Genomic Location: sc0000168_pilon:224946...247262
NR annotation: XP_029205080.2, histone-lysine N-methyltransferase SETD1A-like isoform X1 [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0168.g15.t1 |
| Transcript |
| amur_s0168.g15.t1 |
| Protein |
| amur_s0168.g15.t1 |
| UniProt accession | Description |
|---|---|
| Q1LY77 | Histone-lysine N-methyltransferase SETD1B-A OS=Danio rerio OX=7955 GN=setd1ba PE=1 SV=2 |
| Q8CFT2 | Histone-lysine N-methyltransferase SETD1B OS=Mus musculus OX=10090 GN=Setd1b PE=1 SV=2 |
| Q5F3P8 | Histone-lysine N-methyltransferase SETD1B OS=Gallus gallus OX=9031 GN=SETD1B PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0004215 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF11764 all species → | N-SET | COMPASS (Complex proteins associated with Set1p) component N | Domain | Interproscan |
| PF00856 all species → | SET | SET domain | Family | Interproscan |
| PF00076 all species → | RRM_1 | RNA recognition motif | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001214 all species → | Domain | SET domain | Interproscan |
| IPR003616 all species → | Domain | Post-SET domain | Interproscan |
| IPR024657 all species → | Domain | COMPASS complex Set1 subunit, N-SET domain | Interproscan |
| IPR035979 all species → | Homologous_superfamily | RNA-binding domain superfamily | Interproscan |
| IPR000504 all species → | Domain | RNA recognition motif domain | Interproscan |
| IPR012677 all species → | Homologous_superfamily | Nucleotide-binding alpha-beta plait domain superfamily | Interproscan |
| IPR044570 all species → | Family | Histone-lysine N-methyltransferase Set1-like | Interproscan |
| IPR046341 all species → | Homologous_superfamily | SET domain superfamily | Interproscan |
| IPR037841 all species → | Domain | Histone-lysine N-methyltransferase SETD1A/B-like, SET domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45814 all species → | HISTONE-LYSINE N-METHYLTRANSFERASE SETD1 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0003676 all species → | Molecular Function | nucleic acid binding | Interproscan |
| GO:0003723 all species → | Molecular Function | RNA binding | Interproscan |
| GO:0042800 all species → | Molecular Function | histone H3K4 methyltransferase activity | Interproscan |
| GO:0048188 all species → | Cellular Component | Set1C/COMPASS complex | Interproscan |
| GO:0051568 all species → | Biological Process | obsolete histone H3-K4 methylation | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11422 | SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1 | EC:2.1.1.354 | Chromosome and associated proteins | ko03036 | deepkoala |
Transcript abundance of amur_s0168.g15.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 68 | 9.87 | 26.42 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 26.42 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 23.34 |
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 23.25 |
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 23.11 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 23.00 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 20.97 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 20.76 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 16.33 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 16.28 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 15.82 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 15.75 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 15.67 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 14.33 |
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 14.12 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 14.08 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 13.95 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 13.54 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 13.26 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 13.15 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 12.91 |
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 12.32 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 11.97 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 11.95 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 11.90 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 11.79 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 11.70 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 11.69 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 11.67 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 11.63 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 11.63 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 11.48 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 11.42 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 11.29 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 11.21 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 11.15 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 10.99 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 10.79 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 10.03 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 9.62 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 9.56 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 9.14 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 9.13 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 9.00 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 8.91 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 8.89 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 8.84 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 8.82 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 8.78 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 8.72 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 8.71 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 8.57 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 8.56 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 8.48 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 8.26 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 7.67 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 7.32 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 6.71 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 5.95 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 5.94 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 5.79 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 5.73 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 5.73 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 5.70 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 5.29 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 5.15 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 5.01 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 4.73 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 4.12 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 0.00 |
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 11 | amur_s0302.g24.t1 | 0.753317466685748 |
| Negatively correlated | 5 | amur_s0022.g29.t1 | -0.283983065160211 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |