Detailed information of amur_s0225.g27.t1 in Acropora muricata

Genomic Location: sc0000225_pilon:299510...331295
NR annotation: XP_029211671.2, methionine synthase-like [Acropora millepora]
Species Acropora muricata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q99707Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2
Q9Z2Q4Methionine synthase OS=Rattus norvegicus OX=10116 GN=Mtr PE=1 SV=1
Q4JIJ3Methionine synthase OS=Bos taurus OX=9913 GN=MTR PE=2 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0002666 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF02965
all species →		Met_synt_B12Vitamin B12 dependent methionine synthase, activation domainDomainInterproscan
PF00809
all species →		Pterin_bindPterin binding enzymeDomainInterproscan
PF02310
all species →		B12-bindingB12 binding domainDomainInterproscan
PF02607
all species →		B12-binding_2B12 binding domainDomainInterproscan
PF02574
all species →		S-methyl_transHomocysteine S-methyltransferaseFamilyInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR003759
all species →		DomainCobalamin (vitamin B12)-binding module, cap domainInterproscan
IPR036594
all species →		Homologous_superfamilyMethionine synthase domainInterproscan
IPR011005
all species →		Homologous_superfamilyDihydropteroate synthase-like superfamilyInterproscan
IPR011822
all species →		FamilyCobalamin-dependent methionine synthaseInterproscan
IPR033706
all species →		DomainMethionine synthase, B12-binding domainInterproscan
IPR004223
all species →		DomainVitamin B12-dependent methionine synthase, activation domainInterproscan
IPR006158
all species →		DomainCobalamin (vitamin B12)-binding domainInterproscan
IPR000489
all species →		DomainPterin-binding domainInterproscan
IPR037010
all species →		Homologous_superfamilyVitamin B12-dependent methionine synthase, activation domain superfamilyInterproscan
IPR050554
all species →		FamilyMethionine Synthase/CorrinoidInterproscan
IPR036724
all species →		Homologous_superfamilyCobalamin-binding domain superfamilyInterproscan
IPR036589
all species →		Homologous_superfamilyHomocysteine-binding domain superfamilyInterproscan
IPR003726
all species →		DomainHomocysteine-binding domainInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR45833
all species →		METHIONINE SYNTHASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0044237
all species →		Biological Processobsolete cellular metabolic processInterproscan
GO:0008270
all species →		Molecular Functionzinc ion bindingInterproscan
GO:0008705
all species →		Molecular Functionmethionine synthase activityInterproscan
GO:0009086
all species →		Biological Processmethionine biosynthetic processInterproscan
GO:0031419
all species →		Molecular Functioncobalamin bindingInterproscan
GO:0046872
all species →		Molecular Functionmetal ion bindingInterproscan
GO:0042558
all species →		Biological Processpteridine-containing compound metabolic processInterproscan
GO:0005829
all species →		Cellular ComponentcytosolInterproscan
GO:0046653
all species →		Biological Processtetrahydrofolate metabolic processInterproscan
GO:0050667
all species →		Biological Processhomocysteine metabolic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K00548metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferaseEC:2.1.1.13
Cobalamin transport and metabolismko04980deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of amur_s0225.g27.t1 across 82 RNA-seq samples of Acropora muricata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

82Samples
72TPM > 0
2Conditions
97.5Max TPM
31.7Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Polyps 79 72 32.92 97.50
Severed branch 3 0 0.00 0.00

Per sample · hover a bar for the full sample record

Show the sample table (82 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR27868165 Polyps Polyps regeneration day3 not recorded SRP199550 97.50
SRR12959206 Polyps Polyps E2 day0 not recorded SRP199550 91.37
SRR27868185 Polyps Polyps regeneration day30 not recorded SRP199550 81.47
SRR27868186 Polyps Polyps regeneration day30 not recorded SRP199550 68.42
SRR27868193 Polyps Polyps regeneration day24 not recorded SRP199550 53.06
SRR27868176 Polyps Polyps regeneration day3 not recorded SRP199550 52.66
SRR27868205 Polyps Polyps regeneration day12 not recorded SRP199550 51.38
SRR27868207 Polyps Polyps regeneration day9 not recorded SRP199550 51.25
SRR27868188 Polyps Polyps regeneration day27 not recorded SRP199550 50.29
SRR27868180 Polyps Polyps regeneration day36 not recorded SRP199550 49.77
SRR27868187 Polyps Polyps regeneration day3 not recorded SRP199550 49.17
SRR12959204 Polyps Polyps E2 day15 not recorded SRP199550 49.02
SRR27868177 Polyps Polyps regeneration day39 not recorded SRP199550 48.76
SRR12959217 Polyps Polyps E2 day0 not recorded SRP199550 48.03
SRR12959195 Polyps Polyps E2 day0 not recorded SRP199550 47.49
SRR27868208 Polyps Polyps regeneration day9 not recorded SRP199550 46.93
SRR12959205 Polyps Polyps E2 day15 not recorded SRP199550 46.72
SRR27868189 Polyps Polyps regeneration day27 not recorded SRP199550 44.24
SRR27868181 Polyps Polyps regeneration day33 not recorded SRP199550 43.09
SRR27940226 Polyps Polyps not recorded not recorded SRP199550 41.59
SRR27868183 Polyps Polyps regeneration day33 not recorded SRP199550 40.63
SRR27868206 Polyps Polyps regeneration day12 not recorded SRP199550 39.99
SRR27868204 Polyps Polyps regeneration day12 not recorded SRP199550 39.97
SRR27868179 Polyps Polyps regeneration day36 not recorded SRP199550 38.88
SRR27868197 Polyps Polyps regeneration day18 not recorded SRP199550 38.58
SRR27868200 Polyps Polyps regeneration day18 not recorded SRP199550 38.35
SRR12959220 Polyps Polyps E2 day9 not recorded SRP199550 36.97
SRR12959219 Polyps Polyps E2 day9 not recorded SRP199550 36.94
SRR27868174 Polyps Polyps regeneration day39 not recorded SRP199550 36.17
SRR27868202 Polyps Polyps regeneration day15 not recorded SRP199550 36.11
SRR27868158 Polyps Polyps regeneration day6 not recorded SRP199550 36.05
SRR12959218 Polyps Polyps E2 day9 not recorded SRP199550 35.89
SRR27868178 Polyps Polyps regeneration day36 not recorded SRP199550 34.51
SRR12959192 Polyps Polyps E2 day21 not recorded SRP199550 33.37
SRR27868199 Polyps Polyps regeneration day18 not recorded SRP199550 32.97
SRR27868203 Polyps Polyps regeneration day15 not recorded SRP199550 32.84
SRR12959191 Polyps polyps E2 day21 not recorded SRP199550 32.19
SRR12959231 Polyps Polyps E2 day3 not recorded SRP199550 32.10
SRR27868194 Polyps Polyps regeneration day21 not recorded SRP199550 31.79
SRR12959232 Polyps Polyps E2 day3 not recorded SRP199550 31.71
SRR27868201 Polyps Polyps regeneration day15 not recorded SRP199550 30.75
SRR12959193 Polyps Polyps E2 day21 not recorded SRP199550 30.61
SRR27868190 Polyps Polyps regeneration day27 not recorded SRP199550 30.55
SRR27868159 Polyps Polyps regeneration day6 not recorded SRP199550 29.65
SRR12959233 Polyps Polyps E2 day3 not recorded SRP199550 29.51
SRR27868192 Polyps Polyps regeneration day24 not recorded SRP199550 29.47
SRR12786899 Polyps Polyps OA 2 day0 not recorded SRP199550 29.10
SRR27868182 Polyps Polyps regeneration day33 not recorded SRP199550 28.50
SRR27868209 Polyps Polyps regeneration day0 not recorded SRP199550 27.51
SRR27868195 Polyps Polyps regeneration day21 not recorded SRP199550 27.48
SRR12904785 Polyps Polyps not recorded not recorded SRP199550 27.24
SRR27940225 Polyps Polyps not recorded not recorded SRP199550 27.16
SRR27940222 Polyps Polyps not recorded not recorded SRP199550 26.69
SRR27940224 Polyps Polyps not recorded not recorded SRP199550 26.48
SRR12904784 Polyps Polyps not recorded not recorded SRP199550 26.38
SRR12786900 Polyps Polyps OA 2 day0 not recorded SRP199550 25.79
SRR12786901 Polyps Polyps OA 2 day0 not recorded SRP199550 25.33
SRR12710851 Polyps Polyps OA 2 day3 not recorded SRP199550 24.28
SRR27868160 Polyps Polyps regeneration day6 not recorded SRP199550 23.96
SRR27940227 Polyps Polyps not recorded not recorded SRP199550 23.90
SRR27868196 Polyps Polyps regeneration day21 not recorded SRP199550 23.27
SRR12710850 Polyps Polyps OA 2 day3 not recorded SRP199550 23.03
SRR12710849 Polyps Polyps OA 2 day3 not recorded SRP199550 21.64
SRR27868210 Polyps Polyps regeneration day0 not recorded SRP199550 20.75
SRR27940228 Polyps Polyps not recorded not recorded SRP199550 20.74
SRR12904786 Polyps Polyps not recorded not recorded SRP199550 20.59
SRR27868184 Polyps Polyps regeneration day30 not recorded SRP199550 19.52
SRR27868175 Polyps Polyps regeneration day39 not recorded SRP199550 17.24
SRR27868198 Polyps Polyps regeneration day0 not recorded SRP199550 16.30
SRR12710861 Polyps Polyps OA 2 day9 not recorded SRP199550 15.10
SRR12710860 Polyps Polyps OA 2 day9 not recorded SRP199550 11.96
SRR12710859 Polyps Polyps OA 2 day9 not recorded SRP199550 11.78
SRR12807382 Polyps Polyps OA2 day0 not recorded SRP199550 0.00
SRR12927881 Polyps Polyps E2 day0 not recorded SRP199550 0.00
SRR12959207 Polyps Polyps E2 day15 not recorded SRP199550 0.00
SRR27868191 Polyps Polyps regeneration day24 not recorded SRP199550 0.00
SRR27940229 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9613488 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR9613516 Polyps Polyps not recorded not recorded SRP199550 0.00
SRR12995717 Severed branch Severed branch regeneration day0 not recorded SRP199550 0.00
SRR12996627 Severed branch Severed branch regeneration day0 not recorded SRP199550 0.00
SRR12996628 Severed branch Severed branch regeneration High gene expression not recorded SRP199550 0.00

Source: CnidoSite RNA-seq expression matrices (AMURI_TPM, StringTie quantification over 82 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated42amur_s0329.g26.t10.810676159035636
Negatively correlated3amur_s0022.g29.t1-0.312214387188144

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

DatasetTissue / stageCellsCell typesThis geneMarker of
AMURI_regenPolyps · regeneration8,72128unmapped–

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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