgctgtccattggataacttaattgggtttaaatgcacctatccactggtcggcgatttgtccaatggatagccaaacttgaacaactggagccAGCTGTGTGGAAATGTGGGCGACAAATAGAAATTGCTTTAACAG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q06187	Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3
P35991	Tyrosine-protein kinase BTK OS=Mus musculus OX=10090 GN=Btk PE=1 SV=4
P42680	Tyrosine-protein kinase Tec OS=Homo sapiens OX=9606 GN=TEC PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000425 (this species only) · gene tree & orthology
Ubiquitin family	UBD\|Other\|SH3 · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00779 all species →	BTK	BTK motif	Motif	Interproscan
PF07714 all species →	PK_Tyr_Ser-Thr	Protein tyrosine and serine/threonine kinase	Domain	Interproscan
PF00018 all species →	SH3_1	SH3 domain	Domain	Interproscan
PF00169 all species →	PH	PH domain	Domain	Interproscan
PF00017 all species →	SH2	SH2 domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001849 all species →	Domain	Pleckstrin homology domain	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR001562 all species →	Conserved_site	Zinc finger, Btk motif	Interproscan
IPR020635 all species →	Domain	Tyrosine-protein kinase, catalytic domain	Interproscan
IPR036028 all species →	Homologous_superfamily	SH3-like domain superfamily	Interproscan
IPR000980 all species →	Domain	SH2 domain	Interproscan
IPR001245 all species →	Domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	Interproscan
IPR001452 all species →	Domain	SH3 domain	Interproscan
IPR036860 all species →	Homologous_superfamily	SH2 domain superfamily	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan
IPR050198 all species →	Family	Non-receptor tyrosine kinases involved in cell signaling	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR017441 all species →	Binding_site	Protein kinase, ATP binding site	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR24418 all species →	TYROSINE-PROTEIN KINASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0035556 all species →	Biological Process	intracellular signal transduction	Interproscan
GO:0004713 all species →	Molecular Function	protein tyrosine kinase activity	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0004715 all species →	Molecular Function	non-membrane spanning protein tyrosine kinase activity	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K05855	SYK; spleen tyrosine kinase	EC:2.7.10.2	Protein kinases	ko01001	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora microphthalma tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora microphthalma, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →