Genomic Location: sc0000190_pilon:373470...412085
NR annotation: XP_044174558.1, xanthine dehydrogenase/oxidase-like [Acropora millepora]
Species Acropora muricata · all data for this species · gene families
| CDS |
| amur_s0190.g12.t1 |
| Transcript |
| amur_s0190.g12.t1 |
| Protein |
| amur_s0190.g12.t1 |
| UniProt accession | Description |
|---|---|
| P80457 | Xanthine dehydrogenase/oxidase OS=Bos taurus OX=9913 GN=XDH PE=1 SV=4 |
| P10351 | Xanthine dehydrogenase OS=Drosophila melanogaster OX=7227 GN=ry PE=2 SV=2 |
| P91711 | Xanthine dehydrogenase OS=Drosophila subobscura OX=7241 GN=Xdh PE=3 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000566 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF01315 all species → | Ald_Xan_dh_C | Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain | Domain | Interproscan |
| PF02738 all species → | MoCoBD_1 | Molybdopterin cofactor-binding domain | Domain | Interproscan |
| PF01799 all species → | Fer2_2 | [2Fe-2S] binding domain | Domain | Interproscan |
| PF00941 all species → | FAD_binding_5 | FAD binding domain in molybdopterin dehydrogenase | Family | Interproscan |
| PF20256 all species → | MoCoBD_2 | Molybdopterin cofactor-binding domain | Domain | Interproscan |
| PF00111 all species → | Fer2 | 2Fe-2S iron-sulfur cluster binding domain | Domain | Interproscan |
| PF03450 all species → | CO_deh_flav_C | CO dehydrogenase flavoprotein C-terminal domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000674 all species → | Domain | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead | Interproscan |
| IPR012675 all species → | Homologous_superfamily | Beta-grasp domain superfamily | Interproscan |
| IPR037165 all species → | Homologous_superfamily | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily | Interproscan |
| IPR036318 all species → | Homologous_superfamily | FAD-binding, type PCMH-like superfamily | Interproscan |
| IPR016169 all species → | Homologous_superfamily | FAD-binding, type PCMH, subdomain 2 | Interproscan |
| IPR001041 all species → | Domain | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Interproscan |
| IPR005107 all species → | Domain | CO dehydrogenase flavoprotein, C-terminal | Interproscan |
| IPR008274 all species → | Domain | Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain | Interproscan |
| IPR036884 all species → | Homologous_superfamily | [2Fe-2S]-binding domain superfamily | Interproscan |
| IPR036010 all species → | Homologous_superfamily | 2Fe-2S ferredoxin-like superfamily | Interproscan |
| IPR002888 all species → | Domain | [2Fe-2S]-binding | Interproscan |
| IPR002346 all species → | Domain | Molybdopterin dehydrogenase, FAD-binding | Interproscan |
| IPR016208 all species → | Family | Aldehyde oxidase/xanthine dehydrogenase-like | Interproscan |
| IPR016167 all species → | Homologous_superfamily | FAD-binding, type PCMH, subdomain 1 | Interproscan |
| IPR016166 all species → | Domain | FAD-binding domain, PCMH-type | Interproscan |
| IPR046867 all species → | Domain | Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain | Interproscan |
| IPR036683 all species → | Homologous_superfamily | CO dehydrogenase flavoprotein, C-terminal domain superfamily | Interproscan |
| IPR036856 all species → | Homologous_superfamily | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11908 all species → | XANTHINE DEHYDROGENASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0050660 all species → | Molecular Function | flavin adenine dinucleotide binding | Interproscan |
| GO:0051536 all species → | Molecular Function | iron-sulfur cluster binding | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0005506 all species → | Molecular Function | iron ion binding | Interproscan |
| GO:0071949 all species → | Molecular Function | FAD binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K00106 | XDH; xanthine dehydrogenase/oxidase | EC:1.17.1.4 EC:1.17.3.2 | Exosome | ko04147 | deepkoala |
Transcript abundance of amur_s0190.g12.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Polyps | 79 | 67 | 26.32 | 98.87 | |
| Severed branch | 3 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR27868178 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 98.87 |
| SRR27940225 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 66.12 |
| SRR27940226 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 62.77 |
| SRR27868187 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 59.69 |
| SRR27868184 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 52.39 |
| SRR12959204 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 50.82 |
| SRR12959205 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 46.53 |
| SRR12959206 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 44.56 |
| SRR27868189 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 44.53 |
| SRR27868207 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 43.19 |
| SRR27868176 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 42.66 |
| SRR27868194 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 40.92 |
| SRR27868181 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 40.78 |
| SRR27868208 | Polyps | Polyps | regeneration day9 | not recorded | SRP199550 | 39.29 |
| SRR27868188 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 39.15 |
| SRR27940224 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 36.20 |
| SRR12959220 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 36.08 |
| SRR12959195 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 36.00 |
| SRR27868174 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 35.98 |
| SRR12904784 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 35.94 |
| SRR27868179 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 35.73 |
| SRR27868199 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 35.50 |
| SRR27868206 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 35.01 |
| SRR27868200 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 34.94 |
| SRR27868186 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 34.90 |
| SRR12959219 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 33.97 |
| SRR27868165 | Polyps | Polyps | regeneration day3 | not recorded | SRP199550 | 33.17 |
| SRR27868182 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 32.63 |
| SRR27868180 | Polyps | Polyps | regeneration day36 | not recorded | SRP199550 | 32.55 |
| SRR27868197 | Polyps | Polyps | regeneration day18 | not recorded | SRP199550 | 32.38 |
| SRR12959218 | Polyps | Polyps | E2 day9 | not recorded | SRP199550 | 32.20 |
| SRR27868204 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 32.04 |
| SRR12959217 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 32.04 |
| SRR12904785 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 30.68 |
| SRR27868209 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 30.43 |
| SRR27868198 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 30.34 |
| SRR27868177 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 29.96 |
| SRR27868158 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 28.23 |
| SRR27868202 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 27.90 |
| SRR27868205 | Polyps | Polyps | regeneration day12 | not recorded | SRP199550 | 27.88 |
| SRR27868203 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 26.04 |
| SRR12959231 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 25.44 |
| SRR12959233 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 25.09 |
| SRR27868183 | Polyps | Polyps | regeneration day33 | not recorded | SRP199550 | 24.94 |
| SRR12959193 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 24.44 |
| SRR12959192 | Polyps | Polyps | E2 day21 | not recorded | SRP199550 | 23.70 |
| SRR27868193 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 22.77 |
| SRR27868210 | Polyps | Polyps | regeneration day0 | not recorded | SRP199550 | 22.30 |
| SRR27940228 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 22.29 |
| SRR12904786 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 22.09 |
| SRR12959191 | Polyps | polyps | E2 day21 | not recorded | SRP199550 | 21.19 |
| SRR27940222 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 20.27 |
| SRR12786899 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 19.37 |
| SRR27868195 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 19.17 |
| SRR27868196 | Polyps | Polyps | regeneration day21 | not recorded | SRP199550 | 19.12 |
| SRR12786901 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 18.90 |
| SRR27868192 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 17.84 |
| SRR12786900 | Polyps | Polyps | OA 2 day0 | not recorded | SRP199550 | 17.39 |
| SRR12959232 | Polyps | Polyps | E2 day3 | not recorded | SRP199550 | 15.59 |
| SRR27868160 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 14.92 |
| SRR12710849 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 11.13 |
| SRR12710851 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 10.26 |
| SRR12710850 | Polyps | Polyps | OA 2 day3 | not recorded | SRP199550 | 9.46 |
| SRR12710860 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 8.38 |
| SRR12710859 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 7.96 |
| SRR12710861 | Polyps | Polyps | OA 2 day9 | not recorded | SRP199550 | 7.23 |
| SRR27940227 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 6.85 |
| SRR12807382 | Polyps | Polyps | OA2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12927881 | Polyps | Polyps | E2 day0 | not recorded | SRP199550 | 0.00 |
| SRR12959207 | Polyps | Polyps | E2 day15 | not recorded | SRP199550 | 0.00 |
| SRR27868159 | Polyps | Polyps | regeneration day6 | not recorded | SRP199550 | 0.00 |
| SRR27868175 | Polyps | Polyps | regeneration day39 | not recorded | SRP199550 | 0.00 |
| SRR27868185 | Polyps | Polyps | regeneration day30 | not recorded | SRP199550 | 0.00 |
| SRR27868190 | Polyps | Polyps | regeneration day27 | not recorded | SRP199550 | 0.00 |
| SRR27868191 | Polyps | Polyps | regeneration day24 | not recorded | SRP199550 | 0.00 |
| SRR27868201 | Polyps | Polyps | regeneration day15 | not recorded | SRP199550 | 0.00 |
| SRR27940229 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613488 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR9613516 | Polyps | Polyps | not recorded | not recorded | SRP199550 | 0.00 |
| SRR12995717 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996627 | Severed branch | Severed branch | regeneration day0 | not recorded | SRP199550 | 0.00 |
| SRR12996628 | Severed branch | Severed branch | regeneration High gene expression | not recorded | SRP199550 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (AMURI_TPM,
StringTie quantification over 82 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 15 | amur_s0043.g86.t1 | 0.790329198520968 |
| Negatively correlated | 5 | amur_s3760.g1.t1 | -0.285469687655219 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| AMURI_regen | Polyps · regeneration | 8,721 | 28 | unmapped | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |