Gene detail

Detailed information of amur_s0182.g17.t1 in Acropora muricata

Genomic Location: sc0000182_pilon:216356...229379
NR annotation: XP_029185427.2, merlin-like [Acropora millepora]
Species Acropora muricata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

amur_s0182.g17.t1

TAAGCGGGGGCACGGAAAAAATTCTCGACATAGCAAAGTGAGGATATGTAGGCGACAAATAGCCTTGAAAAACAGAATGCTTAGCATGCTGCAGCTTATTTTACAGGGGTGAAACAACGATCCAAATGCTGGGTCGTTATGCCGAAGACATTTGACGTTCGCATAACGACCTTTGACGCTGAGCTTGAATTTTCTGTGGAGAAAAAATGCACAGGGAAGGAATTGTTTGATCTTATTGTGCGCACATTGGGTGTTCGTGAGACTTGGTATTTCGGTCTACAGTATGTGGACAAGAAAGGCGTTGTTTCGTGGCTCAAATTCAACAAGAGGGTCTTAGATCAAGATATTACTAAGGAGGATCCCGTCAACCTCAGTTTTCGCGTGAAGTTTTATCCTGAAGATGTGGCTGAAGAACTCATGCAAGAAATTACACAGCACTTGTTTTTCCTTCAAGTCAAGGAAGCTATTCTCAACATGGACATTTTCTGTCCACCAGAAGCTTCTGTTCTTTTGGCTTCTTATGCAGTTCAAGCAAAGTATGGAGACTACGACAAAGAGTTTCACAAACCTGGATTCCTGGCAAATGACCTGCTGTTGCCTCAAAGGGTAATTGATCAGTATCAGATGACTGTGGACATGTGGGAAGAAAGGATCACATCTTGGTATGCCGAGCACAAGGAAATGAGAAGAGATGAAGCAGAGATGGAGTATCTGAAAATAGCACAAGACTTGGAGATGTATGGTGTGATGTACTTTGAAATCAAGAACAGAAAAGGAACTGACTTGTGGCTTGGAATTGATGCTCATGGATTAAATATTTATGAAAGAGAAAACAAGTTGAACCCCAAAATCTCTTTTCCTTGGAATGAAACCAGGAATATTTCCTTCCATGATAAAAGGTTTCAGATCAAACCTGTTGACAAGTCATCTCCTGATTTTATATTTCATGCGTTAAAACTGAGGGTCAACAAAGTGATCCTAGACTTGTGTGTCGGTAACCATGAGCTGCACATACGCAGAAGAAAACCAGATACAATGGAAATACAGCAGATGCGATCGCTTGCAAGGGAGGACAAAATGAGGCGCCAGATTGAAAGAGACAAATTAATGAAAGAAAAGCAAACTCGCGAGGAGATTATGAAGCAAAGGGACGAACTAGAGAAAAAATTGCTGGAATTTCAAGAAGAAGCAAGCAGAGTAAAAGAAGCGTTGATTAAATCTGAAGAGATGGGTGAGTTGTTGGCAGAAAAAGCCAGAGTGGCAGAAGAAGAAGCCATATTACTCGGCAAAAAAGCATCTGATGCAGAAGAAGAAATCAAGCGCCTTCGCTTGTGCTTGAGCAAGCAATCTGGTGACGAGAGAATTGCCATCGAGAGAAGAGCTCGAGAAGCAGGAGAAGAAAGATTTAAGAGAGTTCTACAAGAGGCTGAAGCAAGAAAAAGGGAAGCTTTAATTCTGAGAGAGGACTTGATGAAATCTCGACAAGCCGAGAGACTGGCCAAACAAAAACTTGTGGAGATAACTTCGTCTCCGGAGTTGTTTTCTAGGTACAGTGATCCCAGGGAAATCATTGCAGATATTGACCGCAGTGTCAACCAGCTTATGGACGGCGATGTTAATCAGATTTCACGAGAACACGAAAGGGAAAGAAGCGGAAATGTACAACAACAGCTCCAGGACTTAAAAACTCAAATGGAGGGTCTTAAGATCAGTGATCGACAAACGCGATGGGATTACATTCATGACGAGAACATGAGACGTGGCGAAGATAAATATTCTACTCTACAAAAAATTCAGACCGAAACATCCACAGCAAGAGTTCAGTTCTTTGAAGAGTTGTAAAAAGAGCGTAAAGTTATTAATCCGCTTATATGTTGTGCGGGATTTTATGACAATTTTTTTTTCAGtatttagacatataggatatatatatatatataaatatataaatTTTCTGTTATTTTGTGATATTCAACCCAGAGGAACAGATAAACAAATTAGACAAGTGAACTGGCACTTAAATGCACAGGTTTGGTGAAGAATCGCGGGATATCTCGTGCAAGCGTGAAGTGAGACTCACAGGGCGTGTGATATCTCGCGGTTCCAACCTTAAGGCAACCAATTCCTGAAATAGGAATTCAGCAGGTCTTACTTTTATCCAATTTTATTTATGGAATTTGAGCGGAAAATATTTCACTTACTCGATATTTTGTAATTTATTGGAGCACAATTTTTTATAAGGTAGTTTGTTCAGCTCTTTGACTCCATCACAGCAAGTGATTAAATGTACGAAAATTGTCTTCTTGCGTTGGACATAACTATGCATTCGATCAGAGTTACTCTGACTTGTTAGATAAATAGAAAAAGACGCAATTTTTGAAAGATTGTTATCCTATGAATAGTTCGAAAGGCACTGACTATGTTCATCAAGGTGTTACAATATTTTTCGTTGCTTGTACGGCAGAGGTCTTGCAAAAGAAGTTCTGGTAGTCACTTCCGCACAGCCAATACTGCTGTCACGCAGGCAAAAATTTTTAGTTGCTGATTAAAATATGTCTGCGCAT

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P35240	Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1
P59750	Merlin OS=Papio anubis OX=9555 GN=NF2 PE=3 SV=1
P46662	Merlin OS=Mus musculus OX=10090 GN=Nf2 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001415 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF20492 all species →	ERM_helical	Ezrin/radixin/moesin, alpha-helical domain	Coiled-coil	Interproscan
PF00373 all species →	FERM_M	FERM central domain	Domain	Interproscan
PF09379 all species →	FERM_N	FERM N-terminal domain	Domain	Interproscan
PF00769 all species →	ERM_C	Ezrin/radixin/moesin family C terminal	Domain	Interproscan
PF09380 all species →	FERM_C	FERM C-terminal PH-like domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR000299 all species →	Domain	FERM domain	Interproscan
IPR041789 all species →	Domain	ERM family, FERM domain C-lobe	Interproscan
IPR019749 all species →	Domain	Band 4.1 domain	Interproscan
IPR000798 all species →	Family	Ezrin/radixin/moesin-like	Interproscan
IPR018980 all species →	Domain	FERM, C-terminal PH-like domain	Interproscan
IPR019747 all species →	Conserved_site	FERM conserved site	Interproscan
IPR008954 all species →	Homologous_superfamily	Moesin tail domain superfamily	Interproscan
IPR046810 all species →	Domain	Ezrin/radixin/moesin, alpha-helical domain	Interproscan
IPR019748 all species →	Domain	FERM central domain	Interproscan
IPR011174 all species →	Family	Ezrin/radixin/moesin	Interproscan
IPR014352 all species →	Homologous_superfamily	FERM/acyl-CoA-binding protein superfamily	Interproscan
IPR018979 all species →	Domain	FERM, N-terminal	Interproscan
IPR035963 all species →	Homologous_superfamily	FERM superfamily, second domain	Interproscan
IPR029071 all species →	Homologous_superfamily	Ubiquitin-like domain superfamily	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan
IPR011259 all species →	Domain	Ezrin/radixin/moesin, C-terminal	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR23281 all species →	MERLIN/MOESIN/EZRIN/RADIXIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005856 all species →	Cellular Component	cytoskeleton	Interproscan
GO:0008092 all species →	Molecular Function	cytoskeletal protein binding	Interproscan
GO:0003779 all species →	Molecular Function	actin binding	Interproscan
GO:0005178 all species →	Molecular Function	integrin binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0005912 all species →	Cellular Component	adherens junction	Interproscan
GO:0008285 all species →	Biological Process	negative regulation of cell population proliferation	Interproscan
GO:0008360 all species →	Biological Process	regulation of cell shape	Interproscan
GO:0030175 all species →	Cellular Component	filopodium	Interproscan
GO:0035330 all species →	Biological Process	regulation of hippo signaling	Interproscan
GO:0045177 all species →	Cellular Component	apical part of cell	Interproscan
GO:0050839 all species →	Molecular Function	cell adhesion molecule binding	Interproscan
GO:1902115 all species →	Biological Process	regulation of organelle assembly	Interproscan
GO:1902966 all species →	Biological Process	positive regulation of protein localization to early endosome	Interproscan
GO:2000643 all species →	Biological Process	positive regulation of early endosome to late endosome transport	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K16684	NF2; merlin	-	Cytoskeleton proteins	ko04812	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of amur_s0182.g17.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

82Samples

72TPM > 0

2Conditions

170.9Max TPM

78.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
Polyps	79	72	81.80	170.94
Severed branch	3	0	0.00	0.00

Per sample · hover a bar for the full sample record

Show the sample table (82 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR12959207	Polyps	Polyps	E2 day15	not recorded	SRP199550	170.94
SRR27868178	Polyps	Polyps	regeneration day36	not recorded	SRP199550	167.43
SRR27868184	Polyps	Polyps	regeneration day30	not recorded	SRP199550	156.02
SRR27868186	Polyps	Polyps	regeneration day30	not recorded	SRP199550	148.35
SRR27868181	Polyps	Polyps	regeneration day33	not recorded	SRP199550	143.98
SRR27868187	Polyps	Polyps	regeneration day3	not recorded	SRP199550	138.20
SRR27868185	Polyps	Polyps	regeneration day30	not recorded	SRP199550	131.85
SRR27868160	Polyps	Polyps	regeneration day6	not recorded	SRP199550	126.85
SRR12786901	Polyps	Polyps	OA 2 day0	not recorded	SRP199550	125.91
SRR12786900	Polyps	Polyps	OA 2 day0	not recorded	SRP199550	125.66
SRR12786899	Polyps	Polyps	OA 2 day0	not recorded	SRP199550	124.60
SRR27868177	Polyps	Polyps	regeneration day39	not recorded	SRP199550	123.78
SRR27868165	Polyps	Polyps	regeneration day3	not recorded	SRP199550	121.41
SRR12959232	Polyps	Polyps	E2 day3	not recorded	SRP199550	114.27
SRR27868204	Polyps	Polyps	regeneration day12	not recorded	SRP199550	108.65
SRR27868158	Polyps	Polyps	regeneration day6	not recorded	SRP199550	106.14
SRR27868188	Polyps	Polyps	regeneration day27	not recorded	SRP199550	103.87
SRR27868192	Polyps	Polyps	regeneration day24	not recorded	SRP199550	102.51
SRR27868175	Polyps	Polyps	regeneration day39	not recorded	SRP199550	102.43
SRR27868198	Polyps	Polyps	regeneration day0	not recorded	SRP199550	99.42
SRR27868199	Polyps	Polyps	regeneration day18	not recorded	SRP199550	95.81
SRR12959219	Polyps	Polyps	E2 day9	not recorded	SRP199550	95.80
SRR27868189	Polyps	Polyps	regeneration day27	not recorded	SRP199550	95.73
SRR27868179	Polyps	Polyps	regeneration day36	not recorded	SRP199550	93.64
SRR27868197	Polyps	Polyps	regeneration day18	not recorded	SRP199550	92.33
SRR27868207	Polyps	Polyps	regeneration day9	not recorded	SRP199550	91.58
SRR27868174	Polyps	Polyps	regeneration day39	not recorded	SRP199550	91.13
SRR27868206	Polyps	Polyps	regeneration day12	not recorded	SRP199550	90.89
SRR12959218	Polyps	Polyps	E2 day9	not recorded	SRP199550	89.95
SRR27868202	Polyps	Polyps	regeneration day15	not recorded	SRP199550	89.43
SRR27868180	Polyps	Polyps	regeneration day36	not recorded	SRP199550	88.77
SRR27868200	Polyps	Polyps	regeneration day18	not recorded	SRP199550	88.48
SRR12959220	Polyps	Polyps	E2 day9	not recorded	SRP199550	88.17
SRR27868208	Polyps	Polyps	regeneration day9	not recorded	SRP199550	87.80
SRR27868182	Polyps	Polyps	regeneration day33	not recorded	SRP199550	87.00
SRR12959205	Polyps	Polyps	E2 day15	not recorded	SRP199550	86.16
SRR27940224	Polyps	Polyps	not recorded	not recorded	SRP199550	84.72
SRR12904784	Polyps	Polyps	not recorded	not recorded	SRP199550	84.44
SRR12959204	Polyps	Polyps	E2 day15	not recorded	SRP199550	83.07
SRR27940222	Polyps	Polyps	not recorded	not recorded	SRP199550	82.59
SRR12959217	Polyps	Polyps	E2 day0	not recorded	SRP199550	80.72
SRR27868159	Polyps	Polyps	regeneration day6	not recorded	SRP199550	80.32
SRR27868176	Polyps	Polyps	regeneration day3	not recorded	SRP199550	80.18
SRR27868209	Polyps	Polyps	regeneration day0	not recorded	SRP199550	79.46
SRR27868203	Polyps	Polyps	regeneration day15	not recorded	SRP199550	79.14
SRR12904785	Polyps	Polyps	not recorded	not recorded	SRP199550	78.23
SRR12959195	Polyps	Polyps	E2 day0	not recorded	SRP199550	78.06
SRR27868195	Polyps	Polyps	regeneration day21	not recorded	SRP199550	77.81
SRR12959191	Polyps	polyps	E2 day21	not recorded	SRP199550	77.24
SRR12959192	Polyps	Polyps	E2 day21	not recorded	SRP199550	76.38
SRR27868196	Polyps	Polyps	regeneration day21	not recorded	SRP199550	75.71
SRR12959233	Polyps	Polyps	E2 day3	not recorded	SRP199550	70.05
SRR27868194	Polyps	Polyps	regeneration day21	not recorded	SRP199550	69.49
SRR12959193	Polyps	Polyps	E2 day21	not recorded	SRP199550	68.04
SRR27868183	Polyps	Polyps	regeneration day33	not recorded	SRP199550	68.03
SRR27868205	Polyps	Polyps	regeneration day12	not recorded	SRP199550	67.52
SRR12710851	Polyps	Polyps	OA 2 day3	not recorded	SRP199550	66.94
SRR12959231	Polyps	Polyps	E2 day3	not recorded	SRP199550	66.35
SRR27868210	Polyps	Polyps	regeneration day0	not recorded	SRP199550	65.23
SRR27940228	Polyps	Polyps	not recorded	not recorded	SRP199550	65.20
SRR12904786	Polyps	Polyps	not recorded	not recorded	SRP199550	64.94
SRR27868193	Polyps	Polyps	regeneration day24	not recorded	SRP199550	60.84
SRR12710849	Polyps	Polyps	OA 2 day3	not recorded	SRP199550	60.27
SRR27940227	Polyps	Polyps	not recorded	not recorded	SRP199550	58.84
SRR12710850	Polyps	Polyps	OA 2 day3	not recorded	SRP199550	57.53
SRR27940225	Polyps	Polyps	not recorded	not recorded	SRP199550	57.40
SRR27868201	Polyps	Polyps	regeneration day15	not recorded	SRP199550	54.61
SRR27868190	Polyps	Polyps	regeneration day27	not recorded	SRP199550	51.80
SRR12710859	Polyps	Polyps	OA 2 day9	not recorded	SRP199550	50.83
SRR12710861	Polyps	Polyps	OA 2 day9	not recorded	SRP199550	49.31
SRR12959206	Polyps	Polyps	E2 day0	not recorded	SRP199550	49.03
SRR12710860	Polyps	Polyps	OA 2 day9	not recorded	SRP199550	47.06
SRR12807382	Polyps	Polyps	OA2 day0	not recorded	SRP199550	0.00
SRR12927881	Polyps	Polyps	E2 day0	not recorded	SRP199550	0.00
SRR27868191	Polyps	Polyps	regeneration day24	not recorded	SRP199550	0.00
SRR27940226	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR27940229	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613488	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR9613516	Polyps	Polyps	not recorded	not recorded	SRP199550	0.00
SRR12995717	Severed branch	Severed branch	regeneration day0	not recorded	SRP199550	0.00
SRR12996627	Severed branch	Severed branch	regeneration day0	not recorded	SRP199550	0.00
SRR12996628	Severed branch	Severed branch	regeneration High gene expression	not recorded	SRP199550	0.00

Source: CnidoSite RNA-seq expression matrices (AMURI_TPM, StringTie quantification over 82 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	28	amur_s0005.g19.t1	0.831878079177066
Negatively correlated	3	amur_s0022.g29.t1	-0.377811836694177

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

Dataset	Tissue / stage	Cells	Cell types	This gene	Marker of
AMURI_regen	Polyps · regeneration	8,721	28	unmapped	–

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →