Genomic Location: sc0000134_pilon:619326...645874
NR annotation: XP_029209968.1, transitional endoplasmic reticulum ATPase [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0134.g36.t1 |
| Transcript |
| amur_s0134.g36.t1 |
| Protein |
| amur_s0134.g36.t1 |
| UniProt accession | Description |
|---|---|
| Q6GL04 | Transitional endoplasmic reticulum ATPase OS=Xenopus tropicalis OX=8364 GN=vcp PE=2 SV=1 |
| P46462 | Transitional endoplasmic reticulum ATPase OS=Rattus norvegicus OX=10116 GN=Vcp PE=1 SV=3 |
| Q3ZBT1 | Transitional endoplasmic reticulum ATPase OS=Bos taurus OX=9913 GN=VCP PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000716 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF09336 all species → | Vps4_C | Vps4 C terminal oligomerisation domain | Domain | Interproscan |
| PF02359 all species → | CDC48_N | Cell division protein 48 (CDC48), N-terminal domain | Domain | Interproscan |
| PF02933 all species → | CDC48_2 | Cell division protein 48 (CDC48), domain 2 | Domain | Interproscan |
| PF17862 all species → | AAA_lid_3 | AAA+ lid domain | Domain | Interproscan |
| PF00004 all species → | AAA | ATPase family associated with various cellular activities (AAA) | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR027417 all species → | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR005938 all species → | Family | AAA ATPase, CDC48 family | Interproscan |
| IPR009010 all species → | Homologous_superfamily | Aspartate decarboxylase-like domain superfamily | Interproscan |
| IPR015415 all species → | Domain | Spastin/Vps4, C-terminal | Interproscan |
| IPR003338 all species → | Domain | CDC48, N-terminal subdomain | Interproscan |
| IPR004201 all species → | Domain | CDC48, domain 2 | Interproscan |
| IPR003593 all species → | Domain | AAA+ ATPase domain | Interproscan |
| IPR003960 all species → | Conserved_site | ATPase, AAA-type, conserved site | Interproscan |
| IPR050168 all species → | Family | AAA ATPase domain-containing protein | Interproscan |
| IPR029067 all species → | Homologous_superfamily | CDC48 domain 2-like superfamily | Interproscan |
| IPR041569 all species → | Domain | AAA ATPase, AAA+ lid domain | Interproscan |
| IPR003959 all species → | Domain | ATPase, AAA-type, core | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR23077 all species → | AAA-FAMILY ATPASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016787 all species → | Molecular Function | hydrolase activity | Interproscan |
| GO:0016887 all species → | Molecular Function | ATP hydrolysis activity | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0030433 all species → | Biological Process | obsolete ubiquitin-dependent ERAD pathway | Interproscan |
| GO:0030970 all species → | Biological Process | retrograde protein transport, ER to cytosol | Interproscan |
| GO:0031593 all species → | Molecular Function | polyubiquitin modification-dependent protein binding | Interproscan |
| GO:0034098 all species → | Cellular Component | VCP-NPL4-UFD1 AAA ATPase complex | Interproscan |
| GO:0051228 all species → | Biological Process | mitotic spindle disassembly | Interproscan |
| GO:0071712 all species → | Biological Process | obsolete ER-associated misfolded protein catabolic process | Interproscan |
| GO:0097352 all species → | Biological Process | autophagosome maturation | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K13525 | VCP, CDC48; transitional endoplasmic reticulum ATPase | - | Exosome | ko04147 | deepkoala |
Transcript abundance of amur_s0134.g36.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 73 | 194.68 | 540.41 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 540.41 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 348.92 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 344.83 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 338.28 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 335.21 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 288.09 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 283.53 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 282.18 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 270.77 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 270.04 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 267.61 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 261.22 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 258.46 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 258.35 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 258.34 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 253.30 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 249.54 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 247.43 |
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 246.11 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 241.49 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 238.25 |
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 237.75 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 227.93 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 227.01 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 226.05 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 225.79 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 221.84 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 221.77 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 218.10 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 217.51 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 216.62 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 215.00 |
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 211.70 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 207.69 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 202.01 |
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 200.63 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 199.36 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 199.29 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 197.30 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 197.21 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 195.99 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 195.29 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 193.44 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 187.63 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 187.56 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 187.32 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 186.38 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 185.39 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 183.28 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 176.41 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 174.92 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 174.31 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 172.31 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 167.54 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 166.22 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 158.91 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 156.93 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 156.81 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 154.16 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 151.37 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 151.00 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 141.92 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 141.25 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 140.65 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 139.93 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 138.97 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 138.87 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 138.61 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 132.25 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 131.08 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 126.24 |
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 97.87 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 96.03 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 32 | amur_s0013.g61.t1 | 0.834997657772416 |
| Negatively correlated | 3 | amur_s0022.g29.t1 | -0.385328057471262 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |